This paper presents a two-phase genetic algorithm (TPGA) based on the multi- parent genetic algorithm (MPGA). Through analysis we find MPGA will lead the population' s evol vement to diversity or convergence accor...This paper presents a two-phase genetic algorithm (TPGA) based on the multi- parent genetic algorithm (MPGA). Through analysis we find MPGA will lead the population' s evol vement to diversity or convergence according to the population size and the crossover size, so we make it run in different forms during the global and local optimization phases and then forms TPGA. The experiment results show that TPGA is very efficient for the optimization of low-dimension multi-modal functions, usually we can obtain all the global optimal solutions.展开更多
In this paper, a new algorithm for solving multi-modal function optimization problems-two-level subspace evolutionary algorithm is proposed. In the first level, the improved GT algorithm is used to do global recombina...In this paper, a new algorithm for solving multi-modal function optimization problems-two-level subspace evolutionary algorithm is proposed. In the first level, the improved GT algorithm is used to do global recombination search so that the whole population can be separated into several niches according to the position of solutions; then, in the second level, the niche evolutionary strategy is used for local search in the subspaces gotten in the first level till solutions of the problem are found. The new algorithm has been tested on some hard problems and some good results are obtained.展开更多
A novel immune genetic algorithm with the elitist selection and elitist crossover was proposed, which is called the immune genetic algorithm with the elitism (IGAE). In IGAE, the new methods for computing antibody sim...A novel immune genetic algorithm with the elitist selection and elitist crossover was proposed, which is called the immune genetic algorithm with the elitism (IGAE). In IGAE, the new methods for computing antibody similarity, expected reproduction probability, and clonal selection probability were given. IGAE has three features. The first is that the similarities of two antibodies in structure and quality are all defined in the form of percentage, which helps to describe the similarity of two antibodies more accurately and to reduce the computational burden effectively. The second is that with the elitist selection and elitist crossover strategy IGAE is able to find the globally optimal solution of a given problem. The third is that the formula of expected reproduction probability of antibody can be adjusted through a parameter β, which helps to balance the population diversity and the convergence speed of IGAE so that IGAE can find the globally optimal solution of a given problem more rapidly. Two different complex multi-modal functions were selected to test the validity of IGAE. The experimental results show that IGAE can find the globally maximum/minimum values of the two functions rapidly. The experimental results also confirm that IGAE is of better performance in convergence speed, solution variation behavior, and computational efficiency compared with the canonical genetic algorithm with the elitism and the immune genetic algorithm with the information entropy and elitism.展开更多
The emergence of endoscopy for the diagnosis of gastrointestinal diseases and the treatment of gastrointestinal diseases has brought great changes.The mere observation of anatomy with the imaging mode using modern end...The emergence of endoscopy for the diagnosis of gastrointestinal diseases and the treatment of gastrointestinal diseases has brought great changes.The mere observation of anatomy with the imaging mode using modern endoscopy has played a significant role in this regard.However,increasing numbers of endoscopies have exposed additional deficiencies and defects such as anatomically similar diseases.Endoscopy can be used to examine lesions that are difficult to identify and diagnose.Early disease detection requires that substantive changes in biological function should be observed,but in the absence of marked morphological changes,endoscopic detection and diagnosis are difficult.Disease detection requires not only anatomic but also functional imaging to achieve a comprehensive interpretation and understanding.Therefore,we must ask if endoscopic examination can be integrated with both anatomic imaging and functional imaging.In recent years,as molecular biology and medical imaging technology have further developed,more functional imaging methods have emerged.This paper is a review of the literature related to endoscopic optical imaging methods in the hopes of initiating integration of functional imaging and anatomical imaging to yield a new and more effective type of endoscopy.展开更多
