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Information Management in Disaster and Humanitarian Response: A Case in United Nations Office for the Coordination of Humanitarian Affairs
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作者 Solomon M. Zewde 《Intelligent Information Management》 2023年第2期47-65,共19页
To guarantee a unified response to disasters, humanitarian organizations work together via the United Nations Office for the Coordination of Humanitarian Affairs (OCHA). Although the OCHA has made great strides to imp... To guarantee a unified response to disasters, humanitarian organizations work together via the United Nations Office for the Coordination of Humanitarian Affairs (OCHA). Although the OCHA has made great strides to improve its information management and increase the availability of accurate, real-time data for disaster and humanitarian response teams, significant gaps persist. There are inefficiencies in the emergency management of data at every stage of its lifecycle: collection, processing, analysis, distribution, storage, and retrieval. Disaster risk reduction and disaster risk management are the two main tenets of the United Nations’ worldwide plan for disaster management. Information systems are crucial because of the crucial roles they play in capturing, processing, and transmitting data. The management of information is seldom discussed in published works. The goal of this study is to employ qualitative research methods to provide insight by facilitating an expanded comprehension of relevant contexts, phenomena, and individual experiences. Humanitarian workers and OCHA staffers will take part in the research. The study subjects will be chosen using a random selection procedure. Online surveys with both closed- and open-ended questions will be used to compile the data. UN OCHA offers a structure for the handling of information via which all humanitarian actors may contribute to the overall response. This research will enable the UN Office for OCHA better gather, process, analyze, disseminate, store, and retrieve data in the event of a catastrophe or humanitarian crisis. 展开更多
关键词 Information systems Management Information Management UNOCHA (United nations Office for Coordination of Humanitarian Affairs) Humanitarian Emergency Actors DIsAsTER Risk Reduction responsE Emer-gency Management
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Research on Community Cultural Characteristic of She Nationality in East Fujian Province and Its Response to Geological Space
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作者 张光英 《Journal of Landscape Research》 2011年第8期96-99,共4页
With the concept that culture was the product of certain natural environment and social condition, as there were less researches on response of community culture of She Nationality to geological space and on influence... With the concept that culture was the product of certain natural environment and social condition, as there were less researches on response of community culture of She Nationality to geological space and on influence of geological space on She community culture, the study took community culture of She Nationality in East Fujian as the research subject, and analyzed distribution of She Nationality. By taking relevant documents on She Nationality of East Fujian Province for reference, through analysis of characteristic culture and geopolitical background of She community, it was considered that characteristic culture lied in united and friendly community culture, rough and practical sports culture, ancient medicine culture, food culture of mountainous feature and architectural culture. Furthermore, it analyzed response of She community culture to geological space from the perspectives of regional space, geological environment and climate; and pointed out the far-reaching influence of geological space on She community culture. 展开更多
关键词 COMMUNITY culture of sHE nationALITY GEOLOGICAL space responsE
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2022年四川泸定 M_(s)6.8地震强震动特性研究 被引量:2
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作者 张聪 周宝峰 +4 位作者 任叶飞 王晓敏 余桦 张亚军 吴华灯 《世界地震工程》 北大核心 2024年第1期13-24,共12页
