Background: Preterm labor is one of the most public health problems related to neonates admitted to Neonatal Intensive Care Unit (NICU). Poor knowledge among mothers about the care requirements of a preterm neonate is...Background: Preterm labor is one of the most public health problems related to neonates admitted to Neonatal Intensive Care Unit (NICU). Poor knowledge among mothers about the care requirements of a preterm neonate is immediate cause for post-discharge medical problems in premature and neonates readmission to NICU. Hence, this study aims to evaluate mothers’ knowledge of caring for premature infants post-discharge from Neonatal Intensive Care Units in the Gaza strip. Methods: A Quantitative-based cross-sectional designs study was used to survey 120 mothers of preterm neonates at the time of preterm neonates discharge by face-to-face interview at Al-Shifa medical complex and Nasser hospital between February and June 2018. Results: The results showed that only about 58.4% of mothers of premature babies had good knowledge about health care needed for premature infants after discharge from NICU. Furthermore, there was no statistically significant difference between the level of knowledge and mother’s sociodemographic characteristics (P-values > 0.05). Conclusion: Mothers’ knowledge of premature infants care was not at the optimal level, which might put the newborns at risk. Therefore, the study emphasizes the necessity of thoughtful exchange of health information between team members and mothers and establishing pre- and post-discharge plans with mothers to start their healthy transition of preterm neonate to home and to ameliorate family concerns.展开更多
AIMTo study impact of baseline mental health disease on hepatitis C virus (HCV) treatment; and Beck’s Depression Inventory (BDI) changes with sofosbuvir- and interferon-based therapy. METHODSThis is a retros...AIMTo study impact of baseline mental health disease on hepatitis C virus (HCV) treatment; and Beck’s Depression Inventory (BDI) changes with sofosbuvir- and interferon-based therapy. METHODSThis is a retrospective cohort study of participants from 5 studies enrolled from single center trials conducted at the Clinical Research Center of the National Institutes of Health, Bethesda, MD, United States. All participants were adults with chronic HCV genotype 1 infection and naïve to HCV therapy. Two of the studies included HCV mono-infected participants only (SPARE, SYNERGY-A), and 3 included human immunodeficiency virus (HIV)/HCV co-infected participants only (ERADICATE, PFINPK, and ALBIN). Patients were treated for HCV with 3 different regimens: Sofosbuvir and ribavirin in the SPARE trial, ledipasvir and sofosbuvir in SYNERGY-A and ERADICATE trials, and pegylated interferon (IFN) and ribavirin for 48 wk in the PIFNPK and ALBIN trials. Participants with baseline mental health disease (MHD) were identified (defined as either a DSM IV diagnosis of major depression, bipolar disorder, schizophrenia, generalized anxiety, and post-traumatic stress disorder or requiring anti-depressants, antipsychotics, mood stabilizers or psychotropics prescribed by a psychiatrist). For our first aim, we compared sustained virologic response (SVR) and adherence (pill counts, study visits, and in 25 patients, blood levels of the sofosbuvir metabolite, GS-331007) within each study. For our second aim, only patients with HIV coinfection were evaluated. BDI scores were obtained pre-treatment, during treatment, and post-treatment among participants treated with sofosbuvir-based therapy, and compared to scores from participants treated with interferon-based therapy. Statistical differences for both aims were analyzed by Fisher’s Exact, and t-test with significance defined as a P value less than 0.05. RESULTSBaseline characteristics did not differ significantly between all participants with and without MHD groups treated with sofosbuvir-based therapy. Among patients treated with sofosbuvir-based therapy, the percentage of patients with MHD who achieved SVR was the same as those without (SPARE: 60.9% of those MHD compared to 67.6% in those without, P = 0.78; SYNERGY-A: 100% of both groups; ERADICATE: 100% compared to 97.1%). There was no statistically significant difference in pill