Objective To find out more extrema simultaneously including global optimum and multiple local optima existed in multi-modal functions. Methods Germinal center is the generator and selector of high-affinity B cells, a ...Objective To find out more extrema simultaneously including global optimum and multiple local optima existed in multi-modal functions. Methods Germinal center is the generator and selector of high-affinity B cells, a multicellular group's artificial immune algorithm was proposed based on the germinal center reaction mechanism of natural immune systems. Main steps of the algorithm were given, including hyper-mutation, selection, memory, similarity suppression and recruitment of B cells and the convergence of it was proved. Results The algorithm has been tested to optimize various multi-modal functions, and the simulation results show that the artificial immune algorithm proposed here can find multiple extremum of these functions with lower computational cost. Conclusion The algorithm is valid and can converge on the satisfactory solution set D with probability 1 and approach to global solution and many local optimal solutions existed.展开更多
Impaired structure and function of the hippocampus is a valuable predictor of progression from amnestic mild cognitive impairment(a MCI) to Alzheimer's disease(AD). As a part of the medial temporal lobe memory sy...Impaired structure and function of the hippocampus is a valuable predictor of progression from amnestic mild cognitive impairment(a MCI) to Alzheimer's disease(AD). As a part of the medial temporal lobe memory system,the hippocampus is one of the brain regions affected earliest by AD neuropathology,and shows progressive degeneration as a MCI progresses to AD. Currently,no validated biomarkers can precisely predict the conversion from a MCI to AD. Therefore,there is a great need of sensitive tools for the early detection of AD progression. In this review,we summarize the specifi c structural and functional changes in the hippocampus from recent a MCI studies using neurophysiological and neuroimaging data. We suggest that a combination of advanced multi-modal neuroimaging measures in discovering biomarkers will provide more precise and sensitive measures of hippocampal changes than using only one of them. These will potentially affect early diagnosis and disease-modifying treatments. We propose a new sequential and progressive framework in which the impairment spreads from the integrity of fibers to volume and then to function in hippocampal subregions. Meanwhile,this is likely to be accompanied by progressive impairment of behavioral and neuropsychological performance in the progression of a MCI to AD.展开更多
分析了传统的用于多峰函数优化问题的小生境遗传算法的特点和不足,基于免疫系统中的克隆选择原理,运用记忆算子、抑制算子和重组算子等技术对克隆选择算法进行了改造,并引入一种新的小生境技术,提出了一种解决多峰函数优化问题的小生境...分析了传统的用于多峰函数优化问题的小生境遗传算法的特点和不足,基于免疫系统中的克隆选择原理,运用记忆算子、抑制算子和重组算子等技术对克隆选择算法进行了改造,并引入一种新的小生境技术,提出了一种解决多峰函数优化问题的小生境克隆选择算法。最后,实现了该算法对单无人作战飞机(unmanned combat air vehicle,UCAV)多航路规划这类多峰函数优化问题的优化仿真,结果表明该算法简单有效。展开更多
基金Supported by the National Natural Science Foundation of China (70071042,60073043,60133010)
文摘This paper presents a two-phase genetic algorithm (TPGA) based on the multi- parent genetic algorithm (MPGA). Through analysis we find MPGA will lead the population' s evol vement to diversity or convergence according to the population size and the crossover size, so we make it run in different forms during the global and local optimization phases and then forms TPGA. The experiment results show that TPGA is very efficient for the optimization of low-dimension multi-modal functions, usually we can obtain all the global optimal solutions.
基金Supported by the National Natural Science Foundation of China (70071042,60073043,60133010)
文摘In this paper, a new algorithm for solving multi-modal function optimization problems-two-level subspace evolutionary algorithm is proposed. In the first level, the improved GT algorithm is used to do global recombination search so that the whole population can be separated into several niches according to the position of solutions; then, in the second level, the niche evolutionary strategy is used for local search in the subspaces gotten in the first level till solutions of the problem are found. The new algorithm has been tested on some hard problems and some good results are obtained.
