We study the coutrol of gate voltage over the magnetization of a single-molecule magnet (SMM) weakly coupled to a ferromagnetic and a normal metal electrode in the presence of the temperature gradient between two el...We study the coutrol of gate voltage over the magnetization of a single-molecule magnet (SMM) weakly coupled to a ferromagnetic and a normal metal electrode in the presence of the temperature gradient between two electrodes. It is demonstrated that the SMM's magnetization can change periodically with periodic gate voltage due to the driving oI the temperature gradient. Under an appropriate matching of the electrode polarization, the temperature difference and the pulse width of gate voltage, the SMM's magnetization can be completely reversed in a period of gate voltage. The corresponding flipping time can be controlled by the system parameters. In addition, we also investigate the tunneling anisotropic magnetoresistance (TAMFt) of the device in the steady state when the ferromagnetic electrode is noncollinear with the easy axis of the SMM, and show the jump characteristic of the TAMR.展开更多
Owing to the bistable character of the single molecular magnet (SMM), it can generate 100% spin-polarized currents even connected with normal (N) leads. In this work, we study the phonon-assisted spin current in N...Owing to the bistable character of the single molecular magnet (SMM), it can generate 100% spin-polarized currents even connected with normal (N) leads. In this work, we study the phonon-assisted spin current in N- SMM-N systems. We mainly focus on the interplay of SMM's bistable character and electron-phonon coupling. It is found that when SMM is trapped in one of the lowest bistable states, it can generate phonon-assisted spin- polarized currents. At the up-spin transport channel, it is accompanied by a phonon-assisted up-spin current, while at the down-spin transport channel, it is accompanied by a phonon-assisted down-spin current.展开更多
We investigate global entanglement in the ground state of single-molecular magnet Na9[Cu3Na3(H2O)9(α- AsW9O33)2]-26H2O with an external magnetic field. The concurrence, tangle, and measure function Q, which chara...We investigate global entanglement in the ground state of single-molecular magnet Na9[Cu3Na3(H2O)9(α- AsW9O33)2]-26H2O with an external magnetic field. The concurrence, tangle, and measure function Q, which characterize the pairwise entanglement, 3-party entanglement and total entanglement, respectively, are calculated numerically at zero temperature. The results show that the magnitude and direction of the applied magnetic field play a significant role in the properties of three kinds of entanglement measures. We give a physical interpretation of the variation of the global entanglement with the magnetic field. Finally, the phase diagram of the global entanglement characterized by the critical magnetic fields is presented.展开更多
We investigate the formation of optical bistabifity (OB) in a crystal of molecular magnets contained in aunidirectional ring cavity.The crystal is subjected to one dc magnetic field and two (probe and coupling) ac res...We investigate the formation of optical bistabifity (OB) in a crystal of molecular magnets contained in aunidirectional ring cavity.The crystal is subjected to one dc magnetic field and two (probe and coupling) ac resonantmagnetic field.The results show that OB can be controlled efficiently by adjusting the intensity of the control field,the detuning of probe magnetic field and the cooperation parameter.FUrthermore,within certain parameter range,theoptical multistablity (OM) can also be observed in the crystal medium.This investigation can be used for designing newtypes of nonelectronic devices for realizing switching process.展开更多
The macroscopic quantum coherence in a biaxial antiferromagnetic molecular magnet in the presence of magnetic field acting parallel to its hard anisotropy axis is studied within the two-sublattice model. On the basis ...The macroscopic quantum coherence in a biaxial antiferromagnetic molecular magnet in the presence of magnetic field acting parallel to its hard anisotropy axis is studied within the two-sublattice model. On the basis of instanton technique in the spin-coherent-state path-integral representation, both the rigorous Wentzel-Kramers-Brillouin exponent and pre-exponential factor for the ground-state tunnel splitting are obtained. We find that the quantum fluctuations around the classical paths can not only induce a new quantum phase previously reported by Chiolero and Loss (Phys. Rev. Lett. 80 (1998) 169), but also have great influence on the intensity of the ground-state tunnel splitting. Those features clearly have no analogue in the ferromagnetic molecular magnets. We suggest that they may be the universal behaviors in all antiferromagnetic molecular magnets. The analytical results are complemented by exact diagonalization calculation.展开更多
