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Discontinuities of Banana Integrals in Dispersion Relation Representation
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作者 Xu-Liang Chen Peng-Fei Yang and Wei Chen 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第11期12-16,共5页
We derive the discontinuities of banana integrals using the dispersion relation iteratively,and find a series of identities between the parameterized discontinuities of banana integrals(p-DOBIs).Similar to elliptic in... We derive the discontinuities of banana integrals using the dispersion relation iteratively,and find a series of identities between the parameterized discontinuities of banana integrals(p-DOBIs).Similar to elliptic integrals,these identities enable the reduction of various p-DOBIs to be a linear combination of some fundamental ones.We present a practical application of p-DOBIs for deriving the Picard–Fuchs operator.Then we establish the expression of generalized dispersion relation,which enables us to obtain the dispersion relation representation of arbitrary banana integrals.Moreover,we propose a hypothesis for generalized dispersion relation and p-DOBIs,which provides a simple way to calculate the discontinuities and transform dispersion relation representation to p-DOBIs. 展开更多
关键词 DISPERSION integrals enable
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Legendre-Jacobi’s Elliptic Integrals Shed Light on the Luminosity Distance in Cosmology
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作者 Alessandro Trinchera 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2024年第3期930-957,共28页
This article concerns the integral related to the transverse comoving distance and, in turn, to the luminosity distance both in the standard non-flat and flat cosmology. The purpose is to determine a straightforward m... This article concerns the integral related to the transverse comoving distance and, in turn, to the luminosity distance both in the standard non-flat and flat cosmology. The purpose is to determine a straightforward mathematical formulation for the luminosity distance as function of the transverse comoving distance for all cosmology cases with a non-zero cosmological constant by adopting a different mindset. The applied method deals with incomplete elliptical integrals of the first kind associated with the polynomial roots admitted in the comoving distance integral according to the scientific literature. The outcome shows that the luminosity distance can be obtained by the combination of an analytical solution followed by a numerical integration in order to account for the redshift. This solution is solely compared to the current Gaussian quadrature method used as basic recognized algorithm in standard cosmology. 展开更多
关键词 COSMOLOGY Distance Luminosity Transverse Comoving Distance Incomplete Elliptic integrals
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CAUCHY TYPE INTEGRALS AND A BOUNDARY VALUE PROBLEM IN A COMPLEX CLIFFORD ANALYSIS
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作者 曹南斌 李尊凤 +1 位作者 杨贺菊 乔玉英 《Acta Mathematica Scientia》 SCIE CSCD 2024年第1期369-385,共17页
Clifford analysis is an important branch of modern analysis;it has a very important theoretical significance and application value,and its conclusions can be applied to the Maxwell equation,Yang-Mill field theory,quan... Clifford analysis is an important branch of modern analysis;it has a very important theoretical significance and application value,and its conclusions can be applied to the Maxwell equation,Yang-Mill field theory,quantum mechanics and value problems.In this paper,we first give the definition of a quasi-Cauchy type integral in complex Clifford analysis,and get the Plemelj formula for it.Second,we discuss the H?lder continuity for the Cauchy-type integral operators with values in a complex Clifford algebra.Finally,we prove the existence of solutions for a class of linear boundary value problems and give the integral representation for the solution. 展开更多
关键词 Clifford analysis Cauchy type integral Plemelj formula Holder continuous boundary value problems
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Intelligent Small Sample Defect Detection of Concrete Surface Using Novel Deep Learning Integrating Improved YOLOv5 被引量:2
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作者 Yongming Han Lei Wang +1 位作者 Youqing Wang Zhiqiang Geng 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第2期545-547,共3页
Dear Editor,This letter presents an intelligent small sample defect detection of concrete surface using novel deep learning integrating the improved YOLOv5 based on the Wasserstein GAN(WGAN)enhancement algorithm.The p... Dear Editor,This letter presents an intelligent small sample defect detection of concrete surface using novel deep learning integrating the improved YOLOv5 based on the Wasserstein GAN(WGAN)enhancement algorithm.The proposed method is capable of producing top-notch data sets to address the issues of insufficient samples and substandard quality. 展开更多
关键词 CONCRETE integrating ALGORITHM
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3D‑Printed Carbon‑Based Conformal Electromagnetic Interference Shielding Module for Integrated Electronics 被引量:4
