Laser tracers are a three-dimensional coordinate measurement system that are widely used in industrial measurement.We propose a geometric error identification method based on multi-station synchronization laser tracer...Laser tracers are a three-dimensional coordinate measurement system that are widely used in industrial measurement.We propose a geometric error identification method based on multi-station synchronization laser tracers to enable the rapid and high-precision measurement of geometric errors for gantry-type computer numerical control(CNC)machine tools.This method also improves on the existing measurement efficiency issues in the single-base station measurement method and multi-base station time-sharing measurement method.We consider a three-axis gantry-type CNC machine tool,and the geometric error mathematical model is derived and established based on the combination of screw theory and a topological analysis of the machine kinematic chain.The four-station laser tracers position and measurement points are realized based on the multi-point positioning principle.A self-calibration algorithm is proposed for the coordinate calibration process of a laser tracer using the Levenberg-Marquardt nonlinear least squares method,and the geometric error is solved using Taylor’s first-order linearization iteration.The experimental results show that the geometric error calculated based on this modeling method is comparable to the results from the Etalon laser tracer.For a volume of 800 mm×1000 mm×350 mm,the maximum differences of the linear,angular,and spatial position errors were 2.0μm,2.7μrad,and 12.0μm,respectively,which verifies the accuracy of the proposed algorithm.This research proposes a modeling method for the precise measurement of errors in machine tools,and the applied nature of this study also makes it relevant both to researchers and those in the industrial sector.展开更多
Background:Patients with type 2 diabetes are at high risk for developing multiple chronic complications.However,there is a lack of studies of the cumulative number of diabetic complications in China.Methods:A retrospe...Background:Patients with type 2 diabetes are at high risk for developing multiple chronic complications.However,there is a lack of studies of the cumulative number of diabetic complications in China.Methods:A retrospective cohort study was performed from 2009 to 2021.Type 2 diabetes patients who were first diagnosed after the age of 35 years between January 1,2009,and December 31,2017,were included.Five states were defined according to the number of chronic complications:no(S0),one(S1),two(S2),three(S3),and four or more complications(S4).A multi-state Markov model was constructed to estimate transition probability,transition intensity,mean sojourn time,and the possible factors for each state.Results:The study included 32653 type 2 diabetes patients(mean age,59.59 years;15929(48.8%)male),and mean follow-up time of 7.75 years.In all,4375 transitions were observed.The 12-year transition probability of from state S0 to S1 was the lowest at 16.4%,while that from S2 to S3 was the highest,at 45.6%.Higher fasting blood glucose,lower high-density lipoprotein cholesterol,higher total cholesterol,and an unhealthy diet were associated with higher risk of progression from S0 to S1.Being female,less than 60 years old,weekly physical activity,and vegetarian diet decreased this risk.Being female and less than 60 years old reduced the likelihood of transition from S1 to S2,whereas lower high-density lipoprotein cholesterol increased this likelihood.Conclusions:Following the occurrence of two complications in type 2 diabetes patients,the risk for accumulating a third complication within a short time is significantly increased.It is important to take advantage of the stable window period when patients have fewer than two complications,strengthen the monitoring of blood glucose and blood lipids,and encourage patients to maintain good living habits to prevent further deterioration.展开更多
Tribological tests play an important role on the evaluation of long-term bio-tribological performances of prosthetic materials for commercial fabrication.Those tests focus on the motion simulation of a real joint in v...Tribological tests play an important role on the evaluation of long-term bio-tribological performances of prosthetic materials for commercial fabrication.Those tests focus on the motion simulation of a real joint in vitro with only normal loads and constant velocities,which are far from the real friction behavior of human joints characterized with variable loads and multiple directions.In order to accurately obtain the bio-tribological performances of artificial joint materials,a tribological tester with a miniature four-station tribological system is proposed with four distinctive features.Firstly,comparability and repeatability of a test are ensured by four equal stations of the tester.Secondly,cross-linked scratch between tribo-pairs of human joints can be simulated by using a gear-rack meshing mechanism to produce composite motions.With this mechanism,the friction tracks can be designed by varying reciprocating and rotating speeds.Thirdly,variable loading system is realized by using a ball-screw mechanism driven by a stepper motor,by which loads under different gaits during walking are simulated.Fourthly,dynamic friction force and normal load can be measured simultaneously.The verifications of the performances of the developed tester show that the variable frictional tracks can produce different wear debris compared with one-directional tracks,and the accuracy of loading and friction force is within ?5%.Thus the high consistency among different stations can be obtained.Practically,the proposed tester system could provide more comprehensive and accurate bio-tribological evaluations for prosthetic materials.展开更多
Nowadays, the Multi-Shuttle and Multi-Station Transportation System (MMTS)<span><span><span style="font-family:;" "=""> is one of the most interesting research topics in many...Nowadays, the Multi-Shuttle and Multi-Station Transportation System (MMTS)<span><span><span style="font-family:;" "=""> is one of the most interesting research topics in many fields of industries. It is an effective solution to reduce unexpected accidents that occur during transportation as well as increase productivity in manufacturing. The aim of this paper is to introduce the controller design for the MMTS which is built in our BK-Recme BioMech Lab at Ho Chi Minh City University of Technology (VNU-HCM), Viet Nam. Based on the design of this system, the control algorithms will be conducted to check the operation of the whole system. To evaluate the feasibility and effectiveness of this model, we design a series of random instances for different quantities of nodes as well as the different quantities of shuttles. Our system includes 4 stations and 6 shuttles which are assembled in the serial chain system. However, the number of stations and number of shuttles can be expanded to any desired ones which are based on the requirement of the industries. In this paper, we mainly focus on the controller design of this system to make it operate in an effective way that the goods will be transported and delivered to the target station as fast as possible. In order to solve the large</span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "="">scale instances and realistic transport prob<span>lems, we propose three algorithms for three progresses as shuttles calling</span>, path reading and shuttles communicating. The shuttles calling is to decide which <span>shuttle should be called to the star</span></span></span></span><span><span><span style="font-family:;" "="">t</span></span></span><span><span><span style="font-family:;" "="">-node. Path reading to determine the shortest</span></span></span><span><span><span style="font-family:;" "=""> <span>way to go from start-node to end-node. Finally, shuttles communicating,</span> which allow one shuttle to interact with the next shuttles so we have a loop of orders (shuttle 1 to shuttle 2;shuttle 2 to shuttle 3;etc</span></span></span><span><span><span style="font-family:;" "="">.</span></span></span><span><span><span style="font-family:;" "="">;shuttle n-1 to shuttle n). This proposes solution can help us to solve the huge numbers of shuttles <span>and stations in the system. The specific result of this study is applying</span> Dijkstra’s algorithm to propose an algorithm that allows handling a transportation system without caring about the number of shuttles as well as the number of stations for the closed-loop path. Several test problems are carried out in order to check the feasibility and the effectiveness of our purposed control algorithm.</span></span></span>展开更多
