Enhancing Cancer Classification through a Hybrid Bio-Inspired Evolutionary Algorithm for Biomarker Gene Selection

In this study,our aim is to address the problem of gene selection by proposing a hybrid bio-inspired evolutionary algorithm that combines Grey Wolf Optimization(GWO)with Harris Hawks Optimization(HHO)for feature selection.Themotivation for utilizingGWOandHHOstems fromtheir bio-inspired nature and their demonstrated success in optimization problems.We aimto leverage the strengths of these algorithms to enhance the effectiveness of feature selection in microarray-based cancer classification.We selected leave-one-out cross-validation(LOOCV)to evaluate the performance of both two widely used classifiers,k-nearest neighbors(KNN)and support vector machine(SVM),on high-dimensional cancer microarray data.The proposed method is extensively tested on six publicly available cancer microarray datasets,and a comprehensive comparison with recently published methods is conducted.Our hybrid algorithm demonstrates its effectiveness in improving classification performance,Surpassing alternative approaches in terms of precision.The outcomes confirm the capability of our method to substantially improve both the precision and efficiency of cancer classification,thereby advancing the development ofmore efficient treatment strategies.The proposed hybridmethod offers a promising solution to the gene selection problem in microarray-based cancer classification.It improves the accuracy and efficiency of cancer diagnosis and treatment,and its superior performance compared to other methods highlights its potential applicability in realworld cancer classification tasks.By harnessing the complementary search mechanisms of GWO and HHO,we leverage their bio-inspired behavior to identify informative genes relevant to cancer diagnosis and treatment.

Marine Predators Algorithm with Deep Learning-Based Leukemia Cancer Classification on Medical Images

In blood or bone marrow,leukemia is a form of cancer.A person with leukemia has an expansion of white blood cells(WBCs).It primarily affects children and rarely affects adults.Treatment depends on the type of leukemia and the extent to which cancer has established throughout the body.Identifying leukemia in the initial stage is vital to providing timely patient care.Medical image-analysis-related approaches grant safer,quicker,and less costly solutions while ignoring the difficulties of these invasive processes.It can be simple to generalize Computer vision(CV)-based and image-processing techniques and eradicate human error.Many researchers have implemented computer-aided diagnosticmethods andmachine learning(ML)for laboratory image analysis,hopefully overcoming the limitations of late leukemia detection and determining its subgroups.This study establishes a Marine Predators Algorithm with Deep Learning Leukemia Cancer Classification(MPADL-LCC)algorithm onMedical Images.The projectedMPADL-LCC system uses a bilateral filtering(BF)technique to pre-process medical images.The MPADL-LCC system uses Faster SqueezeNet withMarine Predators Algorithm(MPA)as a hyperparameter optimizer for feature extraction.Lastly,the denoising autoencoder(DAE)methodology can be executed to accurately detect and classify leukemia cancer.The hyperparameter tuning process using MPA helps enhance leukemia cancer classification performance.Simulation results are compared with other recent approaches concerning various measurements and the MPADL-LCC algorithm exhibits the best results over other recent approaches.

Classification and reconstructive algorithm for nasal alar defect in Asians

Background:The nasal alar defect in Asians remains a challenging issue,as do clear classification and algorithm guidance,despite numerous previously described surgical techniques.The aim of this study is to propose a surgical algorithm that addresses the appropriate surgical procedures for different types of nasal alar defects in Asian patients.Methods:A retrospective case note review was conducted on 32 patients with nasal alar defect who underwent reconstruction between 2008 and 2022.Based on careful analysis and our clinical experience,we proposed a classification system for nasal alar defects and presented a reconstructive algorithm.Patient data,including age,sex,diagnosis,surgical options,and complications,were assessed.The extent of surgical scar formation was evaluated using standard photography based on a 4-grade scar scale.Results:Among the 32 patients,there were 20 males and 12 females with nasal alar defects.The predominant cause of trauma in China was industrial factors.The majority of alar defects were classified as type Ⅰ C(n=8,25%),comprising 18 cases(56.2%);there were 5 cases(15.6%)of type Ⅱ defect,7(21.9%)of type Ⅲ defect,and 2(6.3%)of type Ⅳ defect.The most common surgical option was auricular composite graft(n=8,25%),followed by bilobed flap(n=6,18.8%),free auricular composite flap(n=4,12.5%),and primary closure(n=3,9.4%).Satisfactory improvements were observed postoperatively.Conclusion:Factors contributing to classifications were analyzed and defined,providing a framework for the proposed classification system.The reconstructive algorithm offers surgeons appropriate procedures for treating nasal alar defect in Asians.

