Artificial facial nerve prostheses are thought to restore eye-closed function in peripheral facial paralysis patients.At present,however,there is no adequate quantitative or qualitative information regarding myoelectr...Artificial facial nerve prostheses are thought to restore eye-closed function in peripheral facial paralysis patients.At present,however,there is no adequate quantitative or qualitative information regarding myoelectric signal(MES)features for healthy orbiculads oculi muscle(OOM).The present study analyzed MES features of normal OOM in rabbits during the natural continuous eye-opening(N1)state,natural continuous eye-closing(N2)state,natural blink(N3)state,and evoked eye-closing(E)state according to time domain and frequency domain analysis.Results showed that OOM electrical activities in N1 and N2 states,as well as myoelectric amplitude,were low and stable.Nevertheless,during N3 and E states,OOM electrical activities were significantly increased and amplitude was much higher in the E state than in the N3 state.In the time domain,differences in MES peak absolute potential were not significant between N1 and N2 states,in the frequency domain,differences in power spectral density peak frequency of electromyogram signals were significant between two sets of four OOM movement states.These results suggest that OOM significantly contracts and induces eyelid-closing action.In addition,OOM is diastolic during the N1state.A N2 state does not require continuous intensive OOM contraction.Moreover,distinctions of quantitative information in time and frequency domain features of MES can be used as an OOM reference to identify muscle movement patterns.展开更多
Objective To investigate the effects of peptide YY (PYY) on the interdigestive migrating myoelectric complex (MMC) in the small intestine in vivo and explore the neural and endocrinal mechanisms of the effects. Method...Objective To investigate the effects of peptide YY (PYY) on the interdigestive migrating myoelectric complex (MMC) in the small intestine in vivo and explore the neural and endocrinal mechanisms of the effects. Methods Sprague-Dawley rats were supplied with a venous catheter and bipolar electrodes in the duodenum and jejunum for electromyography of stomach and small intestine in wake state. PYY,phentolamine,nitro-L-arginine (L-NNA,the inhibitor of nitric oxide synthase) and atropine were served with PYY respectively. The plasma motilin levels before and after the infusion of PYY were observed. Results At all the three recording points,PYY lengthened the circle length of MMC [from (591.90±128.98)s to (999.25±216.59)s,P<0.01] and lowered the frequency of phase Ⅲ [from (39.28±8.40) min-1 to (22.08±3.13) min-1,P<0.01],amplitude of phase Ⅲ [from (0.320±0.060)mV to (0.179±0.030)mV,P<0.01],and the portion of phase Ⅲ over the whole circle length [from (28.61±5.84)% to (15.43±5.16)% ,P<0.01]. Phentolamine had no influence on the role of PYY. Administered L-NNA combined with PYY,the percentage of phase Ⅲ increased [(42.09±8.67)%] compared with that of control (P<0.01) and compared with that of PYY administered alone (P<0.01) too. Atropine combined with PYY showed stronger depressing effects on MMC. No significant difference was found between the plasma motilin levels before and after the infusion of PYY. Conclusion PYY may inhibit the interdigestive intestine motility through the none-adrenergic none-cholinergic tract,while the α-receptor tract and circulating motilin are probably not involved in the depressing effect.展开更多
BACKGROUND: Researches prove that the treatment of cerebral palsy by botulinus toxin (BTX-A) can improve effect and prolong effective duration. Current intensity is the important factor during injection. OBJECTIVE...BACKGROUND: Researches prove that the treatment of cerebral palsy by botulinus toxin (BTX-A) can improve effect and prolong effective duration. Current intensity is the important factor during injection. OBJECTIVE: To observe the changes of motor function and muscular intensity of children with spastic cerebral palsy after injecting BTX-A and analyze correlation between current intensity and effective duration. DESIGN: Cases control trial before and after nerves block SETTING: Capital University of Medical Sciences, China Rehabilitation Research Center PARTICIPANTS: From June 2002 to November 2004, 14 children with spastic cerebral palsy were treated by BTX-A block. All children were hospitalized in the Children Rehabilitation Department of China Rehabilitation Research Center. The children included 9 male and 5 female, and ranged from 4 to 13 years old, and average age was (6±2) years. Muscular tension ranged from grade 1 to grade 3. The diagnosis and the tape of cerebral palsy based on standard of the Fist Nationwide Cerebral Palsy Symposium, and all children were diagnosed with electroencephalogram (EEG), CT and MRI, and permitted by their guardians. METHODS: (1) Locating and calculation: To locate block points by G6805-2A electro-therapeutic apparatus (Shanghai Huayi Electronic Instrument Plant) at the least stimulating current (continuous wave; impulse frequency; 2.667-83.333 Hz; current intensity: 0-6 mA; voltage: 6 V) to touch off muscles contraction. The current intensity of each point was recorded, and the average current intensity of each patient was calculated at the same time. (2) Dose of BTX-A: Basing upon the spastic degree and weight of patients, the dose was made certain: dose (IU)=(scores of Modified Ashworth Scale +2.5) xweight (kg). The number of the block points was in all 4. The dose of injection ranged from 50 IU to 160 IU with the average of (73.6+25.8) IU. The BTX-A was made by Lanzhou Institute of Biological Products, and each bottle contains 100 IU BTX-A. Muscular tension was evaluated by Modified Ashworth Scale. The scale ranged from grade 0 to grade 4, and the scores were from 0 to 4. The higher the scores were, the higher the muscular tension was. (3) Effect: Changes of muscular tension were evaluated by modified Ashworth Scale before and after block. Motor function was evaluated by Physician Rating Scale (PRS) before and after treatment. It contained Gait pattern, Hindfoot (ankle) position (stance-floor contact), Hindfoot position (foot strike), Knee position (degree of recurvation), Crouch and Speed of gait. The scores ranged from 0 to 14. The higher the points were, the better the motor function was. (4) Effective duration: The duration was definited by the recovering of the Modified Ashworth Scale. (5) Statistic analysis: Firstly, the current intensity and the effect duration were analyzed by One-Sample Kolmogorov-Smirnov Test, the current intensity: Z= 0.456, P= 0.985, the effective duration: Z= 0.557, P= 0.915. Both data were normal distribution. Secondly, both data were analyzed by Linear Regression. The efficiency of the BTX-A block was analyzed by paired-samples t test. MAIN OUTCOME MEASURES: (1) Changes of motor function of muscular tension; (2) correlation between current intensity and effective duration. RESULTS: Fourteen children with spastic cerebral palsy were all involved in the final analysis. (1) Therapeutic effect: The average score of Ashworth scale after block was lower than that before block [(1.02±0.34) points vs. (2.12±0.48) points, t= 3.644, P〈 0.01]. The average score of RPS after block was higherthan that before block [(9.75±2.78) points vs. (6.16±0.58) points, t =13.222, P〈 0.01]. (2) Relation between the current intensity and the effective duration: The current intensity was (0.1857±0.0506) mA, and the effective duration was (26.36±4.48) weeks. The current intensity was negative correlation with effective duration (r = -0.775, P = 0.01 ). CONCLUSION: (1) BTX-A occlusion can decrease muscular tension and improve motor function of lower limbs of children with spastic cerebral palsy. (2) The lower the current intensity is, the longer the effective duration is.展开更多
