The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatab...The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets(ODTs) are tested using two different taste sensors. Second, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the disintegration time of ODTs. Finally, we compare the characteristics of the two taste sensors in the evaluation of palatability of various kinds of drug formulations.展开更多
A sweet-sensitive taste sensor was investigated with potetiometric measurement.The transducer was a lipid/polymer membrane composed of tetradodecylammonium bromide,di-n-octylphenylphosphonate and polyvinyl chloride,wh...A sweet-sensitive taste sensor was investigated with potetiometric measurement.The transducer was a lipid/polymer membrane composed of tetradodecylammonium bromide,di-n-octylphenylphosphonate and polyvinyl chloride,which surface was modified with polyphenol and the solvent 30% EtOH,100 mmol/L KC1 and 10 mmol/L KOH.Balancing hydrophobic/ hydrophilic property and charge density on the membrane surface was susceptible to sensitivity for sweetener.Interaction between the membrane and sweet taste substances such as sucrose was detected as membrane potential change.展开更多
There are well-established chemical and turbidity anomalies in the plumes occurring vicinity of hydrothermal vents, which are used to indicate their existence and locations. We here develop a small, accurate multi-cha...There are well-established chemical and turbidity anomalies in the plumes occurring vicinity of hydrothermal vents, which are used to indicate their existence and locations. We here develop a small, accurate multi-channel chemical sensor to detect such anomalies which can be used in deep-sea at depths of more than 4 000 m. The design allowed five all-solid-state electrodes to be mounted on it and each (apart from one reference electrode) could be changed according to chemicals to be measured. Two experiments were conducted using the chemical sensors. The first was a shallow-sea trial which included sample measurements and in situ monitoring. pH, Eh, CO3^2- and SO4^2- electrodes were utilized to demonstrate that the chemical sensor was accurate and stable outside the laboratory. In the second experiment, the chemical sensor was integrated with pH, Eh, CO3^2- and H2S electrodes, and was used in 29 scans of the seabed along the Southwest Indian Ridge (SWIR) to detect hydrothermal vents, from which 27 sets of valid data were obtained. Hydrothermal vents were identified by analyzing the chemical anomalies, the primary judging criteria were decreasing voltages of Eh and H2S, matched by increasing voltages of pH and CO3^2- . We proposed that simultaneous detection of changes in these parameters will indicate a hydrothermal vent. Amongst the 27 valid sets of data, five potential hydrothermal vents were targeted using the proposed method. We suggest that our sensors could be widely employed by marine scientists.展开更多
The purpose of this study was to prepare a poly-γ-glutamic acid hydrogel (PGA gel), to examine its ease of swallowing using texture profile analysis (TPA) and to evaluate its taste-masking effects on basic or acidic ...The purpose of this study was to prepare a poly-γ-glutamic acid hydrogel (PGA gel), to examine its ease of swallowing using texture profile analysis (TPA) and to evaluate its taste-masking effects on basic or acidic drugs using the artificial taste sensor. Using TPA, 0.5% and 1.0% PGA gels, 0.5% and 1.0% agar and 1.0% ι-carrageenan in the absence of drug was examined the hardness, adhesiveness and cohesiveness, ranked according to permission criteria published by the Japanese Consumers Affairs Agency. 0.5% PGA gel and 1.0% agar were classified into grade II. In the taste sensor measurement, the bitterness suppressions by 0.5% PGA gel were larger than that by 1.0% agar in all drugs and the bitterness suppressions of basic drugs in 0.5% PGA gel were more potent than those of acidic drugs in 0.5% PGA gel. 1H-nuclear magnetic resonance spectroscopic analysis was carried out to examine the difference in mechanism of bitterness suppression between basic drugs and acidic drugs mixed with PGA gel. The signals of the proton nearest to the nitrogen atom of basic drugs shifted clearly upfield, suggesting an interaction between the amino group of basic drugs and the carboxyl group of PGA gel. In conclusion, PGA gel is expected to be a useful excipient in formulations contained various drugs, especially basic drugs;it also has advantage for not only increasing ease of swallowing but also masking the bitterness of drugs even though a small amount of a single drug dose might be preferred.展开更多
