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儿童抗逆转录病毒治疗耐药研究进展
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作者 梁富雄 侯文宣 蓝光华 《应用预防医学》 2024年第1期66-70,共5页
2020年底全球有170万名14岁以下的儿童感染艾滋病,艾滋病病毒/艾滋病感染儿童的数量将持续增加。随着抗逆转录病毒疗法(anti-retroviral therapy,ART)的出现和发展,全球艾滋病相关死亡人数有所下降。截至2020年6月,有2 750万艾滋病病毒... 2020年底全球有170万名14岁以下的儿童感染艾滋病,艾滋病病毒/艾滋病感染儿童的数量将持续增加。随着抗逆转录病毒疗法(anti-retroviral therapy,ART)的出现和发展,全球艾滋病相关死亡人数有所下降。截至2020年6月,有2 750万艾滋病病毒感染者正在接受抗逆转录病毒治疗,但随着预防母婴传播(prevention of mother to child transmission,PMTCT)的普及,可能出现HIV-1耐药性(HIVDR),儿童ART计划的成功率面临挑战。有报告显示[1],在一线方案失败的儿童中有90%可检测到耐药突变,突变的频率随治疗时间的延长而增高。 展开更多
关键词 抗逆转录病毒治疗 艾滋病病毒/艾滋病 耐药突变 prevention MOTHER 艾滋病病毒感染者 耐药研究 预防母婴传播
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A sphingolipid message promotes neuronal health across generations
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作者 Wenyue Wang Roger Pocock 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第11期2325-2326,共2页
Maternal nutrition can affect brain function of offspring in later life(Fitzgerald et al.,2020).Emerging studies have also shown that the maternal environment can modify susceptibility to neurodegenerative disease(Boo... Maternal nutrition can affect brain function of offspring in later life(Fitzgerald et al.,2020).Emerging studies have also shown that the maternal environment can modify susceptibility to neurodegenerative disease(Boots et al.,2023).Transmission of environmental information from mother to offspring depends on maternal nutrient provisioning.In the nematode Caenorhabditis elegans,maternal yolk,which is synthesized in the intestine and transferred to nourish oocytes and early embryos,can provide extranuclear inheritance factors to mediate phenotypic plasticity across generations.However,the molecular mechanisms of regulating such intergenerational effects remain largely unknown. 展开更多
关键词 MOTHER INTESTINE TRANSFERRED
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Lacticaseibacillus rhamnosus Probio-M9 may be vertically transmitted from mother to infant during lactation based on faeces metagenomics
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作者 Lan Yang Lai-Yu Kwok +1 位作者 Zhihong Sun Heping Zhang 《Food Science and Human Wellness》 SCIE CSCD 2024年第2期721-728,共8页
Probiotics exert beneficial effects on the host.This study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant gut.This study r... Probiotics exert beneficial effects on the host.This study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant gut.This study recruited one pregnant woman,who ingested Probio-M9 daily from 35 weeks of gestation to delivery.Feces of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant's age for metagenomic sequencing.Probio-M9 genomes were mappable to all infant fecal samples,suggesting the ingested probiotics could be vertically transmitted from mother to infant.Infant-or mother-specific differential metabolic pathways were found between the maternal and infant's gut microbiome,implicating apparent differences in the intestinal metagenomic potential/function between the mother and the infant.In conclusion,maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant gut.The findings provided novel insights into shaping infant's gut microbiota. 展开更多
关键词 Metagenomic analysis Lacticaseibacillus rhamnosus Gut microbiome MOTHER INFANT
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High temperature treatment induced production of unreduced 2n pollen in Camellia oleifera
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作者 Hongda Deng Xiaoyu Zhang +5 位作者 Song Sheng Yuxun Huang Ziqi Ye Tongyue Zhang Xing Liu Zhiqiang Han 《Horticultural Plant Journal》 SCIE CAS CSCD 2024年第3期879-896,共18页
Unreduced gametes through chromosome doubling play a major role in the process of plant polyploidization.Our previous work confirmed that Camellia oleifera can produce natural 2n pollen,and it is possible to induce th... Unreduced gametes through chromosome doubling play a major role in the process of plant polyploidization.Our previous work confirmed that Camellia oleifera can produce natural 2n pollen,and it is possible to induce the 2n pollen formation by high temperature treatment.This study focused on the optimization of the 2n pollen induction technique and the mechanisms of high temperature-induced2n pollen formation in C.oleifera.We found that the optimal protocol for inducing 2n pollen via high temperature was to perform 45℃with4 h at the prophaseⅠstage of the pollen mother cells(PMCs).Meanwhile,high