Adaptive Network Sustainability and Defense Based on Artificial Bees Colony Optimization Algorithm for Nature Inspired Cyber Security

Cyber Defense is becoming a major issue for every organization to keep business continuity intact.The presented paper explores the effectiveness of a meta-heuristic optimization algorithm-Artificial Bees Colony Algorithm(ABC)as an Nature Inspired Cyber Security mechanism to achieve adaptive defense.It experiments on the Denial-Of-Service attack scenarios which involves limiting the traffic flow for each node.Businesses today have adapted their service distribution models to include the use of the Internet,allowing them to effectively manage and interact with their customer data.This shift has created an increased reliance on online services to store vast amounts of confidential customer data,meaning any disruption or outage of these services could be disastrous for the business,leaving them without the knowledge to serve their customers.Adversaries can exploit such an event to gain unauthorized access to the confidential data of the customers.The proposed algorithm utilizes an Adaptive Defense approach to continuously select nodes that could present characteristics of a probable malicious entity.For any changes in network parameters,the cluster of nodes is selected in the prepared solution set as a probable malicious node and the traffic rate with the ratio of packet delivery is managed with respect to the properties of normal nodes to deliver a disaster recovery plan for potential businesses.

Problems and Development Suggestions of Nature Education in Jiangxi Province

The forest coverage rate of Jiangxi Province ranks second in China.It has rich natural resources,a long history of ancient color culture and rich red culture.In the development of nature education,Jiangxi Province has great potential and advantages.This paper introduces the development conditions of nature education in Jiangxi Province,summarizes the problems existing in the development of nature education in Jiangxi Province from the aspects of the types of nature education and the construction of nature education base,such as simple content and single form,imperfect infrastructure and lack of professionals,and puts forward some suggestions on the development of nature education in Jiangxi Province.

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinical trials are required to validate the therapeutic effects of strategies targeting glutathione peroxidase 4 in the treatment of Alzheimer's disease.

“Eternal Motion” as a “Form of Movement of a Special Nature” and the Main Condition for the Creation of the Universe

The article hypothesizes that DE and DM (UCM) are a “Form of Motion of a Special Nature”, where “Form of Motion” means “Eternal Motion” as the power of dynamics of different levels and varying degrees of self-sufficiency, and by “Special Nature”, gravitational and two other properties of matter, “tied” to the “Eternal Movement” and completely dependent on it. Carriers of key properties of a “Special Nature” have been established: “0”-DE particles and “3”-DM particles (UDM). The unity of their inherent “motionally-gravitational” properties and the peculiarity of the relationship between “motion” and “gravity” are revealed: the higher the intensity of “Eternal Motion”, the stronger the gravitational properties of matter are manifested (and vice versa). The relationship of “time” with the “vibration frequency” and the “mass” of photons with the “degree of bonding and deformation properties of the field” is shown. The maximum level of gravity has been determined, which allows Nature to successfully create the Universe: such a landmark is the proximity to the property of the Primary Source—the “pure graviton” of the OSP space, the most powerful “motionally-gravitational” particle of the Universe. The reasons for the emergence of such an identity of the gravitational properties of particles with the indicators of a “pure graviton” are established: for “0”-DE particles, this is the acquisition of the function of “freedom of movement”;for “3”-DM particles (UDM), the creation of a special structure—a “double field” (“Main” and “Small”). The presence in the “double field” of specific “tools” for the creation of the worlds of the Universe—gravitational “waves” gives rise to impulses (shocks) of varying intensity and shape. A list of functions performed by “waves” in the “Main” and “Small” fields has been compiled. The specific conditions for the formation of “UDM Streams”, their transformation into a “Vortex” and, under the influence of a powerful Initial Impulse (push), sending them to the “place” of the creation of galaxies, are shown. It is suggested that there is a “Cycle of Matter in Nature” in the closed structure of our Universe due to the “work” of “waves” and the functioning of special “factories” in the form of exotic space objects—Black holes.