The purpose of the present study was to examine the effect of adenylic acid (adenosine 5-monophosphate;AMP), a known nutritional enhancer, on inhibiting the bitterness of antipsychotic medicines administered to patien...The purpose of the present study was to examine the effect of adenylic acid (adenosine 5-monophosphate;AMP), a known nutritional enhancer, on inhibiting the bitterness of antipsychotic medicines administered to patients with mental illnesses, including children. First, we chose four antipsychotic medicines, amitriptyline hydrochloride (AMT), chlorpromazine hydrochloride (CPZ), haloperidol (HPD) and risperidone (RIS) and evaluated the inhibition of their bitterness by AMP through taste sensor measurements. AMP showed a significant bitterness inhibition effect on all drugs. Second, MarvinSketch analysis revealed the potential formation of electrostatic interactions between ionic forms (IV) of AMP and ionic (cationic) forms of each drug, which resulted in bitterness suppression. Third, chemical shift perturbations in 1H-NMR studies suggested an interaction between the phosphate group of AMP and amino group of AMT, CPZ, HPD and RIS. Last, conventional elution experiments of up to 1 min simulating oral cavity conditions were performed for 1 whole AMT tablet, half AMT tablet, crushed half AMT tablet, and crushed AMT tablet containing AMP powder/solution (1, 3 mM potency). The taste sensor output values of the crushed AMT tablet containing AMP powder/solution (1, 3 mM potency) were significantly lower than those of the crushed tablet.展开更多
Recent advances in wireless sensor technology have enabled simultaneous exploitation of multiple channels in wireless sensor systems. In this paper, a novel time synchronization algorithm is proposed for multi- channe...Recent advances in wireless sensor technology have enabled simultaneous exploitation of multiple channels in wireless sensor systems. In this paper, a novel time synchronization algorithm is proposed for multi- channel Wireless Sensor Networks (WSNs) called Multi-Channel Time Synchronization (MCTS) protocol. Time synchronization is critical for many WSN applications and enables efficient communications between sensor nodes along with intelligent spectrum access. Contrary to many existing protocols that do not exploit multi-channel communications, the protocol takes advantage of potential multiple channels and distributes the synchronization of different nodes to distinct channels and thus, reduces the convergence time of synchronization processes significantly.展开更多
Steel-concrete composite structures(SCCS)have been widely used as primary load-bearing components in large-scale civil infrastructures.As the basis of the co-working ability of steel plate and concrete,the bonding sta...Steel-concrete composite structures(SCCS)have been widely used as primary load-bearing components in large-scale civil infrastructures.As the basis of the co-working ability of steel plate and concrete,the bonding status plays an essential role in guaranteeing the structural performance of SCCS.Accordingly,efficient non-destructive testing(NDT)on interfacial debondings in SCCS has become a prominent research area.Multi-channel analysis of surface waves(MASW)has been validated as an effective NDT technique for interfacial debonding detection for SCCS.However,the feasibility of MASW must be validated using experimental measurements.This study establishes a high-frequency data synchronous acquisition system with 32 channels to perform comparative verification experiments in depth.First,the current sensing approaches for high-frequency vibration and stress waves are summarized.Secondly,three types of contact sensors,namely,piezoelectric lead-zirconate-titanate(PZT)patches,accelerometers,and ultrasonic transducers,are selected for MASW measurement.Then,the selection and optimization of the force hammer head are performed.Comparative experiments are carried out for the optimal selection of ultrasonic transducers,PZT patches,and accelerometers for MASW measurement.In addition,the influence of different pasting methods on the output signal of the sensor array is discussed.Experimental results indicate that optimized PZT patches,acceleration sensors,and ultrasonic transducers can provide efficient data acquisition for MASW-based non-destructive experiments.The research findings in this study lay a solid foundation for analyzing the recognition accuracy of contact MASW measurement using different sensor arrays.展开更多
Cold-junction compensation(CJC)and disconnection detection circuit design of various thermocouples(TC)and multi-channel TC interface circuits were designed.The CJC and disconnection detection circuit consists of a CJC...Cold-junction compensation(CJC)and disconnection detection circuit design of various thermocouples(TC)and multi-channel TC interface circuits were designed.The CJC and disconnection detection circuit consists of a CJC semiconductor device,an instrumentation amplifier(IA),two resistors,and a diode for disconnection detection.Based on the basic circuit,a multi-channel interface circuit was also implemented.The CJC was implemented using compensation semiconductor and IA,and disconnection detection was detected by using two resistors and a diode so that IA input voltage became-0.42 V.As a result of the experiment using R-type TC,the error of the designed circuit was reduced from 0.14 mV to 3μV after CJC in the temperature range of 0°C to 1400°C.In addition,it was confirmed that the output voltage of IA was saturated from 88 mV to-14.2 V when TC was disconnected from normal.The output voltage of the designed circuit was 0 V to 10 V in the temperature range of 0°C to 1400°C.The results of the 4-channel interface experiment using R-type TC were almost identical to the CJC and disconnection detection results for each channel.The implemented multi-channel interface has a feature that can be applied equally to E,J,K,T,R,and S-type TCs by changing the terminals of CJC semiconductor devices and adjusting the IA gain.展开更多
