BACKGROUND Cardiovascular disease,particularly myocardial infarction(MI)profound impact on patients'quality of life and places a substantial burden on the healthcare and economy systems.Developments in medical tec...BACKGROUND Cardiovascular disease,particularly myocardial infarction(MI)profound impact on patients'quality of life and places a substantial burden on the healthcare and economy systems.Developments in medical technology have led to the emer-gence of coronary intervention as an essential method for treating MI.AIM To assess the effects of cardiac rehabilitation care on cardiac function recovery and negative emotions in MI after coronary intervention.METHODS This study included a total of 180 patients with MI during the period from June 2022 to July 2023.Selected patients were divided into two groups:An observation group,which receiving cardiac rehabilitation care;a control group,which re-ceiving conventional care.By comparing multiple observation indicators such as cardiac function indicators,blood pressure,exercise tolerance,occurrence of adverse cardiac events,and negative emotion scores between the two groups of patients.All the data were analyzed and compared between two groups.RESULTS There were 44 males and 46 females in the observation group with an average age of 36.26±9.88 yr;there were 43 males and 47 females in the control group,with an average age of 40.87±10.5 yr.After receiving the appropriate postoperative nursing measures,the results of the observation group showed significant improvement in several indicators compared with the control group.Indicators of cardiac function,such as left ventricular end-diastolic internal diameter and left ventricular ejection fraction were significantly better in the observation group than in the control group(P<0.05).Exercise endurance assessment showed that the 6-minute walking test distance was significantly increased in the patients of the observation group(P<0.01).In addition,the incidence of adverse cardiac events was significantly lower in the observation group,and negative mood scores were significantly reduced(P<0.05).CONCLUSION Cardiac rehabilitation care after coronary intervention has a significant positive impact on functional recovery.This emphasizes the importance of cardiac rehabilitation care to improve patient recovery.展开更多
Development of electrodes with high electrocatalytic activity and stability is essential for solving problems that still restrict the extensive application of vanadium redox flow batteries(VRFBs).Here,we designed a no...Development of electrodes with high electrocatalytic activity and stability is essential for solving problems that still restrict the extensive application of vanadium redox flow batteries(VRFBs).Here,we designed a novel negative electrode with superior electrocatalytic activity by tailoring nitrogen functional groups,such as newly formed nitro and pyridinic-N transformed to pyridonic-N,from the prenitrogen-doped electrode.It was experimentally confirmed that an electrode with pyridonic-N and nitro fuctional groups(tailored nitrogen-doped graphite felt,TNGF) has superior electrocatalytic acivity with enhanced electron and mass transfer.Density functional theory calulations demonstrated the pyridonic-N and nitro functional groups promoted the adsorption,charge transfer,and bond formation with the vanadium species,which is consistent with expermental results.In addition,the V2+/V3+redox reaction mechanism on pyridonic-N and nitro functional groups was estabilised based on density functional theory(DFT) results.When TNGF was applied to a VRFB,it enabled enhanced-electrolyte utilization and energy efficiencies(EE) of 57.9% and 64.6%,respectively,at a current density of 250 mA cm^(-2).These results are 18.6% and 8.9% higher than those of VRFB with electrode containing graphitic-N and pyridinicN groups.Interestingly,TNGF-based VRFB still operated with an EE of 59% at a high current density of300 mA cm^(-2).The TNGF-based VRFB exhibited stable cycling performance without noticeable decay of EE over 450 charge-discharge cycles at a current density of 250 mA cm^(-2).The results of this study suggest that introducing pyridonic-N and nitro groups on the electrode is effective for improving the electrochemical performance of VRFBs.展开更多