temperature significantly decreased the yield and fertility of2n pollen.Through the observation of meiosis,abnormal chromosome and cytological behaviour was discovered under high-temperature treatment,and we confirmed that the formation of 2n pollen is caused by abnormal cell plate.Based on weighted gene co-expression network analysis,fifteen hub genes related to cell cycle control were identified.After male flower buds were exposed to heat shock,polygalacturonase gene(CoPGX3)was significantly upregulated.We inferred that high temperature causes the CoPGX3 gene to be overexpressed and that CoPGX3 is redistributed into the cytosol where it degrades cytoplasmic pectin,which leads to an abnormal cell plate.Furthermore,abnormal cytokinesis resulted in the formation of dyads and triads,and PMCs divided to produce 2n pollen.Our findings provide new insights into the mechanism of 2n pollen induced by high temperature in a woody plant and lay a foundation for further ploidy breeding of C.oleifera. 展开更多
关键词 Camellia oleifera Pollen mother cells(PMCs) High temperature MEIOSIS 2n pollen CoPGX3
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Development and Evaluation of 3D Delivery Animation Software Designed to Improve the Mother’s and Spouse’s Satisfaction with Delivery
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作者 Ayako Sasaki Sachi Chikazawa +4 位作者 Nojima Kumiko Tomita Takako Hatakeyama Keiko Imoto Yasufumi Imoto Nobutane 《Health》 2024年第5期439-458,共20页
Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to disp... Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to display the pelvic region and explain the labor process. The study involved a collaboration with hospital staff who recruited 18 primiparous and 18 multiparous mothers who were hospitalized for delivery at Facility A. The midwife explained the process of delivery using the “Delivery Animation Software”. A self-administered, anonymous questionnaire was distributed and analyzed separately for primiparous and multiparous mothers and their husbands. Results: 1) For both primiparous and multiparous couples, both mothers and their husbands gained a significantly higher level of understanding after delivery than during pregnancy. 2) The Self-Evaluation Scale for Experience of Delivery results were as follows: “I did my best for the baby even if it was painful” was selected more often for “birth coping skills”;“reliable medical staff” was selected more often for “physiological birth process”;“the birth progressed as I expected” was selected frequently by primiparous mothers;and “the birth progressed smoothly” was selected often by multiparous mothers. 3) In terms of husbands’ satisfaction with the delivery, “I was satisfied with the delivery”, “I was given an easy-to-understand explanation”, and “They explained the process to me” was selected of primiparous and multiparous fathers. 4) All primiparous and multiparous mothers positively evaluated whether the delivery animation was helpful in understanding the process of delivery. Conclusion: The delivery animation was effective in improving the understanding and satisfaction of both the mothers and their husbands. 展开更多
关键词 MOTHER SPOUSE SATISFACTION 3D Delivery Animation Software
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Effect of a Nutrition Education Intervention on Food Safety Knowledge, Attitudes and Practices of Mothers of Children under 5 Years in the Peri-Urban Areas of Bobo-Dioulasso: Before and after Study
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作者 Alain Hien Jérome W. Somé +4 位作者 Olivier O. Sombié Isidore Traoré Augustin N. Zeba Georges Anicet Ouedraogo Roland Nâg-Tiero Meda 《Food and Nutrition Sciences》 CAS 2024年第5期401-420,共20页
Background: This study assessed the effect of a nutrition education intervention. This intervention aimed to improve the knowledge, attitudes, and practices of mothers on food safety in the peri-urban areas of Bobo-Di... Background: This study assessed the effect of a nutrition education intervention. This intervention aimed to improve the knowledge, attitudes, and practices of mothers on food safety in the peri-urban areas of Bobo-Dioulasso in Burkina Faso. Methods: A total of 243 mothers of children under 5 years in the peri-urban of Bobo-Dioulasso were administered the FAO questionnaire for food safety knowledge, attitudes, and practices assessment during two cross-sectional surveys, before and after the intervention, in January and October 2017. The intervention included two