In this paper we take photobacterium phosphoreum (T3) as the experimental bacteria, and determine the half-inhibitory concentration (-1gEC50) against the photobacterium phosphoreum of 16 halogenated benzenes. Usin...In this paper we take photobacterium phosphoreum (T3) as the experimental bacteria, and determine the half-inhibitory concentration (-1gEC50) against the photobacterium phosphoreum of 16 halogenated benzenes. Using B3LYP method of DFT in the Gaussian 03 program, we obtain the structural and thermodynamic descriptors of 16 halogenated benzenes by fully-optimized calculation at the 6-311G** level. Taking the structural and thermodynamic descriptors as theoretical descriptors, the 2D QSAR model (R2 = 0.983) was established, which can be utilized to predict -lgEC50 of halogenated benzene according to the corrected linear solvation energy theory based on the experimental data of-lgECs0. In addition, the relationship between the toxicity and 3D spatial structure of the compound is studied by comparing the molecular similarity index analysis (CoMSIA) of 3D-QSAR method. By cross validation, the correlation coefficient q2 of CoMSIA model is 0.687, and the conventional correlation coefficient R2 = 0.958. The model is stable and reliable with great predictive ability. The 3D-QSAR model shows that the toxicity of halogenated benzene compound is mainly affected by the characteristics of hydrophobie field of the substituted halogens.展开更多
Growth of Chlorella marine, Nannochloropsis oculata, Pyramidomonas sp, Platymonas subcordiformis and Phaeodactylum tricornutum exposed to monochlorobezene (MCB), 1, 2-dichlorobenzene (1, 2-DCB), 1, 2, 3, 4-tetrachloro...Growth of Chlorella marine, Nannochloropsis oculata, Pyramidomonas sp, Platymonas subcordiformis and Phaeodactylum tricornutum exposed to monochlorobezene (MCB), 1, 2-dichlorobenzene (1, 2-DCB), 1, 2, 3, 4-tetrachlorobenzene (1, 2, 3, 4-TeCB) and pentachlorobenzene (PeCB) was tested. Tests of 72 h-EC50 values showed that the toxicity ranged in the order: MCB<1,2-DCB<1,2,3,4-TeCB<PeCB,and that toxjcity of chlorinated benzene (CB) alone to marine algae was almost in the order: Pyramidomonas sp.< Platymonas subcordiformis<Nannochloropsis oculata < Chlorella marine< Phaeodactylum tricomutum. Study of the QSAR (Quantitative Structure-Activity Relationship) between Kow and toxicity of CBs to marine algae showed good relationships between-logEC50 and logKow.展开更多
Using a novel freshwater photobacteria — Q67 as an indication organism and the VeritasTM luminometer with 96-well microplate as the testing equipment to determine luminous intensity of photobacteria,the familiar 29 s...Using a novel freshwater photobacteria — Q67 as an indication organism and the VeritasTM luminometer with 96-well microplate as the testing equipment to determine luminous intensity of photobacteria,the familiar 29 substituted benzenes of the median inhibition toxicities(pEC50)were determined,respectively.The quantum chemical parameters of 29 substituted benzenes in the ideal gas state at 298.15 K and 1.013×105 Pa have been calculated at the B3LYP/6-31G* level using Gaussian 03 program.The Quantitative linear relationship(N1)between the pEC50 and two descriptors of 29 substituted benzenes was developed using the variable selection and modeling based on prediction(VSMP).Model N1 showed good estimation ability and stability(r = 0.8777,q = 0.8482),which exhibited the difference between empirical and predicted values of 2,3-dimethylphenol was greater(0.5),so it was given up.Using VSMP to select the optimal descriptors,a 2-variable multiple linear regression model(called model N2)was developed for the pEC50 of substituted benzenes.The r and q for model N2 based on 28 substituted benzenes are 0.8991 and 0.8735,respectively.In order to validate the model,28 substituted benzenes were divided into a training set consisting of 20 compounds and a test set with 8 compounds.The result showed that some main structural factors influencing the pEC50 of substituted benzenes are the lowest unoccupied orbital(ELUMO)and total energy(EHF).展开更多
Dodecyl benzenesulfonic acid(DBSA)surfactant was used in the present study to find the effect of concentrationon its electrical conductance in solution from 293-323 K above and below the critical micelle concentration...Dodecyl benzenesulfonic acid(DBSA)surfactant was used in the present study to find the effect of concentrationon its electrical conductance in solution from 293-323 K above and below the critical micelle concentration(CMC).Themicellization parameters i.e.degree of counter ion binding(β),aggregation number(n)and number of counter ion micelle(m)were measured.The interaction of DBSA with polyvinylpyrrolidone(PVP)was also studied at 293 K throughconductance and surface tension measure ments.A number of important parameters i.e.critical aggregation concentration(CAC),Gibb's free energy(△G)and binding ratio(R)were determined and the effect of NaCl on the CAC and polymersaturation point(PSP)was also investigated.展开更多
