Autism spectrum disorder(ASD)is a group of heterogeneous,multi-factorial,neurodevelopmental disorders resulting from genetic and environmental factors interplay.Infection is a significant trigger of autism,especially ...Autism spectrum disorder(ASD)is a group of heterogeneous,multi-factorial,neurodevelopmental disorders resulting from genetic and environmental factors interplay.Infection is a significant trigger of autism,especially during the critical developmental period.There is a strong interplay between the viral infection as a trigger and a result of ASD.We aim to highlight the mutual relationship between autism and viruses.We performed a thorough literature review and included 158 research in this review.Most of the literature agreed on the possible effects of the viral infection during the critical period of development on the risk of developing autism,especially for specific viral infections such as Rubella,Cytomegalovirus,Herpes Simplex virus,Varicella Zoster Virus,Influenza virus,Zika virus,and severe acute respiratory syndrome coronavirus 2.Viral infection directly infects the brain,triggers immune activation,induces epigenetic changes,and raises the risks of having a child with autism.At the same time,there is some evidence of increased risk of infection,including viral infections in children with autism,due to lots of factors.There is an increased risk of developing autism with a specific viral infection during the early developmental period and an increased risk of viral infections in children with autism.In addition,children with autism are at increased risk of infection,including viruses.Every effort should be made to prevent maternal and early-life infections and reduce the risk of autism.Immune modulation of children with autism should be considered to reduce the risk of infection.展开更多
As a part of certain region,agricultural development has inevitable connection with regional urbanization,and they are highly heterogeneous and complementary in space. Their internal relationship is manifested as agri...As a part of certain region,agricultural development has inevitable connection with regional urbanization,and they are highly heterogeneous and complementary in space. Their internal relationship is manifested as agricultural structure suits demand of urbanization development through adjustment in the process of urbanization,while urbanization is based on development of regional agriculture. From history of world agriculture and urbanization development,agriculture firstly provides primitive accumulation for urbanization development,and drives regional urbanization through promoting agricultural development. When urbanization develops to certain stage,urbanization accumulation increases and reaches the goal of " boosting urbanization through agriculture". If urbanization develops slowly,agricultural adjustment will lack motive force. On the contrary,weak agricultural development will lead to stagnation of urbanization. Therefore,adjustment of agricultural structure and urbanization development are interconnected,mutually promoted and restricted,and interdependent.展开更多
文摘Autism spectrum disorder(ASD)is a group of heterogeneous,multi-factorial,neurodevelopmental disorders resulting from genetic and environmental factors interplay.Infection is a significant trigger of autism,especially during the critical developmental period.There is a strong interplay between the viral infection as a trigger and a result of ASD.We aim to highlight the mutual relationship between autism and viruses.We performed a thorough literature review and included 158 research in this review.Most of the literature agreed on the possible effects of the viral infection during the critical period of development on the risk of developing autism,especially for specific viral infections such as Rubella,Cytomegalovirus,Herpes Simplex virus,Varicella Zoster Virus,Influenza virus,Zika virus,and severe acute respiratory syndrome coronavirus 2.Viral infection directly infects the brain,triggers immune activation,induces epigenetic changes,and raises the risks of having a child with autism.At the same time,there is some evidence of increased risk of infection,including viral infections in children with autism,due to lots of factors.There is an increased risk of developing autism with a specific viral infection during the early developmental period and an increased risk of viral infections in children with autism.In addition,children with autism are at increased risk of infection,including viruses.Every effort should be made to prevent maternal and early-life infections and reduce the risk of autism.Immune modulation of children with autism should be considered to reduce the risk of infection.
基金Supported by Scientific Research Foundation of Hunan Provincial Department of Education(13B143)
文摘As a part of certain region,agricultural development has inevitable connection with regional urbanization,and they are highly heterogeneous and complementary in space. Their internal relationship is manifested as agricultural structure suits demand of urbanization development through adjustment in the process of urbanization,while urbanization is based on development of regional agriculture. From history of world agriculture and urbanization development,agriculture firstly provides primitive accumulation for urbanization development,and drives regional urbanization through promoting agricultural development. When urbanization develops to certain stage,urbanization accumulation increases and reaches the goal of " boosting urbanization through agriculture". If urbanization develops slowly,agricultural adjustment will lack motive force. On the contrary,weak agricultural development will lead to stagnation of urbanization. Therefore,adjustment of agricultural structure and urbanization development are interconnected,mutually promoted and restricted,and interdependent.
