J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy,older Chinese individuals

Background The prospective association of dietary thiamine intake with the risk of cognitive decline among the general older adults remains uncertain.Aims To investigate the association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals.Methods The study included a total of 3106 participants capable of completing repeated cognitive function tests.Dietary nutrient intake information was collected through 3-day dietary recalls and using a 3-day food-weighed method to assess cooking oil and condiment consumption.Cognitive decline was defined as the 5-year decline rate in global or composite cognitive scores based on a subset of items from the Telephone Interview for Cognitive Status-modified.Results The median follow-up duration was 5.9 years.There was a J-shaped relationship between dietary thiamine intake and the 5-year decline rate in global and composite cognitive scores,with an inflection point of 0.68 mg/day(95%confidence interval(Cl):0.56 to 0.80)and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.Before the inflection point,thiamine intake was not significantly associated with cognitive decline.Beyond the inflection point,each unit increase in thiamine intake(mg/day)was associated with a significant decrease of 4.24(95%Cl:2.22 to 6.27)points in the global score and 0.49(95%Cl:0.23 to 0.76)standard units in the composite score within 5 years.A stronger positive association between thiamine intake and cognitive decline was observed in those with hypertension,obesity and those who were non-smokers(all p<0.05).Conclusions This study revealed a J-shaped association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals,with an inflection point at 0.68 mg/day and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.

The interaction between a shaped charge jet and a single moving plate

Reactive armour is a very efficient add-on armour against shaped charge threats.Explosive reactive armour consists of one or several plates that are accelerated by an explosive.Similar but less violent acceleration of plates can also be achieved in a completely inert reactive armour.To be efficient against elongated jets,the motion of the plates needs to be inclined against the jet such that a sliding contact between the jet and the plates is established.This sliding contact causes a deflection and thinning of the jet.Under certain circumstances,the contact will become unstable,leading to severe disturbances on the jet.These disturbances will drastically reduce the jet penetration performance and it is therefore of interest to study the conditions that leads to an unstable contact.Previous studies on the interaction between shaped charge jets and flyer plates have shown that it is mainly the forward moving plate in an explosive reactive armour that is effective in disturbing the jet.This is usually attributed to the higher plate-to-jet mass flux ratio involved in the collision of the forward moving plate compared to the backward moving plate.For slow moving plates,as occurs in inert reactive armour,the difference in mass flux for the forward and backward moving plate is much lesser,and it is therefore of interest to study if other factors than the mass flux influences on the protection capability.In this work,experiments have been performed where a plate is accelerated along its length,interacting with a shaped charge jet that is fired at an oblique angle to the plate’s normal,either against or along the plate’s velocity.The arrangement corresponds to a jet interacting with a flyer plate from a reactive armour,with the exception that the collision velocity is the same for both types of obliquities in these experiments.The experiments show that disturbances on the jet are different in the two cases even though the collision velocities are the same.Numerical simulations of the interaction support the observation.The difference is attributed to the character of the contact pressure in the interaction region.For a backward moving plate,the maximum contact pressure is obtained at the beginning of the interaction zone and the contact pressure is therefore higher upstream than downstream of the jet while the opposite is true for a forward moving plate.A negative interface pressure gradient with respect to the jet motion results in a more stable flow than a positive,which means that the jet-plate contact is more stable for a backward moving plate than for a forward moving plate.A forward moving plate is thus more effective in disturbing the jet than a backward moving plate,not only because of the higher jet to plate mass flux ratio but also because of the character of the contact with the jet.

Machine learning optimization strategy of shaped charge liner structure based on jet penetration efficiency

Shaped charge liner(SCL)has been extensively applied in oil recovery and defense industries.Achieving superior penetration capability through optimizing SCL structures presents a substantial challenge due to intricate rate-dependent processes involving detonation-driven liner collapse,high-speed jet stretching,and penetration.This study introduces an innovative optimization strategy for SCL structures that employs jet penetration efficiency as the primary objective function.The strategy combines experimentally validated finite element method with machine learning(FEM-ML).We propose a novel jet penetration efficiency index derived from enhanced cutoff velocity and shape characteristics of the jet via machine learning.This index effectively evaluates the jet penetration performance.Furthermore,a multi-model fusion based on a machine learning optimization method,called XGBOOST-MFO,is put forward to optimize SCL structure over a large input space.The strategy's feasibility is demonstrated through the optimization of copper SCL implemented via the FEM-ML strategy.Finally,this strategy is extended to optimize the structure of the recently emerging CrMnFeCoNi high-entropy alloy conical liners and hemispherical copper liners.Therefore,the strategy can provide helpful guidance for the engineering design of SCL.