Survival data with amulti-state structure are frequently observed in follow-up studies.An analytic approach based on a multi-state model(MSM)should be used in longitudinal health studies in which a patient experiences...Survival data with amulti-state structure are frequently observed in follow-up studies.An analytic approach based on a multi-state model(MSM)should be used in longitudinal health studies in which a patient experiences a sequence of clinical progression events.One main objective in the MSM framework is variable selection,where attempts are made to identify the risk factors associated with the transition hazard rates or probabilities of disease progression.The usual variable selection methods,including stepwise and penalized methods,do not provide information about the importance of variables.In this context,we present a two-step algorithm to evaluate the importance of variables formulti-state data.Three differentmachine learning approaches(randomforest,gradient boosting,and neural network)as themost widely usedmethods are considered to estimate the variable importance in order to identify the factors affecting disease progression and rank these factors according to their importance.The performance of our proposed methods is validated by simulation and applied to the COVID-19 data set.The results revealed that the proposed two-stage method has promising performance for estimating variable importance.展开更多
In the traditional reliability evaluation based on the Bayesian method,the failure probability of nodes is usually expressed by the average failure rate within a period of time.Aiming at the shortcomings of traditiona...In the traditional reliability evaluation based on the Bayesian method,the failure probability of nodes is usually expressed by the average failure rate within a period of time.Aiming at the shortcomings of traditional Bayesian network reliability evaluation methods,this paper proposes a Bayesian network reliability evaluation method considering dynamics and fuzziness.The fuzzy theory and the dynamic of component failure probability are introduced to construct the dynamic fuzzy set function.Based on the solving characteristics of the dynamic fuzzy set and Bayesian network,the fuzzy dynamic probability and fuzzy dynamic importance degree of the fault state of leaf nodes are solved.Finally,through the dynamic fuzzy reliability analysis of CNC machine tool hydraulic system balance circuit,the application of this method in system reliability evaluation is verified,which provides support for fault diagnosis of CNC machine tools.展开更多
Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system. Traditional importance measures mainly concerned the changing value of the system rel...Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system. Traditional importance measures mainly concerned the changing value of the system reliability caused by the change of the reliability of the component, and seldom considered the joint effect of the probability distribution, improvement rate of the object component. This paper studies the rate of the system reliability upgrading with an improvement of the component reliability for the multi-state consecutive k-out-of-n system. To verify the multi-state consecutive k-out-of-n system reliability upgrading by improving one component based on its improvement rate, an increasing potential importance (IPI) and its physical meaning are described at first. Secondly, the relationship between the IPI and Birnbaum importance measures are discussed. And the IPI for some different improvement actions of the component is further discussed. Thirdly, the characteristics of the IPI are analyzed. Finally, an application to an oil pipeline system is given.展开更多
Classical network reliability problems assume both net- works and components have only binary states, fully working or fully failed states. But many actual networks are multi-state, such as communication networks and ...Classical network reliability problems assume both net- works and components have only binary states, fully working or fully failed states. But many actual networks are multi-state, such as communication networks and transportation networks. The nodes and arcs in the networks may be in intermediate states which are not fully working either fully failed. A simulation ap- proach for computing the two-terminal reliability of a multi-state network is described. Two-terminal reliability is defined as the probability that d units of demand can be supplied from the source to sink nodes under the time threshold T. The capacities of arcs may be in a stochastic state following any discrete or continuous distribution. The transmission time of each arc is also not a fixed number but stochastic according to its current capacity and de- mand. To solve this problem, a capacitated stochastic coloured Petri net is proposed for modelling the system behaviour. Places and transitions respectively stand for the nodes and arcs of a net- work. Capacitated transition and self-modified token colour with route information are defined to describe the multi-state network. By the simulation, the two-terminal reliability and node importance can be estimated and the optimal route whose reliability is highest can also be given. Finally, two examples of different kinds of multi- state networks are given.展开更多
Voltage sags in power system may lead to serious problems such as the off-grid of distributed generation and electrical equipment failures.As a novel type of power electronic equipment,a flexible multi-state switch(FM...Voltage sags in power system may lead to serious problems such as the off-grid of distributed generation and electrical equipment failures.As a novel type of power electronic equipment,a flexible multi-state switch(FMSS)is capable to support the voltage during the grid faults.In this paper,a voltage control strategy to support the voltage in a distribution network is proposed by introducing three-port FMSS.The positive-negative-sequence compensation(PNSC)scheme is adopted to control the active and reactive current.This control scheme eliminates active power oscillations at the port of voltage sags and reduces coupling oscillations of other ports.Based on the characteristics of the voltage support under PNSC scheme,two voltage support strategies are proposed.A proportional-integral controller is introduced to provide the reactive power references,which eliminates the errors when estimating the grid voltage and impedance.A current limiting scheme is adopted to keep the port current in a safe range by adjusting the active and reactive power references.The voltage support strategies in two different voltage sags are simulated,and results show the feasibility and effectiveness of the proposed control strategies.展开更多
To verify the effectiveness of the integrated importance measure (IIM) for multi-state coherent systems of k level, the definition and physical meaning of IIM are demonstrated. Then, the improvement potential and Δ...To verify the effectiveness of the integrated importance measure (IIM) for multi-state coherent systems of k level, the definition and physical meaning of IIM are demonstrated. Then, the improvement potential and Δ-importance measures are generalized to multi-state coherent systems based on the system performance level, and the relationships between IIM and traditional importance measures are discussed. The characteristics of IIM are demonstrated in both series and parallel systems. Also, an application to an oil transportation system is given. The comparison results show that: (i) IIM has some useful properties that are not possessed by traditional importance measures; (ii) IIM is effective in evaluating the component role in multi-state systems when the component reliability and the failure rate are simultaneously considered.展开更多