components consisting of a theoretical phase (counselling and discussion) and cooking demonstrations implemented for ten months. To account for the before-and-after design of the study, the McNemar’s test was used to assess the effect of the intervention on food safety KAP of mothers of children under 5 years. Results: The mean age of mothers was 29 ± 6.2 years and 50.6% of them were between 20 and 29 years old. One for knowledge (cooking thoroughly with, p-value = 0.0001) and another for attitudes (perceived benefits of reheating leftovers before eating them, p-value = 0.0001), significantly increased after the intervention. In terms of food safety practices, all the indicators (cleaning of dirty surfaces, plates and utensils and storage of perishable foods) significantly increased (all p = 0.0001 Conclusion: This study provided some evidence of an effective nutrition education intervention for improving maternal KAP on food safety for their child’s feeding. 展开更多
关键词 Nutrition Education Intervention KNOWLEDGE Attitudes and Practices Food Safety Mothers of Children under 5 Years Burkina Faso
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Representation of Family in the Narratives of Smiling Flower(Gol-e Khandān)
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作者 Somayeh Aghajani Kalkhoran 《Cultural and Religious Studies》 2024年第7期409-416,共8页
The development of a childs personality is profoundly influenced by the environmental stimuli after their formation.Within this context,lullabies and childhood stories assume significant roles in this formative proces... The development of a childs personality is profoundly influenced by the environmental stimuli after their formation.Within this context,lullabies and childhood stories assume significant roles in this formative process.The familial environment serves as the primary locus from which individuals acquire their beliefs and personalities.This research investigates the portrayal of family dynamics within the narrative framework of the Persian story Smiling Flower(Gol-e Khandn).In the majority of narratives of this story,featuring the Laughing Flower,a magical agency is bestowed upon an infant girl,thereby shaping her future.The analysis of this narratives themes prioritizes the familial element,particularly the central figures of parents,who play pivotal roles in the cultivation of the childs personality.Examination of parental representation within this narrative elucidates the prominence of the maternal figure,albeit acknowledging the undeniable influence exerted by the fathers demeanor and character on the childs trajectory. 展开更多
关键词 Gol-e Khandān FAMILY FATHER mother WIFE
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A Lapse of Memory
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作者 TIE NING 《China Today》 2024年第3期63-63,共1页
AT the age of 15,I was obsessed with giving injections.Thus,I asked one of my mother’s friends who worked in a hospital to teach me how to give injections.Once I learned how to give injections,I looked forward to hav... AT the age of 15,I was obsessed with giving injections.Thus,I asked one of my mother’s friends who worked in a hospital to teach me how to give injections.Once I learned how to give injections,I looked forward to having my own patients,whether family members or others.I prepared all the needling instruments and strictly followed procedures.One day,one of my neighbors told me that she had to go to the hospital every day to have a vitamin B12 injection.She said if I could give her the injections,she could avoid the trouble of going to the hospital. 展开更多
关键词 OWN MOTHER VITAMIN
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Safeguarding The Mother River China’s comprehensive measures to protect and manage the Yellow River
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作者 Zhu Mengxiao 《China Report ASEAN》 2024年第7期29-31,共3页
One of two mother rivers of the Chinese nation,the Yellow River has supported the development of Chinese civilization and nurtured the Chinese people for millennia.However,the great river has been suffering from sever... One of two mother rivers of the Chinese nation,the Yellow River has supported the development of Chinese civilization and nurtured the Chinese people for millennia.However,the great river has been suffering from severe crises of interrupted flow and water pollution in recent decades. 展开更多
关键词 HAS interrupted MOTHER
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TUNING INTO UYGUR TRADITION Xinjiang Muqam melodies resonate through the corridors of time