Selection of shaped charges parameters for producing aluminum particles with velocities in the range of 2.5-16 km/s

Testing rocket and space technology objects in ground conditions for resistance to the impact of meteoroids and fragments of space debris can be carried out using shaped charges. To substantiate the design parameters of shaped charges that ensure the formation of aluminum particles in a wide velocity range(from 2.5 to 16 km/s), numerical modeling of the formation process was carried out within the framework of a two-dimensional axisymmetric problem of continuum mechanics using three different computing codes to increase the reliability of the results. The calculations consider shaped charges with a diameter of 20-100 mm with aluminum liners of various shapes. It is shown that the formation of particles with velocities close to the lower limit of the considered range is ensured by gently sloping segmental liners of degressive thickness. To form higher-velocity particles with velocities over 5 km/s, it is proposed to use combined liners, the jet-forming part of which has the shape of a hemisphere of constant thickness or the shape of a semi-ellipsoid or semi-superellipsoid of rotation of degressive thickness.

Arc additive manufacturing of gradient hot forging die with shaped waterways

Under the working environment of high temperature and strong load impact,hot forging die is prone to failure which reduces the service life of die.Using arc additive manufacturing in the die cavity,a gradient material hot forging die with high precision,superior per-formance,and conformal cooling channels is developed.This improves the toughness of the die cavity and reduces the working temperature,thereby forming an isothermal field,which is an effective method to enhance the lifespan of the hot forging die.Three kinds of gradient flux-cored wires are designed for the surface of 5CrNiMo steel,and the microstructure and mechanical properties between gradient interfaces were studied.Based on the spatial curved structure of shaped waterways in the hot forging die cavity,a study was conducted on the strategy of partitioned forming for the manufacturing of the die with shaped waterways.In order to avoid interference with the arc gun,the hot for-ging die is divided into four regions,namely the transition region,upper,middle,and lower region,based on a combination of cavity depth and internal U-shaped and quadrilateral structures.The results show that the developed flux-cored wires have good moldability with straight sides of deposited metal under different process parameters and flat surface without cracks,pores and other defects.Under the same working conditions,the life of hot forging die formed by the gradient materials is more than multiple times that of the single material hot forging die,and the temperature gradient field of the shaped waterway die is 7℃/cm smaller than that of traditional straight waterway.

The Origins of the Arc-Shaped Langshan Uplift and Linhe Trench

In the northern part of the Ordos Basin, there is a 325 km long arc-shaped Langshan uplift and a 15 km-deep Linhe Trench in front of Langshan, which are rare geological phenomena for which origins no one has explained. This article comprehensively analyzes the research achievements over the past 40 years of geology, geomorphology, seismic exploration, paleogeography, and oil and gas exploration in the Ordos Basin and Langshan. It recognizes that the northern part of the Ordos Basin experienced a meteorite impact in the Late Cretaceous period. The impact pushed the block northwest ward, subducting after colliding with igneous rocks in the north. This sudden event formed a clear arc-shaped mountain zone in the north and a wedge-shaped trench in front of the mountain. The chaotic layers, prolonged and continuous faults, and numerous thrust layers in the Langshan, a negative anomaly area in the center of the northern Ordos, abnormal orientation of crystalline basement structures in the north of Ordos, Moho uplift, and distribution of meteorite fragments in the northwest of Langshan, all of these geological phenomena support the occurrence of the meteorite impact event, forming the arc-shaped Langshan and the Trench.

《Six Ideas that Shaped Physics》以及其课程实践——以华盛顿大学“物理学导论”的教学为例

为世界各地100多所高等院校所使用的《Six Ideas》(全称《Six Ideas that Shaped Physics》)一书,以在物理学发展的历史长河中有着不可替代地位的6大物理思想为主线改变了以力学、热学、电磁学、光学等传统物理的编排模式.《Six Ideas》的每一卷均按照历史发展的故事线索展开,强调概念和定律的内在思想和应用条件,范题注重用文字或图形转译问题等框架模式;每一单元的内容编排不仅适合学生自学,同时为教师50分钟课堂教学量身定制;是适合学生"主动学习"教学模式可操作性极强的一本难得的物理学导论教材.本篇以此书为教科书的美国华盛顿大学关于E卷第九单元课堂教学案例,展示关于此书的教与学.