This paper presents a novel biosensor for bitter substance detection on the basis of light addressable potentiometric sensor(LAPS).Taste receptor cells(TRCs)were used as sensitive elements,which can respond to differe...This paper presents a novel biosensor for bitter substance detection on the basis of light addressable potentiometric sensor(LAPS).Taste receptor cells(TRCs)were used as sensitive elements,which can respond to different bitter stimuli with extreme high sensitivity and speci-ficity.TRCs were isolated from the taste buds of rats and cultured on the surface of LAPS chip.Due to the unique advantages such as single-cell recording,light addressable capability,and noninvasiveness,LAPS chip was used as secondary transducer to monitor the responses of TRCs by recording extracelluar potential changes.The results indicate LAPS chip can effectively record the responses of TRCs to different bitter substances used in this study in a real-time manner for a long-term.In addition,by performing principal component analysis on the LAPS recording data,different bitter substances tested can be successfully discriminated.It is suggested this TRCsLAPS hybrid biosensor could be a valuable tool for bitter substance detection.With further improvement and novel design,it has great potentials to be applied in both basic research and practical applications related to bitter taste detection.展开更多
In the presence of background noise,arrival times picked from a surface microseismic data set usually include a number of false picks that can lead to uncertainty in location estimation.To eliminate false picks and im...In the presence of background noise,arrival times picked from a surface microseismic data set usually include a number of false picks that can lead to uncertainty in location estimation.To eliminate false picks and improve the accuracy of location estimates,we develop an association algorithm termed RANSAC-based Arrival Time Event Clustering(RATEC)that clusters picked arrival times into event groups based on random sampling and fitting moveout curves that approximate hyperbolas.Arrival times far from the fitted hyperbolas are classified as false picks and removed from the data set prior to location estimation.Simulations of synthetic data for a 1-D linear array show that RATEC is robust under different noise conditions and generally applicable to various types of subsurface structures.By generalizing the underlying moveout model,RATEC is extended to the case of a 2-D surface monitoring array.The effectiveness of event location for the 2-D case is demonstrated using a data set collected by the 5200-element dense Long Beach array.The obtained results suggest that RATEC is effective in removing false picks and hence can be used for phase association before location estimates.展开更多
Wireless Sensor Networks(WSNs)can be termed as an autoconfigured and infrastructure-less wireless networks to monitor physical or environmental conditions,such as temperature,sound,vibration,pressure and motion etc.WS...Wireless Sensor Networks(WSNs)can be termed as an autoconfigured and infrastructure-less wireless networks to monitor physical or environmental conditions,such as temperature,sound,vibration,pressure and motion etc.WSNs may comprise thousands of Internet of Things(IoT)devices to sense and collect data from its surrounding,process the data and take an automated and mechanized decision.On the other side the proliferation of these devices will soon cause radio spectrum shortage.So,to facilitate these networks,we integrate Cognitive Radio(CR)functionality in these networks.CR can sense the unutilized spectrum of licensed users and then use these empty bands when required.In order to keep the IoT nodes functional all time,continuous energy is required.For this reason the energy harvested techniques are preferred in IoT networks.Mainly it is preferred to harvest Radio Frequency(RF)energy in the network.In this paper a region based multi-channel architecture is proposed.In which the coverage area of primary node is divided as Energy Harvesting Region and Communication Region.The Secondary User(SU)that are the licensed user is IoT enabled with Cognitive Radio(CR)techniques so we call it CR-enabled IoT node/device and is encouraged to harvest energy by utilizing radio frequency energy.To harvest energy efficiently and to reduce the energy consumption during sensing,the concept of overlapping region is given that supports to sense multiple channels simultaneously and help the SU to find best channel for transmitting data or to harvest energy from the ideal channel.From the experimental analysis,it is proved that SU can harvest more energy in overlapping region and this architecture proves to consume less energy during data transmission as compared to single channel.We also show that channel load can be highly reduced and channel utilization is proved to be more proficient.Thus,this proves the proposed architecture cost-effective and energy-efficient.展开更多
文摘The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets(ODTs) are tested using two different taste sensors. Second, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the disintegration time of ODTs. Finally, we compare the characteristics of the two taste sensors in the evaluation of palatability of various kinds of drug formulations.