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作者 Li Fangfang Wang Zhiwei 《China Report ASEAN》 2024年第4期54-55,共2页
As dawn breaks over the ancient Silk Road lands of China’s Xinjiang Uygur Autonomous Region,Dilixiati Parhati is gearing up for yet another busy day.He juggles multiple roles:musician,scholar,leader of a Muqam art tr... As dawn breaks over the ancient Silk Road lands of China’s Xinjiang Uygur Autonomous Region,Dilixiati Parhati is gearing up for yet another busy day.He juggles multiple roles:musician,scholar,leader of a Muqam art troupe and,most recently,a voice in China’s National People’s Congress(NPC)-the country’s top legislature.In all these roles,safeguarding the soul-stirring music of Uygur Muqam,often dubbed“the mother of Uygur music,”for future generations is his mission. 展开更多
关键词 mother XINJIANG STIRRING
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A Future Beyond Imagination
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作者 LIU SHILIN 《China Today》 2024年第7期24-27,共4页
The renewal and cultural revival of its two mother rivers has made Shanghai more beautiful,and now,it must acquire new industrial muscle as well.WHEN American historian Jeffrey Wasserstrom came to Shanghai in March 20... The renewal and cultural revival of its two mother rivers has made Shanghai more beautiful,and now,it must acquire new industrial muscle as well.WHEN American historian Jeffrey Wasserstrom came to Shanghai in March 2009,a year before the World Expo 2010,he exclaimed,“Shanghai’s future is beyond imagination.”At that time,Shanghai had carried out riverbank management in some sections of the Huangpu River,one of the two mother rivers of the city,and restored its cultural functions. 展开更多
关键词 MOTHER BEAUTIFUL claimed
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Parents’s knowledge and awareness about hepatitis B can influence the vaccination of their children
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作者 Nanda Chhavi Geetika Srivastava +4 位作者 Mariya Waseem Abhishek Yadav Surender Singh Rajani Singh Amit Goel 《World Journal of Virology》 2024年第2期96-106,共11页
BACKGROUND Birth-dose(Hep-BD)followed by three additional doses(Hep-B3)of hepatitis B virus(HBV)vaccine are key to eliminating HBV by 2030.Unfortunately,Hep-BD and Hep-B3 coverage in our country is poor.AIM To studied... BACKGROUND Birth-dose(Hep-BD)followed by three additional doses(Hep-B3)of hepatitis B virus(HBV)vaccine are key to eliminating HBV by 2030.Unfortunately,Hep-BD and Hep-B3 coverage in our country is poor.AIM To studied the parent’s knowledge and awareness about HBV infection,its prevention,consequences and vaccination.METHODS Parents of 6 months to 8 years old children were interviewed to assess their knowledge&awareness about hepatitis B,its transmission,prevention,illness caused by this,and vaccination.Eighteen close-ended questions were admini-stered,and responses were recorded as‘yes’,‘no’,or‘not sure’.HBV knowledge score was calculated based on the sum of correct answers.Each correct response scored one point and incorrect,missing or‘not sure’responses received no points.Categorical data are presented as number(%)and numerical data are expressed as median.Data were compared using Chi2 tests and level of significance was kept as P<0.05.RESULTS Parents(58.3%mothers)of 384 children(89.9%age<5 years;82%age-appropriately vaccinated)were included.Three hundred and twenty-two(83.9%)children were Hep-B3 vaccinated.94.3%,87.5%,and 29.2%parents knew about polio,tetanus,and hepatitis B vaccine.Overall,41.2%,15.8%,and 23%parents knew about hepatitis B transmission,consequences of infection,and prevention respectively.Only 7.6%parents knew about three-dose schedule of hepatitis B vaccination.Only 23%parents believed that vaccine could prevent HBV,15.7%knew that HBV affects liver.Parents of Hep-B3 vaccinated children were significantly more aware about HBV than the parents of unvaccinated children(P<0.05 for 17/18 questions).CONCLUSION The knowledge and awareness among the parents about hepatitis B is poor.The Increasing knowledge/awareness about HBV among parents may improve Hep-B3 vaccination coverage. 展开更多
关键词 Hepatitis B Viral hepatitis CIRRHOSIS Hepatocellular carcinoma Hepatotropic viruses Transfusion transmitted infection Mother to child transmission
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Acceptability of Kangaroo Mother Care (KMC) by Mothers with Low-Birth-Weight Babies at Arthur Davison Children’s Hospital, in Ndola, Zambia