A mathematical model formulated as ΔfHθm(g)=a+sum from i=1 to 5bipi(i≠2) was constructed for the relationshipbetween standard formation enthalpy ΔfHθm(g) and path index Pi of substituted benzenes derivatives. An ...A mathematical model formulated as ΔfHθm(g)=a+sum from i=1 to 5bipi(i≠2) was constructed for the relationshipbetween standard formation enthalpy ΔfHθm(g) and path index Pi of substituted benzenes derivatives. An empiric equation for the calculation of ΔfHθm(g) was worked out. The calculated values of standard formation enthalpy based on this model are excellently consistent with those from experimental for 55 organic compounds. The model is shown to be simple and of practical usefulness, particularly when required experimental data are unavailable.展开更多
A quantitative structure-property relationship (QSPR) was made for the prediction of the hyperpolarizabilities(β) ofpara-disubstituted benzenes with the nonlinear optical properties, and the βca12 calculated by this...A quantitative structure-property relationship (QSPR) was made for the prediction of the hyperpolarizabilities(β) ofpara-disubstituted benzenes with the nonlinear optical properties, and the βca12 calculated by this model accorded better with the experimental values (βexpt) compared with theβcall calculated at the CPHF/6-31G*//HF/STO-3G level of theory, especially whenβ was big.展开更多
Ligand exchange reaction is one of the typical reactions of ferrocene. In this paper, ligand exchange reactions were carried out between ferrocene and various substituted benzenes using aluminum chloride catalysis. Th...Ligand exchange reaction is one of the typical reactions of ferrocene. In this paper, ligand exchange reactions were carried out between ferrocene and various substituted benzenes using aluminum chloride catalysis. The product yields of the reactions with alkanoyl- and alkoxybenzenes were low because of the coordination of aluminum chloride to the oxygens of the benzene substituents. Comparing the reactions using o- and p-dimethoxybenzene, the former was revealed to be less reactive;this is likely due to the deviation of the π-electrons of its benzene ring being larger.展开更多
The association constant (Ka) values were calculated by the function-strengthen ing neural networks (FNN) for the inclusion complexation of α-CD with mono- and 1,4-disubstituted benzenes. The lnKa predicted by FNN fr...The association constant (Ka) values were calculated by the function-strengthen ing neural networks (FNN) for the inclusion complexation of α-CD with mono- and 1,4-disubstituted benzenes. The lnKa predicted by FNN from Rm, π and σ constants of substituents are in great agreement with the experimental data.展开更多
A diazafulleroid derivative with adjacent 5-6 junctions has been synthesized by the regioselective addition of 1,2-di(azidomethyl) benzene to [60]fullerene. Reaction of [60]fullerene with 1,4-di(azidomethyl) benzene i...A diazafulleroid derivative with adjacent 5-6 junctions has been synthesized by the regioselective addition of 1,2-di(azidomethyl) benzene to [60]fullerene. Reaction of [60]fullerene with 1,4-di(azidomethyl) benzene in refluxing chlorobenzene gave a copolymer.展开更多
The growth of Chlorella marine, Nannochloris oculate, Pyramimonaos sp., Platymonas subcordiformis and Phaeodactylum tricornutum exposed to chlorobenzene, 1,2-dichlorobenzene, 1,2,3,4-tetrachlorobenzene and pentach-lor...The growth of Chlorella marine, Nannochloris oculate, Pyramimonaos sp., Platymonas subcordiformis and Phaeodactylum tricornutum exposed to chlorobenzene, 1,2-dichlorobenzene, 1,2,3,4-tetrachlorobenzene and pentach-lorobenzene was tested. The Boltzman equation was used to describe organism growth. The time course for uptake of hydrophobic organic chemicals (HOCs) by aquatic organisms was expressed by incorporating growth and, if desired, the effect of metabolism into the HOC bioconcentration process. The probability of any given concentration of HOCs in the organisms causing a specified toxic endpoint was expressed with a modified Weibull distribution function. The combined bioconcentration and probability equations were tested with data for time course of incubation of algae exposed to chlorinated benzenes (CBs). A set of parameters, including the uptake rate constant k 1, the elimination rate constant k 2 and thereafter the bioconcentration factor on a dry weight basis, BCF D, the critical HOC concentration in the organism resulting in a specified toxic endpoint, C* A, and the spread factor, S, could be obtained by fitting only experimental data for percent growth inhibition(%)-time-CB exposure concentration. The average coefficients of variation within CBs were 15.2% for BCF D, 21.0% for k 1, 18.3% for k 2, 8.1% for C* A and 9.7% for S. The variability in toxicity (such as EC 10, EC 50, EC 90) derived from the model equations agreed well with those experimentally observed.展开更多