文摘A sweet-sensitive taste sensor was investigated with potetiometric measurement.The transducer was a lipid/polymer membrane composed of tetradodecylammonium bromide,di-n-octylphenylphosphonate and polyvinyl chloride,which surface was modified with polyphenol and the solvent 30% EtOH,100 mmol/L KC1 and 10 mmol/L KOH.Balancing hydrophobic/ hydrophilic property and charge density on the membrane surface was susceptible to sensitivity for sweetener.Interaction between the membrane and sweet taste substances such as sucrose was detected as membrane potential change.
基金The Open Foundation of Laboratory of Marine Ecosystem and Biogeochemistry,SOA under contract No.LMEB201701
文摘There are well-established chemical and turbidity anomalies in the plumes occurring vicinity of hydrothermal vents, which are used to indicate their existence and locations. We here develop a small, accurate multi-channel chemical sensor to detect such anomalies which can be used in deep-sea at depths of more than 4 000 m. The design allowed five all-solid-state electrodes to be mounted on it and each (apart from one reference electrode) could be changed according to chemicals to be measured. Two experiments were conducted using the chemical sensors. The first was a shallow-sea trial which included sample measurements and in situ monitoring. pH, Eh, CO3^2- and SO4^2- electrodes were utilized to demonstrate that the chemical sensor was accurate and stable outside the laboratory. In the second experiment, the chemical sensor was integrated with pH, Eh, CO3^2- and H2S electrodes, and was used in 29 scans of the seabed along the Southwest Indian Ridge (SWIR) to detect hydrothermal vents, from which 27 sets of valid data were obtained. Hydrothermal vents were identified by analyzing the chemical anomalies, the primary judging criteria were decreasing voltages of Eh and H2S, matched by increasing voltages of pH and CO3^2- . We proposed that simultaneous detection of changes in these parameters will indicate a hydrothermal vent. Amongst the 27 valid sets of data, five potential hydrothermal vents were targeted using the proposed method. We suggest that our sensors could be widely employed by marine scientists.
文摘The purpose of this study was to prepare a poly-γ-glutamic acid hydrogel (PGA gel), to examine its ease of swallowing using texture profile analysis (TPA) and to evaluate its taste-masking effects on basic or acidic drugs using the artificial taste sensor. Using TPA, 0.5% and 1.0% PGA gels, 0.5% and 1.0% agar and 1.0% ι-carrageenan in the absence of drug was examined the hardness, adhesiveness and cohesiveness, ranked according to permission criteria published by the Japanese Consumers Affairs Agency. 0.5% PGA gel and 1.0% agar were classified into grade II. In the taste sensor measurement, the bitterness suppressions by 0.5% PGA gel were larger than that by 1.0% agar in all drugs and the bitterness suppressions of basic drugs in 0.5% PGA gel were more potent than those of acidic drugs in 0.5% PGA gel. 1H-nuclear magnetic resonance spectroscopic analysis was carried out to examine the difference in mechanism of bitterness suppression between basic drugs and acidic drugs mixed with PGA gel. The signals of the proton nearest to the nitrogen atom of basic drugs shifted clearly upfield, suggesting an interaction between the amino group of basic drugs and the carboxyl group of PGA gel. In conclusion, PGA gel is expected to be a useful excipient in formulations contained various drugs, especially basic drugs;it also has advantage for not only increasing ease of swallowing but also masking the bitterness of drugs even though a small amount of a single drug dose might be preferred.
