BACKGROUND Squamous cell carcinoma(SCC)of the nail bed is a poorly reported malignant subungual tumor.Because it presents with nonspecific symptoms and signs,it is frequently misdiagnosed by dermatologists or surgeons...BACKGROUND Squamous cell carcinoma(SCC)of the nail bed is a poorly reported malignant subungual tumor.Because it presents with nonspecific symptoms and signs,it is frequently misdiagnosed by dermatologists or surgeons.A delay in diagnosis and/or wrong treatment might increase the possibility of disease progression.Thus,new perspectives are needed to assist dermatologists and surgeons with diagnosing and treating SCC.This rare case presented with a 2-year delay in the diagnosis of SCC teaches a valuable lesson.CASE SUMMARY A 62-year-old female presented with a non-healing subungual growth in the nail bed of the right middle finger for 2 years.The lesion was first medicated with iodine by the patient herself without any relief.Twenty months later,a dermatologist diagnosed the lesion as paronychia and treated it with nail avulsions repeatedly with no obvious alleviation.A lesionectomy confirmed the lesion was SCC.An extended excision of the tumor with amputation of the distal interphalangeal joint was subsequently performed.A biopsy of sentinel lymph nodes was negative.Due to the result of preoperative positron emission tomography-computed tomography scanning,sweeping of axillary lymph nodes was considered dispensable and was skipped.At the 2-year follow-up,the patient showed a quick recovery and no sign of recurrence.CONCLUSION Our successful diagnosis and treatment of the case highlights the need for additional attention to long-standing non-healing lesions of the nail bed and the necessity for discreet evaluation and customization of surgical interventions.展开更多
Objective: To discuss the diagnosis and treatment of glomus tumor at the nail bed of the finger. Methods: The course and therapeutic outcome of 12 cases of glomus tumor which were resected and confirmed by histology e...Objective: To discuss the diagnosis and treatment of glomus tumor at the nail bed of the finger. Methods: The course and therapeutic outcome of 12 cases of glomus tumor which were resected and confirmed by histology examination were analyzed. Results: All cases were followed up for six months up to 2 years, no recurrences were observed, the shape of the nail was normal. Conclusion: Microsurgical treatment of glomus tumors of the nail bed is effective.展开更多
A systematic, accurate and robust evaluating method for fine pitch printed circuit board （PCB） positioning assessment in testing fixture is developed. Targeting reliability of bed-of-nails tester is successfully eva...A systematic, accurate and robust evaluating method for fine pitch printed circuit board （PCB） positioning assessment in testing fixture is developed. Targeting reliability of bed-of-nails tester is successfully evaluated by the 2D pattern transform. Probe offset vector with its Weibull and Gaussian distribution estimates are obtained for further investigation about the causes of misalignment on the basis of a batch tests for same kind of PCBs.展开更多
基金Supported by the National Natural Science Foundation of China,No.81702135Zhejiang Medical Association Clinical Scientific Research Program,No.2013ZYCA19 and 2015ZYC-A12+1 种基金Zhejiang Medicine and Hygiene Research Program,No.2016KYB101 and 2015KYA100Zhejiang Traditional Chinese Medicine Research Program,No.2016ZA124 and 2017ZB057
文摘BACKGROUND Squamous cell carcinoma(SCC)of the nail bed is a poorly reported malignant subungual tumor.Because it presents with nonspecific symptoms and signs,it is frequently misdiagnosed by dermatologists or surgeons.A delay in diagnosis and/or wrong treatment might increase the possibility of disease progression.Thus,new perspectives are needed to assist dermatologists and surgeons with diagnosing and treating SCC.This rare case presented with a 2-year delay in the diagnosis of SCC teaches a valuable lesson.CASE SUMMARY A 62-year-old female presented with a non-healing subungual growth in the nail bed of the right middle finger for 2 years.The lesion was first medicated with iodine by the patient herself without any relief.Twenty months later,a dermatologist diagnosed the lesion as paronychia and treated it with nail avulsions repeatedly with no obvious alleviation.A lesionectomy confirmed the lesion was SCC.An extended excision of the tumor with amputation of the distal interphalangeal joint was subsequently performed.A biopsy of sentinel lymph nodes was negative.Due to the result of preoperative positron emission tomography-computed tomography scanning,sweeping of axillary lymph nodes was considered dispensable and was skipped.At the 2-year follow-up,the patient showed a quick recovery and no sign of recurrence.CONCLUSION Our successful diagnosis and treatment of the case highlights the need for additional attention to long-standing non-healing lesions of the nail bed and the necessity for discreet evaluation and customization of surgical interventions.
文摘Objective: To discuss the diagnosis and treatment of glomus tumor at the nail bed of the finger. Methods: The course and therapeutic outcome of 12 cases of glomus tumor which were resected and confirmed by histology examination were analyzed. Results: All cases were followed up for six months up to 2 years, no recurrences were observed, the shape of the nail was normal. Conclusion: Microsurgical treatment of glomus tumors of the nail bed is effective.
基金This project is supported by US Pennsylvania Dept. of Community & Economic Development(No.20-906-0015)National Natural Science Foundation of China(No.50390064, No.50575230)National Basic Research Program of China(973 Program, No.2003CB716202).
文摘A systematic, accurate and robust evaluating method for fine pitch printed circuit board （PCB） positioning assessment in testing fixture is developed. Targeting reliability of bed-of-nails tester is successfully evaluated by the 2D pattern transform. Probe offset vector with its Weibull and Gaussian distribution estimates are obtained for further investigation about the causes of misalignment on the basis of a batch tests for same kind of PCBs.