Lithium–sulfur batteries are one of the attractive next-generation energy storage systems owing to theienvironmental friendliness,low cost,and high specific energy densities.However,the low electrical conductivity of...Lithium–sulfur batteries are one of the attractive next-generation energy storage systems owing to theienvironmental friendliness,low cost,and high specific energy densities.However,the low electrical conductivity of sulfur,shuttling of soluble intermediate polysulfides between electrodes,and low capacitretention have hampered their commercial use.To address these issues,we use a halloysitemodulated(H-M)separator in a lithium–sulfur battery to mitigate the shuttling problem.The H-M separator acts as a mutual Coulombic repulsion in lithium-sulfur batteries,thereby selectively permitting Lions and efficiently suppressing the transfer of undesired lithium polysulfides to the Li anode sideMoreover,the use of halloysite switches the surface of the separator from hydrophobic to hydrophilicconsequently improving the electrolyte wettability and adhesion between the separator and cathodeWhen sulfur-multi-walled carbon nanotube(S-MWCNT)composites are used as cathode active materialsa lithium–sulfur battery with an H-M separator exhibits first discharge and charge capacities of 1587 an1527 m Ah g-1,respectively.Moreover,there is a consistent capacity retention up to 100 cyclesAccordingly,our approach demonstrates an economical and easily accessible strategy for commercialization of lithium–sulfur batteries.展开更多
By using the technique of integration within an ordered product (IWOP) of operator we derive Wigner function of density operator for negative binomial distribution of radiation field in the mixed state case, then we...By using the technique of integration within an ordered product (IWOP) of operator we derive Wigner function of density operator for negative binomial distribution of radiation field in the mixed state case, then we derive the Wigner function of squeezed number state, which yields negative binomial distribution by virtue of the entangled state representation and the entangled Wigner operator.展开更多
Double negative in English has three functions: to strengthen the affirmatives, and to affirm euphemism and to strengthen the negative meaning, which are analyzed in the present paper.
Using the thermal-entangled state representation and the operator-ordering method, we investigate Wigner function(WF) for the squeezed negative binomial state(SNBS) and the analytical evolution law of density operator...Using the thermal-entangled state representation and the operator-ordering method, we investigate Wigner function(WF) for the squeezed negative binomial state(SNBS) and the analytical evolution law of density operator in the amplitude decay channel.The results show that the analytical WF is related to the square of the module of single-variable Hermite polynomials, which leads to a new two-variable special function and its generating function, and the parameters s and γplay opposite roles in the WF distributions.Besides, after undergoing this channel, the initial pure SNBS evolves into a new mixed state related to two operator Hermite polynomials within normal ordering, and fully loses its nonclassicality and decays to vacuum at long decay time.展开更多
In this paper we consider the class ∑^*(p,α,β,k,c) consisting of analytic functions with negativecoefficients and fixed second coefficient. The object of the present paper is to give coefficient estimates, conve...In this paper we consider the class ∑^*(p,α,β,k,c) consisting of analytic functions with negativecoefficients and fixed second coefficient. The object of the present paper is to give coefficient estimates, convex linear combinations, some distortion theorems and radii of starlikeness and convexity for f(z) in the class ∑^*(p,α,β,k,c) .展开更多
Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocy-toma formation and progression.In an effort to identify novel gene expression changes associated with astr...Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocy-toma formation and progression.In an effort to identify novel gene expression changes associated with astrocytomaformation,which might reveal new potential targets for glioma therapeutic drug design,we used the B8-RAS-transgenic mouse astrocytoma model.Using multiplex gene expression profiling,we found that展开更多
We study special functions related to Lotka-Volterra equations and negative Volterra equation intro-duced from zero curvature representations . At first we show the relationships between Lotka-Volterra equations intro...We study special functions related to Lotka-Volterra equations and negative Volterra equation intro-duced from zero curvature representations . At first we show the relationships between Lotka-Volterra equations introduced from zero curvature representations and symmetric orthogonal polynomials. Sec-ondarily, we describe the relationships between negative Volterra equations with a special solutions and cylinder functions.展开更多