This paper presents an anthropomorphic prosthetic hand using flexure hinges, which is controlled by the surface electromyography (sEMG) signals from 2 electrodes only. The prosthetic hand has compact structure with ...This paper presents an anthropomorphic prosthetic hand using flexure hinges, which is controlled by the surface electromyography (sEMG) signals from 2 electrodes only. The prosthetic hand has compact structure with 5 fingers and 4 Degree of Freedoms (DoFs) driven by 4 independent actuators. Helical springs are used as elastic joints and the joints of each finger are coupled by tendons. The myoelectric control system which can classify 8 prehensile hand gestures is built. Pattern recognition is employed where Mean Absolute Value (MAV), Variance (VAR), the fourth-order Autoregressive (AR) coefficient and Sample Entropy (SE) are chosen as the optimal feature set and Linear Discriminant Analysis (LDA) is utilized to reduce the dimension. A decision of hand gestures is generated by LDA classifier after the current projected feature set and the previous one are "pre-smoothed", and then the final decision is obtained when the current decision and previous decisions are "post-smoothed" from the decisions flow. The prosthetic hand can perform prehensile postures for activities of daily living and carry objects under the control of EMG signals.展开更多
Objective:To investigate the effects of different acupuncture manipulations on Deqi sensations and surface myoelectricity,and explore the correlation between Deqi sensations and needling manipulations.Methods:Forty-fi...Objective:To investigate the effects of different acupuncture manipulations on Deqi sensations and surface myoelectricity,and explore the correlation between Deqi sensations and needling manipulations.Methods:Forty-five healthy participants accepted twirling,lifting-thrusting,and twirling plus lifting-thrusting manipulanions at right Zusanli(ST 36),respectively.The acupuncturist’s and participants’Deqi sensations were collected by MGH Acupuncture Sensation Scale(MASS).The intensity and occurrence rate of soreness,dull pain,pressure,heaviness,fullness,numbness,sharp pain,warmth,coolness,and throbbing feelings of participants,and tightness,smooth,and tangle feelings of acupuncturist were measured.The correlation between the acupuncturist’s and participant’s Deqi sensations was analyzed.Surface electromyogram(EMG)was recorded before,during and after needling in 30 participants.The integrated EMG(iEMG),mean power frequency(MPF)and media frequency(MF)were analyzed.Result:Both fullness and soreness of participants and tightness of acupuncturist were the most frequently occurred ones.A positive correlation between participants’fullness and acupuncturist’s tightness was observed during the three aforementioned needling manipulations(P<0.05,OR>1).Almost all the needling sensations measured in the present study could be induced by the three needling manipulations.However,strength of Deqi sensations was exhibited as lifting-thrusting>twirling plus lifting-thrusting>twirling according to MASS index.The i EMG values were increased and MPF,MF values were decreased during needling compaired to those before needling,especially during lifting-thrusting(P<0.01).Conclusions:The intensity and occurrence rate of the different Deqi sensations induced by different needling manipulations were basically similar.The fullness and soreness were both the most frequently induced Deqi sensations.The strongest Deqi sensation could be induced by lifting-thrusting manipulation.There is a positive correlation between participants’fullness and acupuncturist’s tightness during the three needling manipulations.The myoelectricity around the acupoint is related to Deqi responses.(Registration No.AMCTR-IOR-20000314).展开更多
It is vital to recognize the intention of finger motions for human-machine interaction(HMI).The latest research focuses on fine myoelectric control through the decoding of neural motor unit action potential trains(MUA...It is vital to recognize the intention of finger motions for human-machine interaction(HMI).The latest research focuses on fine myoelectric control through the decoding of neural motor unit action potential trains(MUAPt) from high-density surface electromyographic(sEMG) signals.However,the existing EMG decoding algorithms rarely obtain the spatial matching relationship between decoded motion units(MU) and designated muscles,and the control interface can only recognize the trained hand gestures.In this study,a semi-supervised HMI based on MU-muscle matching(MMM) is proposed to recognize individual finger motions and even the untrained combined multi-finger actions.Through automatic channel selection from high-density s EMG signals,the optimal spatial positions to monitor the MU activation of finger muscles are determined.Finger tapping experiment is carried out on ten subjects,and the experimental results show that the proposed s EMG decomposition algorithm based on MMM can accurately identify single finger motions with an accuracy of 93.1%±1.4%,which is comparable to that of state-of-the-art pattern recognition methods.Furthermore,the MMM allows unsupervised recognizing the untrained combined multi-finger motions with an accuracy of 73%±3.8%.The outcomes of this study benefit the practical applications of HMI,such as controlling prosthetic hand and virtual keyboard.展开更多
Myoelectric controlled interfaces driven by muscle activities have achieved good performance in ideal conditions and showed many potential medical-related and industrial applications.However,in practical applications,...Myoelectric controlled interfaces driven by muscle activities have achieved good performance in ideal conditions and showed many potential medical-related and industrial applications.However,in practical applications,the performance could be drastically degraded due to the electrode(sensor)shift,which is inevitable in donning and doffing the system.In this study,we presented a novel channel selection method against electrode shift for robust pattern-recognition based myoelectric control.The proposed method was evaluated on twenty-four subjects,including twenty-two able-bodied subjects and two amputees,and compared with two traditional channel selection methods,i.e.,uniform selection(UNI)and sequential feature selection(SFS).We demonstrated that the offline error rates of the proposed method were significantly lower than those of the other two methods(P<0.05),and its online performance in shift conditions was comparable to that in ideal conditions.These outcomes benefit the practical applications of robust myoelectric controlled interfaces.展开更多
Currently, prosthetic hands can only achieve several prespecified and discrete hand motion patterns from popular myoelectric control schemes using electromyography(EMG) signals. To achieve continuous and stable graspi...Currently, prosthetic hands can only achieve several prespecified and discrete hand motion patterns from popular myoelectric control schemes using electromyography(EMG) signals. To achieve continuous and stable grasping within the discrete motion pattern, this paper proposes a control strategy using a customized, flexible capacitance-based proximity-tactile sensor. This sensor is integrated at the fingertip and measures the distance and force before and after contact with an object. During the pregrasping phase, each fingertip’s position is controlled based on the distance between the fingertip and the object to make all fingertips synchronously approach the object at the same distance. Once contact is established, the sensor turns to output the tactile information, by which the contact force of each fingertip is finely controlled. Finally, the method is introduced into the human-machine interaction control for a myoelectric prosthetic hand. The experimental results demonstrate that continuous and stable grasping could be achieved by the proposed control method within the subject’s discrete EMG motion mode. The subject also obtained tactile feedback through the transcutaneous electrical nerve stimulation after contact.展开更多