RESEARCH ON T SHAPED HIGH STRENGTH CONCRETE MEMBERS SUBJECTED TO AXIAL COMPRESSION AND BIAXIAL BENDING

Based on experiments, a computer program is developed. The calculated results agree well with the experimental results. The flexural behavior of T shaped high strength concrete members subjected to axial compression and biaxial bending is studied. The main factors affecting the flexural behavior of T shaped high strength concrete members are loading angle, axial compression ratio and reinforcement ratio.

Delta-shaped术和Billroth Ⅰ术在腹腔镜远端胃癌根治术中的应用效果

目的对比远端胃癌根治手术中实施全腹腔镜下三角吻合术(Delta-shaped)和腹腔镜辅助下毕Ⅰ式吻合术(Billroth Ⅰ)应用效果。方法回顾性分析我院2015年5月~2018年5月实施腹腔镜远端胃癌根治术患者115例,根据手术方式依次分为Delta-shaped术组(33例)和Billroth Ⅰ术组(82例)。两组均实施淋巴结清扫术,其中Delta-shaped术组实施Delta-shaped术,Billroth Ⅰ术组实施Billroth Ⅰ术。观察两组患者术中指标、组织标本情况、术后恢复情况,并统计术后并发症发生率。结果两组患者吻合时间比较差异无统计学意义(P>0.05);Delta-shaped术组初始手术时长长于Billroth Ⅰ术组(P<0.05);Delta-shaped术组学习曲线后手术时长、术中出血量均短于Billroth Ⅰ术组(P<0.05)。两组患者肿瘤大小、淋巴结清扫个数相当(P>0.05);Delta-shaped术组切口长度、切缘距离均低于Billroth Ⅰ术组(P<0.05)。Delta-shaped术组术后镇痛时间、首次通气时间、胃肠功能恢复时间、下地时间、拆线时间、住院时间均短于Billroth Ⅰ术组(P<0.05)。两组术后并发症发生率比较差异无统计学意义(P>0.05)。结论腹腔镜远端胃癌根治手术中实施Delta-shaped术近期优势高于BillrothⅠ术,其手术创伤相对较小,术后恢复较快,临床应用价值较高。

A Ventral Diverterless High Offset S-shaped Inlet at Transonic Speeds

An investigation on the ventral diverterless high offset S-shaped inlet is carried out at Mach numbers from 0.600 to 1.534, angles of attack from -4° to 9.4°, and yaw angles from 0° to 8°. Results indicate： （1） a large region of low total pressure exists at the lower part of the inlet exit caused by the counter-rotating vortices in the S-shaped duct; （2） the performances of the inlet at Mach number 1.000 reach almost the highest, so the propulsion system could work efficiently in terms of aerodynamics; （3） the total pressure recovery increases slowly at first and then remains unvaried as the Mach number rises from 0.6 to 1.0, however, it does in an opposite manner in the conventional diverter-equipped S-shaped inlet; （4） the performances of the inlet are generally insensitive to angles of attack from -4° to 9.4° and yaw angles from 0° to 8° at Mach number 0.850, and angles of attack from -2° to 6° and yaw angles from 0° to 5° at Mach number 1.534.

Experimental investigation of penetration performance of shaped charge into concrete targets

In order to develop a tandem warhead that can effectively destroy concrete targets, this paper explores the penetration performance of shaped charges with different cone angles and liner materials into concrete targets by means of experiments. The penetration process and the destruction mechanism of concrete targets by shaped charges and kinetic energy projectiles are analyzed and compared. Experimental results suggest that both kinetic energetic projectile and shaped charge are capable of destroying concrete targets, but the magnitudes of damage are different. Compared with a kinetic energy projectile, a shaped charge has more significant effect of penetration into the target, and causes very large spalling area. Hence, a shaped charge is quite suitable for first-stage charge of tandem warhead. It is also found that, with the increase of shaped charge liner cone angle, the depth of penetration decreases gradually while the hole diameter becomes larger. Penetration depth with copper liner is larger than of aluminum liner but hole diameter is relatively smaller, and the shaped charge with steel liner is between the above two cases. The shaped charge with a cone angle of 100° can form a jet projectile charge （JPC）. With JPC, a hole with optimum depth and diameter on concrete targets can be formed, which guarantees that the second-stage warhead smoothly penetrates into the hole and explodes at the optimum depth to achieve the desired level of destruction in concrete targets.