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作者 Shaohong Shi Yuheng Jiang +5 位作者 Hao Ren Siwen Deng Jianping Sun Fangchao Cheng Jingjing Jing Yinghong Chen 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第5期87-101,共15页
Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electroni... Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics. 展开更多
关键词 3D printing Carbon-based nanoparticles Conformal electromagnetic interference shielding integrated electronics
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Optimal synthesis of heat-integrated distillation configurations using the two-column superstructure 被引量:1
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作者 Xiaodong Zhang Lu Jin Jinsheng Sun 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第2期238-249,共12页
In the realm of the synthesis of heat-integrated distillation configurations,the conventional approach for exploring more heat integration possibilities typically entails the splitting of a single column into a twocol... In the realm of the synthesis of heat-integrated distillation configurations,the conventional approach for exploring more heat integration possibilities typically entails the splitting of a single column into a twocolumn configuration.However,this approach frequently necessitates tedious enumeration procedures,resulting in a considerable computational burden.To surmount this formidable challenge,the present study introduces an innovative remedy:The proposition of a superstructure that encompasses both single-column and multiple two-column configurations.Additionally,a simultaneous optimization algorithm is applied to optimize both the process parameters and heat integration structures of the twocolumn configurations.The effectiveness of this approach is demonstrated through a case study focusing on industrial organosilicon separation.The results underscore that the superstructure methodology not only substantially mitigates computational time compared to exhaustive enumeration but also furnishes solutions that exhibit comparable performance. 展开更多
关键词 SUPERSTRUCTURE Process synthesis Heat integration Simulation-based optimization Industrial organosilicon separation
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Pixelated non-volatile programmable photonic integrated circuits with 20-level intermediate states 被引量:1
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作者 Wenyu Chen Shiyuan Liu Jinlong Zhu 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第3期477-487,共11页
Multi-level programmable photonic integrated circuits(PICs)and optical metasurfaces have gained widespread attention in many fields,such as neuromorphic photonics,opticalcommunications,and quantum information.In this ... Multi-level programmable photonic integrated circuits(PICs)and optical metasurfaces have gained widespread attention in many fields,such as neuromorphic photonics,opticalcommunications,and quantum information.In this paper,we propose pixelated programmable Si_(3)N_(4)PICs with record-high 20-level intermediate states at 785 nm wavelength.Such flexibility in phase or amplitude modulation is achieved by a programmable Sb_(2)S_(3)matrix,the footprint of whose elements can be as small as 1.2μm,limited only by the optical diffraction limit of anin-house developed pulsed laser writing system.We believe our work lays the foundation for laser-writing ultra-high-level(20 levels and even more)programmable photonic systems and metasurfaces based on phase change materials,which could catalyze diverse applications such as programmable neuromorphic photonics,biosensing,optical computing,photonic quantum computing,and reconfigurable metasurfaces. 展开更多
关键词 programmable photonic integrated circuits phase change materials multi-level intermediate states metasurfaces
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High-chromium vanadium-titanium magnetite all-pellet integrated burden optimization and softening-melting behavior based on flux pellets 被引量:1
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作者 Bojian Chen Tao Jiang +4 位作者 Jing Wen Guangdong Yang Tangxia Yu Fengxiang Zhu Peng Hu 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第3期498-507,共10页
High-chromium vanadium-titanium magnetite(HVTM)is a crucial polymetallic-associated resource to be developed.The allpellet operation is a blast furnace trend that aims to reduce carbon dioxide emissions in the future.... High-chromium vanadium-titanium magnetite(HVTM)is a crucial polymetallic-associated resource to be developed.The allpellet operation is a blast furnace trend that aims to reduce carbon dioxide emissions in the future.By referencing the production data of vanadium-titanium magnetite blast furnaces,this study explored the softening-melting behavior of high-chromium vanadium-titanium magnetite and obtained the optimal integrated burden based on flux pellets.The results show that the burden with a composition of 70wt%flux pellets and 30wt%acid pellets exhibits the best softening-melting properties.In comparison to that of the single burden,the softening-melting characteristic temperature of this burden composition was higher.The melting