Video watermarking plays a crucial role in protecting intellectual property rights and ensuring content authenticity.This study delves into the integration of Galois Field(GF)multiplication tables,especially GF(2^(4))...Video watermarking plays a crucial role in protecting intellectual property rights and ensuring content authenticity.This study delves into the integration of Galois Field(GF)multiplication tables,especially GF(2^(4)),and their interaction with distinct irreducible polynomials.The primary aim is to enhance watermarking techniques for achieving imperceptibility,robustness,and efficient execution time.The research employs scene selection and adaptive thresholding techniques to streamline the watermarking process.Scene selection is used strategically to embed watermarks in the most vital frames of the video,while adaptive thresholding methods ensure that the watermarking process adheres to imperceptibility criteria,maintaining the video's visual quality.Concurrently,careful consideration is given to execution time,crucial in real-world scenarios,to balance efficiency and efficacy.The Peak Signal-to-Noise Ratio(PSNR)serves as a pivotal metric to gauge the watermark's imperceptibility and video quality.The study explores various irreducible polynomials,navigating the trade-offs between computational efficiency and watermark imperceptibility.In parallel,the study pays careful attention to the execution time,a paramount consideration in real-world scenarios,to strike a balance between efficiency and efficacy.This comprehensive analysis provides valuable insights into the interplay of GF multiplication tables,diverse irreducible polynomials,scene selection,adaptive thresholding,imperceptibility,and execution time.The evaluation of the proposed algorithm's robustness was conducted using PSNR and NC metrics,and it was subjected to assessment under the impact of five distinct attack scenarios.These findings contribute to the development of watermarking strategies that balance imperceptibility,robustness,and processing efficiency,enhancing the field's practicality and effectiveness.展开更多
In the case of massive data,matrix operations are very computationally intensive,and the memory limitation in standalone mode leads to the system inefficiencies.At the same time,it is difficult for matrix operations t...In the case of massive data,matrix operations are very computationally intensive,and the memory limitation in standalone mode leads to the system inefficiencies.At the same time,it is difficult for matrix operations to achieve flexible switching between different requirements when implemented in hardware.To address this problem,this paper proposes a matrix operation accelerator based on reconfigurable arrays in the context of the application of recommender systems(RS).Based on the reconfigurable array processor(APR-16)with reconfiguration,a parallelized design of matrix operations on processing element(PE)array is realized with flexibility.The experimental results show that,compared with the proposed central processing unit(CPU)and graphics processing unit(GPU)hybrid implementation matrix multiplication framework,the energy efficiency ratio of the accelerator proposed in this paper is improved by about 35×.Compared with blocked alternating least squares(BALS),its the energy efficiency ratio has been accelerated by about 1×,and the switching of matrix factorization(MF)schemes suitable for different sparsity can be realized.展开更多
With respect to the multiple attribute decision making problems with linguistic preference relations on alternatives in the form of incomplete linguistic judgment matrix, a method is proposed to analyze the decision p...With respect to the multiple attribute decision making problems with linguistic preference relations on alternatives in the form of incomplete linguistic judgment matrix, a method is proposed to analyze the decision problem. The incomplete linguistic judgment matrix is transformed into incomplete fuzzy judgment matrix and an optimization model is developed on the basis of incomplete fuzzy judgment matrix provided by the decision maker and the decision matrix to determine attribute weights by Lagrange multiplier method. Then the overall values of all alternatives are calculated to rank them. A numerical example is given to illustrate the feasibility and practicality of the proposed method.展开更多
In this paper orthogonal matrix polynomials with respect to a right matrix moment functional an introduced. Basic results, important examples and applications to the approximation of matrix integrals are studied. Erro...In this paper orthogonal matrix polynomials with respect to a right matrix moment functional an introduced. Basic results, important examples and applications to the approximation of matrix integrals are studied. Error bounds for the proposed matrix quadrature rules are given.展开更多