A comparative study for the impact performance of shaped charge JET on UHPC targets

With the development of two-stage munitions(a precursor shaped charge(SC)and a following kinetic energy projectile)to attack the hard concrete targets,as well as the increasing applications of ultra-high performance concrete(UHPC)in both civil and military protective structures,a comparative study on the impact performance of SC formed jet on UHPC target is performed experimentally and numerically at present.Firstly,a series of jet penetration/perforation test on the UHPC,45# steel and UHPC/45# steel composite targets are conducted.By assessing the penetration depth and borehole(crater and tunnel)diameter,the influences of target material and configuration as well as the standoff distance of SC on the impact performance of jet are experimentally discussed.Then,by adopting the 2 D multi-material Arbitrary Lagrange-Euler(ALE)algorithm,Fluid-Structure Interaction(FSI)method and erosion algorithm implemented in the finite element code LS-DYNA,the formation and impact performance of jet in the present test are well reproduced.Finally,based on the validated numerical algorithms,constitutive models and the corresponding parameters,the influences of target material(UHPC,NSC and 45# steel),standoff distance,target configuration(stacked and spaced)and weight efficiency on the impact performance of jet are further discussed.The derived conclusions could provide helpful references for evaluating the ballistic performance of jet and designing the protective structures.

3shape Trios 3口内扫描和传统硅橡胶在牙体缺损修复中的失败原因分析

目的分析并比较3shape Trios 3口内扫描和传统硅橡胶在牙体缺损修复中的失败原因,为临床取模以及口内扫描仪性能改善提供参考依据。方法回顾性分析2021年1月至2023年10月实施口腔固定修复治疗并返工的200例患者为研究对象,以取模方式将其分为口扫组(n=97)和硅橡胶组(n=103)。口扫组给予3shape Trios 3口内扫描,硅橡胶组给予传统硅橡胶。比较两组在牙体缺损修复中的失败原因。结果两组的牙体缺损修复失败分布情况比较,差异具有统计学意义(P<0.05);口扫组中,龈下缺损修复失败占比高于龈上(P<0.05)。两组的龈下缺损修复失败原因比较,差异具有统计学意义(P<0.05)。结论相较于传统硅橡胶,3shape Trios 3口内扫描在龈上缺损修复中更有优势,但在龈下缺损修复中,硅橡胶应用效果更佳。

Study on orientation fracture blasting with shaped charge in rock

On the basis of the theories of mechanics of explosive and rock fracture mechanics, the mechanism of crack initiation and its expansion of directional fracture controlled blasting with shaped charges in rock were studied, then the blasting parameters were designed and tested by a model test in laboratory and field experiment. The experimental and test results showed that the energy from blasting is directionally concentrated for the cumulative action. The directional expansion of cracks is satisfactory, the results of the model test and field test suggested that the orientation fracture blasting with shaped charge is a good means of excavating tunnels or cutting rock.

Numerical Simulation of the Shaped Charge Jet Velocity Effected by Warhead Shell

The numerical simulation for the process of shaped charge jet produced with the shell of explosives is performed by means of the ANSYS/LS-DYNA 3D software. The effect of warhead shell on shaped charge jet velocity has been analyzed qualitatively in this paper. The numerical simulation results are creditable and in agreement well with that of the corresponding experiment. The research results show that the jet velocity of explosive with metal shell is higher than that without shell; when the shell thickness increases, jet＇ s head speed also increases; when the shell thickness increased to certain value, the jet velocity will not change any longer; with the same shell thickness, the bigger material density the higher jet＇s head velocity.

Formation of layer-shaped pores in TiC-Fe cermet by combustion synthesis

To study the formation of layer shaped pores in TiC Fe cermet, two Ti C Fe powder compacts containing Ti powders with two size ranges (< 44μm and 135～ 154μm ) respectively were ignited in a special ignition mode. The combustion temperatures of the reactions were measured, the phase constituents of the combustion synthesized products were inspected by X ray diffractometry (XRD), and the structures of the products were observed with scanning electron microscope (SEM). In the case of the finer Ti powder used, TiC Fe cermet and pore rank in an alternately laminar shape, and the shape of the pore is the same as that of the combustion wavefront, implying that the layer shaped pore results from a gather of the retained gas into the combustion wavefront. While in the case of the coarser Ti powder used, the lower combustion temperature causes the gather of the retained gas to be difficult, the pore being present in an arbitrary shape and distributing randomly.