The direct tandem oxidation synthesis of benzenediol from benzene could simplify or even avoid the separation and purification of reaction intermediates, which is promising but challenged because of the further requir...The direct tandem oxidation synthesis of benzenediol from benzene could simplify or even avoid the separation and purification of reaction intermediates, which is promising but challenged because of the further required immediate consecutive activation of intermediate phenol. In this work, a synergistic benzene tandem-oxidation catalyst that V-Cu bimetallic oxides modified nanoporous silica(VCu-NS)was constructed via a facile assembly strategy which involves addictive negative anion citric acid mediating the intercalation of metal-citric acid chelate in mesopore of silica and subsequent thermal calcination inducing dual-metal active site formation. Such a tactic could make amorphous VOxspecies well covered on the surface of mesopore, and ultrafine copper oxide particles surrounded and neighbored by highly dispersed VOxwith strong interplay in mesopore, which was comprehensively confirmed by various characterizations. Benefiting from the unique V-Cu neighboring effect, the desorption of formed phenol over the catalytic site might be restricted therefore easily further activated by the formed reactive oxidative species, 3VCu-NS shows synergetic tandem-oxidation catalytic activities for benzene towards benzenediol with a selectivity of 57%. The result allows optimal 3VCu-NS to be a promising catalyst for benzenediol synthesis from benzene.展开更多
To better understand the benzene alkylation with chloroaluminate ionic liquids(ILs) as catalyst, the interfacial properties between the benzene/butene binary reactants and chloroaluminate ILs with varying cation alkyl...To better understand the benzene alkylation with chloroaluminate ionic liquids(ILs) as catalyst, the interfacial properties between the benzene/butene binary reactants and chloroaluminate ILs with varying cation alkyl chain length and different anions were investigated using molecular dynamics(MD) simulations. The results indicate that ILs can obviously improve the interfacial width, solubility and diffusion of reactants compared to H_(2)SO_(4). The longer alkyl chains of cations present a density enrichment at the interface and protrude into the binary reactants phase. Furthermore, the ILs consisting of 1-octyl-3-methylimidazolium cations([Omim]^(+)) and the stronger acidity heptachlorodialuminate anions([Al_(2)Cl_(7)]^(-)) are more beneficial to promote the interfacial width and facilitate the dissolution and diffusion of benzene in both the IL bulk and the interfacial region in comparison to the ones with shorter alkyl chains cations and weaker acidity anions. The information gives us a better guideline for the design of ILs for benzene alkylation.展开更多
基金supported by the National Natural Science Foundation of China(20977046, 20737001) the Natural Science Foundation of Zhejiang Province(2007Y507280)
文摘In this paper we take photobacterium phosphoreum (T3) as the experimental bacteria, and determine the half-inhibitory concentration (-1gEC50) against the photobacterium phosphoreum of 16 halogenated benzenes. Using B3LYP method of DFT in the Gaussian 03 program, we obtain the structural and thermodynamic descriptors of 16 halogenated benzenes by fully-optimized calculation at the 6-311G** level. Taking the structural and thermodynamic descriptors as theoretical descriptors, the 2D QSAR model (R2 = 0.983) was established, which can be utilized to predict -lgEC50 of halogenated benzene according to the corrected linear solvation energy theory based on the experimental data of-lgECs0. In addition, the relationship between the toxicity and 3D spatial structure of the compound is studied by comparing the molecular similarity index analysis (CoMSIA) of 3D-QSAR method. By cross validation, the correlation coefficient q2 of CoMSIA model is 0.687, and the conventional correlation coefficient R2 = 0.958. The model is stable and reliable with great predictive ability. The 3D-QSAR model shows that the toxicity of halogenated benzene compound is mainly affected by the characteristics of hydrophobie field of the substituted halogens.