In this paper we introduce the class of Hermite's matrix polynomials which appear as finite series solutions of second order matrix differential equations Y'-xAY'+BY=0.An explicit expression for the Hermit...In this paper we introduce the class of Hermite's matrix polynomials which appear as finite series solutions of second order matrix differential equations Y'-xAY'+BY=0.An explicit expression for the Hermite matrix polynomials,the orthogonality property and a Rodrigues' formula are given.展开更多
Pseudo-division algorithm for matrix multivariable polynomial are given, thereby with the view of differential algebra, the sufficient and necessary conditions for transforming a class of partial differential equation...Pseudo-division algorithm for matrix multivariable polynomial are given, thereby with the view of differential algebra, the sufficient and necessary conditions for transforming a class of partial differential equations into infinite dimensional Hamiltonianian system and its concrete form are obtained. Then by combining this method with Wu's method, a new method of constructing general solution of a class of mechanical equations is got, which several examples show very effective.展开更多
The polynomial matrix using the block coefficient matrix representation auto-regressive moving average(referred to as the PM-ARMA)model is constructed in this paper for actively controlled multi-degree-of-freedom(MDOF...The polynomial matrix using the block coefficient matrix representation auto-regressive moving average(referred to as the PM-ARMA)model is constructed in this paper for actively controlled multi-degree-of-freedom(MDOF)structures with time-delay through equivalently transforming the preliminary state space realization into the new state space realization.The PM-ARMA model is a more general formulation with respect to the polynomial using the coefficient representation auto-regressive moving average(ARMA)model due to its capability to cope with actively controlled structures with any given structural degrees of freedom and any chosen number of sensors and actuators.(The sensors and actuators are required to maintain the identical number.)under any dimensional stationary stochastic excitation.展开更多
In this article, the author characterizes orthogonal polynomials on an arbitrary smooth Jordan curve by a semi-conjugate matrix boundary value problem, which is different from the Riemann-Hilbert problems that appear ...In this article, the author characterizes orthogonal polynomials on an arbitrary smooth Jordan curve by a semi-conjugate matrix boundary value problem, which is different from the Riemann-Hilbert problems that appear in the theory of Riemann -Hilbert approach to asymptotic analysis for orthogonal polynomials on a real interval introduced by Fokas, Its, and Kitaev and on the unit circle introduced by Baik, Deift, and Johansson. The author hopes that their characterization may be applied to asymptotic analysis for general orthogonal polynomials by combining with a new extension of steepest descent method which we are looking for.展开更多
In this paper, we introduce a Hermite operational matrix collocation method for solving higher-order linear complex differential equations in rectangular or elliptic domains. We show that based on a linear algebra the...In this paper, we introduce a Hermite operational matrix collocation method for solving higher-order linear complex differential equations in rectangular or elliptic domains. We show that based on a linear algebra theorem, the use of different polynomials such as Hermite, Bessel and Taylor in polynomial collocation methods for solving differential equations leads to an equal solution, and the difference in the numerical results arises from the difference in the coefficient matrix of final linear systems of equations. Some numerical examples will also be given.展开更多
In this paper, we consider the problem of irregular shapes tracking for multiple extended targets by introducing the Gaussian surface matrix(GSM) into the framework of the random finite set(RFS) theory. The Gaussi...In this paper, we consider the problem of irregular shapes tracking for multiple extended targets by introducing the Gaussian surface matrix(GSM) into the framework of the random finite set(RFS) theory. The Gaussian surface function is constructed first by the measurements, and it is used to define the GSM via a mapping function. We then integrate the GSM with the probability hypothesis density(PHD) filter, the Bayesian recursion formulas of GSM-PHD are derived and the Gaussian mixture implementation is employed to obtain the closed-form solutions. Moreover, the estimated shapes are designed to guide the measurement set sub-partition, which can cope with the problem of the spatially close target tracking. Simulation results show that the proposed algorithm can effectively estimate irregular target shapes and exhibit good robustness in cross extended target tracking.展开更多
