As a library of nuclear basic data and nuclear model parameters for nuclear model calculations,Chinese Evaluated Nuclear Parameter Library(CENPL)at Chinese Nuclear Data Center(CNDC)consists of six sub-libraries and is...As a library of nuclear basic data and nuclear model parameters for nuclear model calculations,Chinese Evaluated Nuclear Parameter Library(CENPL)at Chinese Nuclear Data Center(CNDC)consists of six sub-libraries and is still under development.Most of the data fries for this library have beenset up.These sub-libraries have been used to retrieve the data required for nuclear model calculations andother purposes.展开更多
A new method for the rapid and efficient screening of affinity ligands to biological targets is reported. The fusion peptide of influenza virus A was used as the model target and immobilized on the PGMA beads. Antisen...A new method for the rapid and efficient screening of affinity ligands to biological targets is reported. The fusion peptide of influenza virus A was used as the model target and immobilized on the PGMA beads. Antisense peptide YRSKQA of fusion peptide was chosen as the lead compound. The special positional scanning peptide libraries were designed based on YRSKQA and synthesized by utilizing solid phase peptide synthesis manually. The libraries were YRSKQX, YRSKXA, YRSXQA, YRXKQA, YXSKQA and XRSKQA, where X represented 18 L-amino acids(except for Cys and Trp). Each library was screened by affinity chromatography. The eluates from the fusion peptide affinity column were collected and analyzed by RP-HPLC and MS, respectively, in order to determine the kind of X at each position. After the preferred residues of six positions were decided, the two preferred peptide sequences, GRGKHK and TRGKHK, were obtained. The dissociation constants of GRGKHK, TRGKHK and YRSKQA, were 3.35×10 -6, 5.24×10 -6 and 1.15×10 -5 mol·L -1, respectively. The preferred peptides showed the higher affinity binding to immobilized fusion peptide than the lead peptide.展开更多
ENDF/B-Ⅶ.0, which was released by the USA Cross Section Evaluation Working Group （CSEWG） in December 2006, was demonstrated to perform much better than previous ENDF evaluations over a broad range of benchmark expe...ENDF/B-Ⅶ.0, which was released by the USA Cross Section Evaluation Working Group （CSEWG） in December 2006, was demonstrated to perform much better than previous ENDF evaluations over a broad range of benchmark experiments. A high-energy （up to 150 MeV） multi-group library set named HEST1.0 with 253-neutron and 48-photon groups has been developed based on ENDF/B-Ⅶ.0 using the N JOY code. This paper provides a summary of the procedure to produce the library set and a detailed description of the verification of the multi-group library set by several shielding benchmark devices, in particular for high-energy neutron data. In addition, the first application of HEST1.0 to the shielding design of the China Spallation Neutron Source （CSNS） is demonstrated.展开更多
基金①The project supported in part by the International Atomic Energy Agencythe National Natural Science Founda tion of China
文摘As a library of nuclear basic data and nuclear model parameters for nuclear model calculations,Chinese Evaluated Nuclear Parameter Library(CENPL)at Chinese Nuclear Data Center(CNDC)consists of six sub-libraries and is still under development.Most of the data fries for this library have beenset up.These sub-libraries have been used to retrieve the data required for nuclear model calculations andother purposes.
文摘A new method for the rapid and efficient screening of affinity ligands to biological targets is reported. The fusion peptide of influenza virus A was used as the model target and immobilized on the PGMA beads. Antisense peptide YRSKQA of fusion peptide was chosen as the lead compound. The special positional scanning peptide libraries were designed based on YRSKQA and synthesized by utilizing solid phase peptide synthesis manually. The libraries were YRSKQX, YRSKXA, YRSXQA, YRXKQA, YXSKQA and XRSKQA, where X represented 18 L-amino acids(except for Cys and Trp). Each library was screened by affinity chromatography. The eluates from the fusion peptide affinity column were collected and analyzed by RP-HPLC and MS, respectively, in order to determine the kind of X at each position. After the preferred residues of six positions were decided, the two preferred peptide sequences, GRGKHK and TRGKHK, were obtained. The dissociation constants of GRGKHK, TRGKHK and YRSKQA, were 3.35×10 -6, 5.24×10 -6 and 1.15×10 -5 mol·L -1, respectively. The preferred peptides showed the higher affinity binding to immobilized fusion peptide than the lead peptide.
基金Supported by National Natural Science Foundation of China (10875042)Fundamental Research Funds for The Central Universities (10ZG08)Program for New Century Excellent Talents in University
文摘ENDF/B-Ⅶ.0, which was released by the USA Cross Section Evaluation Working Group （CSEWG） in December 2006, was demonstrated to perform much better than previous ENDF evaluations over a broad range of benchmark experiments. A high-energy （up to 150 MeV） multi-group library set named HEST1.0 with 253-neutron and 48-photon groups has been developed based on ENDF/B-Ⅶ.0 using the N JOY code. This paper provides a summary of the procedure to produce the library set and a detailed description of the verification of the multi-group library set by several shielding benchmark devices, in particular for high-energy neutron data. In addition, the first application of HEST1.0 to the shielding design of the China Spallation Neutron Source （CSNS） is demonstrated.