A combined algorithm of K-means and MTRL for multi-class classification

The basic idea of multi-class classification is a disassembly method,which is to decompose a multi-class classification task into several binary classification tasks.In order to improve the accuracy of multi-class classification in the case of insufficient samples,this paper proposes a multi-class classification method combining K-means and multi-task relationship learning(MTRL).The method first uses the split method of One vs.Rest to disassemble the multi-class classification task into binary classification tasks.K-means is used to down sample the dataset of each task,which can prevent over-fitting of the model while reducing training costs.Finally,the sampled dataset is applied to the MTRL,and multiple binary classifiers are trained together.With the help of MTRL,this method can utilize the inter-task association to train the model,and achieve the purpose of improving the classification accuracy of each binary classifier.The effectiveness of the proposed approach is demonstrated by experimental results on the Iris dataset,Wine dataset,Multiple Features dataset,Wireless Indoor Localization dataset and Avila dataset.

Power Quality Disturbance Classification Method Based on Wavelet Transform and SVM Multi-class Algorithms

The accurate identification and classification of various power quality disturbances are keys to ensuring high-quality electrical energy. In this study, the statistical characteristics of the disturbance signal of wavelet transform coefficients and wavelet transform energy distribution constitute feature vectors. These vectors are then trained and tested using SVM multi-class algorithms. Experimental results demonstrate that the SVM multi-class algorithms, which use the Gaussian radial basis function, exponential radial basis function, and hyperbolic tangent function as basis functions, are suitable methods for power quality disturbance classification.

FLIGHT CLASSIFICATION MODEL BASED ON TRANSITIVE CLOSURE ALGORITHM AND APPLICATION TO FLIGHT SEQUENCING PROBLEM

A new arrival and departure flight classification method based on the transitive closure algorithm （TCA） is proposed. Firstly, the fuzzy set theory and the transitive closure algorithm are introduced. Then four different factors are selected to establish the flight classification model and a method is given to calculate the delay cost for each class. Finally, the proposed method is implemented in the sequencing problems of flights in a terminal area, and results are compared with that of the traditional classification method（TCM）. Results show that the new classification model is effective in reducing the expenses of flight delays, thus optimizing the sequences of arrival and departure flights, and improving the efficiency of air traffic control.

LEARNING ALGORITHM OF FEEDFORWARD NEURAL NETWORK WITH HARD LIMITER USED FOR CLASSIFICATION

A learning algorithm based on a hard limiter for feedforward neural networks (NN) is presented,and is applied in solving classification problems on separable convex sets and disjoint sets.It has been proved that the algorithm has stronger classification ability than that of the back propagation (BP) algorithm for the feedforward NN using sigmoid function by simulation.What is more,the models can be implemented with lower cost hardware than that of the BP NN.LEARNIN

Application of QPSO-KM Algorithm in Wine Quality Classification

Since there are many factors affecting the quality of wine, total 17 factors were screened out using principle component analysis. The difference test was conducted on the evaluation data of the two groups of testers. The results showed that the evaluation data of the second group were more reliable compared with those of the first group. At the same time, the KM algorithm was optimized using the QPSO algorithm. The wine classification model was established. Compared with the other two algorithms, the QPSO-KM algorithm was more capable of searching the globally optimum solution, and it could be used to classify the wine samples. In addition,the QPSO-KM algorithm could also be used to solve the issues about clustering.

