A novel pH-sensitive nanoparticle drug delivery system (DDS) derived fl om natural polysaccharide pullulan for doxorubicin (DOX) release was prepared.Pullulan was functionalized by successive carboxymethylization and ...A novel pH-sensitive nanoparticle drug delivery system (DDS) derived fl om natural polysaccharide pullulan for doxorubicin (DOX) release was prepared.Pullulan was functionalized by successive carboxymethylization and amidation to introduce hydrazide groups.DOX was then grafted onto pullulan backbone through the pH-sensitive hydrazone bond to form a pullulan/DOX conjugate.This conjugate self-assembled to form nano-sized particles in aqueous solution as a result of the hydrophobic interaction of the DOX.Trans...展开更多
Taking into account the rising incidence of metabolic diseases,it is an urgent need for effective treatments to control human health problems.Natural polysaccharides have been found effective on metabolic diseases in ...Taking into account the rising incidence of metabolic diseases,it is an urgent need for effective treatments to control human health problems.Natural polysaccharides have been found effective on metabolic diseases in more and more researches.In the context of serious side effects of drugs,natural polysaccharides will be verified in the prevention and treatment of metabolic diseases and show their advantages of low toxicity and high efficiency.This review mainly summarized the activity of polysaccharides from different sources in regulating metabolism,and laid a reference for metabolic diseases by natural polysaccharides.展开更多
The use of new food grade polysaccharides (mucilage) obtained from Hibiscus esculentus and Trigonella foenum graceum,commonly called Okra and Fenugreek,respectively,as flocculants was described.These polysaccharides w...The use of new food grade polysaccharides (mucilage) obtained from Hibiscus esculentus and Trigonella foenum graceum,commonly called Okra and Fenugreek,respectively,as flocculants was described.These polysaccharides were used for removal of solids (suspended solids (SS) and total dissolved solids (TDS)) and dyes from real textile effluents and aqueous solutions of different class of synthetic dyes.Influences of varying polysaccharide concentration,contact time and pH on removal of pollutant from the textile...展开更多
This review summarizes recent progress of the robust and smart hydrogels prepared from natural polymers including polysaccharides, proteins, etc. These hydrogels exhibit outstanding mechanical properties due to their ...This review summarizes recent progress of the robust and smart hydrogels prepared from natural polymers including polysaccharides, proteins, etc. These hydrogels exhibit outstanding mechanical properties due to their nanofibrous aggregated microstructures and special crosslinking networks. Furthermore, these hydrogels show some smart stimuliresponsive behaviors triggered by p H, temperature, light, electricity and magnetism. Hopefully, these hydrogels derived from natural polymers with inherent biodegradation and biocompatibility have great application potential in the fields of biomedicine, tissue engineering, soft robots and bio-machine.展开更多
基金the National Basic Research program of China (No.2005CB623903).
文摘A novel pH-sensitive nanoparticle drug delivery system (DDS) derived fl om natural polysaccharide pullulan for doxorubicin (DOX) release was prepared.Pullulan was functionalized by successive carboxymethylization and amidation to introduce hydrazide groups.DOX was then grafted onto pullulan backbone through the pH-sensitive hydrazone bond to form a pullulan/DOX conjugate.This conjugate self-assembled to form nano-sized particles in aqueous solution as a result of the hydrophobic interaction of the DOX.Trans...
基金This work was financially supported from the Science and Technology Program of Inner Mongolia Autonomous Region(2020GG0144)National Natural Science Foundation of China(82160810)+1 种基金Inner Mongolia Autonomous Region education science Planning project(NGJGH2021181)National Key Research and Development Program(2021YPE0190100).
文摘Taking into account the rising incidence of metabolic diseases,it is an urgent need for effective treatments to control human health problems.Natural polysaccharides have been found effective on metabolic diseases in more and more researches.In the context of serious side effects of drugs,natural polysaccharides will be verified in the prevention and treatment of metabolic diseases and show their advantages of low toxicity and high efficiency.This review mainly summarized the activity of polysaccharides from different sources in regulating metabolism,and laid a reference for metabolic diseases by natural polysaccharides.
文摘The use of new food grade polysaccharides (mucilage) obtained from Hibiscus esculentus and Trigonella foenum graceum,commonly called Okra and Fenugreek,respectively,as flocculants was described.These polysaccharides were used for removal of solids (suspended solids (SS) and total dissolved solids (TDS)) and dyes from real textile effluents and aqueous solutions of different class of synthetic dyes.Influences of varying polysaccharide concentration,contact time and pH on removal of pollutant from the textile...
基金financially supported by the Major Program of National Natural Science Foundation of China(No.21334005)the Major International(Regional)Joint Research Project of National Natural Science Foundation of China(No.21620102004)
文摘This review summarizes recent progress of the robust and smart hydrogels prepared from natural polymers including polysaccharides, proteins, etc. These hydrogels exhibit outstanding mechanical properties due to their nanofibrous aggregated microstructures and special crosslinking networks. Furthermore, these hydrogels show some smart stimuliresponsive behaviors triggered by p H, temperature, light, electricity and magnetism. Hopefully, these hydrogels derived from natural polymers with inherent biodegradation and biocompatibility have great application potential in the fields of biomedicine, tissue engineering, soft robots and bio-machine.
