It is well known that there are huge geographic variations in cancer rates in China's Mainland. For example, The National Cancer Control Office of the Ministry of Public Health (1979) reported that in the 1970s, c...It is well known that there are huge geographic variations in cancer rates in China's Mainland. For example, The National Cancer Control Office of the Ministry of Public Health (1979) reported that in the 1970s, cancer mortality rates for most cancers were found to be more than 20-fold greater in some counties in others (Table 1). Esophageal cancer rates for males are a few hundred fold greater in the highest county when compared with the lowest county. The mortality rate for all cancers combined for males is 21 fold greater in the county with the highest mortality than in the county with the lowest rate.According to Doll and Peto (1981), about one third of human cancer death is avoidable by appropriate modification of the diet. Therefore, diet is very likely to have an important part in causing these huge geographic variations. The possible role of various mutagens and carcinogens (e.g. afiatoxin, N-nitroso compounds) in locally produced and consumed foods has been strongly suggested and widely acknowledged, although much more evidence would be required to confirm their actual functions in human cancer. On the other hand, there are a few reports stating that the human diet also contains powerful antimutagens and anticarcinogens (Ames, 1983). The possible role of these two types of substances in causing the huge geographic variation of cancer risks remains elusive and inadequately explored. In order to make better use of these natural anticarcinogens in cancer prevention, it is important to elucidate their effects and mechanisms. The purpose of this paper is to summarize the available information on the antimutagenic and anticarcinogenic effects of natural foods in the Chinese diet, excluding the effects of essential nutrients, e.g. dietary fibers, vitamins and minerals. Most of the literature cited in this review was published by Chinese scientists.展开更多
In this study,the best manufacturing process will be selected to build an automotive crash box using green oil palm natural fibre-reinforced polyurethane composite materials.This paper introduces an approach consist o...In this study,the best manufacturing process will be selected to build an automotive crash box using green oil palm natural fibre-reinforced polyurethane composite materials.This paper introduces an approach consist of technical aspects(T),the economic point of view(E)and availability(A),and it’s also called as TEA requirement.This approach was developed with the goal of assisting the design engineer in the selection of the best manufacturing process during the design phase at the criteria selection stage.In this study,the TEA requirement will integrate with the analytical hierarchy process(AHP)to assist decision makers or manufacturing engineers in determining the most appropriate manufacturing process to be employed in the manufacture of a composite automotive crash box(ACB)at the early stage of the product development process.It is obvious that a major challenge in the manufacturing selection process is lack of information regarding manufacturing of ACB using natural fibre composite(NFC).There have been no previous studies that examined ranking manufacturability processes in terms of their suitability.Therefore,the TEA-AHP hybrid method was introduced to provide unprejudiced criteria-ranking selection prior to evaluation of pairwise comparisons.At the end of this study,the pulforming process was selected as the best manufacturing process for fabrication of the ACB structural component.展开更多
Neuronal injuries such as stroke,traumatic brain injury,and spinal cord injury are leading causes of major disability and death.Chronic therapy for these neuronal injuries requires the promotion of axonal regeneration...Neuronal injuries such as stroke,traumatic brain injury,and spinal cord injury are leading causes of major disability and death.Chronic therapy for these neuronal injuries requires the promotion of axonal regeneration from the remaining neurons（Schwab and Strittmatter,2014）.展开更多