Targeted muscle reinnervation has been proposed for reconstruction of neuromuscular function in amputees.However,it is unknown whether performing delayed targeted muscle reinnervation after nerve injury will affect re...Targeted muscle reinnervation has been proposed for reconstruction of neuromuscular function in amputees.However,it is unknown whether performing delayed targeted muscle reinnervation after nerve injury will affect restoration of function.In this rat nerve injury study,the median and musculocutaneous nerves of the forelimb were transected.The proximal median nerve stump was sutured to the distal musculocutaneous nerve stump immediately and 2 and 4 weeks after surgery to reinnervate the biceps brachii.After targeted muscle reinnervation,intramuscular myoelectric signals from the biceps brachii were recorded.Signal amplitude gradually increased with time.Biceps brachii myoelectric signals and muscle fiber morphology and grooming behavior did not significantly differ among rats subjected to delayed target muscle innervation for different periods.Targeted muscle reinnervation delayed for 4 weeks can acquire the same nerve function restoration effect as that of immediate reinnervation.展开更多
AIM: To investigate the mechanisms and effects of sphincter of Oddi(SO) motility on cholesterol gallbladder stone formation in guinea pigs.METHODS: Thirty-four adult male Hartley guinea pigs were divided randomly into...AIM: To investigate the mechanisms and effects of sphincter of Oddi(SO) motility on cholesterol gallbladder stone formation in guinea pigs.METHODS: Thirty-four adult male Hartley guinea pigs were divided randomly into two groups, the control group(n = 10) and the cholesterol gallstone group(n = 24), which was sequentially divided into four subgroups with six guinea pigs each according to time of sacrifice. The guinea pigs in the cholesterol gallstone group were fed a cholesterol lithogenic diet and sacrificed after 3, 6, 9, and 12 wk. SO manometry and recording of myoelectric activity were obtained by a multifunctional physiograph at each stage. Cholecystokinin-A receptor(CCKAR) expression levels in SO smooth muscle were detected by quantitative real-time PCR(q RT-PCR) and serum vasoactive intestinal peptide(VIP), gastrin, and cholecystokinin octapeptide(CCK-8) were detected by enzyme-linked immunosorbent assay at each stage in the process of cholesterol gallstone formation.RESULTS: The gallstone formation rate was 0%, 0%, 16.7%, and 83.3% in the 3, 6, 9, and 12 wk groups, respectively. The frequency of myoelectric activity in the 9 wk group, the amplitude of myoelectric activity in the 9 and 12 wk groups, and the amplitude and the frequency of SO in the 9 wk group were all significantly decreased compared to the control group. The SO basal pressure and common bile duct pressure increased markedly in the 12 wk group, and the CCKAR expression levels increased in the 6 and 12 wk groups compared to the control group. Serum VIP was elevated significantly in the 9 and 12 wk groups and gastrin decreased significantly in the 3 and 9 wk groups. There was no difference in serum CCK-8 between the groups.CONCLUSION: A cholesterol gallstone-causing diet can induce SO dysfunction. The increasing tension of the SO along with its decreasing activity may play an important role in cholesterol gallstone formation. Expression changes of CCKAR in SO smooth muscle and serum VIP and CCK-8 may be important causes of SO dysfunction.展开更多
AIM:To investigate the influence of percutaneous local therapy on gastric myoelectrical activity in patients with hepatocellular carcinomas.METHODS:Forty-four patients with hepatocellular carcinoma(HCC) [27 males and ...AIM:To investigate the influence of percutaneous local therapy on gastric myoelectrical activity in patients with hepatocellular carcinomas.METHODS:Forty-four patients with hepatocellular carcinoma(HCC) [27 males and 17 females,ranging in age from 49 to 81 years old(69.7 ± 8.01 years)] who were admitted for percutaneous local therapy were enrolled in this study.We examined clinical abdominal symptoms using the Gastrointestinal Symptom Rating Scale(GSRS) before and 3 d after percutaneous local therapy.We also measured cutaneous fasting and postprandial electrogastrography(EGG) recordings before and 3 d after percutaneous local therapy.RESULTS:We found that the percentage of normogastria in the fasting period was lower in the Child B group than in the Child A group(66.8% ± 8.6% vs 84.0% ± 3.8%).After percutaneous local therapy for HCC,the percentages of normogastria in the fasting period were significantly decreased(81.6% ± 3.5% vs 75.2% ± 4.5%).None of the postprandial EGG parameters changed significantly after percutaneous local therapy for HCC.Percutaneous local therapy for HCC reduced the power ratio(PR).In particular,the PR of tachygastria was significantly decreased after therapy(P < 0.01).However,no significant differences were found in the postprandial EGG parameters.Likewise,no significant differences were found in the calculated GSRS scores obtained from the questionnaire before and after therapy.CONCLUSION:Gastric slow-wave dysrhythmias were induced by percutaneous local therapy in HCC patients,even though the GSRS scores obtained from the questionnaire did not change significantly.展开更多
People's working capability is badly affected when they sufer an amputated arm.Artifcial replacements with prosthetic devices to get a satisfactory level of performance for essential functions with the currently a...People's working capability is badly affected when they sufer an amputated arm.Artifcial replacements with prosthetic devices to get a satisfactory level of performance for essential functions with the currently available prosthetic technology are very dificult.Myoelectric arm prostheses are becoming popular because they are operated by a natural contraction of intact muscles.Hence,SEMG based artifdal arm was fabricated.The system cousists of diferent electronic and mechanical assemblies for operation of hand utilizing microcontroller in order to have minimum signal loss during its processing.With the hep of relay switching connected to low power DC motor,system is capable of opening and closing of grip according to individual wish.展开更多
Due to the difference of the plane of facial nerve lesion,facial paralysis can be classifiedinto nudear paralysis,paralysis of cerebellopontine angle,Hunt’s palsy,Bell’s palsy and simple facialneuritis.The authors t...Due to the difference of the plane of facial nerve lesion,facial paralysis can be classifiedinto nudear paralysis,paralysis of cerebellopontine angle,Hunt’s palsy,Bell’s palsy and simple facialneuritis.The authors treated 78 cases of the of the latter 3 types,compared the therapeutical effect after 2courses of treatment,and meanwhile made dynamic electromyographic observation between the tragusand the quadrate musde of upper lip for those with Bell’s palsy and Hunt’s palsy.The result showsthat acupuncture has a fair effect in treating peripheral facial paralysis and simple facial neuritis andthe myoelectric recovery in Bell’s palsy is quicker than that in Hunt’s palsy.It is suggested that thehfeher the pane of the facial nerve lesion is,the more unsatisfactory the effect is,and the effect ismore favorable otherwise.展开更多
Fabric electrode is an emerging electrode element;due to some of its advantages, it can replace traditional conductive gel to become the next generation of electrode. This paper starts from the definition of fabric el...Fabric electrode is an emerging electrode element;due to some of its advantages, it can replace traditional conductive gel to become the next generation of electrode. This paper starts from the definition of fabric electrode, introduces the definition and working principle of fabric electrode, materials of producing electrodes preparation methods, and highlights the fabric used in the myoelectric prosthetic electrodes, supercapacitors and ECG tests.展开更多
Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate mu...Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate multisensory feedback,especially proprioception feedback,limits the grasping quality.Additionally,a typical non-invasive stimulation scheme for sensation feedback uses stimulation on the stationary site of the skin continuously,which can lead to fatigue and adaptation of sensation,further reduces the feedback consistency,and increases the cognitive burden for the subject.Considering the sensitivity and modality matching of sensation,this study presented a multimodal sensations feedback scheme based on hybrid static-dynamic sensation elicited by multisite Transcutaneous Electrical Nerve Stimulation(TENS)to deliver grasping force and joint position feedback.In the proposed scheme,stimulation of single electrode produced only in-loco tactile sensation under the electrode,and the sensation intensity was adjusted according to grasping force;sequential activation of multi-electrodes produced an illusion dynamic sensation of a stimulus moving,and the velocity and direction of movement were adjusted according to finger joint position.Psychometric test results demonstrated the identifiability of stimulus in the proposed scheme.Further,prosthetic hand closed-loop grasping tasks evaluate the effectiveness of the proposed feedback scheme.The results showed that the proposed feedback scheme could substantially improve the grasping accuracy and efficiency.In addition,the study outcomes also demonstrated the benefit of artificial proprioception feedback in grasping rapidity and security.展开更多
OBJECTIVE: To determine the effect of the area postrema (AP) of the medulla oblongata on gastrointestinal interdigestive migrating motor complex (MMC) and the plasma motilin level. METHODS: Interdigestive MMC activiti...OBJECTIVE: To determine the effect of the area postrema (AP) of the medulla oblongata on gastrointestinal interdigestive migrating motor complex (MMC) and the plasma motilin level. METHODS: Interdigestive MMC activities of the antrum and duodenum were recorded by strain gauge implanted on the serosa of 8 conscious dogs. A cannula was intubated in femoral vein for motilin injection. The plasma motilin concentration was measured by RIA. We observed: (1) normal interdigestive MMC activity and fluctuations in plasma motilin concentration; (2) the effects of electrically damaging the AP on MMC activity and plasma motilin level; (3) whether intravenous injection of motilin could induce phase III contractions after the AP was destroyed. RESULTS: (1) Typical interdigestive MMC with phase I, II, III, and IV was recorded in normal dogs. Phase III was concurrent with the peak of plasma motilin level. (2) In damaged AP dogs, antroduodenal interdigestive MMC contractions were suppressed; cyclic, phasic and migratory pattern of MMC was disrupted. Plasma motilin concentration was decreased. Intravenous injection of motilin could not induce phase III contractions. CONCLUSIONS: The area postrema might play an important role, which is mediated by motilin, on the regulation of interdigestive MMC.展开更多
A lack of myoelectric sources after limb amputation is a critical challenge in the control of multifunctional motorized prostheses. To reconstruct myoelectric sources physiologically related to lost limbs, a newly pro...A lack of myoelectric sources after limb amputation is a critical challenge in the control of multifunctional motorized prostheses. To reconstruct myoelectric sources physiologically related to lost limbs, a newly proposed neural-function construction method, targeted muscle reinnervation(TMR), appears promising. Recent advances in the TMR technique suggest that TMR could provide additional motor command information for the control of multifunctional myoelectric prostheses. However, little is known about the nature of the physiological functional recovery of the reinnervated muscles. More understanding of the underlying mechanism of TMR could help us fine tune the technique to maximize its capability to achieve a much higher performance in the control of multifunctional prostheses. In this study, rats were used as an animal model for TMR surgery involving transferring a median nerve into the pectoralis major, which served as the target muscle. Intramuscular myoelectric signals reconstructed following TMR were recorded by implanted wire electrodes and analyzed to explore the nature of the neural-function reconstruction achieved by reinnervation of targeted muscles. Our results showed that the active myoelectric signal reconstructed in the targeted muscle was acquired one week after TMR surgery, and its amplitude gradually became stronger over time. These preliminary results from rats may serve as a basis for exploring the mechanism of neural-function reconstruction by the TMR technique in human subjects.展开更多
Background The ideal post-gastrectomy reconstruction procedure should maintain the normal digestive function and restore intestinal transit to improve the patient quality of life. The aim of this study was to evaluate...Background The ideal post-gastrectomy reconstruction procedure should maintain the normal digestive function and restore intestinal transit to improve the patient quality of life. The aim of this study was to evaluate the effects of integral continual jejunal interposition after subtotal gastrectomy on the nutritional status, glucose levels, and gastric-intestinal motility. Methods The study investigated the effects of the integral continual jejunal interposition, the Billroth I and Billroth II operations, and the isolated jejunal interposition following subtotal distal gastrectomy on the blood glucose, insulin, routine blood parameters, liver function, and myoelectrical activity in Beagle dogs. Results The weights of the dogs decreased during the first post-operative weeks. Dogs in the integral continual jejunal interposition, Billroth I, and Billroth II groups gained significantly more weight by 8 weeks. The prognosis nutrition index of the dogs decreased in the first 2 post-operative weeks and increased significantly by 4 weeks in the integral continual jejunal interposition and Billroth I groups. The group with duodenal exclusion (Billroth II) had significantly higher glucose levels compared to the normal control group. The insulin curve was much higher in dogs that underwent the Billroth I, continual jejunal interposition, and isolated jejunal interposition than the Billroth II and normal groups. The frequencies of fasting and postprandial jejunal pacesetter potentials (PPs) were greater in the continual jejunal interposition and Billroth I groups than that in the isolated jejunal interposition and Billroth II groups. The percentage of aboral propagation of PPs was greater in the continual jejunal interposition group than the Billroth I, isolated jejunal interposition, and Billroth II groups. Conclusion Continual jejunal interposition after subtotal gastrectomy avoids jejunal transection, maintains the duodenal Dassaqe and food storaae baas, and reduces the influence of blood qlucose and insulin.展开更多
基金the National Natural Science Foundation of China,No.60876082,81070779the grant from Shanghai Committee of Science and Technology,No.0852nm06600the "Shu Guang" Project supported by Shanghai Municipal Educa-tion Commission and Shanghai Education Devel-opment Foundation,No.08SG13
文摘Artificial facial nerve prostheses are thought to restore eye-closed function in peripheral facial paralysis patients.At present,however,there is no adequate quantitative or qualitative information regarding myoelectric signal(MES)features for healthy orbiculads oculi muscle(OOM).The present study analyzed MES features of normal OOM in rabbits during the natural continuous eye-opening(N1)state,natural continuous eye-closing(N2)state,natural blink(N3)state,and evoked eye-closing(E)state according to time domain and frequency domain analysis.Results showed that OOM electrical activities in N1 and N2 states,as well as myoelectric amplitude,were low and stable.Nevertheless,during N3 and E states,OOM electrical activities were significantly increased and amplitude was much higher in the E state than in the N3 state.In the time domain,differences in MES peak absolute potential were not significant between N1 and N2 states,in the frequency domain,differences in power spectral density peak frequency of electromyogram signals were significant between two sets of four OOM movement states.These results suggest that OOM significantly contracts and induces eyelid-closing action.In addition,OOM is diastolic during the N1state.A N2 state does not require continuous intensive OOM contraction.Moreover,distinctions of quantitative information in time and frequency domain features of MES can be used as an OOM reference to identify muscle movement patterns.