Bore-center annular shaped charges with different liner materials penetrating into steel targets

The bore-center annular shaped charge(BCASC)is a new type of shaped charge which can generate a larger-diameter hole in steel targets than classical shaped charges.In this paper,the influence of three liner materials,i.e.molybdenum,nickel and copper,on BCASC formation and penetrating into steel targets was investigated by experiment and numerical simulation.The simulation results were well consistent with the experimental results.This study showed that,at 0.50D standoff distance,the axial velocity of the molybdenum projectile was lower than that of the nickel and copper projectiles.The nickel and copper projectiles had almost the same head velocity.The absolute values of the radial velocity of the molybdenum projectile head was lower than that of the nickel and copper projectiles.However,at 0.75D standoff distance,the absolute values of the radial velocity of the molybdenum projectile head became much greater than that of the nickel and copper projectile heads.The projectile formed by BCASC with the molybdenum liner had the highest penetration depth of 61.5 mm,which was 10.0%and 21.3%higher than that generated by the copper and nickel projectiles.

Buckling-controlled two-way shape memory effect in a ring-shaped bilayer

Shape memory polymers(SMPs)usually have a one-way shape memory effect.In this paper,an easy-operating method to realize a two-way shape memory effect was demonstrated in a ring-shaped bilayer structure where the two layers are SMPs with different thermal transition temperatures.By designing specific thermomechanical processes,the mismatched deformation between the two layers leads to a morphology change of ring-shaped bilayer structures from a smooth ring to a gear-like buckling shape under cooling and a reversible recovery to the smooth shape under heating.Such a morphology change is ascribed to occurrence and recovery of thermoelastic buckling.This method was validated by finite element simulation.We experimentally investigated the influence of pre-strain on buckling,and it was found that both the buckling occurrence and recovery temperature vary with pre-strain.Furthermore,considering a ring-shaped SMP-SMP bilayer structure,finite element analysis was conducted to study the influence of film thickness and modulus ratio of two layers on buckling behavior.The results showed that the critical buckling wavelength was greatly influenced by film thickness and modulus ratio.W e made a theoretical analysis that accorded well with the numerical results.

Shaped binderless ZSM-11 zeolite catalyst prepared via a dry-gel conversion method:Characterization and application for alkylation of benzene with dimethyl ether

Shaped binderless ZSM-11 zeolite catalysts were synthesized via a dry-gel conversion technique from 70ZSM-11/30 SiO;mix extrudates. 1,6-hexanediamine combined with tetrabutylammonium bromide was proved to be the best structure directing agent for the synthesis of the binderless ZSM-11 catalyst, without adding other alkaline materials. The 70HZSM-11/30 SiO;mix serials materials crystallized for different times were detected by X-ray diffraction（XRD）, nuclear magnetic resonance（NMR）, scanning electron microscopy（SEM）, transmission electron microscopy（TEM）, scanning transmission electron microscopy–energy dispersive spectroscopy（STEM–EDS） techniques, and so on. In order to investigate the possible crystallization mechanism, the textural and structural properties of 70HZSM-11/30 SiO;mix serials samples were further characterized by N;adsorption–desorption. Acid properties were determined by temperature-programed desorption of NH;（NH;-TPD） and pyridine adsorption-infrared（Py-IR） measurements. In the alkylation of benzene with dimethyl ether, the serials catalysts exhibited different benzene conversions. 70HZSM-11/30 SiO;mix showed the lowest benzene conversion while sample 70HZSM-11/30 SiO;mix-6.5h synthesized only for 6.5h displayed a higher benzene conversion, even higher than the value over 70HZSM-11/30Al;O;mix. Extending the crystallization time, the obtained samples displayed the increased benzene conversion in general under the same reaction conditions. In the end, the relation of physicochemical properties with the reaction performance was investigated.

Research on the Application of Explosive Network in the Shaped Charge Warhead

With respect to the problems of that the shaped charge warhead currently uses a cover method to improve the penetration power, a method using an explosive network technology as the detonation mode of shaped charge warhead is proposed. In the context of some shaped charge warhead, a synchronous explosive network prototype is designed according to some charge structure parameters, such as the liner and main grain. From the performance comparison test, it can be known that the explosive network not only stably detonates, but also largely improves the penetration power and stability. Experimental results show that explosive network technology is an effective method for improving the penetration power. The results lay a solid foundation for the engineering application of the technology in the shaped charge warhead.