Objective To clarify the effects of repetitive transcranial magnetic stimulation (rTMS) on rat motor cortical excitabi- lity and neurofunction after cerebral ischemia-reperfusion injury. Methods After determined awake...Objective To clarify the effects of repetitive transcranial magnetic stimulation (rTMS) on rat motor cortical excitabi- lity and neurofunction after cerebral ischemia-reperfusion injury. Methods After determined awake resting motor threshold (MT) and motor evoked potentials (MEPs) of right hindlimbs, 20 Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) reperfusion injury, then rTMS were applied to rTMS group (n = 10) at different time, while control group (n = 10) received no stimulation. A week later, MT and MEPs were evaluated again, as well as neurological deficits and infarct volume. The effects of rTMS and MCAO reperfusion injury on these parameters were analyzed. Results After MCAO reperfusion, both MT level and neurological deficit scores increased, distinct focal infarction formed, and latency of MEP elongated. Compared with the control group, the increased extent of MT and neurological scores of rats receiving rTMS were significantly lower (P < 0.05), as well as the infarct volumes reduced significantly(P < 0.05). But MEP was not affected by rTMS obviously. There was a positive linear correlation between postinjury MT and infarct volume (r = 0.64, P < 0.05). Conclusion rTMS may facilitate neurofunction recovery after cerebral ischemia-reperfusion. Postinjury MT could provide prognostic information after MCAO reperfusion injury.展开更多
Introduction: Working in a noisy environment is a risk for employee hearing health. Standard threshold shift (STS) can be used as a screening method to detect early indications of hearing deterioration. Objective: To ...Introduction: Working in a noisy environment is a risk for employee hearing health. Standard threshold shift (STS) can be used as a screening method to detect early indications of hearing deterioration. Objective: To investigate health effects related to STS in motor compressor workers. Methods: A cross sectional study of 464 motor compressor workers was conducted including hearing health examination by audiometer, and noise level in the workplace was monitored. Workers who reported having hobbies relating to noise, e.g. gun shooting, or a personal history of disease relating to the ear were excluded. The relationship between health effects and workers with STS was studied. Results: There were more men 81.90% (aged range 31-40 years old) than women working for the company. The average continuous noise level in the workplace was 84.14 ± 5.21 dB(A). The study showed that working at the factory for more than 14 years (OR= 3.84, 95%CI 1.54-9.56) and being exposed to noise at least 8 hours a day (OR = 2.12, 95%CI = 1.02-4.40) effected to STS. Workers with STS showed significant communication difficulties (OR = 1.89, 95%CI = 1.03-3.49) and stress/nausea more than workers without STS (OR = 1.54, 95%CI = 0.90-2.65) although not statistically significant. Conclusions: Workers exposed to continuous noise in the motor compressor industry are at risk of STS. Duration of exposure to noise is a key factor in respect of harm to hearing health. STS could be used as a tool to screen workers who have hearing health problems.展开更多
目的了解抑郁症患者的运动阈值(motor threshold,MT)与正常人的差异,探讨抑郁症患者的皮层兴奋性变化。方法用单脉冲经颅磁刺激(single-pulse Transcranial Magnetic Stimulation,sTMS)检测均为右利手的21例抑郁症患者和21例正常对照的M...目的了解抑郁症患者的运动阈值(motor threshold,MT)与正常人的差异,探讨抑郁症患者的皮层兴奋性变化。方法用单脉冲经颅磁刺激(single-pulse Transcranial Magnetic Stimulation,sTMS)检测均为右利手的21例抑郁症患者和21例正常对照的MT值。结果抑郁症患者的MT值左侧高于右侧,正常对照的MT值为左侧低于右侧;抑郁症患者左侧的MT值显著高于正常对照(t=2.24,P<0.05),而右侧的MT值与正常对照无显著性差异(t=1.145,P>0.05);抑郁症患者右侧的MT值随着病程的增长而增加(r=0.46,P<0.05);不同性别的抑郁症患者左右侧的MT值无明显差异(P>0.05)。结论抑郁症患者的皮层兴奋性与正常对照存在差异,具体表现为抑郁症患者左、右两侧皮层兴奋性的不对称性与正常对照呈相反表现;抑郁症患者左侧大脑皮层的兴奋性明显降低。展开更多