Quantum phase interference and spin-parity effects are studied in biaxial molecular magnets in a magnetic field at an arbitrarily directed angle. The calculations of the ground-state tunnel splitting are performed on ...Quantum phase interference and spin-parity effects are studied in biaxial molecular magnets in a magnetic field at an arbitrarily directed angle. The calculations of the ground-state tunnel splitting are performed on the basis of the instanton technique in the spin-coherent-state path-integral representation, and complemented by exactly numerical diagonalization. Both the Wentzel-Kramers-Brillouin exponent and the pre-exponential factor are obtained for the entire region of the direction of the field. Our results show that the tunnel splitting oscillates with the field for the small field angle, while for the large field angle the oscillation is completely suppressed. This distinct angular dependence, together with the dependence of the tunnel splitting on the field strength, provides an independent test for spin-parity effects in biaxial molecular magnets. The analytical results for the molecular Fes magnet are found to be in good agreement with the numerical simulations, which suggests that even the molecular magnet with total spin S = 10 is large enough to be treated as a giant spin system.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)ranks second in terms of cancer mortality worldwide.Molecular magnetic resonance imaging(MRI)targeting HCC biomarkers such as alpha-fetoprotein(AFP)or glypican-3(GPC3)offers new...BACKGROUND Hepatocellular carcinoma(HCC)ranks second in terms of cancer mortality worldwide.Molecular magnetic resonance imaging(MRI)targeting HCC biomarkers such as alpha-fetoprotein(AFP)or glypican-3(GPC3)offers new strategies to enhance specificity and help early diagnosis of HCC.However,the existing iron oxide nanoparticle-based MR molecular probes singly target AFP or GPC3,which may hinder their efficiency to detect heterogeneous micro malignant HCC tumors<1 cm(MHCC).We hypothesized that the strategy of double antibody-conjugated iron oxide nanoparticles which simultaneously target AFP and GPC3 antigens may potentially be used to overcome the tumor heterogeneity and enhance the detection rate for MRI-based MHCC diagnosis.AIM To synthesize an AFP/GPC3 double antibody-labeled iron oxide MRI molecular probe and to assess its impact on MRI specificity and sensitivity at the cellular level.METHODS A double antigen-targeted MRI probe for MHCC anti-AFP-USPIO-anti-GPC3(UAG)was developed by simultaneously conjugating AFP andGPC3 antibodies to a 5 nm ultra-small superparamagnetic iron oxide nanoparticle(USPIO).At the same time,the singly labeled probes of anti-AFP-USPIO(UA)and anti-GPC3-USPIO(UG)and non-targeted USPIO(U)were also prepared for comparison.The physical characterization including morphology(transmission electron microscopy),hydrodynamic size,and zeta potential(dynamic light scattering)was conducted for each of the probes.The antigen targeting and MRI ability for these four kinds of USPIO probes were studied in the GPC3-expressing murine hepatoma cell line Hepa1-6/GPC3.First,AFP and GPC3 antigen expression in Hepa1-6/GPC3 cells was confirmed by flow cytometry and immunocytochemistry.Then,the cellular uptake of USPIO probes was investigated by Prussian blue staining assay and in vitro MRI(T2-weighted and T2-map)with a 3.0 Tesla clinical MR scanner.RESULTS Our data showed that the double antibody-conjugated probe UAG had the best specificity in targeting Hepa1-6/GPC3 cells expressing AFP and GPC3 antigens compared with single antibody-conjugated and unconjugated USPIO probes.The iron Prussian blue staining and quantitative T2-map MRI analysis showed that,compared with UA,UG,and U,the uptake of double antigen-targeted UAG probe demonstrated a 23.3%(vs UA),15.4%(vs UG),and 57.3%(vs U)increased Prussian stained cell percentage and a 14.93%(vs UA),9.38%(vs UG),and 15.3%(vs U)reduction of T2 relaxation time,respectively.Such bi-specific probe might have the potential to overcome tumor heterogeneity.Meanwhile,the coupling of two antibodies did not influence the magnetic performance of USPIO,and the relatively small hydrodynamic size(59.60±1.87 nm)of double antibodyconjugated USPIO probe makes it a viable candidate for use in MHCC MRI in vivo,as they are slowly phagocytosed by macrophages.CONCLUSION The bi-specific probe presents enhanced targeting efficiency and MRI sensitivity to HCC cells than singly-or non-targeted USPIO,paving the way for in vivo translation to further evaluate its clinical potential.展开更多