counts, adherence to study visits between groups, nor mean serum concentrations of GS-331007 for each group at week 2 of treatment (P = 0.72). Among patients with HIV co-infection, pre-treatment BDI scores were similar among patients treated with sofosbuvir, and those treated with interferon (sofosbuvir-based 5.24, IFN-based 6.96; P = 0.14); however, a dichotomous effect on was observed during treatment. Among participants treated with directly acting antiviral (DAA)-based therapy, mean BDI scores decreased from 5.24 (pre-treatment) to 3.28 during treatment (1.96 decrease, P = 0.0034) and 2.82 post-treatment. The decrease in mean score from pre- to post-treatment was statistically significant (-2.42, P = 0.0012). Among participants treated with IFN-based therapy, mean BDI score increased from 6.96 at pre-treatment to 9.19 during treatment (an increase of 2.46 points, P = 0.1), and then decreased back to baseline post-treatment (mean BDI score 6.3, P = 0.54). Overall change in mean BDI scores from pre-treatment to during treatment among participants treated with DAA-based and IFN-therapy was statistically significant (-1.96 and +2.23, respectively; P = 0.0032). This change remained statistically significant when analysis was restricted to participants who achieved SVR (-2.0 and +4.36, respectively; P = 0.0004). CONCLUSIONSofosbuvir-based therapy is safe and well tolerated in patients with MHD. A decline in BDI associated with sofosbuvir-based HCV treatment suggests additional MHD benefits, although the duration of these effects is unknown.展开更多
Background Mental health issues among retirees have become increasingly concerning because the aging population presents a significant challenge globally,particularly in Western countries.Previous studies on this issu...Background Mental health issues among retirees have become increasingly concerning because the aging population presents a significant challenge globally,particularly in Western countries.Previous studies on this issue are plagued with bias owing to lacking panel data and estimation strategies.This study investigated the depression levels of European adults around the time of retirement.Methods We used data obtained from Waves 1-7 of the Survey of Health,Ageing,and Retirement in Europe(SHARE)to create panel data covering the 2004-2017 period.Wave 3(SHARELIFE)was excluded from the sample because it provided mismatched information.Fixed-effects(FE)and fixed-effects instrumental variables(FE-IV)models with multiple imputations were employed to examine the impacts of retirement on mental health before and after retirement,where being over pension age(normal and early)was used as the instrument variable.Results Our results indicated that retirement based on aspirational motivations(β=−0.115,p<0.001)and positive circumstances(β=−0.038,p<0.001)significantly reduced depression,whereas retiring under negative circumstances could deteriorate one’s mental health(β=0.087,p<0.001).FE and FE-IV models indicated that overall,retiring reduced retirees’depression(β=−0.096,p<0.001 andβ=−0.261,p<0.001,respectively).The results of FE-IV models showed that adults planning to retire in the next two years experienced less depression compared with others in the workforce(λ=−0.313,p<0.01).These adults must have adjusted their lifestyles in response to their impending retirement,thereby evincing Ashenfelter’s dip.Two years after retirement,when the“honeymoon”phase was over,retirees may have completely adapted to their new lives and the effect of retirement was no longer important.Conclusions Retirement improves mental health before it happens,but not after.Increasing the pension eligibility age may postpone the beneficial effects of retirement on health.However,policy implications should be tailored according to the unique situations of each country,job sector,and population.Providing flexible schemes regarding retirement timing decisions would be better than a generalized retirement policy.展开更多