北京时间2022年9月5日12时52分,四川省甘孜州泸定县发生M_(s)6.8级地震。国家强震动台网获得了133组三分量加速度记录,在对记录进行初步筛选和滤波后,研究了PGA和PGV衰减关系、竖向地震动特点、地震动速度脉冲,对比分析了反应谱和设计谱... 北京时间2022年9月5日12时52分,四川省甘孜州泸定县发生M_(s)6.8级地震。国家强震动台网获得了133组三分量加速度记录,在对记录进行初步筛选和滤波后,研究了PGA和PGV衰减关系、竖向地震动特点、地震动速度脉冲,对比分析了反应谱和设计谱,着重对石棉挖角台站附近震害与地震动的相关性进行了分析,结论如下:1)三种台站强震动记录的PGA和PGV拟合曲线都比较相近,PGA、PGV拟合曲线与霍俊荣的预测模型较为接近;2)竖向地震动偏大,约38.2%的强震动记录V/H大于2/3,可能是屋顶塌落、柱子扭转和天花板坠落等震害现象出现的主要原因;3)识别出具有速度脉冲特性的记录11条,该类记录对长周期结构影响较大;4)所选记录反应谱大多超过了罕遇地震设计谱水平段,具有速度脉冲特性的051SMW台站周围房屋破坏较严重,人员伤亡较重。 展开更多
关键词 泸定M_(s)6.8地震 地震动衰减 竖向地震动 速度脉冲 加速度反应谱
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Evolving National Security: A Roadmap from Present to Future in Renewable and Nonrenewable Energy Policies (A Technical Review) 被引量:1
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作者 Bahman Zohuri 《Journal of Energy and Power Engineering》 2023年第3期102-108,共7页
This comprehensive exploration delves into the intricate dynamics of national security policies in the realm of renewable and nonrenewable energy sources.From the present landscape characterized by the diversification... This comprehensive exploration delves into the intricate dynamics of national security policies in the realm of renewable and nonrenewable energy sources.From the present landscape characterized by the diversification of energy portfolios to the long-term vision encompassing nuclear fusion,this article navigates through the nuanced interplay of technology,resilience,and environmental responsibility.The synthesis of established nuclear fission technologies and evolving renewable sources forms the cornerstone of a strategic approach,addressing challenges and opportunities to ensure a secure,sustainable energy future. 展开更多
关键词 national security policy renewable energy nonrenewable energy nuclear fission nuclear fusion energy resilience sustainability technological innovation environmental responsibility global collaboration.
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A systems perspective on national prioritisation of sustainable development goals:Insights from Australia
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作者 Atie Asadikia Abbas Rajabifard Mohsen Kalantari 《Geography and Sustainability》 CSCD 2023年第3期255-267,共13页
Achieving the Sustainable Development Goals(SDGs)requires effective national initiatives and resource allo-cation.Yet,the simultaneous attainment of all goals is hindered by constraints such as limited budgets and res... Achieving the Sustainable Development Goals(SDGs)requires effective national initiatives and resource allo-cation.Yet,the simultaneous attainment of all goals is hindered by constraints such as limited budgets and resources,varied national priorities,and the intricate nature of the goals.As we approach 2030 and beyond,an urgent need for an effective,data-driven prioritisation system exists to optimise what can be accomplished.A considerable knowledge gap persists in identifying the priority areas that demand concentrated attention and how their improvement would propel overall sustainability goals.To bridge this gap,our study presents a priori-tisation approach that identifies significant SDG indicators based on urgency and impact,utilising Benchmarking,Bivariate,and Network analysis.Furthermore,we introduce an innovative Impact Index(IMIN)to assess an indi-cator’s extensive effect on the SDG network.This system carries significant international relevance by establishing a robust framework to identify key,potent,and interconnected indicators.It supports decision-makers worldwide in comprehending their nation’s SDG performance and promotes efficient resource allocation.In the specific con-text of Australia,our analysis spotlights several impactful,yet underperforming SDG indicators.These include the protection of Freshwater,Terrestrial,and Mountain Key Biodiversity Areas(KBAs),the share of renewable energy and energy intensity level of primary energy,targeted research and development,gender equality in national parliaments,and carbon-efficient manufacturing,amongst others. 展开更多
关键词 sustainable development sDGs national prioritisation sDGs prioritisation Network analysis Australia’s sDGs
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Determination of the Response Amplitude Operator(s) of an FPSO 被引量:1
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作者 Imabibo Ibinabo Daniel T. Tamunodukobipi 《Engineering(科研)》 2019年第9期541-556,共16页