Current and displacement stiffness are important parameters of axial magnetic bearing(AMB)and are usually considered as constants for the control system.However,in actual dynamic work situations,time-varying force lea...Current and displacement stiffness are important parameters of axial magnetic bearing(AMB)and are usually considered as constants for the control system.However,in actual dynamic work situations,time-varying force leads to time-varying currents and air gap with a specific frequency,which makes the stiffness of appear decrease and even worsens control performance for the whole system.In this paper,an AMB dynamic stiffness model considering the flux variation across the air gap due to frequency is established to obtain the accurate dynamic stiffness.The dynamic stiffness characteristics are analyzed by means of the dynamic equivalent magnetic circuit method.The analytical results show that the amplitude of current and displacement stiffness decreases with frequency increasing.Moreover,compared with the stiffness model without considering the variation of flux density across the air gap,the improved dynamic stiffness results are closer to the actual results.Through the dynamic stiffness measurement method of AMB,experiments of AMB in magnetically suspended molecular pump(MSMP)are carried out and the experimental results are consistent with theoretical analysis results.This paper proposes the dynamic stiffness model of axial magnetic bearing considering the variation of flux density across the air gap,which improves the accuracy of the AMB stiffness analysis.展开更多
"Personalized oncology" is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing..."Personalized oncology" is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing need to provide functional information in addition to the morphological data; has led to leaping progress in the field of imaging. Magnetic resonance imaging has undergone tremendous progress with various newer MR techniques providing vital functional information and is becoming the cornerstone of "radiomics/radiogenomics". Diffusionweighted imaging is one such technique which capitalizes on the tendency of water protons to diffuse randomly in a given system. This technique has revolutionized oncological imaging, by giving vital qualitative and quantitative information regarding tumor biology which helps in detection, characterization and post treatment surveillance of the lesions and challenging the notion that "one size fits all". It has been applied at various sites with different clinical experience. We hereby present a brief review of this novel functional imaging tool, with its application in "personalized oncology".展开更多
As an improvement on our previous work [J. Phys. B: At. Mol. Opt. Phys. 45 085101(2012)], an accurate method combining the spheroidal coordinates and B-spline basis is applied to study the ground state 1σg and low...As an improvement on our previous work [J. Phys. B: At. Mol. Opt. Phys. 45 085101(2012)], an accurate method combining the spheroidal coordinates and B-spline basis is applied to study the ground state 1σg and low excited states1σu, 1πg,u, 1δg,u, 2σg of the H+2in magnetic fields ranging from 10^9Gs(1 Gs = 10^-4T) to 4.414 × 10^13 Gs. Comparing the one-center method used in our previous work, the present method has a higher precision with a shorter computing time.Equilibrium distances of the states of the H+2in strong magnetic fields were found to be accurate to 3-5 significant digits(s.d.) and the total energies 6-11 s.d., even for some antibonding state, such as 1πg, which is difficult for the one-center method to give reliable results while the field strength is B ≥ 10^13 Gs. For the large disagreement in previous works, such as the equilibrium distances of the 1πg state at B = 10^9 Gs, the present data may be used as a reference. Further, the potential energy curves(PECs) and the electronic probability density distributions(EPDDs) of the bound states 1σg, 1πu, 1δg and antibonding states 1σu, 1πg, 1δu for B = 1, 10, 100, 1000 a.u.(atomic unit) are compared, so that the different influences of the magnetic fields on the chemical bonds of the bound states and antibonding states are discussed in detail.展开更多