NEWTON’s laws of motion predicted that light would travel faster from a moving source—it doesn’t.Einstein was convinced that unruly electrons had no place in an orderly,understandable universe.Both assumed that hum...NEWTON’s laws of motion predicted that light would travel faster from a moving source—it doesn’t.Einstein was convinced that unruly electrons had no place in an orderly,understandable universe.Both assumed that human knowledge could be perfected,mathematically,and that a coherent scientific account of the world we find ourselves in,not only exists,but is available and open to dedicated human enquiry.This paper argues that Hume,Kant and recent work on Hubble’s Constant render this idealistic position untenable.The remedy proposed is not to tighten scientific definitions ever further,but to reposition Science so as to prioritise the biosphere.This entails placing the process of living organisms centre stage,since they defy the Second Law of Thermodynamics,thereby reducing Uncertainty for all—an approach best exemplified in clinical medicine,where despite unbridgeable gaps in medical knowledge,healing can and does take place.Using Quaker insights developed in the 1650s,a non-theological pathway is offered which emphasises human creativity and social cohesion.Unhappily psychiatry today,under the guise of being 100%scientific in the Einstein way,discards three counts of millennial medical wisdom,with catastrophic consequences,as shown by scientifically valid data.A healthier approach to mental and social health,emphasising trust and consent,is described.展开更多
该文对B/S模式下心理预警系统的构建过程进行了分析。系统基于B/S模式,集在线测评、学习、宣传、管理于一体,实现了无纸化的心理学问卷调查,并能准确地计算测试结果。该系统运用了ASP.NET、SQL Server 2005数据库、网页设计等计算机技术...该文对B/S模式下心理预警系统的构建过程进行了分析。系统基于B/S模式,集在线测评、学习、宣传、管理于一体,实现了无纸化的心理学问卷调查,并能准确地计算测试结果。该系统运用了ASP.NET、SQL Server 2005数据库、网页设计等计算机技术,将心理学研究成果赋予实体,具有较强的先进性和可扩展性。展开更多
Background: The healthy bond that develops prenatally between the mother and her infant is important for the neuropsychological development and development of the child. In stressful situations and mental disorders, t...Background: The healthy bond that develops prenatally between the mother and her infant is important for the neuropsychological development and development of the child. In stressful situations and mental disorders, the development of this bond is inhibited. With this study, an attempt is made to investigate whether the COVID-19 pandemic affected the development of the mother-infant bond. Methods: We have searched in the databases, PubMed, Google Scholar, PsycINFO, from July to October 2023 and we have found 18 related articles. Results: Most studies supported a lower mother-infant attachment during the pandemic period. We also found increased rates of depressive symptoms, anxiety and post-traumatic stress during the pandemic. Conclusions: The period of the pandemic and the psychological factors were the right conditions for the reduced development of the mother-infant bond. In epidemiological outbreaks, the mental health of the mother and her relationship with the infant should be a priority for perinatal care professionals.展开更多
文摘Background: Preterm labor is one of the most public health problems related to neonates admitted to Neonatal Intensive Care Unit (NICU). Poor knowledge among mothers about the care requirements of a preterm neonate is immediate cause for post-discharge medical problems in premature and neonates readmission to NICU. Hence, this study aims to evaluate mothers’ knowledge of caring for premature infants post-discharge from Neonatal Intensive Care Units in the Gaza strip. Methods: A Quantitative-based cross-sectional designs study was used to survey 120 mothers of preterm neonates at the time of preterm neonates discharge by face-to-face interview at Al-Shifa medical complex and Nasser hospital between February and June 2018. Results: The results showed that only about 58.4% of mothers of premature babies had good knowledge about health care needed for premature infants after discharge from NICU. Furthermore, there was no statistically significant difference between the level of knowledge and mother’s sociodemographic characteristics (P-values > 0.05). Conclusion: Mothers’ knowledge of premature infants care was not at the optimal level, which might put the newborns at risk. Therefore, the study emphasizes the necessity of thoughtful exchange of health information between team members and mothers and establishing pre- and post-discharge plans with mothers to start their healthy transition of preterm neonate to home and to ameliorate family concerns.