An Imbalanced Data Classification Method Based on Hybrid Resampling and Fine Cost Sensitive Support Vector Machine

When building a classification model,the scenario where the samples of one class are significantly more than those of the other class is called data imbalance.Data imbalance causes the trained classification model to be in favor of the majority class(usually defined as the negative class),which may do harm to the accuracy of the minority class(usually defined as the positive class),and then lead to poor overall performance of the model.A method called MSHR-FCSSVM for solving imbalanced data classification is proposed in this article,which is based on a new hybrid resampling approach(MSHR)and a new fine cost-sensitive support vector machine(CS-SVM)classifier(FCSSVM).The MSHR measures the separability of each negative sample through its Silhouette value calculated by Mahalanobis distance between samples,based on which,the so-called pseudo-negative samples are screened out to generate new positive samples(over-sampling step)through linear interpolation and are deleted finally(under-sampling step).This approach replaces pseudo-negative samples with generated new positive samples one by one to clear up the inter-class overlap on the borderline,without changing the overall scale of the dataset.The FCSSVM is an improved version of the traditional CS-SVM.It considers influences of both the imbalance of sample number and the class distribution on classification simultaneously,and through finely tuning the class cost weights by using the efficient optimization algorithm based on the physical phenomenon of rime-ice(RIME)algorithm with cross-validation accuracy as the fitness function to accurately adjust the classification borderline.To verify the effectiveness of the proposed method,a series of experiments are carried out based on 20 imbalanced datasets including both mildly and extremely imbalanced datasets.The experimental results show that the MSHR-FCSSVM method performs better than the methods for comparison in most cases,and both the MSHR and the FCSSVM played significant roles.

BACNN: Multi-scale feature fusion-based bilinear attention convolutional neural network for wood NIR classification

Effective development and utilization of wood resources is critical.Wood modification research has become an integral dimension of wood science research,however,the similarities between modified wood and original wood render it challenging for accurate identification and classification using conventional image classification techniques.So,the development of efficient and accurate wood classification techniques is inevitable.This paper presents a one-dimensional,convolutional neural network(i.e.,BACNN)that combines near-infrared spectroscopy and deep learning techniques to classify poplar,tung,and balsa woods,and PVA,nano-silica-sol and PVA-nano silica sol modified woods of poplar.The results show that BACNN achieves an accuracy of 99.3%on the test set,higher than the 52.9%of the BP neural network and 98.7%of Support Vector Machine compared with traditional machine learning methods and deep learning based methods;it is also higher than the 97.6%of LeNet,98.7%of AlexNet and 99.1%of VGGNet-11.Therefore,the classification method proposed offers potential applications in wood classification,especially with homogeneous modified wood,and it also provides a basis for subsequent wood properties studies.

Prediction of geological characteristics from shield operational parameters by integrating grid search and K-fold cross validation into stacking classification algorithm

This study presents a framework for predicting geological characteristics based on integrating a stacking classification algorithm(SCA) with a grid search(GS) and K-fold cross validation(K-CV). The SCA includes two learner layers: a primary learner’s layer and meta-classifier layer. The accuracy of the SCA can be improved by using the GS and K-CV. The GS was developed to match the hyper-parameters and optimise complicated problems. The K-CV is commonly applied to changing the validation set in a training set. In general, a GS is usually combined with K-CV to produce a corresponding evaluation index and select the best hyper-parameters. The torque penetration index(TPI) and field penetration index(FPI) are proposed based on shield parameters to express the geological characteristics. The elbow method(EM) and silhouette coefficient(Si) are employed to determine the types of geological characteristics(K) in a Kmeans++ algorithm. A case study on mixed ground in Guangzhou is adopted to validate the applicability of the developed model. The results show that with the developed framework, the four selected parameters, i.e. thrust, advance rate, cutterhead rotation speed and cutterhead torque, can be used to effectively predict the corresponding geological characteristics.

