A sequential one-pot synthesis of N-sulfonylcyclothioureas from N-monosulfonyl diamines, CS2 and chloroace- tic acid at room temperature in water is described. In the absence of highly toxic thiophosgene and organic s...A sequential one-pot synthesis of N-sulfonylcyclothioureas from N-monosulfonyl diamines, CS2 and chloroace- tic acid at room temperature in water is described. In the absence of highly toxic thiophosgene and organic solvents, this method is environmentally benign. Simple reaction conditions, easy purification of the products, good yields and thioglycolic acid as the useful byproduct are also important attributes of this methodology. The plausible mechanism including tandem reactions is proposed.展开更多
Various addition-elimination approaches have been explored for diastereoselective construction of 1-amino- 1-cyclopropane-carboxylic acid (ACPC) derivatives, and the desired product was obtained from a reaction of cyc...Various addition-elimination approaches have been explored for diastereoselective construction of 1-amino- 1-cyclopropane-carboxylic acid (ACPC) derivatives, and the desired product was obtained from a reaction of cyclo(NAc-L-Val-NAc-Gly) and methyl α-bro-moacrylate under protonic solvent.展开更多
基金Project supported by the National Natural Science Foundation of China （No. 20802049）.
文摘A sequential one-pot synthesis of N-sulfonylcyclothioureas from N-monosulfonyl diamines, CS2 and chloroace- tic acid at room temperature in water is described. In the absence of highly toxic thiophosgene and organic solvents, this method is environmentally benign. Simple reaction conditions, easy purification of the products, good yields and thioglycolic acid as the useful byproduct are also important attributes of this methodology. The plausible mechanism including tandem reactions is proposed.
文摘Various addition-elimination approaches have been explored for diastereoselective construction of 1-amino- 1-cyclopropane-carboxylic acid (ACPC) derivatives, and the desired product was obtained from a reaction of cyclo(NAc-L-Val-NAc-Gly) and methyl α-bro-moacrylate under protonic solvent.
