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Angioarchitecture and CD133^+ tumor stem cell distribution in intracranial hemangiopericytoma A comparative study with meningioma 被引量:2
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作者 Zhongguo Zhang Mingguang Zhao +1 位作者 Zaihua Xu Zhenquan Song 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第34期2687-2693,共7页
Angioarchitecture plays an important role in the malignant development of intracranial hemangiopericytoma. It remains poorly understood whether high frequency of hemorrhage during clinical surgery for intracranial hem... Angioarchitecture plays an important role in the malignant development of intracranial hemangiopericytoma. It remains poorly understood whether high frequency of hemorrhage during clinical surgery for intracranial hemangiopericytoma is associated with angioarchitecture. The present study utilized hematoxylin-eosin staining, and immunohistochemical staining with epithelial membrane antigen, vimentin, CD34, von Willebrand factor (vWF) and CD133 to observe characteristics of angioarchitecture. In addition, silver stains were used to demonstrate changes in reticular fibers in the wall of vessel channels in intracranial hemangiopericytoma and meningioma. Five patterns of angioarchitecture were identified in intracranial hemangiopericytoma, namely tumor cell islands, vasculogenic mimicry, mosaic blood vessels, sprouting angiogenesis, and intussusceptive angiogenesis. Several CD133+ tumor cells were found to form tumor cell islands. A connection between vWF ^+ and vWF channels was detected in the pattern of intussusceptive angiogenesis, and some vimentin^+ tumor cells were embedded in the periodic acid-Schiff positive channel wall. Incomplete threads of reticular fibers formed the walls of larger pseudo-vascular channels and some tumor clumps or scattered tumor cells were detected "floating" in them. The angioarchitecture, specific markers and reticular fibers of intracranial hemangiopericytoma were significantly different from meningioma. Angioarchitecture provides a functional vascular network for vascular evolution in intracranial hemangiopericytoma and contributes to significant intra-operative bleeding. 展开更多
关键词 intracranial hemangiopericytoma ANGIOARCHITECTURE tumor cell islands vasculogenic mimicry mosaic blood vessels sprouting angiogenesis intussusceptive angiogenesis MENINGIOMA CD133
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Association between glioblastoma cell-derived vessels and poor prognosis of the patients 被引量:6
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作者 Xin Mei Yin-Sheng Chen +8 位作者 Qing-Ping Zhang Fu-Rong Chen Shao-Yan Xi Ya-Kang Long Ji Zhang Hai-Ping Cai Chao Ke Jing Wang Zhong-Ping Chen 《Cancer Communications》 SCIE 2020年第5期211-221,共11页
Background:Vessels with different microcirculation patterns are required for glioblastoma(GBM)growth.However,details of the microcirculation patterns in GBM remain unclear.Here,we examined the microcirculation pattern... Background:Vessels with different microcirculation patterns are required for glioblastoma(GBM)growth.However,details of the microcirculation patterns in GBM remain unclear.Here,we examined the microcirculation patterns of GBM and analyzed their roles in patient prognosis together with two well-known GMB prognosis factors(O^(6)-methylguanine DNA methyltransferase[MGMT]promoter methylation status and isocitrate dehydrogenase[IDH]mutations).Methods:Eighty GBM clinical specimens were collected from patients diagnosed between January 2000 and December 2012.The microcirculation patterns,including endothelium-dependent vessels(EDVs),extracellular matrix-dependent vessels(ECMDVs),GBM cell-derived vessels(GDVs),and mosaic vessels(MVs),were evaluated by immunohistochemistry(IHC)and immunofluorescence(IF)staining in both GBM clinical specimens and xenograft tissues.Vascular density assessments and three-dimensional reconstruction were performed.MGMT promoter methylation status was determined by methylation-specific PCR,and IDH1/2 mutations were detected by Sanger sequencing.The relationship between the microcirculation patterns and patient prognosis was analyzed by Kaplan-Meier method.Results:All 4 microcirculation patterns were observed in both GBM clinical specimens and xenograft tissues.EDVs were detected in all tissue samples,while the other three patterns were observed in a small number of tissue samples(ECMDVs in 27.5%,GDVs in 43.8%,and MVs in 52.5%tissue samples).GDV-positive patients had a median survival of 9.56 months versus 13.60 months for GDV-negative patients(P=0.015).In MGMT promoter-methylated cohort,GDV-positive patients had a median survival of 6.76 months versus 14.23 months for GDV-negative patients(P=0.022).Conclusion:GDVs might be a negative predictor for the survival of GBM patients,even in those with MGMT promoter methylation. 展开更多
关键词 endothelial differentiation endothelium-dependent vessel extracellular matrix-dependent vessel glioblastoma cell-derived vessel GLIOBLASTOMA MGMT promoter methylation MICROCIRCULATION mosaic vessel prognosis vasculogenic mimicry
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