A Spectral Convolutional Neural Network Model Based on Adaptive Fick’s Law for Hyperspectral Image Classification

Hyperspectral image classification stands as a pivotal task within the field of remote sensing,yet achieving highprecision classification remains a significant challenge.In response to this challenge,a Spectral Convolutional Neural Network model based on Adaptive Fick’s Law Algorithm(AFLA-SCNN)is proposed.The Adaptive Fick’s Law Algorithm(AFLA)constitutes a novel metaheuristic algorithm introduced herein,encompassing three new strategies:Adaptive weight factor,Gaussian mutation,and probability update policy.With adaptive weight factor,the algorithmcan adjust theweights according to the change in the number of iterations to improve the performance of the algorithm.Gaussianmutation helps the algorithm avoid falling into local optimal solutions and improves the searchability of the algorithm.The probability update strategy helps to improve the exploitability and adaptability of the algorithm.Within the AFLA-SCNN model,AFLA is employed to optimize two hyperparameters in the SCNN model,namely,“numEpochs”and“miniBatchSize”,to attain their optimal values.AFLA’s performance is initially validated across 28 functions in 10D,30D,and 50D for CEC2013 and 29 functions in 10D,30D,and 50D for CEC2017.Experimental results indicate AFLA’s marked performance superiority over nine other prominent optimization algorithms.Subsequently,the AFLA-SCNN model was compared with the Spectral Convolutional Neural Network model based on Fick’s Law Algorithm(FLA-SCNN),Spectral Convolutional Neural Network model based on Harris Hawks Optimization(HHO-SCNN),Spectral Convolutional Neural Network model based onDifferential Evolution(DE-SCNN),SpectralConvolutionalNeuralNetwork(SCNN)model,and SupportVector Machines(SVM)model using the Indian Pines dataset and PaviaUniversity dataset.The experimental results show that the AFLA-SCNN model outperforms other models in terms of Accuracy,Precision,Recall,and F1-score on Indian Pines and Pavia University.Among them,the Accuracy of the AFLA-SCNN model on Indian Pines reached 99.875%,and the Accuracy on PaviaUniversity reached 98.022%.In conclusion,our proposed AFLA-SCNN model is deemed to significantly enhance the precision of hyperspectral image classification.

A novel fast classification filtering algorithm for LiDAR point clouds based on small grid density clustering

Clustering filtering is usually a practical method for light detection and ranging(LiDAR)point clouds filtering according to their characteristic attributes.However,the amount of point cloud data is extremely large in practice,making it impossible to cluster point clouds data directly,and the filtering error is also too large.Moreover,many existing filtering algorithms have poor classification results in discontinuous terrain.This article proposes a new fast classification filtering algorithm based on density clustering,which can solve the problem of point clouds classification in discontinuous terrain.Based on the spatial density of LiDAR point clouds,also the features of the ground object point clouds and the terrain point clouds,the point clouds are clustered firstly by their elevations,and then the plane point clouds are selected.Thus the number of samples and feature dimensions of data are reduced.Using the DBSCAN clustering filtering method,the original point clouds are finally divided into noise point clouds,ground object point clouds,and terrain point clouds.The experiment uses 15 sets of data samples provided by the International Society for Photogrammetry and Remote Sensing(ISPRS),and the results of the proposed algorithm are compared with the other eight classical filtering algorithms.Quantitative and qualitative analysis shows that the proposed algorithm has good applicability in urban areas and rural areas,and is significantly better than other classic filtering algorithms in discontinuous terrain,with a total error of about 10%.The results show that the proposed method is feasible and can be used in different terrains.

Basic Tenets of Classification Algorithms K-Nearest-Neighbor, Support Vector Machine, Random Forest and Neural Network: A Review

In this paper, sixty-eight research articles published between 2000 and 2017 as well as textbooks which employed four classification algorithms: K-Nearest-Neighbor (KNN), Support Vector Machines (SVM), Random Forest (RF) and Neural Network (NN) as the main statistical tools were reviewed. The aim was to examine and compare these nonparametric classification methods on the following attributes: robustness to training data, sensitivity to changes, data fitting, stability, ability to handle large data sizes, sensitivity to noise, time invested in parameter tuning, and accuracy. The performances, strengths and shortcomings of each of the algorithms were examined, and finally, a conclusion was arrived at on which one has higher performance. It was evident from the literature reviewed that RF is too sensitive to small changes in the training dataset and is occasionally unstable and tends to overfit in the model. KNN is easy to implement and understand but has a major drawback of becoming significantly slow as the size of the data in use grows, while the ideal value of K for the KNN classifier is difficult to set. SVM and RF are insensitive to noise or overtraining, which shows their ability in dealing with unbalanced data. Larger input datasets will lengthen classification times for NN and KNN more than for SVM and RF. Among these nonparametric classification methods, NN has the potential to become a more widely used classification algorithm, but because of their time-consuming parameter tuning procedure, high level of complexity in computational processing, the numerous types of NN architectures to choose from and the high number of algorithms used for training, most researchers recommend SVM and RF as easier and wieldy used methods which repeatedly achieve results with high accuracies and are often faster to implement.

