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Exosomes-mediated tumor treatment: One body plays multiple roles 被引量:2
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作者 Na Xu Ranran Guo +3 位作者 Xiaotong Yang Ning Li Jia Yu Peng Zhang 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2022年第3期385-400,共16页
Exosomes are vesicles secreted by a variety of living cells,containing proteins,RNA and other components,which are nanoscale capsules commonly existed in the body.Exosomes play important roles in a variety of physiolo... Exosomes are vesicles secreted by a variety of living cells,containing proteins,RNA and other components,which are nanoscale capsules commonly existed in the body.Exosomes play important roles in a variety of physiological and pathological processes by participating in material and information exchange between cells,which can playmultiple roles in tumor treatment.On the one hand,exosomes can be used as carriers and biomarkers,participate in the apoptosis signaling pathway and improve chemotherapy resistance,thus playing beneficial roles in tumor treatment.On the other hand,exosomes play unfavorable roles in tumor treatment.Tumor cell exosomes contain PD-L1,which is a nuclear weapon for tumor growth,metastasis,and immunosuppression.In addition,exosomes can not only promote the epithelial-mesenchymal transition process,tumor angiogenesis and chemoresistance,but also participate in the autocrine pathway.In this review,the multiple roles of exosomes and their prospects in the treatment of tumor were reviewed in detail. 展开更多
关键词 Extracellular vesicles EXOSOMES multiple roles Tumor treatment
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An Extrinsic Faradaic Layer on CuSn for High-Performance Electrocatalytic CO_(2) Reduction 被引量:1
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作者 Feilong Ren Wenjian Hu +6 位作者 Cheng Wang Pin Wang Wenbo Li Congping Wu Yingfang Yao Wenjun Luo Zhigang Zou 《CCS Chemistry》 CAS 2022年第5期1610-1618,共9页
An intrinsic Faradaic layer on the surface of a metal electrocatalyst is usually considered an active site for CO_(2) reduction.Different strategies have been used to improve the performance of CO_(2) reduction by adj... An intrinsic Faradaic layer on the surface of a metal electrocatalyst is usually considered an active site for CO_(2) reduction.Different strategies have been used to improve the performance of CO_(2) reduction by adjusting the intrinsic Faradaic layer.However,it is still challenging to achieve CO_(2) reduction with high activity,selectivity,and stability.In this study,for the first time,we improve the three parameters simultaneously by introducing a Zn(OH)_(x) over layer onto a CuSn electrocatalyst.We find that the intrinsic Faradaic layer of Sn(OH)_(x) on the surface of CuSn provides active sites for CO_(2) reduction,while Zn(OH)_(x) plays multiple roles as an adsorption/activation layer,a cover layer,and a protective layer.Further studies suggest that the enhanced activity comes from a Faradaic reaction of Zn(OH)_(x) during CO_(2) reduction,which can be considered as an extrinsic Faradaic layer.This new strategy of introducing an extrinsic Faradaic layer can deepen understanding of electrocatalytic process and offers guidance to design other high-performance electrocatalysts. 展开更多
关键词 CO_(2)reduction extrinsic Faradaic layer active sites multiple roles spill over
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