Abstract Using the method of stepwise multivariate linear regression (SMLR), the quantitative structure activity relationships (QSAR) of two isomeric series of taxol and its derivatives have been studied. It was foun...Abstract Using the method of stepwise multivariate linear regression (SMLR), the quantitative structure activity relationships (QSAR) of two isomeric series of taxol and its derivatives have been studied. It was found that the molar refractivity of the C3′substituent of the C13 side chain has significant correlation with its activity. We deduce that structural changes in the C3′substituents may be critical to the anticancer function. It would be useful to the design and synthesis of taxol like compounds with improved activities.展开更多
Recursive algorithms are very useful for computing M-estimators of regression coefficients and scatter parameters. In this article, it is shown that for a nondecreasing ul （t）, under some mild conditions the recursi...Recursive algorithms are very useful for computing M-estimators of regression coefficients and scatter parameters. In this article, it is shown that for a nondecreasing ul （t）, under some mild conditions the recursive M-estimators of regression coefficients and scatter parameters are strongly consistent and the recursive M-estimator of the regression coefficients is also asymptotically normal distributed. Furthermore, optimal recursive M-estimators, asymptotic efficiencies of recursive M-estimators and asymptotic relative efficiencies between recursive M-estimators of regression coefficients are studied.展开更多
Simple linear regression analysis has been used to map QTL for quantitative traits. Many traits of biological interest and/or economical importance in various species show binary phenotypic distributions (e.g., presen...Simple linear regression analysis has been used to map QTL for quantitative traits. Many traits of biological interest and/or economical importance in various species show binary phenotypic distributions (e.g., presence or absence). It has been shown that such a binary trait also can be analyzed with the simple linear regression, subject to virtually no loss in power compared to the generalized linear model analysis. Binary trait is a special case of a multiple categorical trait (e.g., low, medium or high). We propose a mechanism to decompose a multiple categorical trait into an array of correlated binary variables. The categorical trait turned multiple binary traits are analyzed with a multivariate linear regression method. Turning the problem of categorical trait mapping into that of multivariate mapping allows the exploration of pleiotropic effects of QTL for different categories. Efficiency of the method is verified through a series of simulation experiments.展开更多
Productivity is a very important element in the process of construction project management especially with regard to the estimation of the duration of the construction activities, this study aims at developing constru...Productivity is a very important element in the process of construction project management especially with regard to the estimation of the duration of the construction activities, this study aims at developing construction productivity estimating model for marble finishing works of floors using Multivariable Linear Regression technique (MLR). The model was developed based on 100 set of data collected in Iraq for different types of projects such as residential, commercial and educational projects. Which these are used in developing the model and evaluating its performance. Ten influencing factors are utilized for productivity forecasting by MLR model, and they include age, experience, number of the assist labor, height of the floor, size of the marbles tiles, security conditions, health status for the work team, weather conditions, site condition, and availability of construction materials. One model was built for the prediction of the productivity of marble finishing works for floors. It was found that MLR have the ability to predict the productivity for finishing works with excellent degree of accuracy of the coefficient of correlation (R) 90.6%, and average accuracy percentage of 96.3%. This indicates that the relationship between the independent and independent variables of the developed models is good and the predicted values from a forecast model fit with the real-life data.展开更多
When the population, from which the samples are extracted, is not normally distributed, or if the sample size is particularly reduced, become preferable the use of not parametric statistic test. An alternative to the ...When the population, from which the samples are extracted, is not normally distributed, or if the sample size is particularly reduced, become preferable the use of not parametric statistic test. An alternative to the normal model is the permutation or randomization model. The permutation model is nonparametric because no formal assumptions are made about the population parameters of the reference distribution, i.e., the distribution to which an obtained result is compared to determine its probability when the null hypothesis is true. Typically the reference distribution is a sampling distribution for parametric tests and a permutation distribution for many nonparametric tests. Within the regression models, it is possible to use the permutation tests, considering their ownerships of optimality, especially in the multivariate context and the normal distribution of the response variables is not guaranteed. In the literature there are numerous permutation tests applicable to the estimation of the regression models. The purpose of this study is to examine different kinds of permutation tests applied to linear models, focused our attention on the specific test statistic on which they are based. In this paper we focused our attention on permutation test of the independent variables, proposed by Oja, and other methods to effect the inference in non parametric way, in a regression model. Moreover, we show the recent advances in this context and try to compare them.展开更多
文摘Abstract Using the method of stepwise multivariate linear regression (SMLR), the quantitative structure activity relationships (QSAR) of two isomeric series of taxol and its derivatives have been studied. It was found that the molar refractivity of the C3′substituent of the C13 side chain has significant correlation with its activity. We deduce that structural changes in the C3′substituents may be critical to the anticancer function. It would be useful to the design and synthesis of taxol like compounds with improved activities.