Importance analysis quantifies the critical degree of individual component. Compared with the traditional binary state system,importance analysis of the multi-state system is more aligned with the practice. Because th...Importance analysis quantifies the critical degree of individual component. Compared with the traditional binary state system,importance analysis of the multi-state system is more aligned with the practice. Because the multi-valued decision diagram( MDD) can reflect the relationship between the components and the system state bilaterally, it was introduced into the reliability calculation of the multi-state system( MSS). The building method,simplified criteria,and path search and probability algorithm of MSS structure function MDD were given,and the reliability of the system was calculated. The computing methods of importance based on MDD and direct partial logic derivatives( DPLD) were presented. The diesel engine fuel supply system was taken as an example to illustrate the proposed method. The results show that not only the probability of the system in each state can be easily obtained,but also the influence degree of each component and its state on the system reliability can be obtained,which is conducive to the condition monitoring and structure optimization of the system.展开更多
At the vascular injury sites,the ultra-large (UL) multimeric von willebrand Factor (VWF) is released in response to physiological and pathophysiological stimuli,and mediates platelet adhesion,aggregation,and cross-lin...At the vascular injury sites,the ultra-large (UL) multimeric von willebrand Factor (VWF) is released in response to physiological and pathophysiological stimuli,and mediates platelet adhesion,aggregation,and cross-linking to maintain hemostasis.This UL-VWF is specifically cleaved by ADAMTS13(A Disintegrin And Metalloprotease with a ThromboSpondintype-1 motif,member 13)to prevent microvascular thrombosis.Each VWF monomer consists of five types of repeat domains in the order of D1-D2-D’-D3-A1-A2-A3-D4-C1-C2-C3-C4-C5-C6-CK,in which the A2 domain contains the ADAMTS13cleavage site(Tyr1605-Met1606),exposure of which requires mechanical or chemical stimuli.Under flows,fluid shear stress regulates VWF degradation and size distribution through opening the A2 domain and exposing its cleavage site for ADAMTS13.VWF A2 domain contains a C-terminal vicinal disulfide bond,a calcium binding sites,and a flexibleα4-less-loop.These unique structure features together make A2 more sensitive to mechanical signal than other VWF A subdomains,i.e.A1 and A3 domains.It is believed that A2 is first bound with and then cleaved by ADAMTS13,together with force-induced conformation transformation.To reveal molecular basis of this two-step model of VWF hydrolyzation by ADAMTS13,we here examined stretch-induced unfolding processes of VWF A2 domain in more detail by Steered molecular dynamics(SMD)simulations,with the use of crystal structure of VWF A2(PDB ID 3GXB),and observed that there were multiple quasi-stable conformations of stretched A2 until itsβ4-strand and a3-helix were pulled away the central hydrophobic core and the cleavage sites were fully accessible to solvent.Our MD simulation data showed that,in unfolding,at first,the cleavage site residue Tyr1605 was exposed partially and binding sites for Spacer domain of ADAMTS13 were exposed to a high level whenα6-helix was separated from A2 body;then,withβ6-strand and a5-helix been pulled away,the binding sites for Cysrich domain of ADAMTS13 was exposed completely while the exposure degree of Tyr1605 was not improved;further,separation ofβ5-strand andα4-less-loop made Tyr1605 and Met1606 and the respective binding sites for ADAMTS13 Spacer domain,Cys-rich domain,and Disintegrin-like domain be fully exposed to reach the optimal catalytic state;lastly,withβ4-strand separation,the cleavage sites and binding sites all were overstretched,leading to mismatch of ADAMTS13 and A2 conformation especially in the binding sites.This conformational mismatch may cause reduction of ADAMTS13 hydrolysis efficiency.Furthermore,the data of SMD simulations under constant forces demonstrated that,the stretched A2 conformation had different quasi-stable states,which all had the better mechanical stability within simulation time of 100 ns;and the conformational transformation from one state to another must overcome their respective potential barriers.The hydrolysis efficiency should depend on each state of the stretched A2 conformation,because of the exclusive matched-degree of A2 and ADMATS13.This computer prediction on the mechanical stability and multi-states of stretched A2 provides a novel insight into the mechano-chemical regulation on cleavage of A2 by ADAMTS13.It would be helpful for design of related drug targeting the binding sites on A2 and exosites on ADAMTS13 for the treatment of patients with acquired TTP.展开更多
In the paper, excess methods for improving the reliability of multi-state series-parallel systems are presented: for the hot reserve of single components, the cold reserve of single components, and the mixed (hot an...In the paper, excess methods for improving the reliability of multi-state series-parallel systems are presented: for the hot reserve of single components, the cold reserve of single components, and the mixed (hot and cold) reserve of single components. A process is also introduced to improve the reliability of these methods by replacing their components with more reliable ones. New theorems for multi-state limit reliability functions in homogeneous and non-homogeneous series-parallel large systems composed of components with improved reliability are presented, and applied to compare the effects of these systems in different reliability improving methods.展开更多
We present a class of two-dimensional memristive maps with a cosine memristor. The memristive maps do not have any fixed points, so they belong to the category of nonlinear maps with hidden attractors. The rich dynami...We present a class of two-dimensional memristive maps with a cosine memristor. The memristive maps do not have any fixed points, so they belong to the category of nonlinear maps with hidden attractors. The rich dynamical behaviors of these maps are studied and investigated using different numerical tools, including phase portrait, basins of attraction,bifurcation diagram, and Lyapunov exponents. The two-parameter bifurcation analysis of the memristive map is carried out to reveal the bifurcation mechanism of its dynamical behaviors. Based on our extensive simulation studies, the proposed memristive maps can produce hidden periodic, chaotic, and hyper-chaotic attractors, exhibiting extremely hidden multistability, namely the coexistence of infinite hidden attractors, which was rarely observed in memristive maps. Potentially,this work can be used for some real applications in secure communication, such as data and image encryptions.展开更多
The performance and state of multi-state system depend on its structure and different state combinations of the components. In order to evaluate the reliability of multi-state system effectively,a reliability evaluati...The performance and state of multi-state system depend on its structure and different state combinations of the components. In order to evaluate the reliability of multi-state system effectively,a reliability evaluation and sensitivity analysis method based on the time degradation measures was proposed. The equivalence sets of the multi-state system under different output performances were established. The state combinations were classified according to the performance level. The degradation probability models under different states were established,and the new reliability measures,such as dynamic probability of multi-state system,holding time in each state,dynamic expectation function and integrated expectation function of the performance,were proposed and used to implement the dynamic reliability evaluation and sensitivity analysis. A certain diesel engine fuel feeding system was taken as an application example to illustrate the proposed method. The results show that not only the holding time in the desired state of the components and the system can be predicted,but also the best state component in a certain time period can be obtained.展开更多