文摘Growth of Chlorella marine, Nannochloropsis oculata, Pyramidomonas sp, Platymonas subcordiformis and Phaeodactylum tricornutum exposed to monochlorobezene (MCB), 1, 2-dichlorobenzene (1, 2-DCB), 1, 2, 3, 4-tetrachlorobenzene (1, 2, 3, 4-TeCB) and pentachlorobenzene (PeCB) was tested. Tests of 72 h-EC50 values showed that the toxicity ranged in the order: MCB<1,2-DCB<1,2,3,4-TeCB<PeCB,and that toxjcity of chlorinated benzene (CB) alone to marine algae was almost in the order: Pyramidomonas sp.< Platymonas subcordiformis<Nannochloropsis oculata < Chlorella marine< Phaeodactylum tricomutum. Study of the QSAR (Quantitative Structure-Activity Relationship) between Kow and toxicity of CBs to marine algae showed good relationships between-logEC50 and logKow.
基金Sponsored by the Water Pollution Control and Management of Major Special Technology (2008ZX07317-02-03E)the Ministry of Education of Guangxi Zhuang Autonomous Region (200911MS108)Guangxi Key Laboratory of Environmental Engineering,Protection and Assessment (Nos.0801Z026,0801Z027)
文摘Using a novel freshwater photobacteria — Q67 as an indication organism and the VeritasTM luminometer with 96-well microplate as the testing equipment to determine luminous intensity of photobacteria,the familiar 29 substituted benzenes of the median inhibition toxicities(pEC50)were determined,respectively.The quantum chemical parameters of 29 substituted benzenes in the ideal gas state at 298.15 K and 1.013×105 Pa have been calculated at the B3LYP/6-31G* level using Gaussian 03 program.The Quantitative linear relationship(N1)between the pEC50 and two descriptors of 29 substituted benzenes was developed using the variable selection and modeling based on prediction(VSMP).Model N1 showed good estimation ability and stability(r = 0.8777,q = 0.8482),which exhibited the difference between empirical and predicted values of 2,3-dimethylphenol was greater(0.5),so it was given up.Using VSMP to select the optimal descriptors,a 2-variable multiple linear regression model(called model N2)was developed for the pEC50 of substituted benzenes.The r and q for model N2 based on 28 substituted benzenes are 0.8991 and 0.8735,respectively.In order to validate the model,28 substituted benzenes were divided into a training set consisting of 20 compounds and a test set with 8 compounds.The result showed that some main structural factors influencing the pEC50 of substituted benzenes are the lowest unoccupied orbital(ELUMO)and total energy(EHF).
文摘Dodecyl benzenesulfonic acid(DBSA)surfactant was used in the present study to find the effect of concentrationon its electrical conductance in solution from 293-323 K above and below the critical micelle concentration(CMC).Themicellization parameters i.e.degree of counter ion binding(β),aggregation number(n)and number of counter ion micelle(m)were measured.The interaction of DBSA with polyvinylpyrrolidone(PVP)was also studied at 293 K throughconductance and surface tension measure ments.A number of important parameters i.e.critical aggregation concentration(CAC),Gibb's free energy(△G)and binding ratio(R)were determined and the effect of NaCl on the CAC and polymersaturation point(PSP)was also investigated.
基金The National Natural Science Foundation of Hubei Education Committee(99C069)
文摘A mathematical model formulated as ΔfHθm(g)=a+sum from i=1 to 5bipi(i≠2) was constructed for the relationshipbetween standard formation enthalpy ΔfHθm(g) and path index Pi of substituted benzenes derivatives. An empiric equation for the calculation of ΔfHθm(g) was worked out. The calculated values of standard formation enthalpy based on this model are excellently consistent with those from experimental for 55 organic compounds. The model is shown to be simple and of practical usefulness, particularly when required experimental data are unavailable.
文摘A quantitative structure-property relationship (QSPR) was made for the prediction of the hyperpolarizabilities(β) ofpara-disubstituted benzenes with the nonlinear optical properties, and the βca12 calculated by this model accorded better with the experimental values (βexpt) compared with theβcall calculated at the CPHF/6-31G*//HF/STO-3G level of theory, especially whenβ was big.
文摘Ligand exchange reaction is one of the typical reactions of ferrocene. In this paper, ligand exchange reactions were carried out between ferrocene and various substituted benzenes using aluminum chloride catalysis. The product yields of the reactions with alkanoyl- and alkoxybenzenes were low because of the coordination of aluminum chloride to the oxygens of the benzene substituents. Comparing the reactions using o- and p-dimethoxybenzene, the former was revealed to be less reactive;this is likely due to the deviation of the π-electrons of its benzene ring being larger.
文摘The association constant (Ka) values were calculated by the function-strengthen ing neural networks (FNN) for the inclusion complexation of α-CD with mono- and 1,4-disubstituted benzenes. The lnKa predicted by FNN from Rm, π and σ constants of substituents are in great agreement with the experimental data.