The driving necessities of cost reduction and the need to develop fields at ever increasing water depths have led to the use of floating structures. Among these structures are the Floating Production Storage and Offlo... The driving necessities of cost reduction and the need to develop fields at ever increasing water depths have led to the use of floating structures. Among these structures are the Floating Production Storage and Offloading (FPSO) units whose motion analysis is considered in this paper. In actual environmental condition, it is required to accurately determine or predict large amplitude motion of the FPSO before any offshore operation. This paper seeks to present a detailed method of computing the Response Amplitude Operator(s) (RAOs) for the six (6) degrees of freedom using ANSYS AQWA. The results indicate for Heave motion a tendency for the heave peak value to move slightly higher dimensionless encounter-frequency as the wave moves from Head sea to Beam sea direction. A MATLAB source code was developed to validate the result for heave motion at head sea. Although a small difference in predicted heave motion occurred, it is pertinent to note that the comparisons between results generated in the MATLAB program and ANSYS AQWA demonstrate generally good agreement, and the roll response of the FPSO is noted to be critical. 展开更多
关键词 responsE AMPLITUDE Operator(s) FLOATING Production storage and OFFLOADING Unit ANsYs AQWA MATLAB simplified Method
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多孔n-GaN/p-Zn_(x)Cu_(1-x)S异质结的制备及紫外探测性能研究
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作者 杜志伟 贾伟 +5 位作者 贾凯达 任恒磊 李天保 董海亮 贾志刚 许并社 《人工晶体学报》 CAS 北大核心 2024年第8期1326-1336,共11页
本文首先采用紫外光辅助电化学刻蚀(UV-EC)方法制备出了孔隙密度为1.51×10^(10)cm^(-2)、平均孔径为38 nm的多孔n-GaN薄膜;随后在其上通过水浴法沉积了一系列Zn_(x)Cu_(1-x)S复合薄膜,x为0.0、0.2、0.4、0.6、0.8、1.0,形成的多孔n... 本文首先采用紫外光辅助电化学刻蚀(UV-EC)方法制备出了孔隙密度为1.51×10^(10)cm^(-2)、平均孔径为38 nm的多孔n-GaN薄膜;随后在其上通过水浴法沉积了一系列Zn_(x)Cu_(1-x)S复合薄膜,x为0.0、0.2、0.4、0.6、0.8、1.0,形成的多孔n-GaN/p-Zn_(x)Cu_(1-x)S异质结带隙在2.34~3.51 eV调控;最后基于这些异质结构建出p-n结型紫外探测器。I-V曲线结果表明这些探测器均具有良好的整流特性,特别是n-GaN/p-Zn_(0.4)Cu_(0.6)S探测器性能最优。在暗态下,I_(+3 V)/I_(-3 V)约为1.78×10^(5);在偏压为-3 V、光功率密度为432μW/cm^(2)(365 nm)的条件下,光暗电流比超过10^(3),上升/下降时间为0.09/39.8 ms,响应度(R)为0.352 A/W,外量子效率(EQE)为119.6%,探测率(D^(*))为3.21×10^(12)Jones。I-t曲线结果表明,多孔n-GaN/p-Zn_(x)Cu_(1-x)S异质结紫外探测器在连续开-关光循环过程中拥有稳定的光电流响应。该研究为制备异质结紫外探测器提供了一定的理论指导和实验数据。 展开更多
关键词 p-Zn_(x)Cu_(1-x)s 多孔n-GaN 异质结 紫外探测器 光暗电流比 响应度
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Government's Responsibility for Control of Agricultural Environmental Pollution in China 被引量:1
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作者 Dongfang CHEN 《Asian Agricultural Research》 2016年第10期41-43,共3页
In this paper,the current situation of agricultural environmental pollution caused by the increase of chemicals input in agriculture in China was analyzed,and it is found that agricultural pollution is related to agri... In this paper,the current situation of agricultural environmental pollution caused by the increase of chemicals input in agriculture in China was analyzed,and it is found that agricultural pollution is related to agricultural industrial policies,urban-rural economic structure,funds input in pollution control,comprehensive environmental management,laws of pollution control,and so forth. To control agricultural pollution effectively,it is needed to implement integration of agricultural and environmental policies,establish environmentally friendly agricultural technology popularizing system,implement integrated planning and management of a basin,and set up and improve legislation to protect agricultural environment. 展开更多
关键词 China Agricultural environmental pollution Government’s responsibility
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Quantum Mechanics: Harmonic Wave-Packets, Localized by Resonant Response in Dispersion Dynamics
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作者 Antony J. Bourdillon 《Journal of Modern Physics》 CAS 2023年第2期171-182,共12页