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作者 Julia D. Kalito Maureen M. Masumo Chapima Fabian 《Open Journal of Obstetrics and Gynecology》 2024年第5期790-823,共34页
Background: Kangaroo Mother Care is a simple safe method used to care for low-birth-weight babies. Low-birth-weight is a global public health issue that pose significant challenge to perinatal care systems. Globally, ... Background: Kangaroo Mother Care is a simple safe method used to care for low-birth-weight babies. Low-birth-weight is a global public health issue that pose significant challenge to perinatal care systems. Globally, complications due to low-birth-weight are the leading cause of neonatal mortality, resulting in an estimated 1 million deaths annually. Kangaroo Mother Care (KMC) is a low-cost method of care for low-birth-weight infants in areas with inadequate incubators and power outages with positive outcomes. Objectives: To assess factors influencing acceptability of Kangaroo Mother Care (KMC) in NICU at Arthur Davison Children’s Hospital in Ndola, Zambia. Methodology: A cross sectional quantitative analytical study design was used. The study was conducted at Arthur Davison Children’s Hospital (ADCH) in Ndola, Zambia. The purposive sampling method was used to select the study participants and a total of 129 mothers with Low Weight Babies A were selected to participate structured closed ended questionnaire was used to collect data from the participants using an interview. Data was analyzed using a Statistical Package for Social Scientists (SPSS) software version 26. Cross tabulations were done to determine association of variables using a Chi square (x<sup>2</sup>) test at 95% confidence interval and were assumptions where not met, fishers exact test was used. Multivariate binary logistic regression analysis was used to quantify the relationship between the dependent and independent variables. Results: Most of the respondents had male babies 77%, 69% of the babies weighed 1000 g - 1400 g, majority 79% had normal delivery, 71% of the respondents were multigravida and most of the respondents 79% were married. The study reviewed that 85% of those who attained secondary education accepted KMC, 74% of the respondents without monthly income accepted KMC, 80% of the respondents had positive attitude and accepted KMC. 82% of the respondents who had positive perception accepted KMC. Conclusion: Acceptance of Kangaroo Mother Care (KMC) among 75% of the mothers underscores its widespread favourability as a beneficial method for infant care. 展开更多
关键词 ACCEPTABILITY Kangaroo Mother Care Low Birth Weight Babies
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My Good Friend
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作者 任新超 《中学生英语》 2024年第5期6-6,共1页
Hello,everyone! I'm Li Hua.I have a good friend.Her name is Zhang Yufei.Yufei is her last name and Zhang is her first name①.She is 13 years old now.She has a happy family.Her father is a cooker②and her mother is... Hello,everyone! I'm Li Hua.I have a good friend.Her name is Zhang Yufei.Yufei is her last name and Zhang is her first name①.She is 13 years old now.She has a happy family.Her father is a cooker②and her mother is a teacher.Her sister is a middle school student.They are in the same school. 展开更多
关键词 EVERYONE HAS MOTHER
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Mothers’challenges and experiences of children with cerebral palsy:a qualitative meta-synthesis
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作者 Meng-Yun Peng Yi-Fu Lu 《Frontiers of Nursing》 2024年第2期169-179,共11页
Objective:To examine what challenges and experiences a mother faces in caring for children with cerebral palsy(CP).As the main caregiver of children with CP,mothers are under multiple pressures.Even though mothers’ch... Objective:To examine what challenges and experiences a mother faces in caring for children with cerebral palsy(CP).As the main caregiver of children with CP,mothers are under multiple pressures.Even though mothers’challenges and experiences of children with CP will affect their quality of life and the rehabilitation of the children,little is known about their challenges and experiences during the whole care.Methods:A qualitative meta-synthesis was conducted to extract and analyze qualitative research from the PubMed,CINAHL,PsycINFO,Web of Science,Ovid and MEDLINE databases.Thirteen articles were selected and analyzed using thematic syntheses.Results:From 2522 screened abstracts,84 texts were reviewed,and 13 studies met the inclusion criteria.Mothers’challenges and experiences of children with CP include 4 themes,both positive and negative.Conclusions:The mothers of children with CP suffer from physical burden,as well as psychological pressure,in the care experience;social and healthcare support are their main challenges.Interventions to help them face the difficulties and adapt to the role of caregivers as soon as possible should target multiple aspects in order to maximize effectiveness,to promote the healthy growth of children with CP. 展开更多