We use submultiplicative companion matrix norms to provide new bounds for roots for a given polynomial <i>P</i>(<i>X</i>) over the field C[<i>X</i>]. From a <i>n</i>...We use submultiplicative companion matrix norms to provide new bounds for roots for a given polynomial <i>P</i>(<i>X</i>) over the field C[<i>X</i>]. From a <i>n</i>×<i>n</i> Fiedler companion matrix <i>C</i>, sparse companion matrices and triangular Hessenberg matrices are introduced. Then, we identify a special triangular Hessenberg matrix <i>L<sub>r</sub></i>, supposed to provide a good estimation of the roots. By application of Gershgorin’s theorems to this special matrix in case of submultiplicative matrix norms, some estimations of bounds for roots are made. The obtained bounds have been compared to known ones from the literature precisely Cauchy’s bounds, Montel’s bounds and Carmichel-Mason’s bounds. According to the starting formel of <i>L<sub>r</sub></i>, we see that the more we have coefficients closed to zero with a norm less than 1, the more the Sparse method is useful.展开更多
In this paper basic results for a theory of orthogonal matrix polynomials with respect to a conjugate bilinear matrix moment functional are proposed. Properties of orthogonal matrix polynomial sequences including a th...In this paper basic results for a theory of orthogonal matrix polynomials with respect to a conjugate bilinear matrix moment functional are proposed. Properties of orthogonal matrix polynomial sequences including a three term matrix relationship are given. Positive definite conjugate bilinear matrix moment functionals are introduced and a characterization of positive definiteness in terms of a block Haenkel moment matrix is established. For each positive definite conjugate bilinear matrix moment functional an associated matrix inner product is defined.展开更多
An algorithm for simultaneous computation of the adjoint G(s) and determinant d(s) of the matrix polynomial s2J-sA 1-A 2 is presented, where J is a singular matrix. Both G(s) and d(s) are expressed relative to a basis...An algorithm for simultaneous computation of the adjoint G(s) and determinant d(s) of the matrix polynomial s2J-sA 1-A 2 is presented, where J is a singular matrix. Both G(s) and d(s) are expressed relative to a basis of Laguerre orthogonal polynomials. This algorithm is a new extension of Leverrier-Fadeev algorithm..展开更多
In this paper we introduce Humbert matrix polynomials of two variables. Some hypergeometric matrix representations of the Humbert matrix polynomials of two variables, the double generating matrix functions and expansi...In this paper we introduce Humbert matrix polynomials of two variables. Some hypergeometric matrix representations of the Humbert matrix polynomials of two variables, the double generating matrix functions and expansions of the Humbert matrix polynomials of two variables in series of Hermite polynomials are given. Results of Gegenbauer ma-trix polynomials of two variables follow as particular cases of Humbert matrix polynomials of two variables.展开更多
The global stability problem of Takagi-Sugeno(T-S) fuzzy Hopfield neural networks(FHNNs) with time delays is investigated.Novel LMI-based stability criteria are obtained by using Lyapunov functional theory to guar...The global stability problem of Takagi-Sugeno(T-S) fuzzy Hopfield neural networks(FHNNs) with time delays is investigated.Novel LMI-based stability criteria are obtained by using Lyapunov functional theory to guarantee the asymptotic stability of the FHNNs with less conservatism.Firstly,using both Finsler's lemma and an improved homogeneous matrix polynomial technique,and applying an affine parameter-dependent Lyapunov-Krasovskii functional,we obtain the convergent LMI-based stability criteria.Algebraic properties of the fuzzy membership functions in the unit simplex are considered in the process of stability analysis via the homogeneous matrix polynomials technique.Secondly,to further reduce the conservatism,a new right-hand-side slack variables introducing technique is also proposed in terms of LMIs,which is suitable to the homogeneous matrix polynomials setting.Finally,two illustrative examples are given to show the efficiency of the proposed approaches.展开更多
Abstract. Let {L(Ln^(A,λ)(x)}n≥0 be the sequence of monic Laguerre matrix polynomials defined on [0,∞) byLn^(A,λ)(x)=n!/(-λ)^n ∑nk-0(-λ)^k/k!(n-k)!(A+I)n[(A+I)k]^-1x^k,where A ∈ C^r×...Abstract. Let {L(Ln^(A,λ)(x)}n≥0 be the sequence of monic Laguerre matrix polynomials defined on [0,∞) byLn^(A,λ)(x)=n!/(-λ)^n ∑nk-0(-λ)^k/k!(n-k)!(A+I)n[(A+I)k]^-1x^k,where A ∈ C^r×r. It is known that {Ln^(A,λ)(x)}n≥0 is orthogonal with respect to a matrix moment functional when A satisfies the spectral condition that Re(z) 〉 -1 for every z E or(a). In this note we show that forA such that σ(A) does not contain negative integers, the Laguerre matrix polynomials Ln^(A,λ)(x) are orthogonal with respect to a non-diagonal SobolevLaguerre matrix moment functional, which extends two cases: the above matrix case and the known scalar case.展开更多