文摘A diazafulleroid derivative with adjacent 5-6 junctions has been synthesized by the regioselective addition of 1,2-di(azidomethyl) benzene to [60]fullerene. Reaction of [60]fullerene with 1,4-di(azidomethyl) benzene in refluxing chlorobenzene gave a copolymer.
基金supported by National Natural Science Foundation of China(No.49976027,No.49776302,No.40136020)Natural Science Foundation,Shandong(L2000E01)Ministry of Education(01110)and Trans-century Training Program Foundation for the Talents by Ministry of Education.
文摘The growth of Chlorella marine, Nannochloris oculate, Pyramimonaos sp., Platymonas subcordiformis and Phaeodactylum tricornutum exposed to chlorobenzene, 1,2-dichlorobenzene, 1,2,3,4-tetrachlorobenzene and pentach-lorobenzene was tested. The Boltzman equation was used to describe organism growth. The time course for uptake of hydrophobic organic chemicals (HOCs) by aquatic organisms was expressed by incorporating growth and, if desired, the effect of metabolism into the HOC bioconcentration process. The probability of any given concentration of HOCs in the organisms causing a specified toxic endpoint was expressed with a modified Weibull distribution function. The combined bioconcentration and probability equations were tested with data for time course of incubation of algae exposed to chlorinated benzenes (CBs). A set of parameters, including the uptake rate constant k 1, the elimination rate constant k 2 and thereafter the bioconcentration factor on a dry weight basis, BCF D, the critical HOC concentration in the organism resulting in a specified toxic endpoint, C* A, and the spread factor, S, could be obtained by fitting only experimental data for percent growth inhibition(%)-time-CB exposure concentration. The average coefficients of variation within CBs were 15.2% for BCF D, 21.0% for k 1, 18.3% for k 2, 8.1% for C* A and 9.7% for S. The variability in toxicity (such as EC 10, EC 50, EC 90) derived from the model equations agreed well with those experimentally observed.
基金financially supported by the National Natural Science Foundation of China (21908085)Natural Science Foundation of Jiangsu Province, China (BK20190961)+1 种基金Postdoctoral Research Foundation of Jiangsu Province (2020Z291)the Jiangsu Provincial Key Laboratory of Environmental Science and Engineering (JSHJZDSYS-202103)。
文摘The direct tandem oxidation synthesis of benzenediol from benzene could simplify or even avoid the separation and purification of reaction intermediates, which is promising but challenged because of the further required immediate consecutive activation of intermediate phenol. In this work, a synergistic benzene tandem-oxidation catalyst that V-Cu bimetallic oxides modified nanoporous silica(VCu-NS)was constructed via a facile assembly strategy which involves addictive negative anion citric acid mediating the intercalation of metal-citric acid chelate in mesopore of silica and subsequent thermal calcination inducing dual-metal active site formation. Such a tactic could make amorphous VOxspecies well covered on the surface of mesopore, and ultrafine copper oxide particles surrounded and neighbored by highly dispersed VOxwith strong interplay in mesopore, which was comprehensively confirmed by various characterizations. Benefiting from the unique V-Cu neighboring effect, the desorption of formed phenol over the catalytic site might be restricted therefore easily further activated by the formed reactive oxidative species, 3VCu-NS shows synergetic tandem-oxidation catalytic activities for benzene towards benzenediol with a selectivity of 57%. The result allows optimal 3VCu-NS to be a promising catalyst for benzenediol synthesis from benzene.
基金The financial support by State Key Laboratory of Heavy Oil Processing, China University of Petroleum。
文摘To better understand the benzene alkylation with chloroaluminate ionic liquids(ILs) as catalyst, the interfacial properties between the benzene/butene binary reactants and chloroaluminate ILs with varying cation alkyl chain length and different anions were investigated using molecular dynamics(MD) simulations. The results indicate that ILs can obviously improve the interfacial width, solubility and diffusion of reactants compared to H_(2)SO_(4). The longer alkyl chains of cations present a density enrichment at the interface and protrude into the binary reactants phase. Furthermore, the ILs consisting of 1-octyl-3-methylimidazolium cations([Omim]^(+)) and the stronger acidity heptachlorodialuminate anions([Al_(2)Cl_(7)]^(-)) are more beneficial to promote the interfacial width and facilitate the dissolution and diffusion of benzene in both the IL bulk and the interfacial region in comparison to the ones with shorter alkyl chains cations and weaker acidity anions. The information gives us a better guideline for the design of ILs for benzene alkylation.