Coronaviruses caused an outbreak pandemic disease characterized by a severe acute respiratory distress syndrome leading to the infection of more than 200 million patients and the death of more than 4 million individua...Coronaviruses caused an outbreak pandemic disease characterized by a severe acute respiratory distress syndrome leading to the infection of more than 200 million patients and the death of more than 4 million individuals.The primary treatment is either supportive or symptomatic.Natural products have an important role in the development of various drugs.Thus,screening of natural compounds with reported antiviral activities can lead to the discovery of potential inhibitory entities against coronaviruses.In the current study,an in-silico molecular docking experiment was conducted on the effects of some of these natural antiviral phytoconstituents,(e.g.,procyanidin B2,theaflavin,quercetin,ellagic acid,caffeoylquinic acid derivatives,berginin,eudesm-1β,6α,11-triol and arbutin),on the crystal structure of SARS-CoV-2 main protease(PDB ID:6w63)using AutoDock-Vina software.Many of the docked compounds revealed good binding affinity,with procyanidin B2(–8.6 Kcal/mol)and theaflavin(–8.5 Kcal/mol)showing a better or similar binding score as the ligand(–8.5 Kcal/mol).Molecular dynamics simulations were carried out at 100 ns and revealed that procyanidin B2 forms a more stable complex with SARS-CoV-2 main protease than theaflavin.Procyanidin B2,theaflavin,and 4,5-dicaffeoylquinic acid were evaluated for toxicity by ProTox-II webserver and were non-toxic according to the predicted LD50 values and safe on different organs and pathways.Additionally,these phytoconstituents showed good ADME properties and acceptable lipophilicity,as evaluated using WLOGP.Amongst the tested compounds,procyanidin B2 showed the highest lipophilic value.It is worth mentioning that these natural inhibitiors of SARS-CoV-2 main protease are components of green and black tea that can be used as a supporting supplement for COVID patients or as potential nuclei for further drug design and development campaigns.展开更多
Antioxidants are used to minimize lipid oxidation. Antioxidants can act as metal chelators and free radical or oxygen scavengers, which can slow the progression of lipid oxidation. Lipid oxidation may have negative ef...Antioxidants are used to minimize lipid oxidation. Antioxidants can act as metal chelators and free radical or oxygen scavengers, which can slow the progression of lipid oxidation. Lipid oxidation may have negative effects on the quality of meat and meat products, causing changes in sensory attributes such as color, texture, odor and flavor, and nutritional quality. Several synthetic antioxidants have been used to successfully prevent lipid oxidation in the meat industry, but consumers are concerned about the health risks related to consumption of some synthetic antioxidants. Therefore, there has been a growing interest in natural antioxidants. Nowadays, compounds obtained from natural sources such as grains, oilseeds, spices, fruit and vegetables have been investigated to decrease the lipid oxidation. In this review, the potential effects of natural antioxidants were evaluated that are widely used in meat and meat products.展开更多
Uttaranchal is bestowed with numerous rivers, huge forest resources ranging from tropical to temperate, tourists＇ places, pilgrimages and feasible climatic conditions for growing fruits, vegetables, food grains, live...Uttaranchal is bestowed with numerous rivers, huge forest resources ranging from tropical to temperate, tourists＇ places, pilgrimages and feasible climatic conditions for growing fruits, vegetables, food grains, livestock rearing, tea garden practices, etc. The economic development, on the other hand, could not take place partly due to lack of modern technology with innovation in agricultural system and also unwillingness of the people towards using it. Furthermore, due to its harsh climatic conditions, rigorous terrain and distinct identity, as a part of Uttar Pradesh state, the development could not take place and today the state is believed to be one of the poorer states. Infrastructurally, this region is lagged behind due to its inaccessibility. The ideal geographical and agrarian conditions might be used evenly for the developmental processes. Ecologically, the whole region is socio-economic activities, fragile. The diverse harsh traditional beliefs and hard working potentials further change the entire scenario of the state. Only the need of the hours is to frame and implementation of the rational policies and planning for sustainable development of the state. What had appeared during the past, pertaining to the economic development, needs radical changes in policies, planning and beliefs. This paper aims to evaluate the present conditions of resources as a form of natural vegetation, agricultural crops, horticultural farming, herbs, tea garden practices, livestock rearing, hydropower projects and economic development of the Uttaranchal Himalaya.展开更多