Negative symptoms of schizophrenia including social withdrawal, diminished affective response, lack of interest, poor social drive, and decreased sense of purpose or goal directed activity predict poor functional outc...Negative symptoms of schizophrenia including social withdrawal, diminished affective response, lack of interest, poor social drive, and decreased sense of purpose or goal directed activity predict poor functional outcomes for patients with schizophrenia. They may develop and be maintained as a result of structural and functional brain abnormalities, particularly associated with dopamine reward pathways and by environmental and psychosocial factors such as self-defeating cognitions and the relief from overstimulation that accompanies withdrawal from social and role functioning. Negative symptoms are more difficult to treat than the positive symptoms of schizophrenia and represent an unmet therapeutic need for large numbers of patients with schizophrenia. While antipsychotic medications to treat the symptoms of schizophrenia have been around for decades, they have done little to address the significant functional impairments in the disorder that are associated with negative symptoms. Negative symptoms and the resulting loss in productivity are responsible for much of the world-wide personal and economic burden of schizophrenia. Pharmacologic treatments may be somewhat successful in treating secondary causes of negative symptoms, such as antipsychotic side effects and depression. However, in the United States there are no currently approved treatments for severe and persistent negative symptoms(PNS) that are not responsive to treatments for secondary causes. Pharmacotherapy and psychosocial treatments are currently being developed and tested with severe and PNS as their primary targets. Academia, clinicians, the pharmaceutical industry, research funders, payers and regulators will need to work together to pursue novel treatments to address this major public health issue.展开更多
Let Γ?R;be a regular anisotropic fractal. We discuss the problem of the negative spectrum for the Schr?dinger operators associated with the formal expression H;=id-?+βtr;,β∈R,acting in the anisotropic Sobolev spac...Let Γ?R;be a regular anisotropic fractal. We discuss the problem of the negative spectrum for the Schr?dinger operators associated with the formal expression H;=id-?+βtr;,β∈R,acting in the anisotropic Sobolev space W;(R;), where ? is the Dirichlet Laplanian in R;and tr;is a fractal potential(distribution) supported by Γ.展开更多
Previous studies have reported that individual differences in reappraisal use are associated with partJcular patterns of neural activity. We hypothesized that if 'high reappraisers' (individuals who use reappraisal...Previous studies have reported that individual differences in reappraisal use are associated with partJcular patterns of neural activity. We hypothesized that if 'high reappraisers' (individuals who use reappraisal well in a behavioral experiment) completed two training sessions, they would exhibit more reliable patterns of neural activity related to cognitive reappraisal. In the present study, 13 high reappraisers were selected from 27 healthy volunteers through an initial behavioral experiment (first training) followed by a functional MRI experiment (second training). Emotional images selected from the International Affective Picture System were used for both the behavioral and functional MRI sessions of the experiment. The behavioral results revealed that reappraisal reduced subjective unpleasantness. The functional MRI results revealed that the cognitive reappraisal used by high reappraisers decreased the activation of emotion-responsive regions, including the amygdala, insula, and cingulate gyrus, and increased the activation of regulation-related regions, including the inferior prefrontal cortex, orbital prefrontal cortex, and dorsal medial prefrontal cortex. These findings suggest the involvement of inferior orbital and dorsal medial prefrontal cortex in constructing reappraisal strategies that modulate activity in emotion-processing systems.展开更多
Mechanical properties, such as the deformation and stress distributions for venous walls under the combined load of transmural pressure and axial stretch, are examined within the framework of nonlinear elasticity with...Mechanical properties, such as the deformation and stress distributions for venous walls under the combined load of transmural pressure and axial stretch, are examined within the framework of nonlinear elasticity with one kind of hyper-elastic strain energy functions. The negative pressure instability problem of the venous wall is explained through energy comparison. First, the deformation equation of the venous wall under the combined loads is obtained with a thin-walled circular cylindrical tube. The deformation curves and the stress distributions for the venous wall are given under the normal transmural pressure, and the regulations are discussed. Then, the deformation curves of the venous wall under the negative transmural pressure or the internal pressure less than the external pressure are given. Finally, the negative pressure instability problem is discussed through energy comparison.展开更多
