The Effect of Nebulized Budesonide Inhalation in Treating Children with Asthma and its Influence on Immune Indexes

Objective:To explore and analyze the effect of nebulized budesonide inhalation on children with asthma and its influence on immune indexes.Methods:300 children who were with asthma admitted to the Pediatric Respiratory Department of our hospital from January 2021 to January 2023 were selected as the research subjects.The patients were divided into a nebulization group(n=150)and a reference group(n=150)by drawing lots.The nebulization group received routine treatment along with budesonide nebulization inhalation therapy,while the reference group only received routine treatment.The treatment effect,the immune indicators,the time taken for the disappearance of symptoms,and the pulmonary function indicators of both groups were compared.Results:The total efficacy of treatment received in the nebulization group was significantly higher than that in the reference group(P<0.05).Before treatment,there was no statistically significant difference in the CD4^(+),CD8^(+),CD4^(+)/CD8^(+),between the two groups(P>0.05);after treatment,the nebulization group’s CD4^(+),CD8^(+),CD4^(+)/CD8^(+)and other immune indicators were significantly better than the reference group(P<0.05).The time taken for the disappearance of symptoms like wheezing,coughing,crackles,shortness of breath,and other symptoms in the nebulization group was significantly shorter than in the reference group(P<0.05).Before treatment,there was no statistically significant difference in the pulmonary function indexes such as FEV1,PEF,and FVC between the two groups(P>0.05);after treatment,the pulmonary function indexes of the patients in the nebulization group were significantly better than those in the reference group(P<0.05).Conclusion:Nebulized budesonide inhalation therapy has shown significant efficacy in the treatment of pediatric asthma,with notable improvements in immune indicators.Therefore,it is worthy of recommendation and further promotion.

From mesenchymal stem cells to their extracellular vesicles:Progress and prospects for asthma therapy

Asthma is a widespread public health concern,with an increasing incidence.Despite the implementation of current treatment strategies,asthma control,particularly for severe cases,remains suboptimal.Recent research has revealed the encouraging prospects of extracellular vesicles(EVs)secreted by mesenchymal stem cells(MSCs)as a viable therapeutic option for alleviating asthma symptoms.Therefore,the present review aims to provide an overview of the current progress and the therapeutic mechanisms of using MSC-derived EVs(MSC-EVs)for asthma treatment.Additionally,different administration approaches for EVs and their impacts on biodistribution and the curative outcomes of EVs are summarized.Notably,the potential benefits of nebulized inhalation of MSC-EVs are addressed.Also,the possibilities and challenges of using MSC-EVs for asthma treatment in clinics are highlighted.Overall,this reviewis intended to give newinsight into the utilization of MSC-EVs as a potential biological drug for asthma treatment.