A Novel Image Classification Algorithm Based on Extreme Learning Machine

In order to improve the accuracy and reduce the training and testing time in image classification algorithm, a novel image classification scheme based on extreme learning machine(ELM) and linear spatial pyramid matching using sparse coding(Sc SPM) for image classification is proposed. A new structure based on two layer extreme learning machine instead of the original linear SVM classifier is constructed. Firstly, the Sc SPM algorithm is performed to extract features of the multi-scale image blocks, and then each layer feature vector is connected to an ELM. Finally, the mapping features are connected together, and as the input of one ELM based on radial basis kernel function. With experimental evaluations on the well-known dataset benchmarks, the results demonstrate that the proposed algorithm has better performance not only in reducing the training time, but also in improving the accuracy of classification.

A Novel Optimized Deep Convolutional Neural Network for Efficient Seizure Stage Classification

Brain signal analysis from electroencephalogram(EEG)recordings is the gold standard for diagnosing various neural disorders especially epileptic seizure.Seizure signals are highly chaotic compared to normal brain signals and thus can be identified from EEG recordings.In the current seizure detection and classification landscape,most models primarily focus on binary classification—distinguishing between seizure and non-seizure states.While effective for basic detection,these models fail to address the nuanced stages of seizures and the intervals between them.Accurate identification of per-seizure or interictal stages and the timing between seizures is crucial for an effective seizure alert system.This granularity is essential for improving patient-specific interventions and developing proactive seizure management strategies.This study addresses this gap by proposing a novel AI-based approach for seizure stage classification using a Deep Convolutional Neural Network(DCNN).The developed model goes beyond traditional binary classification by categorizing EEG recordings into three distinct classes,thus providing a more detailed analysis of seizure stages.To enhance the model’s performance,we have optimized the DCNN using two advanced techniques:the Stochastic Gradient Algorithm(SGA)and the evolutionary Genetic Algorithm(GA).These optimization strategies are designed to fine-tune the model’s accuracy and robustness.Moreover,k-fold cross-validation ensures the model’s reliability and generalizability across different data sets.Trained and validated on the Bonn EEG data sets,the proposed optimized DCNN model achieved a test accuracy of 93.2%,demonstrating its ability to accurately classify EEG signals.In summary,the key advancement of the present research lies in addressing the limitations of existing models by providing a more detailed seizure classification system,thus potentially enhancing the effectiveness of real-time seizure prediction and management systems in clinical settings.With its inherent classification performance,the proposed approach represents a significant step forward in improving patient outcomes through advanced AI techniques.

Ensemble Filter-Wrapper Text Feature Selection Methods for Text Classification

Feature selection is a crucial technique in text classification for improving the efficiency and effectiveness of classifiers or machine learning techniques by reducing the dataset’s dimensionality.This involves eliminating irrelevant,redundant,and noisy features to streamline the classification process.Various methods,from single feature selection techniques to ensemble filter-wrapper methods,have been used in the literature.Metaheuristic algorithms have become popular due to their ability to handle optimization complexity and the continuous influx of text documents.Feature selection is inherently multi-objective,balancing the enhancement of feature relevance,accuracy,and the reduction of redundant features.This research presents a two-fold objective for feature selection.The first objective is to identify the top-ranked features using an ensemble of three multi-univariate filter methods:Information Gain(Infogain),Chi-Square(Chi^(2)),and Analysis of Variance(ANOVA).This aims to maximize feature relevance while minimizing redundancy.The second objective involves reducing the number of selected features and increasing accuracy through a hybrid approach combining Artificial Bee Colony(ABC)and Genetic Algorithms(GA).This hybrid method operates in a wrapper framework to identify the most informative subset of text features.Support Vector Machine(SVM)was employed as the performance evaluator for the proposed model,tested on two high-dimensional multiclass datasets.The experimental results demonstrated that the ensemble filter combined with the ABC+GA hybrid approach is a promising solution for text feature selection,offering superior performance compared to other existing feature selection algorithms.