Residual dipolar couplings(RDCs)are powerful nuclear magnetic resonance(NMR)probes for the structure calculation of biomacromolecules.Typically,an alignment tensor that defines the orientation of the entire molecule r...Residual dipolar couplings(RDCs)are powerful nuclear magnetic resonance(NMR)probes for the structure calculation of biomacromolecules.Typically,an alignment tensor that defines the orientation of the entire molecule relative to the magnetic field is determined either before refinement of individual bond vectors or simultaneously with this refinement.For single-domain proteins this approach works well since all bond vectors can be described within the same coordinate frame,which is given by the alignment tensor.However,novel approaches are sought after for systems where no universal alignment tensor can be used.Here,we present an approach that can be applied to two-domain proteins that enables the calculation of multiple states within each domain as well as with respect to the relative positions of the two domains.展开更多
A multi-station integration system(MSIS)integrat-ing other multi-type stations provides a new way to realize an intensive development of resources and promote low-carbon en-ergy and its high-efficiency utilization.To ...A multi-station integration system(MSIS)integrat-ing other multi-type stations provides a new way to realize an intensive development of resources and promote low-carbon en-ergy and its high-efficiency utilization.To this end,a novel multi-station integration planning method and coordinated operation strategy model for the MSIS are established in a new business model.In this study,a new business model of the MSIS,with substations as the carrier,integrating distributed photovoltaic,energy storage,electric vehicle charging,data center,and 5G base stations is proposed.From the social environment,natural conditions,and complementary characteristics,a comprehensive index system is established to analyze expansion capability of substations and multi-station combination scheme.Scenario reduction is performed by extracting feature vectors and build-ing a comprehensive evaluation function to select the optimal combination scheme under a specific scenario.Moreover,for the combination scheme in a specific scenario,the optimal ca-pacity configuration and coordinated operation strategy chance-constrained programming model of the MSIS are established under different operating conditions.Finally,simulations are performed on a practical MSIS located in Wuxi,China,and simulation results demonstrate the rationality and effectiveness of the planning method and coordinated operation strategy model for the MSIS.展开更多
In order to make the peak and offset of the signal meet the requirements of artificial equipment,dynamical analysis and geometric control of the laser system have become indispensable.In this paper,a locally active me...In order to make the peak and offset of the signal meet the requirements of artificial equipment,dynamical analysis and geometric control of the laser system have become indispensable.In this paper,a locally active memristor with non-volatile memory is introduced into a complex-valued Lorenz laser system.By using numerical measures,complex dynamical behaviors of the memristive laser system are uncovered.It appears the alternating appearance of quasi-periodic and chaotic oscillations.The mechanism of transformation from a quasi-periodic pattern to a chaotic one is revealed from the perspective of Hamilton energy.Interestingly,initial-values-oriented extreme multi-stability patterns are found,where the coexisting attractors have the same Lyapunov exponents.In addition,the introduction of a memristor greatly improves the complexity of the laser system.Moreover,to control the amplitude and offset of the chaotic signal,two kinds of geometric control methods including amplitude control and rotation control are designed.The results show that these two geometric control methods have revised the size and position of the chaotic signal without changing the chaotic dynamics.Finally,a digital hardware device is developed and the experiment outputs agree fairly well with those of the numerical simulations.展开更多
In recent years,there are numerous studies on chaotic systems with special equilibrium curves having various shapes such as circle,butterfly,heart and apple.This paper describes a new 3-D chaotic dynamical system with...In recent years,there are numerous studies on chaotic systems with special equilibrium curves having various shapes such as circle,butterfly,heart and apple.This paper describes a new 3-D chaotic dynamical system with a capsule-shaped equilibrium curve.The proposed chaotic system has two quadratic,two cubic and two quartic nonlinear terms.It is noted that the proposed chaotic system has a hidden attractor since it has an infinite number of equilibrium points.It is also established that the proposed chaotic system exhibits multi-stability with two coexisting chaotic attractors for the same parameter values but differential initial states.A detailed bifurcation analysis with respect to variations in the system parameters is portrayed for the new chaotic system with capsule equilibrium curve.We have shown MATLAB plots to illustrate the capsule equilibrium curve,phase orbits of the new chaotic system,bifurcation diagrams and multi-stability.As an engineering application,we have proposed a speech cryptosystem with a numerical algorithm,which is based on our novel 3-D chaotic system with a capsule-shaped equilibrium curve.The proposed speech cryptosystem follows its security evolution and implementation on Field Programmable Gate Array(FPGA)platform.Experimental results show that the proposed encryption system utilizes 33%of the FPGA,while the maximum clock frequency is 178.28 MHz.展开更多
With the continued development of multiple Global Navigation Satellite Systems(GNSS)and the emergence of various frequencies,UnDifferenced and UnCombined(UDUC)data processing has become an increasingly attractive opti...With the continued development of multiple Global Navigation Satellite Systems(GNSS)and the emergence of various frequencies,UnDifferenced and UnCombined(UDUC)data processing has become an increasingly attractive option.In this contribution,we provide an overview of the current status of UDUC GNSS data processing activities in China.These activities encompass the formulation of Precise Point Positioning(PPP)models and PPP-Real-Time Kinematic(PPP-RTK)models for processing single-station and multi-station GNSS data,respectively.Regarding single-station data processing,we discuss the advancements in PPP models,particularly the extension from a single system to multiple systems,and from dual frequencies to single and multiple frequencies.Additionally,we introduce the modified PPP model,which accounts for the time variation of receiver code biases,a departure from the conventional PPP model that typically assumes these biases to be time-constant.In the realm of multi-station PPP-RTK data processing,we introduce the ionosphere-weighted PPP-RTK model,which enhances the model strength by considering the spatial correlation of ionospheric delays.We also review the phase-only PPP-RTK model,designed to mitigate the impact of unmodelled code-related errors.Furthermore,we explore GLONASS PPP-RTK,achieved through the application of the integer-estimable model.For large-scale network data processing,we introduce the all-in-view PPP-RTK model,which alleviates the strict common-view requirement at all receivers.Moreover,we present the decentralized PPP-RTK data processing strategy,designed to improve computational efficiency.Overall,this work highlights the various advancements in UDUC GNSS data processing,providing insights into the state-of-the-art techniques employed in China to achieve precise GNSS applications.展开更多
基金Supported by Natural Science Foundation of Shaanxi Province of China(Grant No.2021JM010)Suzhou Municipal Natural Science Foundation of China(Grant Nos.SYG202018,SYG202134).