基金supported by the National Natural Science Foundation of China (No.30170414)
文摘Objective To investigate the effects of peptide YY (PYY) on the interdigestive migrating myoelectric complex (MMC) in the small intestine in vivo and explore the neural and endocrinal mechanisms of the effects. Methods Sprague-Dawley rats were supplied with a venous catheter and bipolar electrodes in the duodenum and jejunum for electromyography of stomach and small intestine in wake state. PYY,phentolamine,nitro-L-arginine (L-NNA,the inhibitor of nitric oxide synthase) and atropine were served with PYY respectively. The plasma motilin levels before and after the infusion of PYY were observed. Results At all the three recording points,PYY lengthened the circle length of MMC [from (591.90±128.98)s to (999.25±216.59)s,P<0.01] and lowered the frequency of phase Ⅲ [from (39.28±8.40) min-1 to (22.08±3.13) min-1,P<0.01],amplitude of phase Ⅲ [from (0.320±0.060)mV to (0.179±0.030)mV,P<0.01],and the portion of phase Ⅲ over the whole circle length [from (28.61±5.84)% to (15.43±5.16)% ,P<0.01]. Phentolamine had no influence on the role of PYY. Administered L-NNA combined with PYY,the percentage of phase Ⅲ increased [(42.09±8.67)%] compared with that of control (P<0.01) and compared with that of PYY administered alone (P<0.01) too. Atropine combined with PYY showed stronger depressing effects on MMC. No significant difference was found between the plasma motilin levels before and after the infusion of PYY. Conclusion PYY may inhibit the interdigestive intestine motility through the none-adrenergic none-cholinergic tract,while the α-receptor tract and circulating motilin are probably not involved in the depressing effect.
文摘BACKGROUND: Researches prove that the treatment of cerebral palsy by botulinus toxin (BTX-A) can improve effect and prolong effective duration. Current intensity is the important factor during injection. OBJECTIVE: To observe the changes of motor function and muscular intensity of children with spastic cerebral palsy after injecting BTX-A and analyze correlation between current intensity and effective duration. DESIGN: Cases control trial before and after nerves block SETTING: Capital University of Medical Sciences, China Rehabilitation Research Center PARTICIPANTS: From June 2002 to November 2004, 14 children with spastic cerebral palsy were treated by BTX-A block. All children were hospitalized in the Children Rehabilitation Department of China Rehabilitation Research Center. The children included 9 male and 5 female, and ranged from 4 to 13 years old, and average age was (6±2) years. Muscular tension ranged from grade 1 to grade 3. The diagnosis and the tape of cerebral palsy based on standard of the Fist Nationwide Cerebral Palsy Symposium, and all children were diagnosed with electroencephalogram (EEG), CT and MRI, and permitted by their guardians. METHODS: (1) Locating and calculation: To locate block points by G6805-2A electro-therapeutic apparatus (Shanghai Huayi Electronic Instrument Plant) at the least stimulating current (continuous wave; impulse frequency; 2.667-83.333 Hz; current intensity: 0-6 mA; voltage: 6 V) to touch off muscles contraction. The current intensity of each point was recorded, and the average current intensity of each patient was calculated at the same time. (2) Dose of BTX-A: Basing upon the spastic degree and weight of patients, the dose was made certain: dose (IU)=(scores of Modified Ashworth Scale +2.5) xweight (kg). The number of the block points was in all 4. The dose of injection ranged from 50 IU to 160 IU with the average of (73.6+25.8) IU. The BTX-A was made by Lanzhou Institute of Biological Products, and each bottle contains 100 IU BTX-A. Muscular tension was evaluated by Modified Ashworth Scale. The scale ranged from grade 0 to grade 4, and the scores were from 0 to 4. The higher the scores were, the higher the muscular tension was. (3) Effect: Changes of muscular tension were evaluated by modified Ashworth Scale before and after block. Motor function was evaluated by Physician Rating Scale (PRS) before and after treatment. It contained Gait pattern, Hindfoot (ankle) position (stance-floor contact), Hindfoot position (foot strike), Knee position (degree of recurvation), Crouch and Speed of gait. The scores ranged from 0 to 14. The higher the points were, the better the motor function was. (4) Effective duration: The duration was definited by the recovering of the Modified Ashworth Scale. (5) Statistic analysis: Firstly, the current intensity and the effect duration were analyzed by One-Sample Kolmogorov-Smirnov Test, the current intensity: Z= 0.456, P= 0.985, the effective duration: Z= 0.557, P= 0.915. Both data were normal distribution. Secondly, both data were analyzed by Linear Regression. The efficiency of the BTX-A block was analyzed by paired-samples t test. MAIN OUTCOME MEASURES: (1) Changes of motor function of muscular tension; (2) correlation between current intensity and effective duration. RESULTS: Fourteen children with spastic cerebral palsy were all involved in the final analysis. (1) Therapeutic effect: The average score of Ashworth scale after block was lower than that before block [(1.02±0.34) points vs. (2.12±0.48) points, t= 3.644, P〈 0.01]. The average score of RPS after block was higherthan that before block [(9.75±2.78) points vs. (6.16±0.58) points, t =13.222, P〈 0.01]. (2) Relation between the current intensity and the effective duration: The current intensity was (0.1857±0.0506) mA, and the effective duration was (26.36±4.48) weeks. The current intensity was negative correlation with effective duration (r = -0.775, P = 0.01 ). CONCLUSION: (1) BTX-A occlusion can decrease muscular tension and improve motor function of lower limbs of children with spastic cerebral palsy. (2) The lower the current intensity is, the longer the effective duration is.