In this paper, we present the critical mass of magnetized, turbulent and rotating star-forming molecular cloud core (MCc) in the presence of magnetic tension. The critical mass of star-forming magnetized cloud is infl...In this paper, we present the critical mass of magnetized, turbulent and rotating star-forming molecular cloud core (MCc) in the presence of magnetic tension. The critical mass of star-forming magnetized cloud is influenced by the magnetic tension, magnetic pressure and other pressures. Applying the method of theoretical modelling by taking into account the basic equations and assumptions, we formulate the critical mass of magnetized MCc in different cases. Accordingly, the minimum critical masses we find in both cases are different. Energy due to magnetic tension significantly triggers the collapse at relatively larger radius of the core. The model shows that when the initial radius of the parent cloud (Ro) is larger than that of collapsing core radius (Rcore) the magnetic tension also has the larger radius of curvature, so it plays a significant role in supporting gravity to collapse the core. The results indicate gravity without magnetic tension may not overcome magnetic pressure, turbulence pressure and pressure due to rotation. This shows the critical mass of MCc for the collapse depends on the tension force that magnetic field lines apply on the envelope. We conclude that if there is magnetic pressure in star-forming MCc, there is also unavoidable magnetic tension, which triggers the collapse of the core. If there is no magnetic tension, the magnetized MCc needs relatively larger mass and higher density within the small size to collapse.展开更多
The structural and magnetic properties of Fe80P9B11 amorphous alloy are investigated through ab initio molecular dynamic simulation. The structure evolution of Fe(80)P9B(11) amorphous alloy can be described in the...The structural and magnetic properties of Fe80P9B11 amorphous alloy are investigated through ab initio molecular dynamic simulation. The structure evolution of Fe(80)P9B(11) amorphous alloy can be described in the framework of topological fluctuation theory, and the fluctuation of atomic hydrostatic stress gradually decreases upon cooling. The left sub peak of the second peak of Fe–B partial pair distribution functions(PDFs) becomes pronounced below the glass transition temperature, which may be the major reason why B promotes the glass formation ability significantly. The magnetization mainly originates from Fe 3d states, while small contribution results from metalloid elements P and B. This work may be helpful for developing Fe-based metallic glasses with both high saturation flux density and glass formation ability.展开更多
利用溶剂热法制备纳米Fe 3 O 4,并将其分散在正硅酸乙酯(TEOS)水解液中,在表面沉积一层SiO_(2).用甲基丙烯酰氧基丙基三甲氧基硅烷(MPS)对SiO_(2)-Fe 3 O 4表面改性,得到MPS-SiO_(2)-Fe 3 O 4.将甲基丙烯酸(MAA)与己烯雌酚(DES)以摩尔比...利用溶剂热法制备纳米Fe 3 O 4,并将其分散在正硅酸乙酯(TEOS)水解液中,在表面沉积一层SiO_(2).用甲基丙烯酰氧基丙基三甲氧基硅烷(MPS)对SiO_(2)-Fe 3 O 4表面改性,得到MPS-SiO_(2)-Fe 3 O 4.将甲基丙烯酸(MAA)与己烯雌酚(DES)以摩尔比4∶1加入乙腈溶剂中,进行12 h自组装,再加入MPS-SiO_(2)-Fe 3 O 4、乙二醇二甲基丙烯酸酯(EGDMA)和偶氮二异丁腈(AIBN),进行超声分散30 min,65℃条件下机械搅拌,反应24 h,制得DES磁性分子印迹聚合物(MMIP).采用透射电镜、振动样品磁强计和吸附试验等方法进行表征分析.结果表明:MMIP的饱和磁化强度为268 kA/m,无磁滞现象,矫顽力为0,表现出超顺磁性,在磁铁作用下17 s就可与溶液分离;室温下,MMIP对DES的静态最大吸附量为7.1 mg/g,动态吸附时MMIP在60 min时可以达到静态最大吸附量的90%以上;MMIP对DES的印迹因子为3.70,因而对DES有较大的识别能力;MMIP可重复使用6次以上,具有良好的再生循环性能.展开更多
The chemical structure of heavy oil fractions obtained by liquid-solid adsorption chromatography was character-ized by 1 H nuclear magnetic resonance and X-ray diffraction.The molecular weight and molecular formula of...The chemical structure of heavy oil fractions obtained by liquid-solid adsorption chromatography was character-ized by 1 H nuclear magnetic resonance and X-ray diffraction.The molecular weight and molecular formula of asphaltene molecules were estimated by combining 1 H nuclear magnetic resonance and X-ray diffraction analyses,and were also ob-tained from vapor pressure osmometry and elemental analysis.Heteroatoms,such as S,N,and O atoms,were considered in the construction of average molecular structure of heavy oils.Two important structural parameters were proposed,including the number of alkyl chain substituents to aromatic rings and the number of total rings with heteroatoms.Ultimately,the av-erage molecular structures of polycyclic aromatics,heavy resins and asphaltene molecules were constructed.The number of α-,β-,γ-,and aromatic hydrogen atoms of the constructed average molecular structures fits well with the number of hydro-gen atoms derived from the experimental spectral data.展开更多
基金Supported by the National Natural Science Foundation of China under Grant No 11274208