文摘Laser tracers are a three-dimensional coordinate measurement system that are widely used in industrial measurement.We propose a geometric error identification method based on multi-station synchronization laser tracers to enable the rapid and high-precision measurement of geometric errors for gantry-type computer numerical control(CNC)machine tools.This method also improves on the existing measurement efficiency issues in the single-base station measurement method and multi-base station time-sharing measurement method.We consider a three-axis gantry-type CNC machine tool,and the geometric error mathematical model is derived and established based on the combination of screw theory and a topological analysis of the machine kinematic chain.The four-station laser tracers position and measurement points are realized based on the multi-point positioning principle.A self-calibration algorithm is proposed for the coordinate calibration process of a laser tracer using the Levenberg-Marquardt nonlinear least squares method,and the geometric error is solved using Taylor’s first-order linearization iteration.The experimental results show that the geometric error calculated based on this modeling method is comparable to the results from the Etalon laser tracer.For a volume of 800 mm×1000 mm×350 mm,the maximum differences of the linear,angular,and spatial position errors were 2.0μm,2.7μrad,and 12.0μm,respectively,which verifies the accuracy of the proposed algorithm.This research proposes a modeling method for the precise measurement of errors in machine tools,and the applied nature of this study also makes it relevant both to researchers and those in the industrial sector.
基金supported by the National Natural Science Foundation of China(grant No.72074011)the Real World Study Project of Hainan Boao Lecheng Pilot Zone(Real World Study Base of NMPA)(HNLC2022RWS012)+1 种基金the fundamental research funds for central public welfare research institutes(2023CZ-11)National Natural Science Foundation of China(No.82003536).
文摘Background:Patients with type 2 diabetes are at high risk for developing multiple chronic complications.However,there is a lack of studies of the cumulative number of diabetic complications in China.Methods:A retrospective cohort study was performed from 2009 to 2021.Type 2 diabetes patients who were first diagnosed after the age of 35 years between January 1,2009,and December 31,2017,were included.Five states were defined according to the number of chronic complications:no(S0),one(S1),two(S2),three(S3),and four or more complications(S4).A multi-state Markov model was constructed to estimate transition probability,transition intensity,mean sojourn time,and the possible factors for each state.Results:The study included 32653 type 2 diabetes patients(mean age,59.59 years;15929(48.8%)male),and mean follow-up time of 7.75 years.In all,4375 transitions were observed.The 12-year transition probability of from state S0 to S1 was the lowest at 16.4%,while that from S2 to S3 was the highest,at 45.6%.Higher fasting blood glucose,lower high-density lipoprotein cholesterol,higher total cholesterol,and an unhealthy diet were associated with higher risk of progression from S0 to S1.Being female,less than 60 years old,weekly physical activity,and vegetarian diet decreased this risk.Being female and less than 60 years old reduced the likelihood of transition from S1 to S2,whereas lower high-density lipoprotein cholesterol increased this likelihood.Conclusions:Following the occurrence of two complications in type 2 diabetes patients,the risk for accumulating a third complication within a short time is significantly increased.It is important to take advantage of the stable window period when patients have fewer than two complications,strengthen the monitoring of blood glucose and blood lipids,and encourage patients to maintain good living habits to prevent further deterioration.
基金Supported by Funding of State Key Laboratory of Mechanical Transmissions,Chongqing University,China(Grant No.SKLMT-KFKT-201504)National Natural Science Foundation of China(Grant No.51275381)Science and Technology Planning Project of Shaanxi Province,China(Grant No.2012GY2-37)
文摘Tribological tests play an important role on the evaluation of long-term bio-tribological performances of prosthetic materials for commercial fabrication.Those tests focus on the motion simulation of a real joint in vitro with only normal loads and constant velocities,which are far from the real friction behavior of human joints characterized with variable loads and multiple directions.In order to accurately obtain the bio-tribological performances of artificial joint materials,a tribological tester with a miniature four-station tribological system is proposed with four distinctive features.Firstly,comparability and repeatability of a test are ensured by four equal stations of the tester.Secondly,cross-linked scratch between tribo-pairs of human joints can be simulated by using a gear-rack meshing mechanism to produce composite motions.With this mechanism,the friction tracks can be designed by varying reciprocating and rotating speeds.Thirdly,variable loading system is realized by using a ball-screw mechanism driven by a stepper motor,by which loads under different gaits during walking are simulated.Fourthly,dynamic friction force and normal load can be measured simultaneously.The verifications of the performances of the developed tester show that the variable frictional tracks can produce different wear debris compared with one-directional tracks,and the accuracy of loading and friction force is within ?5%.Thus the high consistency among different stations can be obtained.Practically,the proposed tester system could provide more comprehensive and accurate bio-tribological evaluations for prosthetic materials.