interval first increased from 307 to 362℃and then decreased to 282℃.The maximum pressure drop(ΔPmax)decreased from 26.76 to 19.01 kPa.The permeability index(S)dropped from 4643.5 to 2446.8 kPa·℃.The softening-melting properties of the integrated burden were apparently improved.The acid pellets played a role in withstanding load during the softening process.The flux pellets in the integrated burden exhibited a higher slag melting point,which increased the melting temperature during the melting process.The slag homogeneity and the TiC produced by over-reduction led to the gas permeability deterioration of the single burden.The segregation of the flux and acid pellets in the HVTM proportion and basicity mainly led to the better softening-melting properties of the integrated burden. 展开更多
关键词 high-chromium vanadium-titanium magnetite softening-melting properties all pellets integrated burden flux pellets
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U-Net Models for Representing Wind Stress Anomalies over the Tropical Pacific and Their Integrations with an Intermediate Coupled Model for ENSO Studies 被引量:1
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作者 Shuangying Du Rong-Hua Zhang 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第7期1403-1416,共14页
El Niño-Southern Oscillation(ENSO)is the strongest interannual climate mode influencing the coupled ocean-atmosphere system in the tropical Pacific,and numerous dynamical and statistical models have been develope... El Niño-Southern Oscillation(ENSO)is the strongest interannual climate mode influencing the coupled ocean-atmosphere system in the tropical Pacific,and numerous dynamical and statistical models have been developed to simulate and predict it.In some simplified coupled ocean-atmosphere models,the relationship between sea surface temperature(SST)anomalies and wind stress(τ)anomalies can be constructed by statistical methods,such as singular value decomposition(SVD).In recent years,the applications of artificial intelligence(AI)to climate modeling have shown promising prospects,and the integrations of AI-based models with dynamical models are active areas of research.This study constructs U-Net models for representing the relationship between SSTAs andτanomalies in the tropical Pacific;the UNet-derivedτmodel,denoted asτUNet,is then used to replace the original SVD-basedτmodel of an intermediate coupled model(ICM),forming a newly AI-integrated ICM,referred to as ICM-UNet.The simulation results obtained from ICM-UNet demonstrate their ability to represent the spatiotemporal variability of oceanic and atmospheric anomaly fields in the equatorial Pacific.In the ocean-only case study,theτUNet-derived wind stress anomaly fields are used to force the ocean component of the ICM,the results of which also indicate reasonable simulations of typical ENSO events.These results demonstrate the feasibility of integrating an AI-derived model with a physics-based dynamical model for ENSO modeling studies.Furthermore,the successful integration of the dynamical ocean models with the AI-based atmospheric wind model provides a novel approach to ocean-atmosphere interaction modeling studies. 展开更多
关键词 U-Net models wind stress anomalies ICM integration of AI and physical components
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Sharp power-type Heronian and Lehmer means inequalities for the complete elliptic integrals
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作者 ZHAO Tie-hong CHU Yu-ming 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2023年第3期467-474,共8页
In the article,we prove that the inequalities H_(p)(K(r);E(r))>π/2;L_(q)(K(r);E(r))>π/2 hold for all r 2(0;1)if and only if p≥3=4 and q≥3=4,where Hp(a;b)and Lq(a;b)are respectively the p-th power-type Heroni... In the article,we prove that the inequalities H_(p)(K(r);E(r))>π/2;L_(q)(K(r);E(r))>π/2 hold for all r 2(0;1)if and only if p≥3=4 and q≥3=4,where Hp(a;b)and Lq(a;b)are respectively the p-th power-type Heronian mean and q-th Lehmer mean of a and b,and K(r)and E(r)are respectively the complete elliptic integrals of the first and second kinds. 展开更多
关键词 power-type Heronian mean Lehmer means complete elliptic integrals
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Multiple parametric Marcinkiewicz integrals with mixed homogeneity along surfaces
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作者 SHEN Jia-wei HE Shao-yong CHEN Jie-cheng 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2023年第3期413-428,共16页
In this paper, the multiple parametric Marcinkiewicz integral operators with mixed homogeneity along surfaces are studied. The Lp-mapping properties for such operators are obtained under the rather weakened size condi... In this paper, the multiple parametric Marcinkiewicz integral operators with mixed homogeneity along surfaces are studied. The Lp-mapping properties for such operators are obtained under the rather weakened size conditions on the integral kernels both on the unit sphere and in the radial direction. The main results essentially improve and extend certain previous results. 展开更多
关键词 parametric Marcinkiewicz integrals rough kernels mixed homogeneity product spaces