文摘We study the coutrol of gate voltage over the magnetization of a single-molecule magnet (SMM) weakly coupled to a ferromagnetic and a normal metal electrode in the presence of the temperature gradient between two electrodes. It is demonstrated that the SMM's magnetization can change periodically with periodic gate voltage due to the driving oI the temperature gradient. Under an appropriate matching of the electrode polarization, the temperature difference and the pulse width of gate voltage, the SMM's magnetization can be completely reversed in a period of gate voltage. The corresponding flipping time can be controlled by the system parameters. In addition, we also investigate the tunneling anisotropic magnetoresistance (TAMFt) of the device in the steady state when the ferromagnetic electrode is noncollinear with the easy axis of the SMM, and show the jump characteristic of the TAMR.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11504210,11504211,11504212,11274207,11274208,11174115 and 11325417the Key Program of the Ministry of Education of China under Grant No 212018+2 种基金Shanxi Provincial Scientific and Technological Project(2015031002-2)Shanxi Provincial Natural Science Foundation under Grant Nos2013011007-2 and 2013021010-5Outstanding Innovative Teams of Higher Learning Institutions of Shanxi Province
文摘Owing to the bistable character of the single molecular magnet (SMM), it can generate 100% spin-polarized currents even connected with normal (N) leads. In this work, we study the phonon-assisted spin current in N- SMM-N systems. We mainly focus on the interplay of SMM's bistable character and electron-phonon coupling. It is found that when SMM is trapped in one of the lowest bistable states, it can generate phonon-assisted spin- polarized currents. At the up-spin transport channel, it is accompanied by a phonon-assisted up-spin current, while at the down-spin transport channel, it is accompanied by a phonon-assisted down-spin current.
基金supported by the National Natural Science Foundation of China(Grant No.11274102)the Program for New Century Excellent Talents in Universities,China(Grant No.NCET-11-0960)the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20134208110001)
文摘We investigate global entanglement in the ground state of single-molecular magnet Na9[Cu3Na3(H2O)9(α- AsW9O33)2]-26H2O with an external magnetic field. The concurrence, tangle, and measure function Q, which characterize the pairwise entanglement, 3-party entanglement and total entanglement, respectively, are calculated numerically at zero temperature. The results show that the magnitude and direction of the applied magnetic field play a significant role in the properties of three kinds of entanglement measures. We give a physical interpretation of the variation of the global entanglement with the magnetic field. Finally, the phase diagram of the global entanglement characterized by the critical magnetic fields is presented.
基金National Natural Science Foundation of China under Grant Nos.10575040,90503010,and 10747133
文摘We investigate the formation of optical bistabifity (OB) in a crystal of molecular magnets contained in aunidirectional ring cavity.The crystal is subjected to one dc magnetic field and two (probe and coupling) ac resonantmagnetic field.The results show that OB can be controlled efficiently by adjusting the intensity of the control field,the detuning of probe magnetic field and the cooperation parameter.FUrthermore,within certain parameter range,theoptical multistablity (OM) can also be observed in the crystal medium.This investigation can be used for designing newtypes of nonelectronic devices for realizing switching process.
文摘The macroscopic quantum coherence in a biaxial antiferromagnetic molecular magnet in the presence of magnetic field acting parallel to its hard anisotropy axis is studied within the two-sublattice model. On the basis of instanton technique in the spin-coherent-state path-integral representation, both the rigorous Wentzel-Kramers-Brillouin exponent and pre-exponential factor for the ground-state tunnel splitting are obtained. We find that the quantum fluctuations around the classical paths can not only induce a new quantum phase previously reported by Chiolero and Loss (Phys. Rev. Lett. 80 (1998) 169), but also have great influence on the intensity of the ground-state tunnel splitting. Those features clearly have no analogue in the ferromagnetic molecular magnets. We suggest that they may be the universal behaviors in all antiferromagnetic molecular magnets. The analytical results are complemented by exact diagonalization calculation.