基金Project(50275150) supported by the National Natural Science Foundation of ChinaProjects(20040533035, 20070533131) supported by the National Research Foundation for the Doctoral Program of Higher Education of China
文摘A novel immune genetic algorithm with the elitist selection and elitist crossover was proposed, which is called the immune genetic algorithm with the elitism (IGAE). In IGAE, the new methods for computing antibody similarity, expected reproduction probability, and clonal selection probability were given. IGAE has three features. The first is that the similarities of two antibodies in structure and quality are all defined in the form of percentage, which helps to describe the similarity of two antibodies more accurately and to reduce the computational burden effectively. The second is that with the elitist selection and elitist crossover strategy IGAE is able to find the globally optimal solution of a given problem. The third is that the formula of expected reproduction probability of antibody can be adjusted through a parameter β, which helps to balance the population diversity and the convergence speed of IGAE so that IGAE can find the globally optimal solution of a given problem more rapidly. Two different complex multi-modal functions were selected to test the validity of IGAE. The experimental results show that IGAE can find the globally maximum/minimum values of the two functions rapidly. The experimental results also confirm that IGAE is of better performance in convergence speed, solution variation behavior, and computational efficiency compared with the canonical genetic algorithm with the elitism and the immune genetic algorithm with the information entropy and elitism.
文摘The emergence of endoscopy for the diagnosis of gastrointestinal diseases and the treatment of gastrointestinal diseases has brought great changes.The mere observation of anatomy with the imaging mode using modern endoscopy has played a significant role in this regard.However,increasing numbers of endoscopies have exposed additional deficiencies and defects such as anatomically similar diseases.Endoscopy can be used to examine lesions that are difficult to identify and diagnose.Early disease detection requires that substantive changes in biological function should be observed,but in the absence of marked morphological changes,endoscopic detection and diagnosis are difficult.Disease detection requires not only anatomic but also functional imaging to achieve a comprehensive interpretation and understanding.Therefore,we must ask if endoscopic examination can be integrated with both anatomic imaging and functional imaging.In recent years,as molecular biology and medical imaging technology have further developed,more functional imaging methods have emerged.This paper is a review of the literature related to endoscopic optical imaging methods in the hopes of initiating integration of functional imaging and anatomical imaging to yield a new and more effective type of endoscopy.
文摘Objective To find out more extrema simultaneously including global optimum and multiple local optima existed in multi-modal functions. Methods Germinal center is the generator and selector of high-affinity B cells, a multicellular group's artificial immune algorithm was proposed based on the germinal center reaction mechanism of natural immune systems. Main steps of the algorithm were given, including hyper-mutation, selection, memory, similarity suppression and recruitment of B cells and the convergence of it was proved. Results The algorithm has been tested to optimize various multi-modal functions, and the simulation results show that the artificial immune algorithm proposed here can find multiple extremum of these functions with lower computational cost. Conclusion The algorithm is valid and can converge on the satisfactory solution set D with probability 1 and approach to global solution and many local optimal solutions existed.
基金supported by the National Natural Science Foundation of China (91332000,81171021,and 91132727)the Key Program for Clinical Medicine and Science and Technology,Jiangsu Provence,China ( BL2013025 and BL2014077)
文摘Impaired structure and function of the hippocampus is a valuable predictor of progression from amnestic mild cognitive impairment(a MCI) to Alzheimer's disease(AD). As a part of the medial temporal lobe memory system,the hippocampus is one of the brain regions affected earliest by AD neuropathology,and shows progressive degeneration as a MCI progresses to AD. Currently,no validated biomarkers can precisely predict the conversion from a MCI to AD. Therefore,there is a great need of sensitive tools for the early detection of AD progression. In this review,we summarize the specifi c structural and functional changes in the hippocampus from recent a MCI studies using neurophysiological and neuroimaging data. We suggest that a combination of advanced multi-modal neuroimaging measures in discovering biomarkers will provide more precise and sensitive measures of hippocampal changes than using only one of them. These will potentially affect early diagnosis and disease-modifying treatments. We propose a new sequential and progressive framework in which the impairment spreads from the integrity of fibers to volume and then to function in hippocampal subregions. Meanwhile,this is likely to be accompanied by progressive impairment of behavioral and neuropsychological performance in the progression of a MCI to AD.
文摘分析了传统的用于多峰函数优化问题的小生境遗传算法的特点和不足,基于免疫系统中的克隆选择原理,运用记忆算子、抑制算子和重组算子等技术对克隆选择算法进行了改造,并引入一种新的小生境技术,提出了一种解决多峰函数优化问题的小生境克隆选择算法。最后,实现了该算法对单无人作战飞机(unmanned combat air vehicle,UCAV)多航路规划这类多峰函数优化问题的优化仿真,结果表明该算法简单有效。