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THE FRACTIONAL TYPE MARCINKIEWICZ INTEGRALS AND COMMUTATORS ON WEIGHTED HARDY SPACES
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作者 韩妍妍 伍火熊 《Acta Mathematica Scientia》 SCIE CSCD 2023年第5期1981-1996,共16页
This paper is devoted to studying the behaviors of the fractional type Marcinkiewicz integralsμΩ,βand the commutatorsμΩ,βb generated byμΩ,βwith b b∈Lloc(Rn)on weighted Hardy spaces.Under the assumption of th... This paper is devoted to studying the behaviors of the fractional type Marcinkiewicz integralsμΩ,βand the commutatorsμΩ,βb generated byμΩ,βwith b b∈Lloc(Rn)on weighted Hardy spaces.Under the assumption of that the homogeneous kernelΩsatisfies certain regularities,the authors obtain the boundedness ofμΩ,βfrom the weighted Hardy spaces Hωpp(Rn)to the weighted Lebesgue spaces Lωqq(Rn)for n/(n+β)≤<p≤1 with 1/q=1/p-β/n,as well as the same(Hωpp,Lωqq)-boudedness ofμΩ,βb when b belongs to BMOωp,p(Rn),which is a non-trivial subspace of BMO(Rn). 展开更多
关键词 fractional type Marcinkiewicz integrals COMMUTATORS Muckenhoupt weights BMO spaces Hardy spaces
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A stable implicit nodal integration-based particle finite element method(N-PFEM)for modelling saturated soil dynamics 被引量:1
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作者 Liang Wang Xue Zhang +1 位作者 Jingjing Meng Qinghua Lei 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第6期2172-2183,共12页
In this study,we present a novel nodal integration-based particle finite element method(N-PFEM)designed for the dynamic analysis of saturated soils.Our approach incorporates the nodal integration technique into a gene... In this study,we present a novel nodal integration-based particle finite element method(N-PFEM)designed for the dynamic analysis of saturated soils.Our approach incorporates the nodal integration technique into a generalised Hellinger-Reissner(HR)variational principle,creating an implicit PFEM formulation.To mitigate the volumetric locking issue in low-order elements,we employ a node-based strain smoothing technique.By discretising field variables at the centre of smoothing cells,we achieve nodal integration over cells,eliminating the need for sophisticated mapping operations after re-meshing in the PFEM.We express the discretised governing equations as a min-max optimisation problem,which is further reformulated as a standard second-order cone programming(SOCP)problem.Stresses,pore water pressure,and displacements are simultaneously determined using the advanced primal-dual interior point method.Consequently,our numerical model offers improved accuracy for stresses and pore water pressure compared to the displacement-based PFEM formulation.Numerical experiments demonstrate that the N-PFEM efficiently captures both transient and long-term hydro-mechanical behaviour of saturated soils with high accuracy,obviating the need for stabilisation or regularisation techniques commonly employed in other nodal integration-based PFEM approaches.This work holds significant implications for the development of robust and accurate numerical tools for studying saturated soil dynamics. 展开更多
关键词 Particle finite element method Nodal integration Dynamic saturated media Second-order cone programming(SOCP)
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Trajectory tracking guidance of interceptor via prescribed performance integral sliding mode with neural network disturbance observer 被引量:1
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作者 Wenxue Chen Yudong Hu +1 位作者 Changsheng Gao Ruoming An 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期412-429,共18页
This paper investigates interception missiles’trajectory tracking guidance problem under wind field and external disturbances in the boost phase.Indeed,the velocity control in such trajectory tracking guidance system... This paper investigates interception missiles’trajectory tracking guidance problem under wind field and external disturbances in the boost phase.Indeed,the velocity control in such trajectory tracking guidance systems of missiles is challenging.As our contribution,the velocity control channel is designed to deal with the intractable velocity problem and improve tracking accuracy.The global prescribed performance function,which guarantees the tracking error within the set range and the global convergence of the tracking guidance system,is first proposed based on the traditional PPF.Then,a tracking guidance strategy is derived using the integral sliding mode control techniques to make the sliding manifold and tracking errors converge to zero and avoid singularities.Meanwhile,an improved switching control law is introduced into the designed tracking guidance algorithm to deal with the chattering problem.A back propagation neural network(BPNN)extended state observer(BPNNESO)is employed in the inner loop to identify disturbances.The obtained results indicate that the proposed tracking guidance approach achieves the trajectory tracking guidance objective without and with disturbances and outperforms the existing tracking guidance schemes with the lowest tracking errors,convergence times,and overshoots. 展开更多