Remyelination failure is one of the main characteristics of multiple sclerosis and is potentially correlated with disease progression.Previous research has shown that the extracellular matrix is associated with remyel...Remyelination failure is one of the main characteristics of multiple sclerosis and is potentially correlated with disease progression.Previous research has shown that the extracellular matrix is associated with remyelination failure because remodeling of the matrix often fails in both chronic and progressive multiple sclerosis.Fibronectin aggregates are assembled and persistently exist in chronic multiple sclerosis,thus inhibiting remyelination.Although many advances have been made in the mechanisms and treatment of multiple sclerosis,it remains very difficult for drugs to reach pathological brain tissues;this is due to the complexity of brain structure and function,especially the existence of the blood-brain barrier.Therefore,herein,we review the effects of fibronectin aggregates on multiple sclerosis and the efficacy of different forms of drug delivery across the blood-brain barrier in the treatment of this disease.展开更多
文摘Video watermarking plays a crucial role in protecting intellectual property rights and ensuring content authenticity.This study delves into the integration of Galois Field(GF)multiplication tables,especially GF(2^(4)),and their interaction with distinct irreducible polynomials.The primary aim is to enhance watermarking techniques for achieving imperceptibility,robustness,and efficient execution time.The research employs scene selection and adaptive thresholding techniques to streamline the watermarking process.Scene selection is used strategically to embed watermarks in the most vital frames of the video,while adaptive thresholding methods ensure that the watermarking process adheres to imperceptibility criteria,maintaining the video's visual quality.Concurrently,careful consideration is given to execution time,crucial in real-world scenarios,to balance efficiency and efficacy.The Peak Signal-to-Noise Ratio(PSNR)serves as a pivotal metric to gauge the watermark's imperceptibility and video quality.The study explores various irreducible polynomials,navigating the trade-offs between computational efficiency and watermark imperceptibility.In parallel,the study pays careful attention to the execution time,a paramount consideration in real-world scenarios,to strike a balance between efficiency and efficacy.This comprehensive analysis provides valuable insights into the interplay of GF multiplication tables,diverse irreducible polynomials,scene selection,adaptive thresholding,imperceptibility,and execution time.The evaluation of the proposed algorithm's robustness was conducted using PSNR and NC metrics,and it was subjected to assessment under the impact of five distinct attack scenarios.These findings contribute to the development of watermarking strategies that balance imperceptibility,robustness,and processing efficiency,enhancing the field's practicality and effectiveness.
基金the National Key R&D Program of China(No.2022ZD0119001)the National Natural Science Foundation of China(No.61834005)+3 种基金the Shaanxi Province Key R&D Plan(No.2022GY-027)the Key Scientific Research Project of Shaanxi Department of Education(No.22JY060)the Education Research Project of Xi'an University of Posts and Telecommunications(No.JGA202108)the Graduate Student Innovation Fund of Xi’an University of Posts and Telecommunications(No.CXJJYL2022035).
文摘In the case of massive data,matrix operations are very computationally intensive,and the memory limitation in standalone mode leads to the system inefficiencies.At the same time,it is difficult for matrix operations to achieve flexible switching between different requirements when implemented in hardware.To address this problem,this paper proposes a matrix operation accelerator based on reconfigurable arrays in the context of the application of recommender systems(RS).Based on the reconfigurable array processor(APR-16)with reconfiguration,a parallelized design of matrix operations on processing element(PE)array is realized with flexibility.The experimental results show that,compared with the proposed central processing unit(CPU)and graphics processing unit(GPU)hybrid implementation matrix multiplication framework,the energy efficiency ratio of the accelerator proposed in this paper is improved by about 35×.Compared with blocked alternating least squares(BALS),its the energy efficiency ratio has been accelerated by about 1×,and the switching of matrix factorization(MF)schemes suitable for different sparsity can be realized.
基金the National Natural Science Foundation of China (70701008)National Science Foundationfor Distinguished Young Scholars of China (70525002)
文摘With respect to the multiple attribute decision making problems with linguistic preference relations on alternatives in the form of incomplete linguistic judgment matrix, a method is proposed to analyze the decision problem. The incomplete linguistic judgment matrix is transformed into incomplete fuzzy judgment matrix and an optimization model is developed on the basis of incomplete fuzzy judgment matrix provided by the decision maker and the decision matrix to determine attribute weights by Lagrange multiplier method. Then the overall values of all alternatives are calculated to rank them. A numerical example is given to illustrate the feasibility and practicality of the proposed method.