From a combination of Maxwell’s electromagnetism with Planck’s law and the de Broglie hypothesis, we arrive at quantized photonic wave groups whose constant phase velocity is equal to the speed of light c = ω/k and... From a combination of Maxwell’s electromagnetism with Planck’s law and the de Broglie hypothesis, we arrive at quantized photonic wave groups whose constant phase velocity is equal to the speed of light c = ω/k and to their group velocity dω/dk. When we include special relativity expressed in simplest units, we find that, for particulate matter, the square of rest mass , i.e., angular frequency squared minus wave vector squared. This equation separates into a conservative part and a uniform responsive part. A wave function is derived in manifold rank 4, and from it are derived uncertainties and internal motion. The function solves four anomalies in quantum physics: the point particle with prescribed uncertainties;spooky action at a distance;time dependence that is consistent with the uncertainties;and resonant reduction of the wave packet by localization during measurement. A comparison between contradictory mathematical and physical theories leads to similar empirical conclusions because probability amplitudes express hidden variables. The comparison supplies orthodox postulates that are compared to physical principles that formalize the difference. The method is verified by dual harmonics found in quantized quasi-Bloch waves, where the quantum is physical;not axiomatic. 展开更多
关键词 Wave Packet Reduction Phase Velocity Hidden Variables Young’s slits Resonant response Dispersion Dynamics Quantum Physics
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强化硫化黑染色废水中S^(2-)去除的电絮凝体系
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作者 李明辉 姚继明 +1 位作者 张维 谢源 《针织工业》 北大核心 2024年第11期89-94,共6页
为提高硫化黑染色废水中S-去除效率,以镁、铁作为交替阳极,选择交流电源构建电絮凝-芬顿耦合体系。采用响应曲面法(RSM)对体系参数如施加电压、电解时间、初始pH值、H_(2)O_(2)用量进行优化设计与验证,探究其对S^(2-)去除、色度、化学... 为提高硫化黑染色废水中S-去除效率,以镁、铁作为交替阳极,选择交流电源构建电絮凝-芬顿耦合体系。采用响应曲面法(RSM)对体系参数如施加电压、电解时间、初始pH值、H_(2)O_(2)用量进行优化设计与验证,探究其对S^(2-)去除、色度、化学需氧量(COD)的影响。结果表明:H_(2)O_(2)添加量对废水COD去除率和S^(2-)去除率有一定影响,S^(2-)浓度受多因素的复合效果影响较明显。在施加电压27V、电解时间40min、初始pH值为5.9、H_(2)O_(2)为0.4mL,S^(2-)去除率最高,达到79.41%,此时COD去除率为48.08%,色度30倍。 展开更多
关键词 硫化黑染色废水 交流电絮凝 响应曲面法 s^(2-)去除率 电芬顿
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Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats
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作者 Samira Behrad Sina Pourranjbar +4 位作者 Mohammad Pourranjbar Saeid Abbasi-Maleki Samira Rostami Mehr Reza Hossein Gholizadeh Salmani Nasrollah Moradikor 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2024年第11期500-506,共7页
Objective:To evaluate the effect of Grifola frondosa polysaccharides(GFP)in a rat model of Alzheimer’s disease(AD).Methods:Seventy-five rats were divided into five groups:the normal control group and the AD group tre... Objective:To evaluate the effect of Grifola frondosa polysaccharides(GFP)in a rat model of Alzheimer’s disease(AD).Methods:Seventy-five rats were divided into five groups:the normal control group and the AD group treated with or without GFP(100,200,and 400 mg/kg).Behavioral responses in the open field test and elevated plus maze test were assessed.Additionally,the levels of malondialdehyde and ferric-reducing ability of plasma,and the mRNA expressions of TNF-α,IL-6,and IL-1βin the hippocampus were measured.Results:Treatment with GFP significantly improved AD-induced behavioral changes in the open field test and elevated plus maze test(P<0.05).In addition,the level of malondialdehyde and the mRNA expressions of TNF-α,IL-6,and IL-1βwere decreased by GFP treatment in a dose-dependent manner in AD rats(P<0.05),while the level of ferric-reducing ability of plasma was significantly increased(P<0.05).Conclusions:Oral administration of GFP can reduce inflammation and oxidative stress,as well as improve behavioral responses associated with AD,suggesting its potential use in AD treatment.However,additional studies are needed to elucidate its underlying mechanisms and efficacy. 展开更多
关键词 Grifola frondosa POLYsACCHARIDEs DEMENTIA Behavioral responses INFLAMMATION Alzheimer’s disease
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乌什M_(S)7.1地震引起新55井、新46井水位水温同震响应分析
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作者 贾永斌 闫玮 +1 位作者 祖丽皮牙·艾尼瓦尔 汪成国 《内陆地震》 2024年第2期158-165,共8页
为研究乌什M_(S)7.1地震引起新55井、新46井水位不同程度的响应变化,对比分析观测井水位的同震响应特征,从含水层渗透性变化和地震波能量密度探讨了同震响应机理。结果表明:①伽师新55井和乌什新46井同震响应形态主要表现为井水位的大... 为研究乌什M_(S)7.1地震引起新55井、新46井水位不同程度的响应变化,对比分析观测井水位的同震响应特征,从含水层渗透性变化和地震波能量密度探讨了同震响应机理。结果表明:①伽师新55井和乌什新46井同震响应形态主要表现为井水位的大幅快速上升。②固体潮计算分析结果表明当地震波作用于新55井和新46井时,前者垂向水力交换增强,水平向水力交换减弱,含水层的水与井水进行交换,引起井水位同震上升变化;后者含水层渗透性增加,含水层水与井水进行交换,引起井水位同震上升变化。③地震能量密度计算结果显示新55井比新46井容易触发同震响应,这种差异性的响应可能与井含水层岩性有关。 展开更多
关键词 乌什M_(s)7.1地震 新55井 新46井 水位水温 同震响应
