Polyfunctional aziridine/polyester microcapsules as control-release waterborne cross-linker were synthesized by multiple emulsion-solvent evaporation method. The results show that,a lower surface free energy with shel...Polyfunctional aziridine/polyester microcapsules as control-release waterborne cross-linker were synthesized by multiple emulsion-solvent evaporation method. The results show that,a lower surface free energy with shell polyester is more favourable for the formation of microcapsules. Full encapsulating microcapsules are synthesized with the polyester with a surface free energy of 34.5 mJ/m2. Shell-to-core feeding mass ratio has a significant influence on the morphology and core content of the resulting microcapsules. Well defined spherical microcapsules with uniform shell thickness and core content at around 22% are produced at a shell-to-core mass ratio of 1:1. When 2.5% of colloid stabilizer is used,hollow spherical microcapsules are obtained. A high solvent evaporation rate results in wrinkling and porosity of the microcapsules,and an evaporation rate equivalent to solvent elimination in about 2 h provides a uniform rate of surface hardening. The characterization of the microcapsules by SEM and FTIR demonstrates that polyfunctional aziridine is encapsulated at the centre of the microcapsule. The microcapsules synthesized can be broken at a high shear rate.展开更多
Drug delivery by nanocarriers requires characterizations of suitable particle size, high drug loading and safety. In this work, we prepared an amphiphilic dendrimer modified PEG-PLA mixed nanoparticles（NPs） by a dou...Drug delivery by nanocarriers requires characterizations of suitable particle size, high drug loading and safety. In this work, we prepared an amphiphilic dendrimer modified PEG-PLA mixed nanoparticles（NPs） by a double emulsion-solvent evaporation（DESE） method. The particle size and drug encapsulation efficacy（EE） were compared to evaluate and optimize the preparation parameters. The mixed NPs had average size ranging from（102±1） nm to（137±5） nm, and the zeta potential turned to positive with incorporation of the amphiphilic dendrimer. The NPs showed different EE of docetaxel（DTX） and paclitaxel（PTX） with higher affinity to more lipophilic PTX. The blank mixed NPs showed little cytotoxicity, and the DTX-loaded NPs could effectively facilitate the antiproliferation activity on PC-3 cells. The NPs could be used as an effective drug delivery system, and its anti-tumor effect is worthy of further study.展开更多
基金Project(50903031) supported by the National Natural Science Foundation of ChinaProject(2009ZM0046) supported by the Fundamental Research Funds for the Central Universities in ChinaProject(N9100240) supported by the Foundation for Distinguished Young Talents in Higher Education of Guangdong Province, China
文摘Polyfunctional aziridine/polyester microcapsules as control-release waterborne cross-linker were synthesized by multiple emulsion-solvent evaporation method. The results show that,a lower surface free energy with shell polyester is more favourable for the formation of microcapsules. Full encapsulating microcapsules are synthesized with the polyester with a surface free energy of 34.5 mJ/m2. Shell-to-core feeding mass ratio has a significant influence on the morphology and core content of the resulting microcapsules. Well defined spherical microcapsules with uniform shell thickness and core content at around 22% are produced at a shell-to-core mass ratio of 1:1. When 2.5% of colloid stabilizer is used,hollow spherical microcapsules are obtained. A high solvent evaporation rate results in wrinkling and porosity of the microcapsules,and an evaporation rate equivalent to solvent elimination in about 2 h provides a uniform rate of surface hardening. The characterization of the microcapsules by SEM and FTIR demonstrates that polyfunctional aziridine is encapsulated at the centre of the microcapsule. The microcapsules synthesized can be broken at a high shear rate.
基金National Natural Science Foundation of China(Grant No.81473156,81673365,81273454)Doctoral Foundation of the Ministry of Education(Grant No.20130001110055)National Key Basic Research Program(Grant No.2013CB932501)
文摘Drug delivery by nanocarriers requires characterizations of suitable particle size, high drug loading and safety. In this work, we prepared an amphiphilic dendrimer modified PEG-PLA mixed nanoparticles（NPs） by a double emulsion-solvent evaporation（DESE） method. The particle size and drug encapsulation efficacy（EE） were compared to evaluate and optimize the preparation parameters. The mixed NPs had average size ranging from（102±1） nm to（137±5） nm, and the zeta potential turned to positive with incorporation of the amphiphilic dendrimer. The NPs showed different EE of docetaxel（DTX） and paclitaxel（PTX） with higher affinity to more lipophilic PTX. The blank mixed NPs showed little cytotoxicity, and the DTX-loaded NPs could effectively facilitate the antiproliferation activity on PC-3 cells. The NPs could be used as an effective drug delivery system, and its anti-tumor effect is worthy of further study.