文摘AIMTo study impact of baseline mental health disease on hepatitis C virus (HCV) treatment; and Beck’s Depression Inventory (BDI) changes with sofosbuvir- and interferon-based therapy. METHODSThis is a retrospective cohort study of participants from 5 studies enrolled from single center trials conducted at the Clinical Research Center of the National Institutes of Health, Bethesda, MD, United States. All participants were adults with chronic HCV genotype 1 infection and naïve to HCV therapy. Two of the studies included HCV mono-infected participants only (SPARE, SYNERGY-A), and 3 included human immunodeficiency virus (HIV)/HCV co-infected participants only (ERADICATE, PFINPK, and ALBIN). Patients were treated for HCV with 3 different regimens: Sofosbuvir and ribavirin in the SPARE trial, ledipasvir and sofosbuvir in SYNERGY-A and ERADICATE trials, and pegylated interferon (IFN) and ribavirin for 48 wk in the PIFNPK and ALBIN trials. Participants with baseline mental health disease (MHD) were identified (defined as either a DSM IV diagnosis of major depression, bipolar disorder, schizophrenia, generalized anxiety, and post-traumatic stress disorder or requiring anti-depressants, antipsychotics, mood stabilizers or psychotropics prescribed by a psychiatrist). For our first aim, we compared sustained virologic response (SVR) and adherence (pill counts, study visits, and in 25 patients, blood levels of the sofosbuvir metabolite, GS-331007) within each study. For our second aim, only patients with HIV coinfection were evaluated. BDI scores were obtained pre-treatment, during treatment, and post-treatment among participants treated with sofosbuvir-based therapy, and compared to scores from participants treated with interferon-based therapy. Statistical differences for both aims were analyzed by Fisher’s Exact, and t-test with significance defined as a P value less than 0.05. RESULTSBaseline characteristics did not differ significantly between all participants with and without MHD groups treated with sofosbuvir-based therapy. Among patients treated with sofosbuvir-based therapy, the percentage of patients with MHD who achieved SVR was the same as those without (SPARE: 60.9% of those MHD compared to 67.6% in those without, P = 0.78; SYNERGY-A: 100% of both groups; ERADICATE: 100% compared to 97.1%). There was no statistically significant difference in pill counts, adherence to study visits between groups, nor mean serum concentrations of GS-331007 for each group at week 2 of treatment (P = 0.72). Among patients with HIV co-infection, pre-treatment BDI scores were similar among patients treated with sofosbuvir, and those treated with interferon (sofosbuvir-based 5.24, IFN-based 6.96; P = 0.14); however, a dichotomous effect on was observed during treatment. Among participants treated with directly acting antiviral (DAA)-based therapy, mean BDI scores decreased from 5.24 (pre-treatment) to 3.28 during treatment (1.96 decrease, P = 0.0034) and 2.82 post-treatment. The decrease in mean score from pre- to post-treatment was statistically significant (-2.42, P = 0.0012). Among participants treated with IFN-based therapy, mean BDI score increased from 6.96 at pre-treatment to 9.19 during treatment (an increase of 2.46 points, P = 0.1), and then decreased back to baseline post-treatment (mean BDI score 6.3, P = 0.54). Overall change in mean BDI scores from pre-treatment to during treatment among participants treated with DAA-based and IFN-therapy was statistically significant (-1.96 and +2.23, respectively; P = 0.0032). This change remained statistically significant when analysis was restricted to participants who achieved SVR (-2.0 and +4.36, respectively; P = 0.0004). CONCLUSIONSofosbuvir-based therapy is safe and well tolerated in patients with MHD. A decline in BDI associated with sofosbuvir-based HCV treatment suggests additional MHD benefits, although the duration of these effects is unknown.