文摘In this paper orthogonal matrix polynomials with respect to a right matrix moment functional an introduced. Basic results, important examples and applications to the approximation of matrix integrals are studied. Error bounds for the proposed matrix quadrature rules are given.
文摘In this paper we introduce the class of Hermite's matrix polynomials which appear as finite series solutions of second order matrix differential equations Y'-xAY'+BY=0.An explicit expression for the Hermite matrix polynomials,the orthogonality property and a Rodrigues' formula are given.
文摘Pseudo-division algorithm for matrix multivariable polynomial are given, thereby with the view of differential algebra, the sufficient and necessary conditions for transforming a class of partial differential equations into infinite dimensional Hamiltonianian system and its concrete form are obtained. Then by combining this method with Wu's method, a new method of constructing general solution of a class of mechanical equations is got, which several examples show very effective.
基金The project supported by the National Natural Science Foundation of China(50278054)
文摘The polynomial matrix using the block coefficient matrix representation auto-regressive moving average(referred to as the PM-ARMA)model is constructed in this paper for actively controlled multi-degree-of-freedom(MDOF)structures with time-delay through equivalently transforming the preliminary state space realization into the new state space realization.The PM-ARMA model is a more general formulation with respect to the polynomial using the coefficient representation auto-regressive moving average(ARMA)model due to its capability to cope with actively controlled structures with any given structural degrees of freedom and any chosen number of sensors and actuators.(The sensors and actuators are required to maintain the identical number.)under any dimensional stationary stochastic excitation.
基金RFDP of Higher Education(20060486001)NNSF of China(10471107)
文摘In this article, the author characterizes orthogonal polynomials on an arbitrary smooth Jordan curve by a semi-conjugate matrix boundary value problem, which is different from the Riemann-Hilbert problems that appear in the theory of Riemann -Hilbert approach to asymptotic analysis for orthogonal polynomials on a real interval introduced by Fokas, Its, and Kitaev and on the unit circle introduced by Baik, Deift, and Johansson. The author hopes that their characterization may be applied to asymptotic analysis for general orthogonal polynomials by combining with a new extension of steepest descent method which we are looking for.
文摘In this paper, we introduce a Hermite operational matrix collocation method for solving higher-order linear complex differential equations in rectangular or elliptic domains. We show that based on a linear algebra theorem, the use of different polynomials such as Hermite, Bessel and Taylor in polynomial collocation methods for solving differential equations leads to an equal solution, and the difference in the numerical results arises from the difference in the coefficient matrix of final linear systems of equations. Some numerical examples will also be given.
基金supported by the National Natural Science Foundation of China(6130501761304264+1 种基金61402203)the Natural Science Foundation of Jiangsu Province(BK20130154)
文摘In this paper, we consider the problem of irregular shapes tracking for multiple extended targets by introducing the Gaussian surface matrix(GSM) into the framework of the random finite set(RFS) theory. The Gaussian surface function is constructed first by the measurements, and it is used to define the GSM via a mapping function. We then integrate the GSM with the probability hypothesis density(PHD) filter, the Bayesian recursion formulas of GSM-PHD are derived and the Gaussian mixture implementation is employed to obtain the closed-form solutions. Moreover, the estimated shapes are designed to guide the measurement set sub-partition, which can cope with the problem of the spatially close target tracking. Simulation results show that the proposed algorithm can effectively estimate irregular target shapes and exhibit good robustness in cross extended target tracking.
文摘We use submultiplicative companion matrix norms to provide new bounds for roots for a given polynomial <i>P</i>(<i>X</i>) over the field C[<i>X</i>]. From a <i>n</i>×<i>n</i> Fiedler companion matrix <i>C</i>, sparse companion matrices and triangular Hessenberg matrices are introduced. Then, we identify a special triangular Hessenberg matrix <i>L<sub>r</sub></i>, supposed to provide a good estimation of the roots. By application of Gershgorin’s theorems to this special matrix in case of submultiplicative matrix norms, some estimations of bounds for roots are made. The obtained bounds have been compared to known ones from the literature precisely Cauchy’s bounds, Montel’s bounds and Carmichel-Mason’s bounds. According to the starting formel of <i>L<sub>r</sub></i>, we see that the more we have coefficients closed to zero with a norm less than 1, the more the Sparse method is useful.
基金This work is supported by the Chinese Outstanding Youth Foundation (No. 69925308) Program for Changjiang Scholars and Innovative Research Team in University.