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of SUMOylation.We used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other cancers.We demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by nutlin-3.This underscores the intricate relationship between natural compounds such as nutlin-3 and immune regulation.Using comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma progression.We also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic simulation.Nutlin-3a inhibited glioma cell proliferation and activated the p53 pathway.Its efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or exercise.Experiments using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway regulation.Notably,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing cells.These results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma management.Our research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

Ubiquitin-specific protease 1 facilitates tumor immune escape from natural killer cells and predicts the prognosis in small cell lung cancer

Objective:Small cell lung cancer(SCLC)is commonly recognized as the most fatal lung cancer type.Despite substantial advances in immune checkpoint blockade therapies for treating solid cancers,their benefits are limited to a minority of patients with SCLC.In the present study,novel indicators for predicting the outcomes and molecular targets for SCLC treatment were elucidated.Methods:We conducted bioinformatics analysis to identify the key genes associated with tumor-infiltrating lymphocytes in SCLC.The functional role of the key gene identified in SCLC was determined both in vitro and in vivo.Results:A significant correlation was observed between patient survival and CD56dim natural killer(NK)cell proportion.Furthermore,we noted that the hub gene ubiquitin-specific protease 1(USP1)is closely correlated with both CD56dim NK cells and overall survival in SCLC.Bioinformatics analysis revealed that USP1 is upregulated in SCLC.In addition,gene set enrichment analysis revealed that USP1 overexpression hinders NK cell-mediated immune responses.By co-cultivating NK-92 cells with SCLC cells,we demonstrated that NK cell cytotoxicity against SCLC could be improved either via USP1 knock-down or pharmacological inhibition.Furthermore,using a nude-mice xenograft tumor model,we noted that USP1 inhibition effectively suppressed tumor proliferation and increased the expression of NK cell-associated markers.Conclusions:Our study findings highlight the importance of NK cells in regulating SCLC.USP1 overexpression can inhibit NK cell-mediated immunity;therefore,USP1 may serve not only as a prognostic biomarker but also as a potential molecular target of SCLC therapy.

Formation, distribution, and nature of Picea mongolica in China

Picea mongolica is an endemic and endangered species in China. Ecosystem made of Picea mongolica is a special sandy forest ecosystem in China. It is found at ecotone between forest and steppe, or agricultural district and pastoral area. Based on investigation, this paper discussed the formation and distribution of Picea mongolica and studied its nature according to ecotone theory. It is clarified that Picea mongolica belongs to Picea meyeri series. That is to say, it became a local race through long-term adaptation to the local climate, then formed allopatric semi-species, and finally turned into a taxonomical species. Picea mongolica forest is a super zonal climax community developing in ecotone between forest zone and steppe zone.

Population Density and Habitat Utilization of Ibex(Capra ibex)in Tomur National Nature Reserve,Xinjiang,China

Surveys was conducted to study the population density and habitat utilization of the ibex （Capra ibex） in Tomur National Nature Reserve during October- December 2005. The results are as follows： ① The mean group size of the ibex in Tomur Nature Reserve is 8.43 and the population density is 269.76/100 km^2; ② The ibex prefer areas with steep slope （between 30° -45°）, broken substrates and cliffs nearby （ 〈 100 m）. They avoid grasslands and fiat hillsides; ③The probable reason for this habitat selection is serf-protection.

Discussion on Action and Potential of Fenlong Megascience in the Symbiosis between Human and Nature

The fourth new farming model Fenlong is identified as megascience for the first time. Fenlong can be directly applied to farming of farmland, remoulding of mortar black soil and saline alkali land and development of degraded grassland. Deep loosening can create huge soil reservoirs, reduce fertilization, promote indi- rectly the improvement of river water fisheries and water sources and the upgrading of shaping and hydropower industry, thus making a new round of mobilization and pooling of natural resources. As a result, the nature is able to produce good food needed by human, the spatial dimension of the land is increased, the natural pre- cipitation storage is increased, the flood and drought disasters are reduced, the eco-environment is improved, and the economic benefits are increased. Fenlong is not restricted to global application by ecological region and crop variety and is not subject to the time-space constraints for a hundred thousand years. On the basis of utilizing the heaven and earth resources, it brings about a huge effect of mega- science. Compare with traditional farming, the depth under the mode of Fenlong is increased by 2-3 times, the contents of nutrient, water, oxygen and microorganism in the soil are increased by 10%-200%, the content of pale salt is increased by 20%-40%, the temperature is increased by 2-4 ~C, and the photosynthetic efficiency of crops is improved by 10%. Under the cultivation mode of Fenlong, the yield of crop applied with no fertilizers is increased by more than 10%, crop yield is still in- creased by more than 5% when the application amount of chemical fertilizer is re- duced by 10%-20%. Under the farming mode of Fenlong combined with no in- crease in fertilization, the crop yield, crop quality, farming efficiency, natural precipi- tation storage and air humidity are increased by 10%-50%, 5%, 15%, 100% and 5%, respectively, and the emissions of methane and other gases are reduced by more than 5%. Even in mortar black soil, saline alkali land and degraded grassland, the yield is still increased by 15%-50%. These improvement effects can last for many years, helping achieve the real harmonious coexistence between human and nature.