文摘The purpose of the present study was to examine the effect of adenylic acid (adenosine 5-monophosphate;AMP), a known nutritional enhancer, on inhibiting the bitterness of antipsychotic medicines administered to patients with mental illnesses, including children. First, we chose four antipsychotic medicines, amitriptyline hydrochloride (AMT), chlorpromazine hydrochloride (CPZ), haloperidol (HPD) and risperidone (RIS) and evaluated the inhibition of their bitterness by AMP through taste sensor measurements. AMP showed a significant bitterness inhibition effect on all drugs. Second, MarvinSketch analysis revealed the potential formation of electrostatic interactions between ionic forms (IV) of AMP and ionic (cationic) forms of each drug, which resulted in bitterness suppression. Third, chemical shift perturbations in 1H-NMR studies suggested an interaction between the phosphate group of AMP and amino group of AMT, CPZ, HPD and RIS. Last, conventional elution experiments of up to 1 min simulating oral cavity conditions were performed for 1 whole AMT tablet, half AMT tablet, crushed half AMT tablet, and crushed AMT tablet containing AMP powder/solution (1, 3 mM potency). The taste sensor output values of the crushed AMT tablet containing AMP powder/solution (1, 3 mM potency) were significantly lower than those of the crushed tablet.
基金supported in part by TEKES(Finnish Funding Agency for Technology and Innovation)as part of the Wireless Sensor and Actuator Networks for Measurement and Control(WiSA-II)programby the U.S.Army Research Office under Cooperative Agreement W911NF-04-2-0054.
文摘Recent advances in wireless sensor technology have enabled simultaneous exploitation of multiple channels in wireless sensor systems. In this paper, a novel time synchronization algorithm is proposed for multi- channel Wireless Sensor Networks (WSNs) called Multi-Channel Time Synchronization (MCTS) protocol. Time synchronization is critical for many WSN applications and enables efficient communications between sensor nodes along with intelligent spectrum access. Contrary to many existing protocols that do not exploit multi-channel communications, the protocol takes advantage of potential multiple channels and distributes the synchronization of different nodes to distinct channels and thus, reduces the convergence time of synchronization processes significantly.
基金National Natural Science Foundation of China under Grant (Nos.52192662,52020105005,51908320)the Beijing Nova Program under Grant No.20220484012+1 种基金the Interdisciplinary Research Project for Young Teachers of USTB (Fundamental Research Funds for the Central Universities,FRF-IDRY-22-013)the Key Laboratory for Intelligent Infrastructure and Monitoring of Fujian Province (Huaqiao University,IIM-01-05)。
文摘Steel-concrete composite structures(SCCS)have been widely used as primary load-bearing components in large-scale civil infrastructures.As the basis of the co-working ability of steel plate and concrete,the bonding status plays an essential role in guaranteeing the structural performance of SCCS.Accordingly,efficient non-destructive testing(NDT)on interfacial debondings in SCCS has become a prominent research area.Multi-channel analysis of surface waves(MASW)has been validated as an effective NDT technique for interfacial debonding detection for SCCS.However,the feasibility of MASW must be validated using experimental measurements.This study establishes a high-frequency data synchronous acquisition system with 32 channels to perform comparative verification experiments in depth.First,the current sensing approaches for high-frequency vibration and stress waves are summarized.Secondly,three types of contact sensors,namely,piezoelectric lead-zirconate-titanate(PZT)patches,accelerometers,and ultrasonic transducers,are selected for MASW measurement.Then,the selection and optimization of the force hammer head are performed.Comparative experiments are carried out for the optimal selection of ultrasonic transducers,PZT patches,and accelerometers for MASW measurement.In addition,the influence of different pasting methods on the output signal of the sensor array is discussed.Experimental results indicate that optimized PZT patches,acceleration sensors,and ultrasonic transducers can provide efficient data acquisition for MASW-based non-destructive experiments.The research findings in this study lay a solid foundation for analyzing the recognition accuracy of contact MASW measurement using different sensor arrays.
