To study the transition dynamics of resistant-type human immunodeficiency virus 1 （HIV-1） in highly active antiretroviral therapy （HAART） and the affect of neutral mutation in the evolution of HIV-1, a mathematica...To study the transition dynamics of resistant-type human immunodeficiency virus 1 （HIV-1） in highly active antiretroviral therapy （HAART） and the affect of neutral mutation in the evolution of HIV-1, a mathematical model is proposed when mutation occurs mainly during reproduction. The derived results show that the resistant-type will certainly colonize in patients once mutation occurs. Furthermore, a neutral mutation is closely related to the colonized pattern of resistant-type HIV-1 quasispecies and there are some changes in the pattern of transmission dynamics when mutation occurs mainly during reproduction or in the absence of reproduction, which may lead to significant strategies for predicting or checking HIV-1 drug resistance in HAART.展开更多
基金Acknowledgments This work is supported by the National Natural Science Fund of P. R. China （No. 11271369） and the Natural Science Foundation Project of CQ CSTC （2010BB5020）.
文摘To study the transition dynamics of resistant-type human immunodeficiency virus 1 （HIV-1） in highly active antiretroviral therapy （HAART） and the affect of neutral mutation in the evolution of HIV-1, a mathematical model is proposed when mutation occurs mainly during reproduction. The derived results show that the resistant-type will certainly colonize in patients once mutation occurs. Furthermore, a neutral mutation is closely related to the colonized pattern of resistant-type HIV-1 quasispecies and there are some changes in the pattern of transmission dynamics when mutation occurs mainly during reproduction or in the absence of reproduction, which may lead to significant strategies for predicting or checking HIV-1 drug resistance in HAART.