关键词 BP network neural integral sliding mode control(ISMC) Missile defense Prescribed performance function(PPF) State observer Tracking guidance system
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Silicon-based optoelectronic heterogeneous integration for optical interconnection
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作者 李乐良 李贵柯 +5 位作者 张钊 刘剑 吴南健 王开友 祁楠 刘力源 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期1-9,共9页
The performance of optical interconnection has improved dramatically in recent years.Silicon-based optoelectronic heterogeneous integration is the key enabler to achieve high performance optical interconnection,which ... The performance of optical interconnection has improved dramatically in recent years.Silicon-based optoelectronic heterogeneous integration is the key enabler to achieve high performance optical interconnection,which not only provides the optical gain which is absent from native Si substrates and enables complete photonic functionalities on chip,but also improves the system performance through advanced heterogeneous integrated packaging.This paper reviews recent progress of silicon-based optoelectronic heterogeneous integration in high performance optical interconnection.The research status,development trend and application of ultra-low loss optical waveguides,high-speed detectors,high-speed modulators,lasers and 2D,2.5D,3D and monolithic integration are focused on. 展开更多
关键词 silicon-based heterogeneous integration heterogeneous integrated materials heterogeneous integrated packaging optical interconnection
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The Stability of the Gauss-Laguerre Rule for Cauchy P.V. Integrals on the Half Line
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作者 Maria Rosaria Capobianco Giuliana Criscuolo 《American Journal of Computational Mathematics》 2023年第4期505-511,共7页
In this paper, the authors give a different and more precise analysis of the stability of the classical Gauss-Laguerre quadrature rule for the Cauchy P.V. integrals on the half line. Moreover, in order to obtain this ... In this paper, the authors give a different and more precise analysis of the stability of the classical Gauss-Laguerre quadrature rule for the Cauchy P.V. integrals on the half line. Moreover, in order to obtain this result they give some new estimates for the distance of the zeros of the Laguerre polynomials that can be useful also in other contests. 展开更多
关键词 Gauss Quadrature Exponential Weights Cauchy P.V. integrals Stability
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Astrocytes integrate time and space
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作者 Justin Lines 《Neural Regeneration Research》 SCIE CAS 2025年第2期467-468,共2页
Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have ... Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have revealed that astrocytes exhibit two distinct states of intracellular calcium activity:(1)graded subcellular localized clusters with independently active microdomains,likely influenced by nearby synaptic events,and(2)whole-cell astrocyte calcium surges,believed to result from the coordinated activation of multiple synapses.Notably,astrocyte calcium responses are not solely graded;instead,a spatial threshold of intracellular calcium activity can be overcome to elicit an astrocyte calcium surge.Together these calcium responses,in turn,initiate downstream signaling pathways capable of modifying synaptic communication and overall network activity.In summary,astrocytes can function as integrators of local synaptic events,actively contributing to information processing within the brain. 展开更多
关键词 GRADED integrATE instead
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Theory and practice for assessing structural integrity and dynamical integrity of high-speed trains
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作者 Weihua Zhang Yuanchen Zeng +1 位作者 Dongli Song Zhiwei Wang 《Railway Sciences》 2024年第2期113-127,共15页
Purpose–The safety and reliability of high-speed trains rely on the structural integrity of their components and the dynamic performance of the entire vehicle system.This paper aims to define and substantiate the ass... Purpose–The safety and reliability of high-speed trains rely on the structural integrity of their components and the dynamic performance of the entire vehicle system.This paper aims to define and substantiate the assessment of the structural integrity and dynamical integrity of high-speed trains in both theory and practice.The key principles and approacheswill be proposed,and their applications to high-speed trains in Chinawill be presented.Design/methodology/approach–First,the structural integrity and dynamical integrity of high-speed trains are defined,and their relationship is introduced.Then,the principles for assessing the structural integrity of structural and dynamical components are presented and practical examples of gearboxes and dampers are provided.Finally,the principles and approaches for assessing the dynamical integrity of highspeed trains are presented and a novel operational assessment method is further presented.Findings–Vehicle system dynamics is the core of the