基金This work is supported by National Natural Science Foundation of China (Grant Nos. 51575187 and 91223201), Science and Technology Program of Guangzhou (Grant No. 2014Y2-00217), Science and Technology Major Project of Huangpu District of Guang-Zhou (Grant No, 20150000661), the Fundamental Research Funds for the Central University (Grant No. 2015ZZ007) and Natural Science Foundation of Guangdong Province (Grant No. S2013030013355).
文摘This paper presents an anthropomorphic prosthetic hand using flexure hinges, which is controlled by the surface electromyography (sEMG) signals from 2 electrodes only. The prosthetic hand has compact structure with 5 fingers and 4 Degree of Freedoms (DoFs) driven by 4 independent actuators. Helical springs are used as elastic joints and the joints of each finger are coupled by tendons. The myoelectric control system which can classify 8 prehensile hand gestures is built. Pattern recognition is employed where Mean Absolute Value (MAV), Variance (VAR), the fourth-order Autoregressive (AR) coefficient and Sample Entropy (SE) are chosen as the optimal feature set and Linear Discriminant Analysis (LDA) is utilized to reduce the dimension. A decision of hand gestures is generated by LDA classifier after the current projected feature set and the previous one are "pre-smoothed", and then the final decision is obtained when the current decision and previous decisions are "post-smoothed" from the decisions flow. The prosthetic hand can perform prehensile postures for activities of daily living and carry objects under the control of EMG signals.
基金Supported by the National Natural Science Foundation of China(No.81973758)China Academy of Chinese Medical Sciences Foundation(Nos.ZZ11-048,ZZ-ZR2017004,and ZZ08010)。
文摘Objective:To investigate the effects of different acupuncture manipulations on Deqi sensations and surface myoelectricity,and explore the correlation between Deqi sensations and needling manipulations.Methods:Forty-five healthy participants accepted twirling,lifting-thrusting,and twirling plus lifting-thrusting manipulanions at right Zusanli(ST 36),respectively.The acupuncturist’s and participants’Deqi sensations were collected by MGH Acupuncture Sensation Scale(MASS).The intensity and occurrence rate of soreness,dull pain,pressure,heaviness,fullness,numbness,sharp pain,warmth,coolness,and throbbing feelings of participants,and tightness,smooth,and tangle feelings of acupuncturist were measured.The correlation between the acupuncturist’s and participant’s Deqi sensations was analyzed.Surface electromyogram(EMG)was recorded before,during and after needling in 30 participants.The integrated EMG(iEMG),mean power frequency(MPF)and media frequency(MF)were analyzed.Result:Both fullness and soreness of participants and tightness of acupuncturist were the most frequently occurred ones.A positive correlation between participants’fullness and acupuncturist’s tightness was observed during the three aforementioned needling manipulations(P<0.05,OR>1).Almost all the needling sensations measured in the present study could be induced by the three needling manipulations.However,strength of Deqi sensations was exhibited as lifting-thrusting>twirling plus lifting-thrusting>twirling according to MASS index.The i EMG values were increased and MPF,MF values were decreased during needling compaired to those before needling,especially during lifting-thrusting(P<0.01).Conclusions:The intensity and occurrence rate of the different Deqi sensations induced by different needling manipulations were basically similar.The fullness and soreness were both the most frequently induced Deqi sensations.The strongest Deqi sensation could be induced by lifting-thrusting manipulation.There is a positive correlation between participants’fullness and acupuncturist’s tightness during the three needling manipulations.The myoelectricity around the acupoint is related to Deqi responses.(Registration No.AMCTR-IOR-20000314).
基金supported in part by the China National Key R&D Program(Grant No.2018YFB1307200)the National Natural Science Foundation of China (Grant Nos.51905339&91948302)。
文摘It is vital to recognize the intention of finger motions for human-machine interaction(HMI).The latest research focuses on fine myoelectric control through the decoding of neural motor unit action potential trains(MUAPt) from high-density surface electromyographic(sEMG) signals.However,the existing EMG decoding algorithms rarely obtain the spatial matching relationship between decoded motion units(MU) and designated muscles,and the control interface can only recognize the trained hand gestures.In this study,a semi-supervised HMI based on MU-muscle matching(MMM) is proposed to recognize individual finger motions and even the untrained combined multi-finger actions.Through automatic channel selection from high-density s EMG signals,the optimal spatial positions to monitor the MU activation of finger muscles are determined.Finger tapping experiment is carried out on ten subjects,and the experimental results show that the proposed s EMG decomposition algorithm based on MMM can accurately identify single finger motions with an accuracy of 93.1%±1.4%,which is comparable to that of state-of-the-art pattern recognition methods.Furthermore,the MMM allows unsupervised recognizing the untrained combined multi-finger motions with an accuracy of 73%±3.8%.The outcomes of this study benefit the practical applications of HMI,such as controlling prosthetic hand and virtual keyboard.
基金supported by the China National Key R&D Program(Grant No.2018YFB1307200)the National Natural Science Foundation of China(Grant Nos.91948302,51620105002)the Science and Technology Commission of Shanghai Municipality(Grant No.18JC1410400)。
文摘Myoelectric controlled interfaces driven by muscle activities have achieved good performance in ideal conditions and showed many potential medical-related and industrial applications.However,in practical applications,the performance could be drastically degraded due to the electrode(sensor)shift,which is inevitable in donning and doffing the system.In this study,we presented a novel channel selection method against electrode shift for robust pattern-recognition based myoelectric control.The proposed method was evaluated on twenty-four subjects,including twenty-two able-bodied subjects and two amputees,and compared with two traditional channel selection methods,i.e.,uniform selection(UNI)and sequential feature selection(SFS).We demonstrated that the offline error rates of the proposed method were significantly lower than those of the other two methods(P<0.05),and its online performance in shift conditions was comparable to that in ideal conditions.These outcomes benefit the practical applications of robust myoelectric controlled interfaces.