Research on classification method of high myopic maculopathy based on retinal fundus images and optimized ALFA-Mix active learning algorithm

AIM:To conduct a classification study of high myopic maculopathy(HMM)using limited datasets,including tessellated fundus,diffuse chorioretinal atrophy,patchy chorioretinal atrophy,and macular atrophy,and minimize annotation costs,and to optimize the ALFA-Mix active learning algorithm and apply it to HMM classification.METHODS:The optimized ALFA-Mix algorithm(ALFAMix+)was compared with five algorithms,including ALFA-Mix.Four models,including Res Net18,were established.Each algorithm was combined with four models for experiments on the HMM dataset.Each experiment consisted of 20 active learning rounds,with 100 images selected per round.The algorithm was evaluated by comparing the number of rounds in which ALFA-Mix+outperformed other algorithms.Finally,this study employed six models,including Efficient Former,to classify HMM.The best-performing model among these models was selected as the baseline model and combined with the ALFA-Mix+algorithm to achieve satisfactor y classification results with a small dataset.RESULTS:ALFA-Mix+outperforms other algorithms with an average superiority of 16.6,14.75,16.8,and 16.7 rounds in terms of accuracy,sensitivity,specificity,and Kappa value,respectively.This study conducted experiments on classifying HMM using several advanced deep learning models with a complete training set of 4252 images.The Efficient Former achieved the best results with an accuracy,sensitivity,specificity,and Kappa value of 0.8821,0.8334,0.9693,and 0.8339,respectively.Therefore,by combining ALFA-Mix+with Efficient Former,this study achieved results with an accuracy,sensitivity,specificity,and Kappa value of 0.8964,0.8643,0.9721,and 0.8537,respectively.CONCLUSION:The ALFA-Mix+algorithm reduces the required samples without compromising accuracy.Compared to other algorithms,ALFA-Mix+outperforms in more rounds of experiments.It effectively selects valuable samples compared to other algorithms.In HMM classification,combining ALFA-Mix+with Efficient Former enhances model performance,further demonstrating the effectiveness of ALFA-Mix+.

Evolving Neural Network Using Variable String Genetic Algorithm for Color Infrared Aerial Image Classification

Coastal wetlands are characterized by complex patterns both in their geomorphlc and ecological teatures. Besides field observations, it is necessary to analyze the land cover of wetlands through the color infrared （CIR） aerial photography or remote sensing image. In this paper, we designed an evolving neural network classifier using variable string genetic algorithm （VGA） for the land cover classification of CIR aerial image. With the VGA, the classifier that we designed is able to evolve automatically the appropriate number of hidden nodes for modeling the neural network topology optimally and to find a near-optimal set of connection weights globally. Then, with backpropagation algorithm （BP）, it can find the best connection weights. The VGA-BP classifier, which is derived from hybrid algorithms mentioned above, is demonstrated on CIR images classification effectively. Compared with standard classifiers, such as Bayes maximum-likelihood classifier, VGA classifier and BP-MLP （multi-layer perception） classifier, it has shown that the VGA-BP classifier can have better performance on highly resolution land cover classification.

An Experimental Comparative Study on Three Classification Algorithms

Classification algorithm is one of the key techniques to affect text automatic classification system’s performance, play an important role in automatic classification research area. This paper comparatively analyzed k-NN. VSM and hybrid classification algorithm presented by our research group. Some 2000 pieces of Internet news provided by ChinaInfoBank are used in the experiment. The result shows that the hybrid algorithm’s performance presented by the groups is superior to the other two algorithms.