基金funded by the European Commission through FP5(QLK6-CT-2001-00360)FP6(SHARE-I3:RII-CT-2006-062193,COMPARE:CIT5-CT-2005-028857,SHARELIFE:CIT4-CT-2006-028812)+1 种基金FP7(SHARE-PREP:No.211909,SHARE-LEAP:No.227822,SHARE M4:No.261982)funding from the German Ministry of Education and Research,the Max Planck Society for the Advancement of Science,the U.S.National Institute on Aging(U01 AG09740-13S2,P01 AG005842,P01 AG08291,P30 AG12815,r21 AG025169,Y1-AG-4553-01,IAG BSR06-11,OGHA 04-064,HHSN271201300071C)。
文摘Background Mental health issues among retirees have become increasingly concerning because the aging population presents a significant challenge globally,particularly in Western countries.Previous studies on this issue are plagued with bias owing to lacking panel data and estimation strategies.This study investigated the depression levels of European adults around the time of retirement.Methods We used data obtained from Waves 1-7 of the Survey of Health,Ageing,and Retirement in Europe(SHARE)to create panel data covering the 2004-2017 period.Wave 3(SHARELIFE)was excluded from the sample because it provided mismatched information.Fixed-effects(FE)and fixed-effects instrumental variables(FE-IV)models with multiple imputations were employed to examine the impacts of retirement on mental health before and after retirement,where being over pension age(normal and early)was used as the instrument variable.Results Our results indicated that retirement based on aspirational motivations(β=−0.115,p<0.001)and positive circumstances(β=−0.038,p<0.001)significantly reduced depression,whereas retiring under negative circumstances could deteriorate one’s mental health(β=0.087,p<0.001).FE and FE-IV models indicated that overall,retiring reduced retirees’depression(β=−0.096,p<0.001 andβ=−0.261,p<0.001,respectively).The results of FE-IV models showed that adults planning to retire in the next two years experienced less depression compared with others in the workforce(λ=−0.313,p<0.01).These adults must have adjusted their lifestyles in response to their impending retirement,thereby evincing Ashenfelter’s dip.Two years after retirement,when the“honeymoon”phase was over,retirees may have completely adapted to their new lives and the effect of retirement was no longer important.Conclusions Retirement improves mental health before it happens,but not after.Increasing the pension eligibility age may postpone the beneficial effects of retirement on health.However,policy implications should be tailored according to the unique situations of each country,job sector,and population.Providing flexible schemes regarding retirement timing decisions would be better than a generalized retirement policy.
文摘NEWTON’s laws of motion predicted that light would travel faster from a moving source—it doesn’t.Einstein was convinced that unruly electrons had no place in an orderly,understandable universe.Both assumed that human knowledge could be perfected,mathematically,and that a coherent scientific account of the world we find ourselves in,not only exists,but is available and open to dedicated human enquiry.This paper argues that Hume,Kant and recent work on Hubble’s Constant render this idealistic position untenable.The remedy proposed is not to tighten scientific definitions ever further,but to reposition Science so as to prioritise the biosphere.This entails placing the process of living organisms centre stage,since they defy the Second Law of Thermodynamics,thereby reducing Uncertainty for all—an approach best exemplified in clinical medicine,where despite unbridgeable gaps in medical knowledge,healing can and does take place.Using Quaker insights developed in the 1650s,a non-theological pathway is offered which emphasises human creativity and social cohesion.Unhappily psychiatry today,under the guise of being 100%scientific in the Einstein way,discards three counts of millennial medical wisdom,with catastrophic consequences,as shown by scientifically valid data.A healthier approach to mental and social health,emphasising trust and consent,is described.
文摘该文对B/S模式下心理预警系统的构建过程进行了分析。系统基于B/S模式,集在线测评、学习、宣传、管理于一体,实现了无纸化的心理学问卷调查,并能准确地计算测试结果。该系统运用了ASP.NET、SQL Server 2005数据库、网页设计等计算机技术,将心理学研究成果赋予实体,具有较强的先进性和可扩展性。
文摘Background: The healthy bond that develops prenatally between the mother and her infant is important for the neuropsychological development and development of the child. In stressful situations and mental disorders, the development of this bond is inhibited. With this study, an attempt is made to investigate whether the COVID-19 pandemic affected the development of the mother-infant bond. Methods: We have searched in the databases, PubMed, Google Scholar, PsycINFO, from July to October 2023 and we have found 18 related articles. Results: Most studies supported a lower mother-infant attachment during the pandemic period. We also found increased rates of depressive symptoms, anxiety and post-traumatic stress during the pandemic. Conclusions: The period of the pandemic and the psychological factors were the right conditions for the reduced development of the mother-infant bond. In epidemiological outbreaks, the mental health of the mother and her relationship with the infant should be a priority for perinatal care professionals.