Postprandial metabolism plays major roles in many pathological conditions.The n-6/n-3 polyunsaturated fatty acid(PUFA)ratio is closely related to various physiological disorders.This study aimed to investigate the eff...Postprandial metabolism plays major roles in many pathological conditions.The n-6/n-3 polyunsaturated fatty acid(PUFA)ratio is closely related to various physiological disorders.This study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control(NC)and hypertriglyceridemia(HTG)rats.The postprandial response of triglyceride(TG)in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio meals.The HTG groups showed higher postprandial total cholesterol(TC)responses than NC groups after 1:1 and 20:1 ratio meals.The 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factorα(TNF-α)than 1:1 and 10:1 ratios in HTG groups.The postprandial malondialdehyde(MDA)response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG groups.The 1:1 ratio resulted in a lower postprandial reactive oxygen species(ROS)level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC groups.The results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats.A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats.展开更多
目的评估老年肌少症患者的营养状况和炎症因子,探讨n-3脂肪酸(n-3 fatty acids,n-3 PUFA)在老年肌少症患者中的作用。方法选取2020年1月至6月在湖南省人民医院老年科住院及体检科健康体检的70岁以上能行走的老年人,根据欧洲老年人肌少...目的评估老年肌少症患者的营养状况和炎症因子,探讨n-3脂肪酸(n-3 fatty acids,n-3 PUFA)在老年肌少症患者中的作用。方法选取2020年1月至6月在湖南省人民医院老年科住院及体检科健康体检的70岁以上能行走的老年人,根据欧洲老年人肌少症工作组(European working group on sarcopenia in the elderly,EWGSOP)诊断标准分为无肌少症组和肌少症组,检测入选者的营养指标,测定炎性细胞因子水平。肌少症组患者分为实验组和对照组,在高蛋白饮食[1.2g/(kg·d)]并维持营养指标正常的基础上实验组患者补充n-3 PUFA 1000mg/d,比较分析补充后炎性细胞因子水平的变化。结果肌少症组患者的外周血25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]、血钙、血磷及血红蛋白较无肌少症组降低,差异有统计学意义(P<0.05)。肌少症组患者的外周血肿瘤坏死因子α(tumornecrosisfactorα,TNF-α)、白细胞介素(interleukin,IL)-6、C反应蛋白(C-reactive protein,CRP)高于对照组,差异有统计学意义(P<0.05),补充n-3 PUFA24周后患者的TNF-α、IL-6、CRP下降,但差异无统计学意义(P>0.05)。补充n-3 PUFA 48周后患者的TNF-α、IL-6、CRP继续下降,差异有统计学意义(P<0.05),IL-10升高,差异无统计学意义(P>0.05)。结论肌少症患者的血25(OH)D、血钙、血磷及血红蛋白等营养指标减少、致炎因子增加可能是老年人肌少症的发病机制之一,补充n-3 PUFA可通过抑制炎症成为肌少症的防治手段之一。展开更多
基金supported by National Key Research and Development Plan(2016YFD0400604)National Natural Science Foundation of China(82073551).
文摘Postprandial metabolism plays major roles in many pathological conditions.The n-6/n-3 polyunsaturated fatty acid(PUFA)ratio is closely related to various physiological disorders.This study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control(NC)and hypertriglyceridemia(HTG)rats.The postprandial response of triglyceride(TG)in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio meals.The HTG groups showed higher postprandial total cholesterol(TC)responses than NC groups after 1:1 and 20:1 ratio meals.The 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factorα(TNF-α)than 1:1 and 10:1 ratios in HTG groups.The postprandial malondialdehyde(MDA)response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG groups.The 1:1 ratio resulted in a lower postprandial reactive oxygen species(ROS)level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC groups.The results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats.A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats.
文摘目的评估老年肌少症患者的营养状况和炎症因子,探讨n-3脂肪酸(n-3 fatty acids,n-3 PUFA)在老年肌少症患者中的作用。方法选取2020年1月至6月在湖南省人民医院老年科住院及体检科健康体检的70岁以上能行走的老年人,根据欧洲老年人肌少症工作组(European working group on sarcopenia in the elderly,EWGSOP)诊断标准分为无肌少症组和肌少症组,检测入选者的营养指标,测定炎性细胞因子水平。肌少症组患者分为实验组和对照组,在高蛋白饮食[1.2g/(kg·d)]并维持营养指标正常的基础上实验组患者补充n-3 PUFA 1000mg/d,比较分析补充后炎性细胞因子水平的变化。结果肌少症组患者的外周血25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]、血钙、血磷及血红蛋白较无肌少症组降低,差异有统计学意义(P<0.05)。肌少症组患者的外周血肿瘤坏死因子α(tumornecrosisfactorα,TNF-α)、白细胞介素(interleukin,IL)-6、C反应蛋白(C-reactive protein,CRP)高于对照组,差异有统计学意义(P<0.05),补充n-3 PUFA24周后患者的TNF-α、IL-6、CRP下降,但差异无统计学意义(P>0.05)。补充n-3 PUFA 48周后患者的TNF-α、IL-6、CRP继续下降,差异有统计学意义(P<0.05),IL-10升高,差异无统计学意义(P>0.05)。结论肌少症患者的血25(OH)D、血钙、血磷及血红蛋白等营养指标减少、致炎因子增加可能是老年人肌少症的发病机制之一,补充n-3 PUFA可通过抑制炎症成为肌少症的防治手段之一。