In this paper,dependent and independent variable transformations are introduced to solve the negativemKdV equation systematically by using the knowledge of elliptic equation and Jacobian elliptic functions.It is shown...In this paper,dependent and independent variable transformations are introduced to solve the negativemKdV equation systematically by using the knowledge of elliptic equation and Jacobian elliptic functions.It is shownthat different kinds of solutions can be obtained to the negative mKdV equation,including breather lattice solution andperiodic wave solution.展开更多
Objective :To overall evaluate the change of global cardiac systolic performance and diastolic filling in hypovoleamia by LBNP, Methods:10 healthy male subjects were placed in a standard LBNP chamber. Baseline haemo...Objective :To overall evaluate the change of global cardiac systolic performance and diastolic filling in hypovoleamia by LBNP, Methods:10 healthy male subjects were placed in a standard LBNP chamber. Baseline haemodynamic and echocardiographic measurements were made after a period of least 10 min resting supine within the chamber. Pressure was then decreased to -10,-20 and -30 mmHg, with each pressure maintained for 15 rain. The indices of four transvalvular and SVC flow were measured using Doppler echocardiography. Results :The results showed that S wave, Re wave ,and VTI of SVC progressively decreased with increasing LBNP. At -30 mmHg stage, S wave decreased by 35.4 % (change of 0.21±0.03 m/s, P 〈 0.001). This reduction in pre-load Was associated with a progressive decrease in SV(by 21.5 ± 4.5 ml at -30 mmHg,P 〈 0.001 ), decrease in CO(by 1.2 ± 0.2 L min^-1 at -30 mmHg LBNP,P 〈 0.001 ). The diastolic filling of mitral and tricuspid flow also reduced significantly. At -30 mmHg stage, the E wave of MVF and TVF decreased 31% and 32% respectively (change of 0.23 ± 0.05 m/s,P 〈 0.001 and 0.18 ± 0.01 m/s,P 〈 0.001). VTI of MVF and TVF decreased 27% and 27.7% respectively(change of 5.55 ± 1.41cm,P 〈 0.01 and 4.25 ± 0.44 cm,P 〈 0.01). A wave of both sides did not change significantly. Conclusion:Doppler indices changes in different LBNP stage can roughly reflect the degree of hypovoleamia caused by blood volume redistribution. The indices of Doppler echocardiography are more sensitive than traditional physiological indexes in evaluating cardiovascular responses of LBNP. Echocardiography techniques overall can evaluate the global cardiac function including systolic performance and diastolic filling.展开更多
Zero-inflated negative binomial distribution is characterized in this paper through a linear differential equation satisfied by its probability generating function.
A kind of mixed tensor product negative Bemstein-B6zier basis function is presented in this paper. Some important prop- erties of this kind of basis function are discussed and mixed tensor product negative Bemstein-B6...A kind of mixed tensor product negative Bemstein-B6zier basis function is presented in this paper. Some important prop- erties of this kind of basis function are discussed and mixed tensor product negative Bemstein-B6zier is defined based on it. The ba- sic properties of the such surface are discussed. Via de Casteljan algorithm, the evaluation algorithm and subdivision algorithm for mixed tensor product negative Bernstein-B6zier surfaces are derived as extensions of the algorithms of B6zier curves and negative Bernstein curves.展开更多
In China,numerous cities are expanding into sloping land,yet the quantitative distribution patterns of urban built-up land density along the slope gradient remain unclear,limiting the understanding of sloping land urb...In China,numerous cities are expanding into sloping land,yet the quantitative distribution patterns of urban built-up land density along the slope gradient remain unclear,limiting the understanding of sloping land urbanization.In this paper,a simple negative exponential function was presented to verify its applicability in 19 typical sloping urban areas in China.The function fits well for all case urban areas(R^(2)≥0.951,p<0.001).The parameters of this function clearly describe two fundamental attributes:initial value a and decline rate b.Between 2000 and 2020,a tends to increase,while b tends to decrease in all urban areas,confirming the hypothesis of mutual promotion between flatland densification and sloping land expansion.Multiple regression analysis indicates that the built-up land density and the ruggedness of background land can explain 70.7%of a,while the average slope ratio of built-up land to background land,the built-up land density and the built-up land area can explain 82.1%of b.This work provides a quantitative investigative tool for distribution of urban built-up land density along slope gradient,aiding in the study of the globally increasing phenomenon of sloping land urbanization from a new perspective.展开更多
BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitiv...BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitive function,anxiety,and depression in patients undergoing this procedure.AIM To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function,anxiety,depression,and organ function in patients undergoing radical resection of gastric cancer.METHODS A total of 80 patients were involved in this research.The subjects were divided into two groups:Propofol group and sevoflurane group.The evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment(LOTCA),and anxiety and depression were assessed with the aid of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Hemodynamic indicators,oxidative stress levels,and pulmonary function were also measured.RESULTS The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane group.Additionally,the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol group.The sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol group.Moreover,the sevoflurane group displayed better pulmonary function and less lung injury than the propofol group.CONCLUSION Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric cancer.Propofol anesthesia has a minimal effect on patients'pulmonary function,consequently enhancing their postoperative recovery.Sevoflurane anesthesia causes less impairment on patients'cognitive function and mitigates negative emotions,leading to an improved postoperative mental state.Therefore,the selection of anesthetic agents should be based on the individual patient's specific circumstances.展开更多
文摘BACKGROUND Cardiovascular disease,particularly myocardial infarction(MI)profound impact on patients'quality of life and places a substantial burden on the healthcare and economy systems.Developments in medical technology have led to the emer-gence of coronary intervention as an essential method for treating MI.AIM To assess the effects of cardiac rehabilitation care on cardiac function recovery and negative emotions in MI after coronary intervention.METHODS This study included a total of 180 patients with MI during the period from June 2022 to July 2023.Selected patients were divided into two groups:An observation group,which receiving cardiac rehabilitation care;a control group,which re-ceiving conventional care.By comparing multiple observation indicators such as cardiac function indicators,blood pressure,exercise tolerance,occurrence of adverse cardiac events,and negative emotion scores between the two groups of patients.All the data were analyzed and compared between two groups.RESULTS There were 44 males and 46 females in the observation group with an average age of 36.26±9.88 yr;there were 43 males and 47 females in the control group,with an average age of 40.87±10.5 yr.After receiving the appropriate postoperative nursing measures,the results of the observation group showed significant improvement in several indicators compared with the control group.Indicators of cardiac function,such as left ventricular end-diastolic internal diameter and left ventricular ejection fraction were significantly better in the observation group than in the control group(P<0.05).Exercise endurance assessment showed that the 6-minute walking test distance was significantly increased in the patients of the observation group(P<0.01).In addition,the incidence of adverse cardiac events was significantly lower in the observation group,and negative mood scores were significantly reduced(P<0.05).CONCLUSION Cardiac rehabilitation care after coronary intervention has a significant positive impact on functional recovery.This emphasizes the importance of cardiac rehabilitation care to improve patient recovery.
基金financially supported by the Research Program from Korea Institute of Industrial Technology(EM220011)the Technology Innovation Program(20020229,Development of technology for manufacturing catalysts and electrode parts by use of low contents precious metals of rare metals) funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea)+2 种基金the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT)(2022R1F1A1072569)supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science,ICT & Future Planning(NRF2020R1C1C1010493)“Regional Innovation Strategy(RIS)” through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(MOE)(2021RIS-004)。
文摘Development of electrodes with high electrocatalytic activity and stability is essential for solving problems that still restrict the extensive application of vanadium redox flow batteries(VRFBs).Here,we designed a novel negative electrode with superior electrocatalytic activity by tailoring nitrogen functional groups,such as newly formed nitro and pyridinic-N transformed to pyridonic-N,from the prenitrogen-doped electrode.It was experimentally confirmed that an electrode with pyridonic-N and nitro fuctional groups(tailored nitrogen-doped graphite felt,TNGF) has superior electrocatalytic acivity with enhanced electron and mass transfer.Density functional theory calulations demonstrated the pyridonic-N and nitro functional groups promoted the adsorption,charge transfer,and bond formation with the vanadium species,which is consistent with expermental results.In addition,the V2+/V3+redox reaction mechanism on pyridonic-N and nitro functional groups