The control synthesis of nanoparticles was the implementation process of material ideal design. Nano-hydroxyapatite(HAP) was prepared by a hydrothermal method with calcium nitrate and diammonium hydrogen phosphate as ...The control synthesis of nanoparticles was the implementation process of material ideal design. Nano-hydroxyapatite(HAP) was prepared by a hydrothermal method with calcium nitrate and diammonium hydrogen phosphate as raw material, to study its characteristics for morphology modification by arginine-functionalization and doping with rare earth such as Tb^(3+). The crystallization, grain size and dispersibility of the sample HAP were analyzed and discussed. The results show that the surface Zeta potential of arginine-functionalized HAP is changed, and the growth rate of HAP is inhibited to a certain extent during the synthesis. The structure of HAP/Arg is not affected during the synthesis by a small amount of rare earth ions doped such as Tb^(3+), and has a single phase of HAP with good dispersibility. The synthesized HAP is also of nano-sized level. Nano-hydroxyapatite argininefunctionalized and doped with rare earth such as Tb^(3+), is suitable for the application of gene delivery as a gene carrier.展开更多
基金Project(2013SK2024)supported by the Key Projects in Social Development Pillar Program of Hunan Province,ChinaProject(20130162120094)supported by Specialized Research Fund for the Doctoral Program of Higher Education(SRFDP),Ministry of Education,ChinaProject supported by State Key Laboratory of Powder Metallurgy,Central South University,China
文摘The control synthesis of nanoparticles was the implementation process of material ideal design. Nano-hydroxyapatite(HAP) was prepared by a hydrothermal method with calcium nitrate and diammonium hydrogen phosphate as raw material, to study its characteristics for morphology modification by arginine-functionalization and doping with rare earth such as Tb^(3+). The crystallization, grain size and dispersibility of the sample HAP were analyzed and discussed. The results show that the surface Zeta potential of arginine-functionalized HAP is changed, and the growth rate of HAP is inhibited to a certain extent during the synthesis. The structure of HAP/Arg is not affected during the synthesis by a small amount of rare earth ions doped such as Tb^(3+), and has a single phase of HAP with good dispersibility. The synthesized HAP is also of nano-sized level. Nano-hydroxyapatite argininefunctionalized and doped with rare earth such as Tb^(3+), is suitable for the application of gene delivery as a gene carrier.