基金supported by the National Key R&D Program of China(Grant No. 2018YFB1307201)the National Natural Science Foundation of China (Grant Nos. U1813209 and 51875120)。
文摘Currently, prosthetic hands can only achieve several prespecified and discrete hand motion patterns from popular myoelectric control schemes using electromyography(EMG) signals. To achieve continuous and stable grasping within the discrete motion pattern, this paper proposes a control strategy using a customized, flexible capacitance-based proximity-tactile sensor. This sensor is integrated at the fingertip and measures the distance and force before and after contact with an object. During the pregrasping phase, each fingertip’s position is controlled based on the distance between the fingertip and the object to make all fingertips synchronously approach the object at the same distance. Once contact is established, the sensor turns to output the tactile information, by which the contact force of each fingertip is finely controlled. Finally, the method is introduced into the human-machine interaction control for a myoelectric prosthetic hand. The experimental results demonstrate that continuous and stable grasping could be achieved by the proposed control method within the subject’s discrete EMG motion mode. The subject also obtained tactile feedback through the transcutaneous electrical nerve stimulation after contact.
基金supported in part by the National Natural Science Foundation of China,Nos.U1913601,81927804the Key-Area Research and Development Program of Guangdong Province,No.2020B0909020004(GL)the National Natural Science Foundation of China,Nos.81960419,82260456(both to LY)。
文摘Targeted muscle reinnervation has been proposed for reconstruction of neuromuscular function in amputees.However,it is unknown whether performing delayed targeted muscle reinnervation after nerve injury will affect restoration of function.In this rat nerve injury study,the median and musculocutaneous nerves of the forelimb were transected.The proximal median nerve stump was sutured to the distal musculocutaneous nerve stump immediately and 2 and 4 weeks after surgery to reinnervate the biceps brachii.After targeted muscle reinnervation,intramuscular myoelectric signals from the biceps brachii were recorded.Signal amplitude gradually increased with time.Biceps brachii myoelectric signals and muscle fiber morphology and grooming behavior did not significantly differ among rats subjected to delayed target muscle innervation for different periods.Targeted muscle reinnervation delayed for 4 weeks can acquire the same nerve function restoration effect as that of immediate reinnervation.
基金Supported by Natural Science Foundation of Shandong Province,China,No.ZR 2012 HM-079
文摘AIM: To investigate the mechanisms and effects of sphincter of Oddi(SO) motility on cholesterol gallbladder stone formation in guinea pigs.METHODS: Thirty-four adult male Hartley guinea pigs were divided randomly into two groups, the control group(n = 10) and the cholesterol gallstone group(n = 24), which was sequentially divided into four subgroups with six guinea pigs each according to time of sacrifice. The guinea pigs in the cholesterol gallstone group were fed a cholesterol lithogenic diet and sacrificed after 3, 6, 9, and 12 wk. SO manometry and recording of myoelectric activity were obtained by a multifunctional physiograph at each stage. Cholecystokinin-A receptor(CCKAR) expression levels in SO smooth muscle were detected by quantitative real-time PCR(q RT-PCR) and serum vasoactive intestinal peptide(VIP), gastrin, and cholecystokinin octapeptide(CCK-8) were detected by enzyme-linked immunosorbent assay at each stage in the process of cholesterol gallstone formation.RESULTS: The gallstone formation rate was 0%, 0%, 16.7%, and 83.3% in the 3, 6, 9, and 12 wk groups, respectively. The frequency of myoelectric activity in the 9 wk group, the amplitude of myoelectric activity in the 9 and 12 wk groups, and the amplitude and the frequency of SO in the 9 wk group were all significantly decreased compared to the control group. The SO basal pressure and common bile duct pressure increased markedly in the 12 wk group, and the CCKAR expression levels increased in the 6 and 12 wk groups compared to the control group. Serum VIP was elevated significantly in the 9 and 12 wk groups and gastrin decreased significantly in the 3 and 9 wk groups. There was no difference in serum CCK-8 between the groups.CONCLUSION: A cholesterol gallstone-causing diet can induce SO dysfunction. The increasing tension of the SO along with its decreasing activity may play an important role in cholesterol gallstone formation. Expression changes of CCKAR in SO smooth muscle and serum VIP and CCK-8 may be important causes of SO dysfunction.
文摘AIM:To investigate the influence of percutaneous local therapy on gastric myoelectrical activity in patients with hepatocellular carcinomas.METHODS:Forty-four patients with hepatocellular carcinoma(HCC) [27 males and 17 females,ranging in age from 49 to 81 years old(69.7 ± 8.01 years)] who were admitted for percutaneous local therapy were enrolled in this study.We examined clinical abdominal symptoms using the Gastrointestinal Symptom Rating Scale(GSRS) before and 3 d after percutaneous local therapy.We also measured cutaneous fasting and postprandial electrogastrography(EGG) recordings before and 3 d after percutaneous local therapy.RESULTS:We found that the percentage of normogastria in the fasting period was lower in the Child B group than in the Child A group(66.8% ± 8.6% vs 84.0% ± 3.8%).After percutaneous local therapy for HCC,the percentages of normogastria in the fasting period were significantly decreased(81.6% ± 3.5% vs 75.2% ± 4.5%).None of the postprandial EGG parameters changed significantly after percutaneous local therapy for HCC.Percutaneous local therapy for HCC reduced the power ratio(PR).In particular,the PR of tachygastria was significantly decreased after therapy(P < 0.01).However,no significant differences were found in the postprandial EGG parameters.Likewise,no significant differences were found in the calculated GSRS scores obtained from the questionnaire before and after therapy.CONCLUSION:Gastric slow-wave dysrhythmias were induced by percutaneous local therapy in HCC patients,even though the GSRS scores obtained from the questionnaire did not change significantly.
文摘People's working capability is badly affected when they sufer an amputated arm.Artifcial replacements with prosthetic devices to get a satisfactory level of performance for essential functions with the currently available prosthetic technology are very dificult.Myoelectric arm prostheses are becoming popular because they are operated by a natural contraction of intact muscles.Hence,SEMG based artifdal arm was fabricated.The system cousists of diferent electronic and mechanical assemblies for operation of hand utilizing microcontroller in order to have minimum signal loss during its processing.With the hep of relay switching connected to low power DC motor,system is capable of opening and closing of grip according to individual wish.
文摘Due to the difference of the plane of facial nerve lesion,facial paralysis can be classifiedinto nudear paralysis,paralysis of cerebellopontine angle,Hunt’s palsy,Bell’s palsy and simple facialneuritis.The authors treated 78 cases of the of the latter 3 types,compared the therapeutical effect after 2courses of treatment,and meanwhile made dynamic electromyographic observation between the tragusand the quadrate musde of upper lip for those with Bell’s palsy and Hunt’s palsy.The result showsthat acupuncture has a fair effect in treating peripheral facial paralysis and simple facial neuritis andthe myoelectric recovery in Bell’s palsy is quicker than that in Hunt’s palsy.It is suggested that thehfeher the pane of the facial nerve lesion is,the more unsatisfactory the effect is,and the effect ismore favorable otherwise.