文摘In this paper basic results for a theory of orthogonal matrix polynomials with respect to a conjugate bilinear matrix moment functional are proposed. Properties of orthogonal matrix polynomial sequences including a three term matrix relationship are given. Positive definite conjugate bilinear matrix moment functionals are introduced and a characterization of positive definiteness in terms of a block Haenkel moment matrix is established. For each positive definite conjugate bilinear matrix moment functional an associated matrix inner product is defined.
文摘An algorithm for simultaneous computation of the adjoint G(s) and determinant d(s) of the matrix polynomial s2J-sA 1-A 2 is presented, where J is a singular matrix. Both G(s) and d(s) are expressed relative to a basis of Laguerre orthogonal polynomials. This algorithm is a new extension of Leverrier-Fadeev algorithm..
文摘In this paper we introduce Humbert matrix polynomials of two variables. Some hypergeometric matrix representations of the Humbert matrix polynomials of two variables, the double generating matrix functions and expansions of the Humbert matrix polynomials of two variables in series of Hermite polynomials are given. Results of Gegenbauer ma-trix polynomials of two variables follow as particular cases of Humbert matrix polynomials of two variables.
基金Project supported by the National Natural Science Foundation of China (Grant No. 60974004)the Natural Science Foundation of Jilin Province,China (Grant No. 201115222)
文摘The global stability problem of Takagi-Sugeno(T-S) fuzzy Hopfield neural networks(FHNNs) with time delays is investigated.Novel LMI-based stability criteria are obtained by using Lyapunov functional theory to guarantee the asymptotic stability of the FHNNs with less conservatism.Firstly,using both Finsler's lemma and an improved homogeneous matrix polynomial technique,and applying an affine parameter-dependent Lyapunov-Krasovskii functional,we obtain the convergent LMI-based stability criteria.Algebraic properties of the fuzzy membership functions in the unit simplex are considered in the process of stability analysis via the homogeneous matrix polynomials technique.Secondly,to further reduce the conservatism,a new right-hand-side slack variables introducing technique is also proposed in terms of LMIs,which is suitable to the homogeneous matrix polynomials setting.Finally,two illustrative examples are given to show the efficiency of the proposed approaches.
基金Supported by the National Natural Science Foundation of China(No.10571122)the Beijing Natural Science Foundation(No.1052006)+1 种基金the Project of Excellent Young Teachersthe Doctoral Programme Foundation of National Education Ministry of China
文摘Abstract. Let {L(Ln^(A,λ)(x)}n≥0 be the sequence of monic Laguerre matrix polynomials defined on [0,∞) byLn^(A,λ)(x)=n!/(-λ)^n ∑nk-0(-λ)^k/k!(n-k)!(A+I)n[(A+I)k]^-1x^k,where A ∈ C^r×r. It is known that {Ln^(A,λ)(x)}n≥0 is orthogonal with respect to a matrix moment functional when A satisfies the spectral condition that Re(z) 〉 -1 for every z E or(a). In this note we show that forA such that σ(A) does not contain negative integers, the Laguerre matrix polynomials Ln^(A,λ)(x) are orthogonal with respect to a non-diagonal SobolevLaguerre matrix moment functional, which extends two cases: the above matrix case and the known scalar case.
基金supported by the National Natural Science Foundation of China,Nos.82001282(to PW)and 81960232(to PW)Overseas Students’Innovation and Entrepreneurship Individual Project of Ningxia(2021)(to PW)+1 种基金Youth Talents Supporting Program of Ningxia Medical University and Ningxia,Nos.XT2019018(to PW),TJGC2019081(to PW)College Students’Innovation and En trepreneurship Training Program,No.X202210752038(to FYY)。
文摘Remyelination failure is one of the main characteristics of multiple sclerosis and is potentially correlated with disease progression.Previous research has shown that the extracellular matrix is associated with remyelination failure because remodeling of the matrix often fails in both chronic and progressive multiple sclerosis.Fibronectin aggregates are assembled and persistently exist in chronic multiple sclerosis,thus inhibiting remyelination.Although many advances have been made in the mechanisms and treatment of multiple sclerosis,it remains very difficult for drugs to reach pathological brain tissues;this is due to the complexity of brain structure and function,especially the existence of the blood-brain barrier.Therefore,herein,we review the effects of fibronectin aggregates on multiple sclerosis and the efficacy of different forms of drug delivery across the blood-brain barrier in the treatment of this disease.