文摘Nowadays, the Multi-Shuttle and Multi-Station Transportation System (MMTS)<span><span><span style="font-family:;" "=""> is one of the most interesting research topics in many fields of industries. It is an effective solution to reduce unexpected accidents that occur during transportation as well as increase productivity in manufacturing. The aim of this paper is to introduce the controller design for the MMTS which is built in our BK-Recme BioMech Lab at Ho Chi Minh City University of Technology (VNU-HCM), Viet Nam. Based on the design of this system, the control algorithms will be conducted to check the operation of the whole system. To evaluate the feasibility and effectiveness of this model, we design a series of random instances for different quantities of nodes as well as the different quantities of shuttles. Our system includes 4 stations and 6 shuttles which are assembled in the serial chain system. However, the number of stations and number of shuttles can be expanded to any desired ones which are based on the requirement of the industries. In this paper, we mainly focus on the controller design of this system to make it operate in an effective way that the goods will be transported and delivered to the target station as fast as possible. In order to solve the large</span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "="">scale instances and realistic transport prob<span>lems, we propose three algorithms for three progresses as shuttles calling</span>, path reading and shuttles communicating. The shuttles calling is to decide which <span>shuttle should be called to the star</span></span></span></span><span><span><span style="font-family:;" "="">t</span></span></span><span><span><span style="font-family:;" "="">-node. Path reading to determine the shortest</span></span></span><span><span><span style="font-family:;" "=""> <span>way to go from start-node to end-node. Finally, shuttles communicating,</span> which allow one shuttle to interact with the next shuttles so we have a loop of orders (shuttle 1 to shuttle 2;shuttle 2 to shuttle 3;etc</span></span></span><span><span><span style="font-family:;" "="">.</span></span></span><span><span><span style="font-family:;" "="">;shuttle n-1 to shuttle n). This proposes solution can help us to solve the huge numbers of shuttles <span>and stations in the system. The specific result of this study is applying</span> Dijkstra’s algorithm to propose an algorithm that allows handling a transportation system without caring about the number of shuttles as well as the number of stations for the closed-loop path. Several test problems are carried out in order to check the feasibility and the effectiveness of our purposed control algorithm.</span></span></span>
文摘Survival data with amulti-state structure are frequently observed in follow-up studies.An analytic approach based on a multi-state model(MSM)should be used in longitudinal health studies in which a patient experiences a sequence of clinical progression events.One main objective in the MSM framework is variable selection,where attempts are made to identify the risk factors associated with the transition hazard rates or probabilities of disease progression.The usual variable selection methods,including stepwise and penalized methods,do not provide information about the importance of variables.In this context,we present a two-step algorithm to evaluate the importance of variables formulti-state data.Three differentmachine learning approaches(randomforest,gradient boosting,and neural network)as themost widely usedmethods are considered to estimate the variable importance in order to identify the factors affecting disease progression and rank these factors according to their importance.The performance of our proposed methods is validated by simulation and applied to the COVID-19 data set.The results revealed that the proposed two-stage method has promising performance for estimating variable importance.
基金This research was supported by the Sichuan Science and Technology Depart-ment under Contract Nos.2019YJ0396 and 2018JY0516the National Natural Science Foundation of China under the Contract No.51705041.
文摘In the traditional reliability evaluation based on the Bayesian method,the failure probability of nodes is usually expressed by the average failure rate within a period of time.Aiming at the shortcomings of traditional Bayesian network reliability evaluation methods,this paper proposes a Bayesian network reliability evaluation method considering dynamics and fuzziness.The fuzzy theory and the dynamic of component failure probability are introduced to construct the dynamic fuzzy set function.Based on the solving characteristics of the dynamic fuzzy set and Bayesian network,the fuzzy dynamic probability and fuzzy dynamic importance degree of the fault state of leaf nodes are solved.Finally,through the dynamic fuzzy reliability analysis of CNC machine tool hydraulic system balance circuit,the application of this method in system reliability evaluation is verified,which provides support for fault diagnosis of CNC machine tools.
基金supported by the National Natural Science Foundation of China (71271170 71101116)+1 种基金the National High Technology Research and Development Program of China (863 Progrom) (2012AA040914)the Basic Research Foundation of Northwestern Polytechnical University (JC20120228)
文摘Importance measures in reliability systems are used to identify weak components in contributing to a proper function of the system. Traditional importance measures mainly concerned the changing value of the system reliability caused by the change of the reliability of the component, and seldom considered the joint effect of the probability distribution, improvement rate of the object component. This paper studies the rate of the system reliability upgrading with an improvement of the component reliability for the multi-state consecutive k-out-of-n system. To verify the multi-state consecutive k-out-of-n system reliability upgrading by improving one component based on its improvement rate, an increasing potential importance (IPI) and its physical meaning are described at first. Secondly, the relationship between the IPI and Birnbaum importance measures are discussed. And the IPI for some different improvement actions of the component is further discussed. Thirdly, the characteristics of the IPI are analyzed. Finally, an application to an oil pipeline system is given.
基金supported by the National Natural Science Foundation of China (70971132)
文摘Classical network reliability problems assume both net- works and components have only binary states, fully working or fully failed states. But many actual networks are multi-state, such as communication networks and transportation networks. The nodes and arcs in the networks may be in intermediate states which are not fully working either fully failed. A simulation ap- proach for computing the two-terminal reliability of a multi-state network is described. Two-terminal reliability is defined as the probability that d units of demand can be supplied from the source to sink nodes under the time threshold T. The capacities of arcs may be in a stochastic state following any discrete or continuous distribution. The transmission time of each arc is also not a fixed number but stochastic according to its current capacity and de- mand. To solve this problem, a capacitated stochastic coloured Petri net is proposed for modelling the system behaviour. Places and transitions respectively stand for the nodes and arcs of a net- work. Capacitated transition and self-modified token colour with route information are defined to describe the multi-state network. By the simulation, the two-terminal reliability and node importance can be estimated and the optimal route whose reliability is highest can also be given. Finally, two examples of different kinds of multi- state networks are given.
基金This work was supported by the National Key R&D Program of China(No.2017YFB0903100)Science and Technology Projects of State Grid Corporation of China(No.521104170043).
文摘Voltage sags in power system may lead to serious problems such as the off-grid of distributed generation and electrical equipment failures.As a novel type of power electronic equipment,a flexible multi-state switch(FMSS)is capable to support the voltage during the grid faults.In this paper,a voltage control strategy to support the voltage in a distribution network is proposed by introducing three-port FMSS.The positive-negative-sequence compensation(PNSC)scheme is adopted to control the active and reactive current.This control scheme eliminates active power oscillations at the port of voltage sags and reduces coupling oscillations of other ports.Based on the characteristics of the voltage support under PNSC scheme,two voltage support strategies are proposed.A proportional-integral controller is introduced to provide the reactive power references,which eliminates the errors when estimating the grid voltage and impedance.A current limiting scheme is adopted to keep the port current in a safe range by adjusting the active and reactive power references.The voltage support strategies in two different voltage sags are simulated,and results show the feasibility and effectiveness of the proposed control strategies.
基金supported by the National Natural Science Foundation of China (7110111671271170)+2 种基金the National Basic Research Program of China (973 Progrom) (2010CB328000)the National High Technology Research and Development Program of China (863 Progrom) (2012AA040914)the Basic Research Foundation of Northwestern Polytechnical University (JC20120228)
文摘To verify the effectiveness of the integrated importance measure (IIM) for multi-state coherent systems of k level, the definition and physical meaning of IIM are demonstrated. Then, the improvement potential and Δ-importance measures are generalized to multi-state coherent systems based on the system performance level, and the relationships between IIM and traditional importance measures are discussed. The characteristics of IIM are demonstrated in both series and parallel systems. Also, an application to an oil transportation system is given. The comparison results show that: (i) IIM has some useful properties that are not possessed by traditional importance measures; (ii) IIM is effective in evaluating the component role in multi-state systems when the component reliability and the failure rate are simultaneously considered.