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National Spirit Mobilization in Response to Pandemics
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作者 Zhan Xiaomei Jie Xijie 《学术界》 CSSCI 北大核心 2020年第4期193-202,共10页
The cohesion of social“emotion–norm–goal”in response to major pandemics means the intention coordination of the involved group attitude,the value regulation of joint participations and the system optimization of p... The cohesion of social“emotion–norm–goal”in response to major pandemics means the intention coordination of the involved group attitude,the value regulation of joint participations and the system optimization of power concentration.Social cohesive mobilization includes the core role and key variables of the government’s initiative and public response,with social rectification functions of centralized leadership,social coordination and public participation as derivatives.The mobilization of national spirit in the process of cohesion emphasizes the formation of guidance,persuasion and influence of internal driving force based on value concept,which are mainly represented in the form of emotional mobilization,normative mobilization and goal mobilization.The“emotional paradigm”of national spirit mobilization that enters the practical level focuses on the“heart-warming”function of emotional strategy rituals;“normative paradigm”shows the function of“heart-winning”in the sense of norms and shapes interpretation scheme as well as social regulations of social cohesion value reproduction;“goal paradigm”reflects the“confidence strengthening”function led by collective actions,and conducts the goal transmission and framework construction of“idea+action”. 展开更多
关键词 major PANDEMIC responsE sOCIAL COHEsION national sPIRIT MOBILIZATION
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Treat to target in Crohn’s disease:A practical guide for clinicians
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作者 Ashish R Srinivasan 《World Journal of Gastroenterology》 SCIE CAS 2024年第1期50-69,共20页
A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's disease.The Selecting Therapeutic Targets in Inflammatory Bowel Disea... A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's disease.The Selecting Therapeutic Targets in Inflammatory Bowel Disease(STRIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these timepoints.Scheduled appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or modified.Consensus treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic healing.Although the STRIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all patients.This underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment targets.The use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural healing.Two randomised clinical trials,namely,CALM and STARDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s disease.Findings from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be clarified.Moreover,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world studies.Despite the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its uptake.This highlights the need to describe strategies,processes,and models of care capable of supporting the integration and execution of a T2T approach in real-world clinical practice.Hence,this review seeks to examine the current and emerging literature to provide clinicians with practical guidance on how to incorporate the principles of T2T into routine clinical practice for the management of Crohn’s disease. 展开更多
关键词 Treat to target Inflammatory bowel disease Crohn’s disease Treatment targets Endoscopic remission Transmural healing Time to response Intestinal ultrasound
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乌什M_(S)7.1地震前地倾斜、地应变加卸载响应比异常分析
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作者 范亚玲 赵彬彬 《内陆地震》 2024年第2期151-157,共7页
基于岩石应力的本构关系,以2024年1月23日乌什M_(S)7.1地震前震中及周边500 km范围内地倾斜、地应变数据作为“响应量”,利用库伦应力触发模型的加卸载响应比方法进行计算,结果显示,乌什洞体应变等3个测项均出现震前LURR异常,这表明震... 基于岩石应力的本构关系,以2024年1月23日乌什M_(S)7.1地震前震中及周边500 km范围内地倾斜、地应变数据作为“响应量”,利用库伦应力触发模型的加卸载响应比方法进行计算,结果显示,乌什洞体应变等3个测项均出现震前LURR异常,这表明震源区介质存在明显的应力积累过程,同时也说明从倾斜、应变的潮汐频段中能够提取出地震预测的有效信息。 展开更多
关键词 加载卸载响应比(LURR) 地倾斜 地应变 乌什M_(s)7.1地震
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The Impact of Some Family Variables on the Dimension of Social Responsibility