POPULATION AND CONSERVATION OF BLACK CRESTED GIBBONS ( Hylobates concolor jingdongensis ) IN WULIANG NATURE RESERVE,JINGDONG,YUNNAN

Population estimates of black crested gibbons in Wuliang Nature Reserve,Jingdong,Yunnan,China,with two techniques,average group density total area and average home rang forest coverage,produced quite similar results.The population was estimated around 115 groups in the Reserve.The paper also discussed the conservation problems of the Reserve.At present,the main threat to the gibbons is habitat fragmentation and population isolation.Thus,it is urgent to prohibit hunting and protect the habitat and forest corridors or habitat bridges.

Conflicts and Countermeasures between Haba Snow Mountain Nature Reserve and Development of Peripheral Communities

Using research approaches such as questionnaire investigation, interview, and Participatory Rural Appraisal (PAR), the relationship between Haba Snow Mountain Nature Reserve and peripheral communities was studied. The results showed that there are lots of conflicts between Haba Snow Mountain Nature Reserve and peripheral communities. On the one hand, conservation of natural environment brings inconvenience to the development of peripheral communities, such as limiting the use of resources, constraining space of development, resulting in economic losses, reducing tourist income, and low compensation. On the other hand, peripheral communities' development threats conservation of the natural environment, for instance, illegal deforestation, illegal mining, over-harvesting, over-grazing and non-ecotourism. Therefore, effective suggestions were given as "scientific planning of functional areas, enhancing economic compensation, devoting more in ecotourism development, and realizing the cooperation of communities".

Analysis of Forest Landscape Pattern in Nanling National Nature Reserve,Guangdong

[Objective] The study was to analyze the forest landscape in Nanling Na- tional Nature Reserve to provide information for the protection of local forest ecosys- tems. [Method] With the documents of 1：10 000 topographic maps, updated Forest Resource Inventory Data, based on the GIS platform and Fragstats software, the paper analyzed the patterns and heterogeneity of forest landscapes by adopting the landscape ecological theory and the method of landscape index. [Result] The forest landscape types, in terms of area occupation from large to small, are in the order of evergreen broad-leaved forest, coniferous mixed forest, evergreen and deciduous broad-leaved mixed forest, shrubs, mixed needle leaf forest, suitable land for forest deciduous broad-leaved forest and non-forest. [Conclusion] Overall, the Reserve had maintained sufficient forest landscape diversity with a low level fragmentation. The distribution of various types of forest landscape was extremely uneven, dominated by several types such as evergreen broad-leaved forest, coniferous forest, etc.

Discussion on Planning and Construction of Villages and Towns in Nature Reserve——A Case Study of Weitun Town of Hengshui City in China

The development of nature reserve was closely related with that of villages and towns at its surrounding area.It was the core issue to be discussed in the paper as to how to form mutually beneficial relation between them and achieve both protection of nature reserve and economic development of villages and towns.Through analysis on internal relation between nature reserve and villages and towns,it put forward three methods for planning and construction of villages and towns around the nature reserve.By taking Hengshui Lake National Nature Reserve in Weitun Town for example,it hoped to serve as a modest spur to induce exchange and discussion in the field.

