There were 4 Acinetobacter lwoffii obtained from soil samples.The antimicrobial susceptibility of the strains to 16 antimicrobial agents was investigated using K-B method.Three isolates showed the multi-drug resistanc...There were 4 Acinetobacter lwoffii obtained from soil samples.The antimicrobial susceptibility of the strains to 16 antimicrobial agents was investigated using K-B method.Three isolates showed the multi-drug resistance.The presence of resistance genes and integrons was determined using PCR.The aadA 1,aac（3＇）-IIc,aph（3＇）-VII,aac（6＇）-Ib,sul2,cat2,floR,and tet（K）genes were detected,respectively.展开更多
Objective:To determine the risk factors and outcomes of imipenem-resistant Acinetobacter baumannii(IRAB) bloodstream infection(BSI) cases,since there is very little publication on Aeinetobacter baumannii infections fr...Objective:To determine the risk factors and outcomes of imipenem-resistant Acinetobacter baumannii(IRAB) bloodstream infection(BSI) cases,since there is very little publication on Aeinetobacter baumannii infections from Malaysia.Methods:A cross sectional study of 41 cases(73.2%) of imipenem-sensitive Acinetobacter baumanii(ISAB) and 15 cases(26.8%) of IRAB was conducted in a teaching hospital which was located at North-Eastern state of Malaysia.Results:There was no independent risk factor for IRAB BSI identified but IRAB BSI was significantly associated with longer bacteraemic days[OR 1.23(95%CI 1.01,1.50)].Although prior use of carbepenems and cephalosporin were higher among IRAB than ISAB group,statistically they were not significant.There was no significant difference in term of outcomes between the two groups.Conclusions:Although statistically not significant,this analysis compliments previous publication highlighting the importance of appropriate empiric antibiotic usage in hospital especially carbepenems and need further evaluation with bigger subjects.展开更多
Background:With various changes implemented such as perioperative antibiotics for tangential excision,this retrospective study reviews the infection profile of burn patients at Singapore's only centralized burns u...Background:With various changes implemented such as perioperative antibiotics for tangential excision,this retrospective study reviews the infection profile of burn patients at Singapore's only centralized burns unit.Worldwide,the appearance of multidrug-resistant(MDR)strains of Acinetobacter baumanni(A.baumanni)continues to worsen patient outcomes.This study also surveys the role of blood cultures in burns at our unit.Methods:Four hundred fifty-two burn patients admitted to the unit between 2011 and 2013,and with cultures performed,were included in the study.The yields of various cultures were evaluated and 2684 samples were amassed,of which 984(36.7%)were positive.Patient variables for predictors of MDR A.baumanni infection acquisition and bacteremia were evaluated through multivariate analyses.Results:Pseuodomonas aeruginosa(P.aeruginosa)(67 patients)was the most common organism in those with total body surface area(TBSA)burn<20%while MDR A.baumanni(39 patients)was most prevalent in those with TBSA burn≥20%.We found a yield of 1.1%positive blood cultures for TBSA burn<20%and a yield of 18.6%positive cultures in TBSA burn≥20%.The median time between surgery and bacteremia was 6.5 days(range-18 to 68 days,interquartile range 4.5);2.9 and 8.8%of bacteremic episodes occurred within 24 and 48 h,respectively.This is a decrease from a predeceasing study(45.3%for 24 h and 60%for 48 h).Multivariate analysis revealed that length of hospital stay and TBSA burn≥20%were predictors of MDR A.baumanni infection and positive blood cultures.Conclusions:MDR A.baumanni infection burdens patient management,especially in those with TBSA burn≥20%and longer hospital stay.Prophylactic antibiotics may reduce perioperative bacteremia,but their role in MDR infections needs to be evaluated.The role of blood cultures in TBSA burn<20%needs reconsideration.展开更多
基金supported by the Innovation Project Foundation of Chinese Academy of Agricultural Sciences(20140204066NY)Development Plan of Science and Technology in Jilin Province(20150520128JH)the Special Fund for Agro-Scientific Research in the Public Interest from the Ministry of Agriculture,China(201303042)
文摘There were 4 Acinetobacter lwoffii obtained from soil samples.The antimicrobial susceptibility of the strains to 16 antimicrobial agents was investigated using K-B method.Three isolates showed the multi-drug resistance.The presence of resistance genes and integrons was determined using PCR.The aadA 1,aac（3＇）-IIc,aph（3＇）-VII,aac（6＇）-Ib,sul2,cat2,floR,and tet（K）genes were detected,respectively.
基金Supported by Universiti Sains Malaysia(No:304/PPSP/6131378)
文摘Objective:To determine the risk factors and outcomes of imipenem-resistant Acinetobacter baumannii(IRAB) bloodstream infection(BSI) cases,since there is very little publication on Aeinetobacter baumannii infections from Malaysia.Methods:A cross sectional study of 41 cases(73.2%) of imipenem-sensitive Acinetobacter baumanii(ISAB) and 15 cases(26.8%) of IRAB was conducted in a teaching hospital which was located at North-Eastern state of Malaysia.Results:There was no independent risk factor for IRAB BSI identified but IRAB BSI was significantly associated with longer bacteraemic days[OR 1.23(95%CI 1.01,1.50)].Although prior use of carbepenems and cephalosporin were higher among IRAB than ISAB group,statistically they were not significant.There was no significant difference in term of outcomes between the two groups.Conclusions:Although statistically not significant,this analysis compliments previous publication highlighting the importance of appropriate empiric antibiotic usage in hospital especially carbepenems and need further evaluation with bigger subjects.
文摘Background:With various changes implemented such as perioperative antibiotics for tangential excision,this retrospective study reviews the infection profile of burn patients at Singapore's only centralized burns unit.Worldwide,the appearance of multidrug-resistant(MDR)strains of Acinetobacter baumanni(A.baumanni)continues to worsen patient outcomes.This study also surveys the role of blood cultures in burns at our unit.Methods:Four hundred fifty-two burn patients admitted to the unit between 2011 and 2013,and with cultures performed,were included in the study.The yields of various cultures were evaluated and 2684 samples were amassed,of which 984(36.7%)were positive.Patient variables for predictors of MDR A.baumanni infection acquisition and bacteremia were evaluated through multivariate analyses.Results:Pseuodomonas aeruginosa(P.aeruginosa)(67 patients)was the most common organism in those with total body surface area(TBSA)burn<20%while MDR A.baumanni(39 patients)was most prevalent in those with TBSA burn≥20%.We found a yield of 1.1%positive blood cultures for TBSA burn<20%and a yield of 18.6%positive cultures in TBSA burn≥20%.The median time between surgery and bacteremia was 6.5 days(range-18 to 68 days,interquartile range 4.5);2.9 and 8.8%of bacteremic episodes occurred within 24 and 48 h,respectively.This is a decrease from a predeceasing study(45.3%for 24 h and 60%for 48 h).Multivariate analysis revealed that length of hospital stay and TBSA burn≥20%were predictors of MDR A.baumanni infection and positive blood cultures.Conclusions:MDR A.baumanni infection burdens patient management,especially in those with TBSA burn≥20%and longer hospital stay.Prophylactic antibiotics may reduce perioperative bacteremia,but their role in MDR infections needs to be evaluated.The role of blood cultures in TBSA burn<20%needs reconsideration.