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作者 Seham Ahmed Alazab 《Sociology Study》 2016年第8期527-538,共12页
The current study discusses the social and psychological studies conducted on the concept of the social responsibility, as well as the symbolic interactive trend as a theoretical basis for interpretation; moreover, di... The current study discusses the social and psychological studies conducted on the concept of the social responsibility, as well as the symbolic interactive trend as a theoretical basis for interpretation; moreover, discussing the social responsibility in the light of family variables. The aim of this study is to investigate the family variables, including domicile, parents' education, their age, the type of work they do, family size, and family income. As to the social responsibility's dimensions for sample selected for this study; hence, it includes personal, ethical, national, environmental, health, and social responsibility. The current study adopted the descriptive approach along with a demographic data form and the social responsibility's scale. The sample selected consisted of 330 female students from various colleges within King Abdulaziz University. The results indicated that there was an impact on all the variables, thus such impact was in favor of those living in rural areas as to the ethical dimension and in favor of urban people as to the dimensions of accountability, parents' level of education, parents' seniority, working mothers, greater family size, and higher income. 展开更多
关键词 Personal responsibility ethical responsibility national responsibility social responsibility environmental health responsibility
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Thoughts on International Situation and China's Response
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作者 楚树龙 王在邦 《Contemporary International Relations》 1999年第9期1-13,共13页
As a major event at the turn of the century, NATO’s world-shocking air strikesagainst Yugoslavia represent certain dangerous trends in US global strategyand international strategic configuration. The event has arouse... As a major event at the turn of the century, NATO’s world-shocking air strikesagainst Yugoslavia represent certain dangerous trends in US global strategyand international strategic configuration. The event has aroused widespread con-cern and heightened vigilance among the international community. Althoughflames of war have died out in the Balkans, yet the dust there has yet to settle. It,therefore, remains a matter of urgency to engage in some comprehensive, in-depth, strategic reflections on the major event itself, its international 展开更多
关键词 Us In Thoughts on International situation and China’s response NATO
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Bruton’s tyrosine kinase inhibitors in primary central nervous system lymphoma:New hopes on the horizon
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作者 Leonardo S Lino-Silva Sabrina B Martínez-Villavicencio Luisa Fernanda Rivera-Moncada 《World Journal of Clinical Oncology》 2024年第5期587-590,共4页
In this editorial,we comment on the article by Wang et al.This manuscript explores the potential synergistic effects of combining zanubrutinib,a novel oral inhibitor of Bruton’s tyrosine kinase,with high-dose methotr... In this editorial,we comment on the article by Wang et al.This manuscript explores the potential synergistic effects of combining zanubrutinib,a novel oral inhibitor of Bruton’s tyrosine kinase,with high-dose methotrexate(HD-MTX)as a therapeutic intervention for primary central nervous system lymphoma(PCNSL).The study involves a retrospective analysis of 19 PCNSL patients,highlighting clinicopathological characteristics,treatment outcomes,and genomic biomarkers.The results indicate the combination’s good tolerance and strong antitumor activity,with an 84.2%overall response rate.The authors emphasize the potential of zanubrutinib to modulate key genomic features of PCNSL,particularly mutations in myeloid differentiation primary response 88 and cluster of differentiation 79B.Furthermore,the study investigates the role of circulating tumor DNA in cerebrospinal fluid for disease surveillance and treatment response monitoring.In essence,the study provides valuable insights into the potential of combining zanubrutinib with HD-MTX as a frontline therapeutic regimen for PCNSL.The findings underscore the importance of exploring alternative treatment modalities and monitoring genomic and liquid biopsy markers to optimize patient outcomes.While the findings suggest promise,the study’s limitations should be considered,and further research is needed to establish the clinical relevance of this therapeutic approach for PCNSL. 展开更多