基金supported by the Natural Sciences and Engineering Research Council of Canadathe National Natural Science Foundation of China+2 种基金the Doctorial Fund of Education Ministry of Chinasupported by the Natural Sciences and Engineering Research Council of Canadasupported by the National Natural Science Foundation of China
文摘Recursive algorithms are very useful for computing M-estimators of regression coefficients and scatter parameters. In this article, it is shown that for a nondecreasing ul （t）, under some mild conditions the recursive M-estimators of regression coefficients and scatter parameters are strongly consistent and the recursive M-estimator of the regression coefficients is also asymptotically normal distributed. Furthermore, optimal recursive M-estimators, asymptotic efficiencies of recursive M-estimators and asymptotic relative efficiencies between recursive M-estimators of regression coefficients are studied.
基金Item supported by national natural sciencefoundation( No.30471236)
文摘Simple linear regression analysis has been used to map QTL for quantitative traits. Many traits of biological interest and/or economical importance in various species show binary phenotypic distributions (e.g., presence or absence). It has been shown that such a binary trait also can be analyzed with the simple linear regression, subject to virtually no loss in power compared to the generalized linear model analysis. Binary trait is a special case of a multiple categorical trait (e.g., low, medium or high). We propose a mechanism to decompose a multiple categorical trait into an array of correlated binary variables. The categorical trait turned multiple binary traits are analyzed with a multivariate linear regression method. Turning the problem of categorical trait mapping into that of multivariate mapping allows the exploration of pleiotropic effects of QTL for different categories. Efficiency of the method is verified through a series of simulation experiments.
文摘Productivity is a very important element in the process of construction project management especially with regard to the estimation of the duration of the construction activities, this study aims at developing construction productivity estimating model for marble finishing works of floors using Multivariable Linear Regression technique (MLR). The model was developed based on 100 set of data collected in Iraq for different types of projects such as residential, commercial and educational projects. Which these are used in developing the model and evaluating its performance. Ten influencing factors are utilized for productivity forecasting by MLR model, and they include age, experience, number of the assist labor, height of the floor, size of the marbles tiles, security conditions, health status for the work team, weather conditions, site condition, and availability of construction materials. One model was built for the prediction of the productivity of marble finishing works for floors. It was found that MLR have the ability to predict the productivity for finishing works with excellent degree of accuracy of the coefficient of correlation (R) 90.6%, and average accuracy percentage of 96.3%. This indicates that the relationship between the independent and independent variables of the developed models is good and the predicted values from a forecast model fit with the real-life data.
文摘When the population, from which the samples are extracted, is not normally distributed, or if the sample size is particularly reduced, become preferable the use of not parametric statistic test. An alternative to the normal model is the permutation or randomization model. The permutation model is nonparametric because no formal assumptions are made about the population parameters of the reference distribution, i.e., the distribution to which an obtained result is compared to determine its probability when the null hypothesis is true. Typically the reference distribution is a sampling distribution for parametric tests and a permutation distribution for many nonparametric tests. Within the regression models, it is possible to use the permutation tests, considering their ownerships of optimality, especially in the multivariate context and the normal distribution of the response variables is not guaranteed. In the literature there are numerous permutation tests applicable to the estimation of the regression models. The purpose of this study is to examine different kinds of permutation tests applied to linear models, focused our attention on the specific test statistic on which they are based. In this paper we focused our attention on permutation test of the independent variables, proposed by Oja, and other methods to effect the inference in non parametric way, in a regression model. Moreover, we show the recent advances in this context and try to compare them.
