Effects of Bagging with Paper Bags and Non-woven Bags on Flavor Compounds of Feicheng Peach

With Hongli Feicheng Peach as the test material, the effects of bagging with 4 kinds of paper bags and 3 kinds of non-woven bags on the soluble sugar, organic acids and aroma compounds in peach fruits were investigated using headspace solid-phase microextraction （HS-SPME） combined with gas chromatogra- phy-mass spectrometry （GC-MS） and high-performance liquid chromatography （HPLC）. The results showed that there were significant differences in sugar and acids contents of peach fruits between different bagging treatments. The sugar con- tent of peach fruits was increased when bagged with single-layer inner-black outer- yellow paper bags and double-layer inner-white outer-yellow paper bags. The organ- ic acid content in peach fruits bagged with all the types of bags except the single- layer inner-black outer-yellow paper bag was increased greatly. The count and rela- tive content of aroma compounds were all decreased after bagging. Combined with the detection results of soluble sugar, organic acids and aroma compounds, the sin- gle-layer inner-black outer-yellow paper bag was suitable for bagging of Hongli Fe- icheng peach.

基于NF-κB通路探讨中医药治疗糖尿病心肌病研究进展

核转录因子-κB(nuclear factor kappa-B,NF-κB)是调控基因转录的重要因子,参与炎症反应及心肌纤维化等多种疾病的病理过程,中医药激活NF-κB通路且通过控制不同基因参与氧化应激、炎症、内皮功能障碍和细胞凋亡等过程而调控糖尿病心肌病。目前,靶向作用于NF-κB信号通路传导途径治疗糖尿病心肌病的中药单体、中成药、中药复方的相关研究存在以下问题:(1)相关研究多针对中药提取物,单味中药、复方及中药制剂的作用研究较少;(2)这些研究一般只针对NF-κB这一个通路,并未就通路间相互复杂联系进行交叉研究,明确各通路之间相互作用是阐明中药作用机制的重点;(3)大部分研究以体外细胞实验和动物实验为主,缺乏临床研究来进一步验证和支持。今后,应逐步拓宽研究对象范围,不仅包含中药单体,还应涉及单味中药、中药复方及中药制剂,也应涵盖多种剂型,突出中药区别于西药的特色;同时也要注重信号通路之间的关联,明确中药作用于疾病的完整作用机制;还应着重于从分子学、细胞学、生物学等多角度多学科对这一通路的调控作用进行更深入的实验和临床研究。

SYNTHESIS AND CHARACTERIZATION OF A NEW COMPOUND :K_6Ti_0.67Nb_15.33O_42

A new compound K6Ti0.67Nb15.33O42 was prepared for the first time by solid state reaction in K2O-Ni2O3-Nb2O5 ternary system. The new compound was characterized by electron probe, X-ray powder diffraction and DTA. The result of X-ray powder diffraction shows that K6Ti0.67Nb15.33O42 crystallizes the hexagonal system with unit cell parameters a = 9. 1341(5) A ,c=12. 090(1)A . and space group P62/mcm(193 ).

华佗再造丸中单体成分的细胞保护活性研究

目的:鉴定华佗再造丸中具有细胞保护作用的化合物。方法:采用PC12细胞和小鼠脑微血管内皮细胞(b End.3)氧化损伤和缺糖缺氧再灌注(OGR)损伤模型测定,从中得到的72种单体成分中具有细胞保护活性和促神经细胞增殖活性的化合物。结果:可提高氧化损伤的PC12细胞存活率的化合物有槲皮素和异鼠李素;可提高OGR损伤的PC12细胞存活率的单体有异甘草素、3-咖啡酰奎尼酸和人参皂苷Rb1。可促进正常PC12细胞增殖的单体化合物有人参皂苷Rg2、胆酸钠等8种化合物。可提高氧化损伤的b End.3细胞存活率的单体有槲皮素、芍药苷等6种化合物。可提高OGR损伤的b End.3细胞存活率的单体有槲皮素、人参皂苷Rg1等6种化合物。结论:除槲皮素对不同细胞不同损伤模型细胞均有保护作用,为广谱细胞保护剂外,其余化合物均有一定的细胞选择性或模型选择性保护作用,对神经细胞增殖有促进作用的化合物未见有细胞保护作用。这些结果为华佗再造丸治疗脑血管疾病提供了进一步的药理学依据。