文摘Fabric electrode is an emerging electrode element;due to some of its advantages, it can replace traditional conductive gel to become the next generation of electrode. This paper starts from the definition of fabric electrode, introduces the definition and working principle of fabric electrode, materials of producing electrodes preparation methods, and highlights the fabric used in the myoelectric prosthetic electrodes, supercapacitors and ECG tests.
基金supported by the National Key Research and Development Program of China(Grant No.2018YFB1307201)the National Natural Science Foundation of China(Grant Nos.51875120,91948302,U1813209).
文摘Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate multisensory feedback,especially proprioception feedback,limits the grasping quality.Additionally,a typical non-invasive stimulation scheme for sensation feedback uses stimulation on the stationary site of the skin continuously,which can lead to fatigue and adaptation of sensation,further reduces the feedback consistency,and increases the cognitive burden for the subject.Considering the sensitivity and modality matching of sensation,this study presented a multimodal sensations feedback scheme based on hybrid static-dynamic sensation elicited by multisite Transcutaneous Electrical Nerve Stimulation(TENS)to deliver grasping force and joint position feedback.In the proposed scheme,stimulation of single electrode produced only in-loco tactile sensation under the electrode,and the sensation intensity was adjusted according to grasping force;sequential activation of multi-electrodes produced an illusion dynamic sensation of a stimulus moving,and the velocity and direction of movement were adjusted according to finger joint position.Psychometric test results demonstrated the identifiability of stimulus in the proposed scheme.Further,prosthetic hand closed-loop grasping tasks evaluate the effectiveness of the proposed feedback scheme.The results showed that the proposed feedback scheme could substantially improve the grasping accuracy and efficiency.In addition,the study outcomes also demonstrated the benefit of artificial proprioception feedback in grasping rapidity and security.
基金supported by the National Climbing Program (No.95-Ⅷ-19-222); the National Natural science Foundation of China(No.39770285)
文摘OBJECTIVE: To determine the effect of the area postrema (AP) of the medulla oblongata on gastrointestinal interdigestive migrating motor complex (MMC) and the plasma motilin level. METHODS: Interdigestive MMC activities of the antrum and duodenum were recorded by strain gauge implanted on the serosa of 8 conscious dogs. A cannula was intubated in femoral vein for motilin injection. The plasma motilin concentration was measured by RIA. We observed: (1) normal interdigestive MMC activity and fluctuations in plasma motilin concentration; (2) the effects of electrically damaging the AP on MMC activity and plasma motilin level; (3) whether intravenous injection of motilin could induce phase III contractions after the AP was destroyed. RESULTS: (1) Typical interdigestive MMC with phase I, II, III, and IV was recorded in normal dogs. Phase III was concurrent with the peak of plasma motilin level. (2) In damaged AP dogs, antroduodenal interdigestive MMC contractions were suppressed; cyclic, phasic and migratory pattern of MMC was disrupted. Plasma motilin concentration was decreased. Intravenous injection of motilin could not induce phase III contractions. CONCLUSIONS: The area postrema might play an important role, which is mediated by motilin, on the regulation of interdigestive MMC.
基金Project supported by the National Basic Research Program(973)of China(No.2013CB329505)the National Natural Science Foundation of China(Nos.61135004 and 61201114)+2 种基金the China Postdoctoral Science Foundation(No.2013M541046)the Shenzhen Governmental Basic Research Grant(No.JCYJ20120617115010496)the State Key Laboratory of Bioelectronics of Southeast University
文摘A lack of myoelectric sources after limb amputation is a critical challenge in the control of multifunctional motorized prostheses. To reconstruct myoelectric sources physiologically related to lost limbs, a newly proposed neural-function construction method, targeted muscle reinnervation(TMR), appears promising. Recent advances in the TMR technique suggest that TMR could provide additional motor command information for the control of multifunctional myoelectric prostheses. However, little is known about the nature of the physiological functional recovery of the reinnervated muscles. More understanding of the underlying mechanism of TMR could help us fine tune the technique to maximize its capability to achieve a much higher performance in the control of multifunctional prostheses. In this study, rats were used as an animal model for TMR surgery involving transferring a median nerve into the pectoralis major, which served as the target muscle. Intramuscular myoelectric signals reconstructed following TMR were recorded by implanted wire electrodes and analyzed to explore the nature of the neural-function reconstruction achieved by reinnervation of targeted muscles. Our results showed that the active myoelectric signal reconstructed in the targeted muscle was acquired one week after TMR surgery, and its amplitude gradually became stronger over time. These preliminary results from rats may serve as a basis for exploring the mechanism of neural-function reconstruction by the TMR technique in human subjects.
文摘Background The ideal post-gastrectomy reconstruction procedure should maintain the normal digestive function and restore intestinal transit to improve the patient quality of life. The aim of this study was to evaluate the effects of integral continual jejunal interposition after subtotal gastrectomy on the nutritional status, glucose levels, and gastric-intestinal motility. Methods The study investigated the effects of the integral continual jejunal interposition, the Billroth I and Billroth II operations, and the isolated jejunal interposition following subtotal distal gastrectomy on the blood glucose, insulin, routine blood parameters, liver function, and myoelectrical activity in Beagle dogs. Results The weights of the dogs decreased during the first post-operative weeks. Dogs in the integral continual jejunal interposition, Billroth I, and Billroth II groups gained significantly more weight by 8 weeks. The prognosis nutrition index of the dogs decreased in the first 2 post-operative weeks and increased significantly by 4 weeks in the integral continual jejunal interposition and Billroth I groups. The group with duodenal exclusion (Billroth II) had significantly higher glucose levels compared to the normal control group. The insulin curve was much higher in dogs that underwent the Billroth I, continual jejunal interposition, and isolated jejunal interposition than the Billroth II and normal groups. The frequencies of fasting and postprandial jejunal pacesetter potentials (PPs) were greater in the continual jejunal interposition and Billroth I groups than that in the isolated jejunal interposition and Billroth II groups. The percentage of aboral propagation of PPs was greater in the continual jejunal interposition group than the Billroth I, isolated jejunal interposition, and Billroth II groups. Conclusion Continual jejunal interposition after subtotal gastrectomy avoids jejunal transection, maintains the duodenal Dassaqe and food storaae baas, and reduces the influence of blood qlucose and insulin.