关键词 CHALLENGES children with cerebral palsy EXPERIENCE META-SYNTHESIS mothers
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数字妈妈
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作者 孙启禄 《疯狂英语(新读写)》 2024年第8期22-26,75,76,共7页
“Mom,I want to eat Moo Shu Pork,”Zhu Rui exclaimed eagerly.“Okay,let me prepare the meat.I'll let you know when I'm done,”his mother replied with a warm smile.Sitting comfortably in her chair dressed in ro... “Mom,I want to eat Moo Shu Pork,”Zhu Rui exclaimed eagerly.“Okay,let me prepare the meat.I'll let you know when I'm done,”his mother replied with a warm smile.Sitting comfortably in her chair dressed in rosy pajamas featuring a large picture of Mickey Mouse,she looked at her son through the computer screen with tender eyes. 展开更多
关键词 MOTHER DRESS claimed
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My Route to School
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作者 沈大翔 李兰(指导) 《疯狂英语(双语世界)》 2024年第1期68-69,共2页
Hello,I am Shen Daxiang,a student from Class 8,Grade 6 at Xiqiao Experimental Primary School.I always commute to school by car,and I’d like to share the route I take to get there.The journey starts from my home,which... Hello,I am Shen Daxiang,a student from Class 8,Grade 6 at Xiqiao Experimental Primary School.I always commute to school by car,and I’d like to share the route I take to get there.The journey starts from my home,which is approximately 20 kilometers away from the school.My mother kindly drives me to school every day. 展开更多
关键词 MOTHER SCHOOL JOURNEY
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《詹姆斯与大仙桃》(节选)
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作者 罗尔德·达尔 《疯狂英语(新读写)》 2024年第6期52-53,77,78,共4页
Until he was four years old,James Henry Trotter had a happy life.He lived peacefully with his mother and father in a beautiful house beside the sea.There were always plenty of other children for him to play with,and t... Until he was four years old,James Henry Trotter had a happy life.He lived peacefully with his mother and father in a beautiful house beside the sea.There were always plenty of other children for him to play with,and there was the sandy beach for him to run about on,and the ocean to paddle in.It was the perfect life for a small boy. 展开更多
关键词 plenty MOTHER BEAUTIFUL
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《小鹿斑比》(节选)
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作者 费利克斯·萨尔腾 《疯狂英语(新读写)》 2024年第8期55-57,78,共4页
Deep in among the trees was a place that belonged to Bambi's mother.It lay only a few steps from the narrow path used by the deer as they made their way through the wood but it was nearly impossible to find for an... Deep in among the trees was a place that belonged to Bambi's mother.It lay only a few steps from the narrow path used by the deer as they made their way through the wood but it was nearly impossible to find for anyone who did not know where the little gap through the dense bushes was. 展开更多
关键词 MOTHER NARROW STEPS
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教室里的团聚
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作者 孙竹芳 《疯狂英语(新读写)》 2024年第5期51-51,77,共2页
A classroom of high school students helped their teacher welcome her overseas soldier son back after being apart for over five years,and it had us in tears.A video of the reunion has caught the attention of more than ... A classroom of high school students helped their teacher welcome her overseas soldier son back after being apart for over five years,and it had us in tears.A video of the reunion has caught the attention of more than 40 million people.It shows the son wearing his military uniform and carrying flowers and a sign that reads,“Im home.”When his mother walks into the class,he hides behind the door and then sneaks behind a whiteboard so the students can prime her for the big secret. 展开更多
关键词 FLOWERS MOTHER UNION
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