文摘Cold-junction compensation(CJC)and disconnection detection circuit design of various thermocouples(TC)and multi-channel TC interface circuits were designed.The CJC and disconnection detection circuit consists of a CJC semiconductor device,an instrumentation amplifier(IA),two resistors,and a diode for disconnection detection.Based on the basic circuit,a multi-channel interface circuit was also implemented.The CJC was implemented using compensation semiconductor and IA,and disconnection detection was detected by using two resistors and a diode so that IA input voltage became-0.42 V.As a result of the experiment using R-type TC,the error of the designed circuit was reduced from 0.14 mV to 3μV after CJC in the temperature range of 0°C to 1400°C.In addition,it was confirmed that the output voltage of IA was saturated from 88 mV to-14.2 V when TC was disconnected from normal.The output voltage of the designed circuit was 0 V to 10 V in the temperature range of 0°C to 1400°C.The results of the 4-channel interface experiment using R-type TC were almost identical to the CJC and disconnection detection results for each channel.The implemented multi-channel interface has a feature that can be applied equally to E,J,K,T,R,and S-type TCs by changing the terminals of CJC semiconductor devices and adjusting the IA gain.
基金This work was supported by the grants from the National Natural Science Foundation of China(Grant Nos.60725102,31000448)the China Postdoctoral Science Foundation(Grant Nos.20100471737,201104734)the Key Project of Zhejiang Province(Grant No.2010C14006).
文摘This paper presents a novel biosensor for bitter substance detection on the basis of light addressable potentiometric sensor(LAPS).Taste receptor cells(TRCs)were used as sensitive elements,which can respond to different bitter stimuli with extreme high sensitivity and speci-ficity.TRCs were isolated from the taste buds of rats and cultured on the surface of LAPS chip.Due to the unique advantages such as single-cell recording,light addressable capability,and noninvasiveness,LAPS chip was used as secondary transducer to monitor the responses of TRCs by recording extracelluar potential changes.The results indicate LAPS chip can effectively record the responses of TRCs to different bitter substances used in this study in a real-time manner for a long-term.In addition,by performing principal component analysis on the LAPS recording data,different bitter substances tested can be successfully discriminated.It is suggested this TRCsLAPS hybrid biosensor could be a valuable tool for bitter substance detection.With further improvement and novel design,it has great potentials to be applied in both basic research and practical applications related to bitter taste detection.
文摘In the presence of background noise,arrival times picked from a surface microseismic data set usually include a number of false picks that can lead to uncertainty in location estimation.To eliminate false picks and improve the accuracy of location estimates,we develop an association algorithm termed RANSAC-based Arrival Time Event Clustering(RATEC)that clusters picked arrival times into event groups based on random sampling and fitting moveout curves that approximate hyperbolas.Arrival times far from the fitted hyperbolas are classified as false picks and removed from the data set prior to location estimation.Simulations of synthetic data for a 1-D linear array show that RATEC is robust under different noise conditions and generally applicable to various types of subsurface structures.By generalizing the underlying moveout model,RATEC is extended to the case of a 2-D surface monitoring array.The effectiveness of event location for the 2-D case is demonstrated using a data set collected by the 5200-element dense Long Beach array.The obtained results suggest that RATEC is effective in removing false picks and hence can be used for phase association before location estimates.
文摘Wireless Sensor Networks(WSNs)can be termed as an autoconfigured and infrastructure-less wireless networks to monitor physical or environmental conditions,such as temperature,sound,vibration,pressure and motion etc.WSNs may comprise thousands of Internet of Things(IoT)devices to sense and collect data from its surrounding,process the data and take an automated and mechanized decision.On the other side the proliferation of these devices will soon cause radio spectrum shortage.So,to facilitate these networks,we integrate Cognitive Radio(CR)functionality in these networks.CR can sense the unutilized spectrum of licensed users and then use these empty bands when required.In order to keep the IoT nodes functional all time,continuous energy is required.For this reason the energy harvested techniques are preferred in IoT networks.Mainly it is preferred to harvest Radio Frequency(RF)energy in the network.In this paper a region based multi-channel architecture is proposed.In which the coverage area of primary node is divided as Energy Harvesting Region and Communication Region.The Secondary User(SU)that are the licensed user is IoT enabled with Cognitive Radio(CR)techniques so we call it CR-enabled IoT node/device and is encouraged to harvest energy by utilizing radio frequency energy.To harvest energy efficiently and to reduce the energy consumption during sensing,the concept of overlapping region is given that supports to sense multiple channels simultaneously and help the SU to find best channel for transmitting data or to harvest energy from the ideal channel.From the experimental analysis,it is proved that SU can harvest more energy in overlapping region and this architecture proves to consume less energy during data transmission as compared to single channel.We also show that channel load can be highly reduced and channel utilization is proved to be more proficient.Thus,this proves the proposed architecture cost-effective and energy-efficient.