基金National Natural Science Foundation of China(No.61164009)the Science and Technology Research Project,Department of Education of Jiangxi Province,China(No.GJJ14420)Natural Science Foundation of Jiangxi Province,China(No.20132BAB206026)
文摘Importance analysis quantifies the critical degree of individual component. Compared with the traditional binary state system,importance analysis of the multi-state system is more aligned with the practice. Because the multi-valued decision diagram( MDD) can reflect the relationship between the components and the system state bilaterally, it was introduced into the reliability calculation of the multi-state system( MSS). The building method,simplified criteria,and path search and probability algorithm of MSS structure function MDD were given,and the reliability of the system was calculated. The computing methods of importance based on MDD and direct partial logic derivatives( DPLD) were presented. The diesel engine fuel supply system was taken as an example to illustrate the proposed method. The results show that not only the probability of the system in each state can be easily obtained,but also the influence degree of each component and its state on the system reliability can be obtained,which is conducive to the condition monitoring and structure optimization of the system.
基金supported by National Natural Science Foundation of China Grants 11672109 ( to Y. F.) and 11432006 ( to J. W.)
文摘At the vascular injury sites,the ultra-large (UL) multimeric von willebrand Factor (VWF) is released in response to physiological and pathophysiological stimuli,and mediates platelet adhesion,aggregation,and cross-linking to maintain hemostasis.This UL-VWF is specifically cleaved by ADAMTS13(A Disintegrin And Metalloprotease with a ThromboSpondintype-1 motif,member 13)to prevent microvascular thrombosis.Each VWF monomer consists of five types of repeat domains in the order of D1-D2-D’-D3-A1-A2-A3-D4-C1-C2-C3-C4-C5-C6-CK,in which the A2 domain contains the ADAMTS13cleavage site(Tyr1605-Met1606),exposure of which requires mechanical or chemical stimuli.Under flows,fluid shear stress regulates VWF degradation and size distribution through opening the A2 domain and exposing its cleavage site for ADAMTS13.VWF A2 domain contains a C-terminal vicinal disulfide bond,a calcium binding sites,and a flexibleα4-less-loop.These unique structure features together make A2 more sensitive to mechanical signal than other VWF A subdomains,i.e.A1 and A3 domains.It is believed that A2 is first bound with and then cleaved by ADAMTS13,together with force-induced conformation transformation.To reveal molecular basis of this two-step model of VWF hydrolyzation by ADAMTS13,we here examined stretch-induced unfolding processes of VWF A2 domain in more detail by Steered molecular dynamics(SMD)simulations,with the use of crystal structure of VWF A2(PDB ID 3GXB),and observed that there were multiple quasi-stable conformations of stretched A2 until itsβ4-strand and a3-helix were pulled away the central hydrophobic core and the cleavage sites were fully accessible to solvent.Our MD simulation data showed that,in unfolding,at first,the cleavage site residue Tyr1605 was exposed partially and binding sites for Spacer domain of ADAMTS13 were exposed to a high level whenα6-helix was separated from A2 body;then,withβ6-strand and a5-helix been pulled away,the binding sites for Cysrich domain of ADAMTS13 was exposed completely while the exposure degree of Tyr1605 was not improved;further,separation ofβ5-strand andα4-less-loop made Tyr1605 and Met1606 and the respective binding sites for ADAMTS13 Spacer domain,Cys-rich domain,and Disintegrin-like domain be fully exposed to reach the optimal catalytic state;lastly,withβ4-strand separation,the cleavage sites and binding sites all were overstretched,leading to mismatch of ADAMTS13 and A2 conformation especially in the binding sites.This conformational mismatch may cause reduction of ADAMTS13 hydrolysis efficiency.Furthermore,the data of SMD simulations under constant forces demonstrated that,the stretched A2 conformation had different quasi-stable states,which all had the better mechanical stability within simulation time of 100 ns;and the conformational transformation from one state to another must overcome their respective potential barriers.The hydrolysis efficiency should depend on each state of the stretched A2 conformation,because of the exclusive matched-degree of A2 and ADMATS13.This computer prediction on the mechanical stability and multi-states of stretched A2 provides a novel insight into the mechano-chemical regulation on cleavage of A2 by ADAMTS13.It would be helpful for design of related drug targeting the binding sites on A2 and exosites on ADAMTS13 for the treatment of patients with acquired TTP.
文摘In the paper, excess methods for improving the reliability of multi-state series-parallel systems are presented: for the hot reserve of single components, the cold reserve of single components, and the mixed (hot and cold) reserve of single components. A process is also introduced to improve the reliability of these methods by replacing their components with more reliable ones. New theorems for multi-state limit reliability functions in homogeneous and non-homogeneous series-parallel large systems composed of components with improved reliability are presented, and applied to compare the effects of these systems in different reliability improving methods.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 11972173 and 12172340)。
文摘We present a class of two-dimensional memristive maps with a cosine memristor. The memristive maps do not have any fixed points, so they belong to the category of nonlinear maps with hidden attractors. The rich dynamical behaviors of these maps are studied and investigated using different numerical tools, including phase portrait, basins of attraction,bifurcation diagram, and Lyapunov exponents. The two-parameter bifurcation analysis of the memristive map is carried out to reveal the bifurcation mechanism of its dynamical behaviors. Based on our extensive simulation studies, the proposed memristive maps can produce hidden periodic, chaotic, and hyper-chaotic attractors, exhibiting extremely hidden multistability, namely the coexistence of infinite hidden attractors, which was rarely observed in memristive maps. Potentially,this work can be used for some real applications in secure communication, such as data and image encryptions.
基金National Natural Science Foundations of China(Nos.61164009,61463021)the Science Foundation of Education Commission of Jiangxi Province,China(No.GJJ14420)+1 种基金the Young Scientists Object Program of Jiangxi Province,China(No.20144BCB23037)the Graduate Innovation Foundation of Jiangxi Province,China(No.YC2014-S364)
文摘The performance and state of multi-state system depend on its structure and different state combinations of the components. In order to evaluate the reliability of multi-state system effectively,a reliability evaluation and sensitivity analysis method based on the time degradation measures was proposed. The equivalence sets of the multi-state system under different output performances were established. The state combinations were classified according to the performance level. The degradation probability models under different states were established,and the new reliability measures,such as dynamic probability of multi-state system,holding time in each state,dynamic expectation function and integrated expectation function of the performance,were proposed and used to implement the dynamic reliability evaluation and sensitivity analysis. A certain diesel engine fuel feeding system was taken as an application example to illustrate the proposed method. The results show that not only the holding time in the desired state of the components and the system can be predicted,but also the best state component in a certain time period can be obtained.