文摘Quantum phase interference and spin-parity effects are studied in biaxial molecular magnets in a magnetic field at an arbitrarily directed angle. The calculations of the ground-state tunnel splitting are performed on the basis of the instanton technique in the spin-coherent-state path-integral representation, and complemented by exactly numerical diagonalization. Both the Wentzel-Kramers-Brillouin exponent and the pre-exponential factor are obtained for the entire region of the direction of the field. Our results show that the tunnel splitting oscillates with the field for the small field angle, while for the large field angle the oscillation is completely suppressed. This distinct angular dependence, together with the dependence of the tunnel splitting on the field strength, provides an independent test for spin-parity effects in biaxial molecular magnets. The analytical results for the molecular Fes magnet are found to be in good agreement with the numerical simulations, which suggests that even the molecular magnet with total spin S = 10 is large enough to be treated as a giant spin system.
基金Supported by CAMS Innovation Fund for Medical Sciences,No.2016-I2M-1-001PUMC Youth Fund,No.2017320010+1 种基金Chinese Academy of Medical Sciences Research Fund,No.ZZ2016B01Beijing HopeRun Special Fund of Cancer Foundation of China,No.LC2016B15
文摘BACKGROUND Hepatocellular carcinoma(HCC)ranks second in terms of cancer mortality worldwide.Molecular magnetic resonance imaging(MRI)targeting HCC biomarkers such as alpha-fetoprotein(AFP)or glypican-3(GPC3)offers new strategies to enhance specificity and help early diagnosis of HCC.However,the existing iron oxide nanoparticle-based MR molecular probes singly target AFP or GPC3,which may hinder their efficiency to detect heterogeneous micro malignant HCC tumors<1 cm(MHCC).We hypothesized that the strategy of double antibody-conjugated iron oxide nanoparticles which simultaneously target AFP and GPC3 antigens may potentially be used to overcome the tumor heterogeneity and enhance the detection rate for MRI-based MHCC diagnosis.AIM To synthesize an AFP/GPC3 double antibody-labeled iron oxide MRI molecular probe and to assess its impact on MRI specificity and sensitivity at the cellular level.METHODS A double antigen-targeted MRI probe for MHCC anti-AFP-USPIO-anti-GPC3(UAG)was developed by simultaneously conjugating AFP andGPC3 antibodies to a 5 nm ultra-small superparamagnetic iron oxide nanoparticle(USPIO).At the same time,the singly labeled probes of anti-AFP-USPIO(UA)and anti-GPC3-USPIO(UG)and non-targeted USPIO(U)were also prepared for comparison.The physical characterization including morphology(transmission electron microscopy),hydrodynamic size,and zeta potential(dynamic light scattering)was conducted for each of the probes.The antigen targeting and MRI ability for these four kinds of USPIO probes were studied in the GPC3-expressing murine hepatoma cell line Hepa1-6/GPC3.First,AFP and GPC3 antigen expression in Hepa1-6/GPC3 cells was confirmed by flow cytometry and immunocytochemistry.Then,the cellular uptake of USPIO probes was investigated by Prussian blue staining assay and in vitro MRI(T2-weighted and T2-map)with a 3.0 Tesla clinical MR scanner.RESULTS Our data showed that the double antibody-conjugated probe UAG had the best specificity in targeting Hepa1-6/GPC3 cells expressing AFP and GPC3 antigens compared with single antibody-conjugated and unconjugated USPIO probes.The iron Prussian blue staining and quantitative T2-map MRI analysis showed that,compared with UA,UG,and U,the uptake of double antigen-targeted UAG probe demonstrated a 23.3%(vs UA),15.4%(vs UG),and 57.3%(vs U)increased Prussian stained cell percentage and a 14.93%(vs UA),9.38%(vs UG),and 15.3%(vs U)reduction of T2 relaxation time,respectively.Such bi-specific probe might have the potential to overcome tumor heterogeneity.Meanwhile,the coupling of two antibodies did not influence the magnetic performance of USPIO,and the relatively small hydrodynamic size(59.60±1.87 nm)of double antibodyconjugated USPIO probe makes it a viable candidate for use in MHCC MRI in vivo,as they are slowly phagocytosed by macrophages.CONCLUSION The bi-specific probe presents enhanced targeting efficiency and MRI sensitivity to HCC cells than singly-or non-targeted USPIO,paving the way for in vivo translation to further evaluate its clinical potential.
