An electronic circuit has been designed to mimic glycolysis, the Citric Acid (TCA) cycle and the electron transport chain. Enzymes play a vital role in metabolic pathways; similarly transistors play a vital role in e...An electronic circuit has been designed to mimic glycolysis, the Citric Acid (TCA) cycle and the electron transport chain. Enzymes play a vital role in metabolic pathways; similarly transistors play a vital role in electronic circuits; the characteristics of enzymes in comparison with those of transistors suggests that the properties are analagous. Enzymes possess an active site into which the substrate binds, similarly the transistor possess a layer in which the recombination of holes and electrons takes place. Hence the applied voltage in the circuit is considered as the substrate. The enthalpy values of the enzymes are converted into volts, which is to be applied to the circuit. ATP is the energy source in the metabolic pathway which functions like a potential in the electronic circuit. Some enzymes can function only with the help of a cofactor; here modelled as a switch. Using all the above electronic circuit analogues, which possess the similar characteristics of the metabolic pathway constituents, circuits have been designed.展开更多
Spectroscopy is a crucial laboratory technique for understanding quantum systems through their interactions with the electromagnetic radiation.Particularly,spectroscopy is capable of revealing the physical structure o...Spectroscopy is a crucial laboratory technique for understanding quantum systems through their interactions with the electromagnetic radiation.Particularly,spectroscopy is capable of revealing the physical structure of molecules,leading to the development of the maser—the forerunner of the laser.However,real-world applications of molecular spectroscopy are mostly confined to equilibrium states,due to computational and technological constraints;a potential breakthrough can be achieved by utilizing the emerging technology of quantum simulation.Here we experimentally demonstrate through a toy model,a superconducting quantum simulator capable of generating molecular spectra for both equilibrium and non-equilibrium states,reliably producing the vibronic structure of diatomic molecules.Furthermore,our quantum simulator is applicable not only to molecules with a wide range of electronic-vibronic coupling strength,characterized by the Huang-Rhys parameter,but also to molecular spectra not readily accessible under normal laboratory conditions.These results point to a new direction for predicting and understanding molecular spectroscopy,exploiting the power of quantum simulation.展开更多
文摘An electronic circuit has been designed to mimic glycolysis, the Citric Acid (TCA) cycle and the electron transport chain. Enzymes play a vital role in metabolic pathways; similarly transistors play a vital role in electronic circuits; the characteristics of enzymes in comparison with those of transistors suggests that the properties are analagous. Enzymes possess an active site into which the substrate binds, similarly the transistor possess a layer in which the recombination of holes and electrons takes place. Hence the applied voltage in the circuit is considered as the substrate. The enthalpy values of the enzymes are converted into volts, which is to be applied to the circuit. ATP is the energy source in the metabolic pathway which functions like a potential in the electronic circuit. Some enzymes can function only with the help of a cofactor; here modelled as a switch. Using all the above electronic circuit analogues, which possess the similar characteristics of the metabolic pathway constituents, circuits have been designed.
文摘以壳聚糖为功能基体、吡虫啉(imidacloprid,IMI)为模板分子、戊二醛为交联剂,应用恒电位沉积法制备了分子印迹电极并构建了吡虫啉印迹传感器(IMI-MIP/F-CNTs/GCE)。利用循环伏安法(cyclic voltammetry,CV)、差分脉冲伏安法(differential pulse voltammetry,DPV)及交流阻抗法(electrochemical impedance spectroscopy,EIS)考察了新型传感器对吡虫啉的检测性能并构建等效电路模型。结果表明:成功制备了新型分子印迹电化学传感器;传感器表观表面积比裸电极显著提高;新型传感器具有良好的印迹效果,相较于其他结构类似的烟碱化合物(如啶虫脒等),IMIMIP/F-CNTs/GCE对吡虫啉表现出高效的选择识别能力,且在cI M I≤1.0×10-6mol/L范围内传感器峰电流与cI M I存在定量关系;数据模拟分析获得传感器电学阻抗谱等效电路模型为R1(C1(R2(CPE2(R3)))),计算等效电路各元件参数证明该模型能有效模拟传感器检测吡虫啉的传感机理。所得结果可为烟碱类农药残留检测提供一种新的分析方法,为农药残留检测传感器分析机理研究提供有益参考。
基金the Guangdong Innovative and En-trepreneurial Research Team Program(2016ZT06D348)the Science Technology and Innovation Commission of Shenzhen Municipality(ZDSYS20170303165926217 and JCYJ20170412152620376)+1 种基金the support from the National Natural Science Foundation of China(11474177)the 1000 Youth Fellowship Program in China
文摘Spectroscopy is a crucial laboratory technique for understanding quantum systems through their interactions with the electromagnetic radiation.Particularly,spectroscopy is capable of revealing the physical structure of molecules,leading to the development of the maser—the forerunner of the laser.However,real-world applications of molecular spectroscopy are mostly confined to equilibrium states,due to computational and technological constraints;a potential breakthrough can be achieved by utilizing the emerging technology of quantum simulation.Here we experimentally demonstrate through a toy model,a superconducting quantum simulator capable of generating molecular spectra for both equilibrium and non-equilibrium states,reliably producing the vibronic structure of diatomic molecules.Furthermore,our quantum simulator is applicable not only to molecules with a wide range of electronic-vibronic coupling strength,characterized by the Huang-Rhys parameter,but also to molecular spectra not readily accessible under normal laboratory conditions.These results point to a new direction for predicting and understanding molecular spectroscopy,exploiting the power of quantum simulation.