This study addresses the synthesis of nanoscale zero-valent iron(n ZVI) in the presence of natural bentonite(B-n ZVI) using green tea extract. The natural bentonite and B-n ZVI were then applied for the removal of pho...This study addresses the synthesis of nanoscale zero-valent iron(n ZVI) in the presence of natural bentonite(B-n ZVI) using green tea extract. The natural bentonite and B-n ZVI were then applied for the removal of phosphorus from aqueous solutions at various concentrations, p H levels and contact time. The desorption of phosphorus(P) from adsorbents was done immediately after sorption at the maximum initial concentration using the successive dilution method. The characterization of FTIR, SEM, and XRD indicated that n ZVI was successfully loaded to the surface of natural bentonite. The sorption of phosphorus on B-n ZVI was observed to be p H-dependent, with maximum phosphorus removal occurring at the p H range of 2 to 5. The results demonstrate that the maximum sorption capacities of natural bentonite and B-n ZVI were 4.61 and 27.63 mg·g^(-1), respectively.Langmuir, Freundlich, and Redlich–Peterson models properly described the sorption isotherm data. For either adsorbent, desorption isotherms did not coincide with their corresponding sorption isotherms, suggesting the occurrence of irreversibility and hysteresis. The average percentages of retained phosphorus released from natural bentonite and B-n ZVI were 80% and 9%, respectively. The results indicated that sorption kinetics was best described by the pseudo-second-order model. The present study suggests that B-n ZVI could be used as a suitable adsorbent for the removal of phosphorus from aqueous solutions.展开更多
文摘It is well known that there are huge geographic variations in cancer rates in China's Mainland. For example, The National Cancer Control Office of the Ministry of Public Health (1979) reported that in the 1970s, cancer mortality rates for most cancers were found to be more than 20-fold greater in some counties in others (Table 1). Esophageal cancer rates for males are a few hundred fold greater in the highest county when compared with the lowest county. The mortality rate for all cancers combined for males is 21 fold greater in the county with the highest mortality than in the county with the lowest rate.According to Doll and Peto (1981), about one third of human cancer death is avoidable by appropriate modification of the diet. Therefore, diet is very likely to have an important part in causing these huge geographic variations. The possible role of various mutagens and carcinogens (e.g. afiatoxin, N-nitroso compounds) in locally produced and consumed foods has been strongly suggested and widely acknowledged, although much more evidence would be required to confirm their actual functions in human cancer. On the other hand, there are a few reports stating that the human diet also contains powerful antimutagens and anticarcinogens (Ames, 1983). The possible role of these two types of substances in causing the huge geographic variation of cancer risks remains elusive and inadequately explored. In order to make better use of these natural anticarcinogens in cancer prevention, it is important to elucidate their effects and mechanisms. The purpose of this paper is to summarize the available information on the antimutagenic and anticarcinogenic effects of natural foods in the Chinese diet, excluding the effects of essential nutrients, e.g. dietary fibers, vitamins and minerals. Most of the literature cited in this review was published by Chinese scientists.
文摘In this study,the best manufacturing process will be selected to build an automotive crash box using green oil palm natural fibre-reinforced polyurethane composite materials.This paper introduces an approach consist of technical aspects(T),the economic point of view(E)and availability(A),and it’s also called as TEA requirement.This approach was developed with the goal of assisting the design engineer in the selection of the best manufacturing process during the design phase at the criteria selection stage.In this study,the TEA requirement will integrate with the analytical hierarchy process(AHP)to assist decision makers or manufacturing engineers in determining the most appropriate manufacturing process to be employed in the manufacture of a composite automotive crash box(ACB)at the early stage of the product development process.It is obvious that a major challenge in the manufacturing selection process is lack of information regarding manufacturing of ACB using natural fibre composite(NFC).There have been no previous studies that examined ranking manufacturability processes in terms of their suitability.Therefore,the TEA-AHP hybrid method was introduced to provide unprejudiced criteria-ranking selection prior to evaluation of pairwise comparisons.At the end of this study,the pulforming process was selected as the best manufacturing process for fabrication of the ACB structural component.
文摘Neuronal injuries such as stroke,traumatic brain injury,and spinal cord injury are leading causes of major disability and death.Chronic therapy for these neuronal injuries requires the promotion of axonal regeneration from the remaining neurons（Schwab and Strittmatter,2014）.