proposed framework that provides the loads and vibrations on train components and the dynamic performance of the entire vehicle system.For assessing the structural integrity of structural components,an open-loop analysis considering both normal and abnormal vehicle conditions is needed.For assessing the structural integrity of dynamical components,a closed-loop analysis involving the influence of wear and degradation on vehicle system dynamics is needed.The analysis of vehicle system dynamics should follow the principles of complete objects,conditions and indices.Numerical,experimental and operational approaches should be combined to achieve effective assessments.Originality/value–The practical applications demonstrate that assessing the structural integrity and dynamical integrity of high-speed trains can support better control of critical defects,better lifespan management of train components and better maintenance decision-making for high-speed trains. 展开更多
关键词 Structural integrity Dynamical integrity Vehicle system dynamics High-speed trains BOGIE integrity assessment FATIGUE
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Aging impairs the osteocytic regulation of collagen integrity and bone quality
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作者 Charles A.Schurman Serra Kaya +12 位作者 Neha Dole Nadja M.Maldonado Luna Natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons Christina D.King Jordan B.Burton Birgit Schilling Simon Melov Simon Tang Eric Schaible Tamara Alliston 《Bone Research》 SCIE CAS CSCD 2024年第1期78-94,共17页
Poor bone quality is a major factor in skeletal fragility in elderly individuals.The molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily d... Poor bone quality is a major factor in skeletal fragility in elderly individuals.The molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by osteocytes.We hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material properties.We examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses PLR.The control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)bone.This relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical tests.The effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity. 展开更多
关键词 MAINTAIN primarily integrITY
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Gelatin and lipidoid integrate to create gelasomes to enhance siRNA delivery with low toxicity
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作者 Abilash Gangula Dhananjay Suresh +3 位作者 Agasthya Suresh Babu Zhaohui Li Anandhi Upendran Raghuraman Kannan 《Bioactive Materials》 SCIE CSCD 2024年第10期557-570,共14页
RNAi therapeutics possess the potential to cure many uncurable human diseases.For instance,RNAi therapeutics using liposomes showed remarkable survival benefits in patients with liver diseases.However,the extension of... RNAi therapeutics possess the potential to cure many uncurable human diseases.For instance,RNAi therapeutics using liposomes showed remarkable survival benefits in patients with liver diseases.However,the extension of liposomes to deliver RNA to cure other ailments has largely been unsuccessful.Therefore,researchers are focusing on designing and testing different combinations of materials for versatile RNA delivery applications.Yet,an efficient and safe RNA delivery platform has not been identified.In this work,we have developed a new class of RNA-delivery vehicle called“Gelasomes,”using an incongruous combination of gelatin and lipidoid to exploit each material’s unique properties while overcoming their inherent limitations.The low in vivo toxicity of Gelasomes is attributed to the exterior gelatin layers that shield the exposure of cationic lipidoid-siRNA clusters and yet present a biocompatible surface.Indeed,toxicity studies in mice indicate that repeated administration of Gelasomes(up to 48 mg/kg BW)is well-tolerated with no notable changes in body weight,hematology,or serum chemistry.Interestingly,the gelatin outer layer efficiently protects siRNA from serum degradation(48 h),preserving its functionality beyond two months of storage.Notably,Gelasomes possess dual siRNA conjugation modes,i.e.,electrostatic binding with lipidoid core and covalent attachment to gelatin surface.The bivalency coupled with lipidoids’high transfection efficiency rendered Gelasomes with remarkably high gene silencing efficiency(>90%)at very low treatment doses in vitro(40μg/mL).In vivo studies further confirmed the high gene silencing ability of Gelasomes in non-small cell lung tumor mouse models.This new platform is tunable on all fronts:size,degree of surface coating,and biomolecule functionalization.Truncating the lipidoid C14-tail to a C8-tail yielded Gelasomes of reduced size.As lipidoids with different carbon lengths are synthesizable,we can develop a library of Gelasomes with different sizes.The surface coating with less gelatin resulted in high transfection efficiency at low doses of Gelasomes.The structure of Gelasomes offers chemical handles to couple target-specific molecules like antibodies to tune their properties for efficient biological application. 展开更多
关键词 doses integrATE RENDER
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