Study on the Epistemology Development of the Correlation between Human Beings and Nature

This study aimed to alert people that the harmony between human beings and nature has already become an urgent problem. All people are responsible for maintaining the harmony, which is the also the inexorable trend of historical development. Reviewing the evolution history of human kind, the relationship between human beings and nature from harmony to imbalance, from imbalance to a new harmony was analyzed from the macro perspective, and it was pointed out that the present society is in the transitional phase from imbalance to a new harmony and also a phase that people are consciously coordinating their relationship with nature. It was found through the study that a harmonious society relies on the harmony between human beings and nature, and the latter is a necessary condition for a real harmonious society, however, people always forget such a principle. The imbalanced relationship between human beings and nature has seriously influenced many aspects of social harmony, and become instable factors in China and international society, even threatened the development and survival of human beings. Thus, all people should make joint efforts in creating win-win conditions for the development between human beings and nature, and ensuring offspring a healthy and green earth.

Remote Sensing Monitoring and Analysis of Responses of Ma Yang Francois Nature Reserve to Impoundment of Pengshui Reservoir

The ecological environmental changes of Francois langur natural reserve was monitored during Pengshui Reservoir construction and influence of reservoir fil-ing on the habitat of the natural reserve was analyzed to provide the scientific basis and basic data for scientific evaluation and protection of original ecological environ-ment of the natural reserve and Francois langur’s habitat, and vegetation recover. The results showed that 4.8 hm2 of the nature reserve was submerged after reser-voir fil ing, which occupied for 0.1% of total area of the natural reserve only. The main influence area was in the submerged area of Hongdu River basin. The water level rise resulted in partial changes in land utilization and soil erosion, which indi-cates that reservoir fil ing has insignificant effect on ecological environment of the whole natural reserve.

Chemistry:The Molecular Nature of Matter and Change评述

从内容编排、栏目设置、插图与版式设计等几个角度对美国普通化学教材Chemistry:The Molecular Nature ofMatter and Change的编写特色进行评析,以期对我国同类教材的编写提供参考。

Characteristics and the Issue of Eco-safety for the Plant Biodiversity in Longtan Nature Reserve

The characteristic and status quo of plant biodiversity in Longtan Nature Reserve was evaluated from the three aspects of species diversity, genetic diversity and ecosystem dioversity. And the primary eco-safety influencing factors for plant biodiversity in Longtan nature reserve were put forward. The results show that the plant species in Longtan Nature Reserve was abundant, including 2 821 species of vascular bundle plants belonging to 1029 genera, 205 families. The main problems influencing eco-safety included the destruction of endangered wild plants and exotic species invasion.

ON THE DIFFERENCES OF THE NATURES OF AUPOINTS AND CHINESE HERBAL MEDICINES

The acupoints and Chinese herbal medicines are quite different in their natures. In the present paper, the authors expound the differences of the natures between the acupoints and Chinese herbal medicines from a） substance carriers, b） the underlying mechanism in actions, and c） individual characteristics, etc..

Study on the Construction of "Near Nature" Waterfront Greening Landscape

The construction of 'Near Nature' waterfront greening landscape is a kind of waterfront construction model that complies with the nature and balances ecological landscape and regional development, which is of great significance to restore the healthy waterfront ecosystem and sustainable development. Starting from the conception and characteristics of 'Near Nature' waterfront greening areas, the design principles and construction schemes of waterfront greening landscape such as river, lake, canal and wetland were studied.

The Ecological Landscape with the Integration of Humanistic Culture and Nature Environment —A Case Study of Landscape Transformation in Baoyan Eco-Tourism Garden of Changshu City

Based on the landscape ecology theory,this paper analyzed the ecology concept and the existing misconceptions of landscape design from the perspective of ecology.The misconceptions included the excessive using of ecological concepts,undue emphasis on the natural features of ecology,and endowing landscape with human cultural blindly.Taking Baoyan eco-tourism garden landscape renovation as an example,this study analyzed the superior natural conditions of this garden,the negative status in the current development process which included the conservative development and construction,singleness of entertainment,cultural educational and the other activities,disorder of landscape structure,lack of cultural landscape,weakness of landscape features and the unremarkable competitive advantages.To construct an ecological landscape with integration of humanistic and nature features,this paper proposed "ecological gardens" as the theme,following the design concept which made full integration of creating cultural landscape with the improvement and protection of natural ecological environment.Finally,the author elaborated such kind of ecological landscape from the following 4 aspects,including the integration,protection,restoration,and creation of landscape.