目的了解首发(未用药)精神分裂症患者及其未患病的一级亲属的运动阈值(motor threshold,MT)与正常人的差异,以探讨首发精神分裂症患者及其一级亲属的皮层兴奋性变化。方法采用单脉冲经颅磁刺激(singnal-pulse Transcranial Magnetic Sti...目的了解首发(未用药)精神分裂症患者及其未患病的一级亲属的运动阈值(motor threshold,MT)与正常人的差异,以探讨首发精神分裂症患者及其一级亲属的皮层兴奋性变化。方法采用单脉冲经颅磁刺激(singnal-pulse Transcranial Magnetic Sti mulation,sTMS)检测均为右利手的37例首发精神分裂症患者、37例患者未患病的一级亲属及39例正常对照的MT值。结果(1)首发精神分裂症患者及其未患病的一级亲属的MT值左右两侧间比较,均无显著性差异(P均>0.05);而正常对照的MT值为左侧低于右侧,差异有非常显著性(t=3.18,P<0.01)。(2)左侧及右侧的MT值三组间比较均无显著性差异(P均>0.05)。(3)首发精神分裂症患者左右侧的MT值与年龄、性别、精神分裂症分型及病程均无显著相关性(P均>0.05)。结论首发精神分裂症患者及其一级亲属的皮层兴奋性与正常对照存在差异,具体表现为正常对照左、右两侧的皮层兴奋性存在不对称,而首发精神分裂症患者及其一级亲属这种不对称性消失,原因可能与优势半球神经元突触传递易化作用减弱或消失有关。展开更多
文摘Objective To clarify the effects of repetitive transcranial magnetic stimulation (rTMS) on rat motor cortical excitabi- lity and neurofunction after cerebral ischemia-reperfusion injury. Methods After determined awake resting motor threshold (MT) and motor evoked potentials (MEPs) of right hindlimbs, 20 Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) reperfusion injury, then rTMS were applied to rTMS group (n = 10) at different time, while control group (n = 10) received no stimulation. A week later, MT and MEPs were evaluated again, as well as neurological deficits and infarct volume. The effects of rTMS and MCAO reperfusion injury on these parameters were analyzed. Results After MCAO reperfusion, both MT level and neurological deficit scores increased, distinct focal infarction formed, and latency of MEP elongated. Compared with the control group, the increased extent of MT and neurological scores of rats receiving rTMS were significantly lower (P < 0.05), as well as the infarct volumes reduced significantly(P < 0.05). But MEP was not affected by rTMS obviously. There was a positive linear correlation between postinjury MT and infarct volume (r = 0.64, P < 0.05). Conclusion rTMS may facilitate neurofunction recovery after cerebral ischemia-reperfusion. Postinjury MT could provide prognostic information after MCAO reperfusion injury.
文摘Introduction: Working in a noisy environment is a risk for employee hearing health. Standard threshold shift (STS) can be used as a screening method to detect early indications of hearing deterioration. Objective: To investigate health effects related to STS in motor compressor workers. Methods: A cross sectional study of 464 motor compressor workers was conducted including hearing health examination by audiometer, and noise level in the workplace was monitored. Workers who reported having hobbies relating to noise, e.g. gun shooting, or a personal history of disease relating to the ear were excluded. The relationship between health effects and workers with STS was studied. Results: There were more men 81.90% (aged range 31-40 years old) than women working for the company. The average continuous noise level in the workplace was 84.14 ± 5.21 dB(A). The study showed that working at the factory for more than 14 years (OR= 3.84, 95%CI 1.54-9.56) and being exposed to noise at least 8 hours a day (OR = 2.12, 95%CI = 1.02-4.40) effected to STS. Workers with STS showed significant communication difficulties (OR = 1.89, 95%CI = 1.03-3.49) and stress/nausea more than workers without STS (OR = 1.54, 95%CI = 0.90-2.65) although not statistically significant. Conclusions: Workers exposed to continuous noise in the motor compressor industry are at risk of STS. Duration of exposure to noise is a key factor in respect of harm to hearing health. STS could be used as a tool to screen workers who have hearing health problems.
文摘目的了解抑郁症患者的运动阈值(motor threshold,MT)与正常人的差异,探讨抑郁症患者的皮层兴奋性变化。方法用单脉冲经颅磁刺激(single-pulse Transcranial Magnetic Stimulation,sTMS)检测均为右利手的21例抑郁症患者和21例正常对照的MT值。结果抑郁症患者的MT值左侧高于右侧,正常对照的MT值为左侧低于右侧;抑郁症患者左侧的MT值显著高于正常对照(t=2.24,P<0.05),而右侧的MT值与正常对照无显著性差异(t=1.145,P>0.05);抑郁症患者右侧的MT值随着病程的增长而增加(r=0.46,P<0.05);不同性别的抑郁症患者左右侧的MT值无明显差异(P>0.05)。结论抑郁症患者的皮层兴奋性与正常对照存在差异,具体表现为抑郁症患者左、右两侧皮层兴奋性的不对称性与正常对照呈相反表现;抑郁症患者左侧大脑皮层的兴奋性明显降低。
文摘目的了解首发(未用药)精神分裂症患者及其未患病的一级亲属的运动阈值(motor threshold,MT)与正常人的差异,以探讨首发精神分裂症患者及其一级亲属的皮层兴奋性变化。方法采用单脉冲经颅磁刺激(singnal-pulse Transcranial Magnetic Sti mulation,sTMS)检测均为右利手的37例首发精神分裂症患者、37例患者未患病的一级亲属及39例正常对照的MT值。结果(1)首发精神分裂症患者及其未患病的一级亲属的MT值左右两侧间比较,均无显著性差异(P均>0.05);而正常对照的MT值为左侧低于右侧,差异有非常显著性(t=3.18,P<0.01)。(2)左侧及右侧的MT值三组间比较均无显著性差异(P均>0.05)。(3)首发精神分裂症患者左右侧的MT值与年龄、性别、精神分裂症分型及病程均无显著相关性(P均>0.05)。结论首发精神分裂症患者及其一级亲属的皮层兴奋性与正常对照存在差异,具体表现为正常对照左、右两侧的皮层兴奋性存在不对称,而首发精神分裂症患者及其一级亲属这种不对称性消失,原因可能与优势半球神经元突触传递易化作用减弱或消失有关。
