Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1-42 aggregation in plaque formation...Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1-42 aggregation in plaque formation,leading to brain lesions and cognitive impairment,numerous studies have aimed to reduce Aβaggregation and slow AD progression.The diphenylalanine(FF)sequence is critical for amyloid aggregation,and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic rings.In this study,we examined the effects of a moderate-intensity rotating magnetic field(RMF)on Aβaggregation and AD pathogenesis.Results indicated that the RMF directly inhibited Aβamyloid fibril formation and reduced Aβ-induced cytotoxicity in neural cells in vitro.Using the AD mouse model APP/PS1,RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments,including exploration and spatial and non-spatial memory abilities.Tissue examinations demonstrated that RMF reduced amyloid plaque accumulation,attenuated microglial activation,and reduced oxidative stress in the APP/PS1 mouse brain.These findings suggest that RMF holds considerable potential as a non-invasive,high-penetration physical approach for AD treatment.展开更多
为分析高速永磁同步电动机定子各区域的铁耗分布情况,以一台额定功率为250 k W、额定转速为67 002 r/min的高速永磁同步电机为例,建立高速永磁同步电机的二维有限元计算模型,对定子区域进行划分,研究一个周期内各个区域径向磁密和切向...为分析高速永磁同步电动机定子各区域的铁耗分布情况,以一台额定功率为250 k W、额定转速为67 002 r/min的高速永磁同步电机为例,建立高速永磁同步电机的二维有限元计算模型,对定子区域进行划分,研究一个周期内各个区域径向磁密和切向磁密的变化规律,采用不同的铁耗计算模型计算出定子铁心各区域铁耗的分布特性,将定子铁耗计算结果与有限元计算结果相比较,并进一步分析高速永磁同步电机的铁耗密度分布特点。计算结果表明,高速永磁同步电机稳定运行在较高的频率时,定子铁心中的涡流损耗占总铁心损耗的比重最大,附加损耗占比最小。当考虑旋转磁场和谐波分量的影响时,定子铁心损耗的大小明显高于仅考虑交变磁场影响时的损耗,更接近有限元计算结果。虽然定子齿顶的铁耗最小,但该区域的损耗密度最大,此外,定子铁心的各个区域还存在大量的谐波铁耗。此研究可为后续高速永磁同步电机设计提供一定参考。展开更多
大功率单绕组双速电机转子通常采用直槽结构,无法通过斜槽来削弱齿谐波。为了研究直槽情况下,定转子槽配合变化对单绕组双速电机空载磁场及损耗的影响,以一台定子槽数为48的15/3 k W,4/8极单绕组双速电机为例,利用时步有限元法对比分析...大功率单绕组双速电机转子通常采用直槽结构,无法通过斜槽来削弱齿谐波。为了研究直槽情况下,定转子槽配合变化对单绕组双速电机空载磁场及损耗的影响,以一台定子槽数为48的15/3 k W,4/8极单绕组双速电机为例,利用时步有限元法对比分析了不同槽配合时电机内部磁场及铁耗、定转子铜耗的变化规律。结果表明:随转子槽数增加,气隙径向磁场基本不变而切向磁场高次谐波含量增加;与少槽配合相比,多槽配合时定子铜耗和转子高频附加铁耗均略微增加;转子铜耗先减小后增加且在多槽配合时远大于少槽配合。样机实验对比验证了该分析的正确性。研究结果可为合理选择单绕组双速电机槽配合提供重要的理论依据。展开更多
基金National Key R&D Program of China(2023YFB3507004)National Natural Science Foundation of China(U21A20148)+2 种基金International Partnership Program of Chinese Academy of Sciences(116134KYSB20210052)Heye Health Technology Chong Ming Project(HYCMP2021010)CASHIPS Director’s Fund(BJPY2021A06)。
文摘Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1-42 aggregation in plaque formation,leading to brain lesions and cognitive impairment,numerous studies have aimed to reduce Aβaggregation and slow AD progression.The diphenylalanine(FF)sequence is critical for amyloid aggregation,and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic rings.In this study,we examined the effects of a moderate-intensity rotating magnetic field(RMF)on Aβaggregation and AD pathogenesis.Results indicated that the RMF directly inhibited Aβamyloid fibril formation and reduced Aβ-induced cytotoxicity in neural cells in vitro.Using the AD mouse model APP/PS1,RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments,including exploration and spatial and non-spatial memory abilities.Tissue examinations demonstrated that RMF reduced amyloid plaque accumulation,attenuated microglial activation,and reduced oxidative stress in the APP/PS1 mouse brain.These findings suggest that RMF holds considerable potential as a non-invasive,high-penetration physical approach for AD treatment.
文摘为分析高速永磁同步电动机定子各区域的铁耗分布情况,以一台额定功率为250 k W、额定转速为67 002 r/min的高速永磁同步电机为例,建立高速永磁同步电机的二维有限元计算模型,对定子区域进行划分,研究一个周期内各个区域径向磁密和切向磁密的变化规律,采用不同的铁耗计算模型计算出定子铁心各区域铁耗的分布特性,将定子铁耗计算结果与有限元计算结果相比较,并进一步分析高速永磁同步电机的铁耗密度分布特点。计算结果表明,高速永磁同步电机稳定运行在较高的频率时,定子铁心中的涡流损耗占总铁心损耗的比重最大,附加损耗占比最小。当考虑旋转磁场和谐波分量的影响时,定子铁心损耗的大小明显高于仅考虑交变磁场影响时的损耗,更接近有限元计算结果。虽然定子齿顶的铁耗最小,但该区域的损耗密度最大,此外,定子铁心的各个区域还存在大量的谐波铁耗。此研究可为后续高速永磁同步电机设计提供一定参考。
文摘大功率单绕组双速电机转子通常采用直槽结构,无法通过斜槽来削弱齿谐波。为了研究直槽情况下,定转子槽配合变化对单绕组双速电机空载磁场及损耗的影响,以一台定子槽数为48的15/3 k W,4/8极单绕组双速电机为例,利用时步有限元法对比分析了不同槽配合时电机内部磁场及铁耗、定转子铜耗的变化规律。结果表明:随转子槽数增加,气隙径向磁场基本不变而切向磁场高次谐波含量增加;与少槽配合相比,多槽配合时定子铜耗和转子高频附加铁耗均略微增加;转子铜耗先减小后增加且在多槽配合时远大于少槽配合。样机实验对比验证了该分析的正确性。研究结果可为合理选择单绕组双速电机槽配合提供重要的理论依据。