基金Excellent Youth Science Foundation of China(Grant No.51722501)National Natural Science Foundation of China(Grant No.51575025)+1 种基金National Natural Science Foundation of China-Youth Science Foundation(Grant No.61603052)Opening Foundation of State Key Laboratory of Advanced Welding and Joining(Grant No.AWJ-20-R02).
文摘Current and displacement stiffness are important parameters of axial magnetic bearing(AMB)and are usually considered as constants for the control system.However,in actual dynamic work situations,time-varying force leads to time-varying currents and air gap with a specific frequency,which makes the stiffness of appear decrease and even worsens control performance for the whole system.In this paper,an AMB dynamic stiffness model considering the flux variation across the air gap due to frequency is established to obtain the accurate dynamic stiffness.The dynamic stiffness characteristics are analyzed by means of the dynamic equivalent magnetic circuit method.The analytical results show that the amplitude of current and displacement stiffness decreases with frequency increasing.Moreover,compared with the stiffness model without considering the variation of flux density across the air gap,the improved dynamic stiffness results are closer to the actual results.Through the dynamic stiffness measurement method of AMB,experiments of AMB in magnetically suspended molecular pump(MSMP)are carried out and the experimental results are consistent with theoretical analysis results.This paper proposes the dynamic stiffness model of axial magnetic bearing considering the variation of flux density across the air gap,which improves the accuracy of the AMB stiffness analysis.
文摘"Personalized oncology" is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing need to provide functional information in addition to the morphological data; has led to leaping progress in the field of imaging. Magnetic resonance imaging has undergone tremendous progress with various newer MR techniques providing vital functional information and is becoming the cornerstone of "radiomics/radiogenomics". Diffusionweighted imaging is one such technique which capitalizes on the tendency of water protons to diffuse randomly in a given system. This technique has revolutionized oncological imaging, by giving vital qualitative and quantitative information regarding tumor biology which helps in detection, characterization and post treatment surveillance of the lesions and challenging the notion that "one size fits all". It has been applied at various sites with different clinical experience. We hereby present a brief review of this novel functional imaging tool, with its application in "personalized oncology".
基金Project supported by the National Natural Science Foundation of China(Grant No.11204389)the Natural Science Foundation Project of Chongqing(Grant Nos.CSTC2012jj A50015 and CSTC2012jj A00012)
文摘As an improvement on our previous work [J. Phys. B: At. Mol. Opt. Phys. 45 085101(2012)], an accurate method combining the spheroidal coordinates and B-spline basis is applied to study the ground state 1σg and low excited states1σu, 1πg,u, 1δg,u, 2σg of the H+2in magnetic fields ranging from 10^9Gs(1 Gs = 10^-4T) to 4.414 × 10^13 Gs. Comparing the one-center method used in our previous work, the present method has a higher precision with a shorter computing time.Equilibrium distances of the states of the H+2in strong magnetic fields were found to be accurate to 3-5 significant digits(s.d.) and the total energies 6-11 s.d., even for some antibonding state, such as 1πg, which is difficult for the one-center method to give reliable results while the field strength is B ≥ 10^13 Gs. For the large disagreement in previous works, such as the equilibrium distances of the 1πg state at B = 10^9 Gs, the present data may be used as a reference. Further, the potential energy curves(PECs) and the electronic probability density distributions(EPDDs) of the bound states 1σg, 1πu, 1δg and antibonding states 1σu, 1πg, 1δu for B = 1, 10, 100, 1000 a.u.(atomic unit) are compared, so that the different influences of the magnetic fields on the chemical bonds of the bound states and antibonding states are discussed in detail.