关键词 Primary central nervous system lymphoma Zanubrutinib Bruton’s tyrosine kinase PROGNOsIs Myeloid differentiation primary response 88 gene Cluster of differentiation 79B gene
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On the Government's Responsibility in China's Rural Land Transfer
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作者 Dongfang CHEN 《Asian Agricultural Research》 2016年第8期72-73,共2页
There is an urgent need for China's rural land transfer in order to develop modern agriculture,ensure food security,transfer rural population,and accelerate industrialization and urbanization.At present,there is s... There is an urgent need for China's rural land transfer in order to develop modern agriculture,ensure food security,transfer rural population,and accelerate industrialization and urbanization.At present,there is still disordered transfer of rural land in China,making the interests of the transferors and transferees difficult to be effectively guaranteed;there is inefficient transfer,leading to decline in actual agricultural production level after transfer;there is jobless transfer,leading to difficult placement for rural surplus labor after transfer,seriously restricting rural land transfer.Therefore,the Chinese government's legal responsibility,economic responsibility and social responsibility in rural land transfer should be further strengthened. 展开更多
关键词 China Rural land transfer Government’s responsibility
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Verification of the Physiological Therapeutic Effects of Harvesting Activities in a Patient with Moderate Alzheimer’s Disease with Long-Term Agricultural Experience
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作者 Kikuo Eguchi Seigo Koura +1 位作者 Nao Eguchi Akihiko Kondou 《Open Journal of Therapy and Rehabilitation》 2024年第3期236-244,共9页
Background: Harvesting activities have proven effective in reducing stress in patients with dementia. At a psychiatric hospital, occupational therapists (OT) made patients with dementia perform vegetable harvesting ac... Background: Harvesting activities have proven effective in reducing stress in patients with dementia. At a psychiatric hospital, occupational therapists (OT) made patients with dementia perform vegetable harvesting activities as a part of their treatment. The patients became calmer and began to smile not only after but also before and during harvesting activity. Therefore, this study aimed to measure autonomic nervous system (ANS) responses over time in a female patient in her 80s with moderate Alzheimer’s disease (AD) who had experience in farming when performing harvesting activities. Additionally, this study aimed to consider factors associated with changes in ANS responses over time and to verify the physiological therapeutic effects of harvesting activities. Methods: An OT with more than 10 years of experience and a good relationship with the patient conducted one-on-one sessions with the patient. Harvesting activity was performed in a courtyard with trees. The patient harvested lettuce (three lettuce plants) grown in a planter while sitting on a chair. Additionally, the planter was set up on a desk. ANS responses were measured over time from before to after the activity for different events at six time periods. Changes in the patient’s ANS responses were assessed during each period. Results: With the involvement of environmental factors and OT during harvesting activities, parasympathetic nervous system (PNS) activity significantly increased. This may lead to improved mental stability. Conclusion: The findings of this study indicate that implementing harvesting activities may have a positive effect on the PNS in patients with AD with long-term agricultural experience. However, further studies with a larger sample size and multidimensional evaluations are needed. 展开更多
关键词 Alzheimer’s Disease Autonomic Nervous response Harvesting Activity Therapeutic Effects
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