文摘Coronaviruses caused an outbreak pandemic disease characterized by a severe acute respiratory distress syndrome leading to the infection of more than 200 million patients and the death of more than 4 million individuals.The primary treatment is either supportive or symptomatic.Natural products have an important role in the development of various drugs.Thus,screening of natural compounds with reported antiviral activities can lead to the discovery of potential inhibitory entities against coronaviruses.In the current study,an in-silico molecular docking experiment was conducted on the effects of some of these natural antiviral phytoconstituents,(e.g.,procyanidin B2,theaflavin,quercetin,ellagic acid,caffeoylquinic acid derivatives,berginin,eudesm-1β,6α,11-triol and arbutin),on the crystal structure of SARS-CoV-2 main protease(PDB ID:6w63)using AutoDock-Vina software.Many of the docked compounds revealed good binding affinity,with procyanidin B2(–8.6 Kcal/mol)and theaflavin(–8.5 Kcal/mol)showing a better or similar binding score as the ligand(–8.5 Kcal/mol).Molecular dynamics simulations were carried out at 100 ns and revealed that procyanidin B2 forms a more stable complex with SARS-CoV-2 main protease than theaflavin.Procyanidin B2,theaflavin,and 4,5-dicaffeoylquinic acid were evaluated for toxicity by ProTox-II webserver and were non-toxic according to the predicted LD50 values and safe on different organs and pathways.Additionally,these phytoconstituents showed good ADME properties and acceptable lipophilicity,as evaluated using WLOGP.Amongst the tested compounds,procyanidin B2 showed the highest lipophilic value.It is worth mentioning that these natural inhibitiors of SARS-CoV-2 main protease are components of green and black tea that can be used as a supporting supplement for COVID patients or as potential nuclei for further drug design and development campaigns.
文摘Antioxidants are used to minimize lipid oxidation. Antioxidants can act as metal chelators and free radical or oxygen scavengers, which can slow the progression of lipid oxidation. Lipid oxidation may have negative effects on the quality of meat and meat products, causing changes in sensory attributes such as color, texture, odor and flavor, and nutritional quality. Several synthetic antioxidants have been used to successfully prevent lipid oxidation in the meat industry, but consumers are concerned about the health risks related to consumption of some synthetic antioxidants. Therefore, there has been a growing interest in natural antioxidants. Nowadays, compounds obtained from natural sources such as grains, oilseeds, spices, fruit and vegetables have been investigated to decrease the lipid oxidation. In this review, the potential effects of natural antioxidants were evaluated that are widely used in meat and meat products.
文摘Uttaranchal is bestowed with numerous rivers, huge forest resources ranging from tropical to temperate, tourists＇ places, pilgrimages and feasible climatic conditions for growing fruits, vegetables, food grains, livestock rearing, tea garden practices, etc. The economic development, on the other hand, could not take place partly due to lack of modern technology with innovation in agricultural system and also unwillingness of the people towards using it. Furthermore, due to its harsh climatic conditions, rigorous terrain and distinct identity, as a part of Uttar Pradesh state, the development could not take place and today the state is believed to be one of the poorer states. Infrastructurally, this region is lagged behind due to its inaccessibility. The ideal geographical and agrarian conditions might be used evenly for the developmental processes. Ecologically, the whole region is socio-economic activities, fragile. The diverse harsh traditional beliefs and hard working potentials further change the entire scenario of the state. Only the need of the hours is to frame and implementation of the rational policies and planning for sustainable development of the state. What had appeared during the past, pertaining to the economic development, needs radical changes in policies, planning and beliefs. This paper aims to evaluate the present conditions of resources as a form of natural vegetation, agricultural crops, horticultural farming, herbs, tea garden practices, livestock rearing, hydropower projects and economic development of the Uttaranchal Himalaya.
文摘This study addresses the synthesis of nanoscale zero-valent iron(n ZVI) in the presence of natural bentonite(B-n ZVI) using green tea extract. The natural bentonite and B-n ZVI were then applied for the removal of phosphorus from aqueous solutions at various concentrations, p H levels and contact time. The desorption of phosphorus(P) from adsorbents was done immediately after sorption at the maximum initial concentration using the successive dilution method. The characterization of FTIR, SEM, and XRD indicated that n ZVI was successfully loaded to the surface of natural bentonite. The sorption of phosphorus on B-n ZVI was observed to be p H-dependent, with maximum phosphorus removal occurring at the p H range of 2 to 5. The results demonstrate that the maximum sorption capacities of natural bentonite and B-n ZVI were 4.61 and 27.63 mg·g^(-1), respectively.Langmuir, Freundlich, and Redlich–Peterson models properly described the sorption isotherm data. For either adsorbent, desorption isotherms did not coincide with their corresponding sorption isotherms, suggesting the occurrence of irreversibility and hysteresis. The average percentages of retained phosphorus released from natural bentonite and B-n ZVI were 80% and 9%, respectively. The results indicated that sorption kinetics was best described by the pseudo-second-order model. The present study suggests that B-n ZVI could be used as a suitable adsorbent for the removal of phosphorus from aqueous solutions.