文摘In this paper, we present the critical mass of magnetized, turbulent and rotating star-forming molecular cloud core (MCc) in the presence of magnetic tension. The critical mass of star-forming magnetized cloud is influenced by the magnetic tension, magnetic pressure and other pressures. Applying the method of theoretical modelling by taking into account the basic equations and assumptions, we formulate the critical mass of magnetized MCc in different cases. Accordingly, the minimum critical masses we find in both cases are different. Energy due to magnetic tension significantly triggers the collapse at relatively larger radius of the core. The model shows that when the initial radius of the parent cloud (Ro) is larger than that of collapsing core radius (Rcore) the magnetic tension also has the larger radius of curvature, so it plays a significant role in supporting gravity to collapse the core. The results indicate gravity without magnetic tension may not overcome magnetic pressure, turbulence pressure and pressure due to rotation. This shows the critical mass of MCc for the collapse depends on the tension force that magnetic field lines apply on the envelope. We conclude that if there is magnetic pressure in star-forming MCc, there is also unavoidable magnetic tension, which triggers the collapse of the core. If there is no magnetic tension, the magnetized MCc needs relatively larger mass and higher density within the small size to collapse.
基金supported by the National Natural Science Foundation of China(Grant No.51571115)a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘The structural and magnetic properties of Fe80P9B11 amorphous alloy are investigated through ab initio molecular dynamic simulation. The structure evolution of Fe(80)P9B(11) amorphous alloy can be described in the framework of topological fluctuation theory, and the fluctuation of atomic hydrostatic stress gradually decreases upon cooling. The left sub peak of the second peak of Fe–B partial pair distribution functions(PDFs) becomes pronounced below the glass transition temperature, which may be the major reason why B promotes the glass formation ability significantly. The magnetization mainly originates from Fe 3d states, while small contribution results from metalloid elements P and B. This work may be helpful for developing Fe-based metallic glasses with both high saturation flux density and glass formation ability.
文摘利用溶剂热法制备纳米Fe 3 O 4,并将其分散在正硅酸乙酯(TEOS)水解液中,在表面沉积一层SiO_(2).用甲基丙烯酰氧基丙基三甲氧基硅烷(MPS)对SiO_(2)-Fe 3 O 4表面改性,得到MPS-SiO_(2)-Fe 3 O 4.将甲基丙烯酸(MAA)与己烯雌酚(DES)以摩尔比4∶1加入乙腈溶剂中,进行12 h自组装,再加入MPS-SiO_(2)-Fe 3 O 4、乙二醇二甲基丙烯酸酯(EGDMA)和偶氮二异丁腈(AIBN),进行超声分散30 min,65℃条件下机械搅拌,反应24 h,制得DES磁性分子印迹聚合物(MMIP).采用透射电镜、振动样品磁强计和吸附试验等方法进行表征分析.结果表明:MMIP的饱和磁化强度为268 kA/m,无磁滞现象,矫顽力为0,表现出超顺磁性,在磁铁作用下17 s就可与溶液分离;室温下,MMIP对DES的静态最大吸附量为7.1 mg/g,动态吸附时MMIP在60 min时可以达到静态最大吸附量的90%以上;MMIP对DES的印迹因子为3.70,因而对DES有较大的识别能力;MMIP可重复使用6次以上,具有良好的再生循环性能.
基金the funding of the National Basic Research Program of China (Grant No.2006CB202505)
文摘The chemical structure of heavy oil fractions obtained by liquid-solid adsorption chromatography was character-ized by 1 H nuclear magnetic resonance and X-ray diffraction.The molecular weight and molecular formula of asphaltene molecules were estimated by combining 1 H nuclear magnetic resonance and X-ray diffraction analyses,and were also ob-tained from vapor pressure osmometry and elemental analysis.Heteroatoms,such as S,N,and O atoms,were considered in the construction of average molecular structure of heavy oils.Two important structural parameters were proposed,including the number of alkyl chain substituents to aromatic rings and the number of total rings with heteroatoms.Ultimately,the av-erage molecular structures of polycyclic aromatics,heavy resins and asphaltene molecules were constructed.The number of α-,β-,γ-,and aromatic hydrogen atoms of the constructed average molecular structures fits well with the number of hydro-gen atoms derived from the experimental spectral data.