基金supported by NIH Grant R01GM130694-01A1,a start-up package by the University of Colorado to B.V.,University of Colorado Cancer Center Support Grant P30 CA046934NIH Biomedical Research Support Shared Grant S10 OD025020-01.
文摘Residual dipolar couplings(RDCs)are powerful nuclear magnetic resonance(NMR)probes for the structure calculation of biomacromolecules.Typically,an alignment tensor that defines the orientation of the entire molecule relative to the magnetic field is determined either before refinement of individual bond vectors or simultaneously with this refinement.For single-domain proteins this approach works well since all bond vectors can be described within the same coordinate frame,which is given by the alignment tensor.However,novel approaches are sought after for systems where no universal alignment tensor can be used.Here,we present an approach that can be applied to two-domain proteins that enables the calculation of multiple states within each domain as well as with respect to the relative positions of the two domains.
基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(KYCX22_0606)。
文摘A multi-station integration system(MSIS)integrat-ing other multi-type stations provides a new way to realize an intensive development of resources and promote low-carbon en-ergy and its high-efficiency utilization.To this end,a novel multi-station integration planning method and coordinated operation strategy model for the MSIS are established in a new business model.In this study,a new business model of the MSIS,with substations as the carrier,integrating distributed photovoltaic,energy storage,electric vehicle charging,data center,and 5G base stations is proposed.From the social environment,natural conditions,and complementary characteristics,a comprehensive index system is established to analyze expansion capability of substations and multi-station combination scheme.Scenario reduction is performed by extracting feature vectors and build-ing a comprehensive evaluation function to select the optimal combination scheme under a specific scenario.Moreover,for the combination scheme in a specific scenario,the optimal ca-pacity configuration and coordinated operation strategy chance-constrained programming model of the MSIS are established under different operating conditions.Finally,simulations are performed on a practical MSIS located in Wuxi,China,and simulation results demonstrate the rationality and effectiveness of the planning method and coordinated operation strategy model for the MSIS.
基金Project supported by the National Natural Science Foundation of China(Grant No.61773010)Taishan Scholar Foundation of Shandong Province of China(Grant No.ts20190938)。
文摘In order to make the peak and offset of the signal meet the requirements of artificial equipment,dynamical analysis and geometric control of the laser system have become indispensable.In this paper,a locally active memristor with non-volatile memory is introduced into a complex-valued Lorenz laser system.By using numerical measures,complex dynamical behaviors of the memristive laser system are uncovered.It appears the alternating appearance of quasi-periodic and chaotic oscillations.The mechanism of transformation from a quasi-periodic pattern to a chaotic one is revealed from the perspective of Hamilton energy.Interestingly,initial-values-oriented extreme multi-stability patterns are found,where the coexisting attractors have the same Lyapunov exponents.In addition,the introduction of a memristor greatly improves the complexity of the laser system.Moreover,to control the amplitude and offset of the chaotic signal,two kinds of geometric control methods including amplitude control and rotation control are designed.The results show that these two geometric control methods have revised the size and position of the chaotic signal without changing the chaotic dynamics.Finally,a digital hardware device is developed and the experiment outputs agree fairly well with those of the numerical simulations.
基金funded by the Center for Research Excellence,Incubation Management Center,Universiti Sultan Zainal Abidin via an internal grant UniSZA/2021/SRGSIC/07.
文摘In recent years,there are numerous studies on chaotic systems with special equilibrium curves having various shapes such as circle,butterfly,heart and apple.This paper describes a new 3-D chaotic dynamical system with a capsule-shaped equilibrium curve.The proposed chaotic system has two quadratic,two cubic and two quartic nonlinear terms.It is noted that the proposed chaotic system has a hidden attractor since it has an infinite number of equilibrium points.It is also established that the proposed chaotic system exhibits multi-stability with two coexisting chaotic attractors for the same parameter values but differential initial states.A detailed bifurcation analysis with respect to variations in the system parameters is portrayed for the new chaotic system with capsule equilibrium curve.We have shown MATLAB plots to illustrate the capsule equilibrium curve,phase orbits of the new chaotic system,bifurcation diagrams and multi-stability.As an engineering application,we have proposed a speech cryptosystem with a numerical algorithm,which is based on our novel 3-D chaotic system with a capsule-shaped equilibrium curve.The proposed speech cryptosystem follows its security evolution and implementation on Field Programmable Gate Array(FPGA)platform.Experimental results show that the proposed encryption system utilizes 33%of the FPGA,while the maximum clock frequency is 178.28 MHz.
基金National Natural Science Foundation of China(No.42022025)。
文摘With the continued development of multiple Global Navigation Satellite Systems(GNSS)and the emergence of various frequencies,UnDifferenced and UnCombined(UDUC)data processing has become an increasingly attractive option.In this contribution,we provide an overview of the current status of UDUC GNSS data processing activities in China.These activities encompass the formulation of Precise Point Positioning(PPP)models and PPP-Real-Time Kinematic(PPP-RTK)models for processing single-station and multi-station GNSS data,respectively.Regarding single-station data processing,we discuss the advancements in PPP models,particularly the extension from a single system to multiple systems,and from dual frequencies to single and multiple frequencies.Additionally,we introduce the modified PPP model,which accounts for the time variation of receiver code biases,a departure from the conventional PPP model that typically assumes these biases to be time-constant.In the realm of multi-station PPP-RTK data processing,we introduce the ionosphere-weighted PPP-RTK model,which enhances the model strength by considering the spatial correlation of ionospheric delays.We also review the phase-only PPP-RTK model,designed to mitigate the impact of unmodelled code-related errors.Furthermore,we explore GLONASS PPP-RTK,achieved through the application of the integer-estimable model.For large-scale network data processing,we introduce the all-in-view PPP-RTK model,which alleviates the strict common-view requirement at all receivers.Moreover,we present the decentralized PPP-RTK data processing strategy,designed to improve computational efficiency.Overall,this work highlights the various advancements in UDUC GNSS data processing,providing insights into the state-of-the-art techniques employed in China to achieve precise GNSS applications.