Natural products（NPs） have long been recognized as a valuable resource for drug discovery, and bringing NP-related features to virtual libraries is believed to be an effective way to increase the coverage of druggab...Natural products（NPs） have long been recognized as a valuable resource for drug discovery, and bringing NP-related features to virtual libraries is believed to be an effective way to increase the coverage of druggable chemical space. Here, deep learning-based molecule generative model, which is a recent technique in de novo molecule design, was applied to generate virtual libraries with NP-like properties. Results demonstrated that the model was effective in generating molecules that highly resemble NPs. Moreover, the model was also found to be capable of generating NP-like molecules that were also easy to synthesize, significantly increasing the practical value of the compound library.展开更多
随着计算机算力的提升和智能设备的普及,社会逐步进入智慧化时代。高校图书馆作为高校的文献信息中心,进行智慧化转型提升服务质量是时代所需。因此,文章借助智能问答技术,设计了基于自然语言处理(Natural Language Processing,NLP)的...随着计算机算力的提升和智能设备的普及,社会逐步进入智慧化时代。高校图书馆作为高校的文献信息中心,进行智慧化转型提升服务质量是时代所需。因此,文章借助智能问答技术,设计了基于自然语言处理(Natural Language Processing,NLP)的图书馆智能问答系统,创新图书馆参考咨询服务模式,提高图书馆服务水平和效率。展开更多
This paper provides an overview of South Korea’s 20-year journey in adopting building information modeling(BIM) and future direction. It first discusses the six phases of BIM adoption in South Korea, starting from th...This paper provides an overview of South Korea’s 20-year journey in adopting building information modeling(BIM) and future direction. It first discusses the six phases of BIM adoption in South Korea, starting from the use of BIM as a marketing tool to its current intelligent BIM phase. The government’s support for BIM-related research and development projects is also highlighted, with a focus on the artificail intelligence (AI)-based architectural design automation project. As the future direction, it explores the integration of AI with BIM in both local and global contexts. The paper presents AIpowered architectural design methods, including AI-powered early architectural design generation and architectural detailing.Compared to AI-based early architectural design generation, architectural detailing is an unexplored research topic. This paper introduces two AI-and BIM-based architectural detailing methods, being developed at Yonsei University:namely,BIM library transplant and Natural language-based Architectural Detailing through Interaction with AI (NADIA). These methods demonstrate how AI-enhanced BIM can enable architects to interactively develop building details using a language model as a conversational AI and a knowledge base, and a BIM authoring tool as a design platform, in the near future.展开更多
The experiment combine high throughput preparation technology with the new drug finding of Ⅱ diabetes mellitus, through making use of modern separation and purification technology prepared for the natural product lib...The experiment combine high throughput preparation technology with the new drug finding of Ⅱ diabetes mellitus, through making use of modern separation and purification technology prepared for the natural product library of Ⅱ diabetes mellitus. The library offered more and more comprehensive compound to drug screening, and made the drug screening of Ⅱ diabetes mellitus realize high throughput, also it broke a new path for the therapy of Ⅱ diabetes mellitus.展开更多
基金The National Natural Science Foundation of China(Grant No.81573273,81673279,21572010 and 21772005)National Major Scientific and Technological Special Project for"Significant New Drugs Development"(Grant No.2018ZX09735001-003)
文摘Natural products（NPs） have long been recognized as a valuable resource for drug discovery, and bringing NP-related features to virtual libraries is believed to be an effective way to increase the coverage of druggable chemical space. Here, deep learning-based molecule generative model, which is a recent technique in de novo molecule design, was applied to generate virtual libraries with NP-like properties. Results demonstrated that the model was effective in generating molecules that highly resemble NPs. Moreover, the model was also found to be capable of generating NP-like molecules that were also easy to synthesize, significantly increasing the practical value of the compound library.
文摘随着计算机算力的提升和智能设备的普及,社会逐步进入智慧化时代。高校图书馆作为高校的文献信息中心,进行智慧化转型提升服务质量是时代所需。因此,文章借助智能问答技术,设计了基于自然语言处理(Natural Language Processing,NLP)的图书馆智能问答系统,创新图书馆参考咨询服务模式,提高图书馆服务水平和效率。
基金funded by the Civil Engineering Graphics Branch of China Graphicsthe Korea Agency for Infrastructure Technology Advancement (KAIA) grant funded by the Ministry of Land,Infrastructure and Transport (Grant RS-2021-KA163269)。
文摘This paper provides an overview of South Korea’s 20-year journey in adopting building information modeling(BIM) and future direction. It first discusses the six phases of BIM adoption in South Korea, starting from the use of BIM as a marketing tool to its current intelligent BIM phase. The government’s support for BIM-related research and development projects is also highlighted, with a focus on the artificail intelligence (AI)-based architectural design automation project. As the future direction, it explores the integration of AI with BIM in both local and global contexts. The paper presents AIpowered architectural design methods, including AI-powered early architectural design generation and architectural detailing.Compared to AI-based early architectural design generation, architectural detailing is an unexplored research topic. This paper introduces two AI-and BIM-based architectural detailing methods, being developed at Yonsei University:namely,BIM library transplant and Natural language-based Architectural Detailing through Interaction with AI (NADIA). These methods demonstrate how AI-enhanced BIM can enable architects to interactively develop building details using a language model as a conversational AI and a knowledge base, and a BIM authoring tool as a design platform, in the near future.
文摘The experiment combine high throughput preparation technology with the new drug finding of Ⅱ diabetes mellitus, through making use of modern separation and purification technology prepared for the natural product library of Ⅱ diabetes mellitus. The library offered more and more comprehensive compound to drug screening, and made the drug screening of Ⅱ diabetes mellitus realize high throughput, also it broke a new path for the therapy of Ⅱ diabetes mellitus.