was estabilised based on density functional theory(DFT) results.When TNGF was applied to a VRFB,it enabled enhanced-electrolyte utilization and energy efficiencies(EE) of 57.9% and 64.6%,respectively,at a current density of 250 mA cm^(-2).These results are 18.6% and 8.9% higher than those of VRFB with electrode containing graphitic-N and pyridinicN groups.Interestingly,TNGF-based VRFB still operated with an EE of 59% at a high current density of300 mA cm^(-2).The TNGF-based VRFB exhibited stable cycling performance without noticeable decay of EE over 450 charge-discharge cycles at a current density of 250 mA cm^(-2).The results of this study suggest that introducing pyridonic-N and nitro groups on the electrode is effective for improving the electrochemical performance of VRFBs.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIP)(No.2018R1C1B6004689)the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(No.2020R1I1A306182111)the Electronics and Telecommunications Research Institute(ETRI)grant funded by the Korean government(21ZB1200,Development of ICT Materials,Components and Equipment Technologies)。
文摘Lithium–sulfur batteries are one of the attractive next-generation energy storage systems owing to theienvironmental friendliness,low cost,and high specific energy densities.However,the low electrical conductivity of sulfur,shuttling of soluble intermediate polysulfides between electrodes,and low capacitretention have hampered their commercial use.To address these issues,we use a halloysitemodulated(H-M)separator in a lithium–sulfur battery to mitigate the shuttling problem.The H-M separator acts as a mutual Coulombic repulsion in lithium-sulfur batteries,thereby selectively permitting Lions and efficiently suppressing the transfer of undesired lithium polysulfides to the Li anode sideMoreover,the use of halloysite switches the surface of the separator from hydrophobic to hydrophilicconsequently improving the electrolyte wettability and adhesion between the separator and cathodeWhen sulfur-multi-walled carbon nanotube(S-MWCNT)composites are used as cathode active materialsa lithium–sulfur battery with an H-M separator exhibits first discharge and charge capacities of 1587 an1527 m Ah g-1,respectively.Moreover,there is a consistent capacity retention up to 100 cyclesAccordingly,our approach demonstrates an economical and easily accessible strategy for commercialization of lithium–sulfur batteries.
基金the Natural Science Foundation of Heze University of Shandong Province of China under Grant Nos.XY07WL01 and XY05WL01the University Experimental Technology Foundation of Shandong Province of China under Grant No.S04W138
文摘By using the technique of integration within an ordered product (IWOP) of operator we derive Wigner function of density operator for negative binomial distribution of radiation field in the mixed state case, then we derive the Wigner function of squeezed number state, which yields negative binomial distribution by virtue of the entangled state representation and the entangled Wigner operator.
文摘Double negative in English has three functions: to strengthen the affirmatives, and to affirm euphemism and to strengthen the negative meaning, which are analyzed in the present paper.
基金Project supported by the National Natural Science Foundation of China(Grant No.11347026)the Natural Science Foundation of Shandong Province,China(Grant Nos.ZR2016AM03 and ZR2017MA011)
文摘Using the thermal-entangled state representation and the operator-ordering method, we investigate Wigner function(WF) for the squeezed negative binomial state(SNBS) and the analytical evolution law of density operator in the amplitude decay channel.The results show that the analytical WF is related to the square of the module of single-variable Hermite polynomials, which leads to a new two-variable special function and its generating function, and the parameters s and γplay opposite roles in the WF distributions.Besides, after undergoing this channel, the initial pure SNBS evolves into a new mixed state related to two operator Hermite polynomials within normal ordering, and fully loses its nonclassicality and decays to vacuum at long decay time.
基金The work is supported by UKM grant ST-028-2003 IRPA grant 09-02-02-80 EA208, Malysia.
文摘In this paper we consider the class ∑^*(p,α,β,k,c) consisting of analytic functions with negativecoefficients and fixed second coefficient. The object of the present paper is to give coefficient estimates, convex linear combinations, some distortion theorems and radii of starlikeness and convexity for f(z) in the class ∑^*(p,α,β,k,c) .
文摘Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocy-toma formation and progression.In an effort to identify novel gene expression changes associated with astrocytomaformation,which might reveal new potential targets for glioma therapeutic drug design,we used the B8-RAS-transgenic mouse astrocytoma model.Using multiplex gene expression profiling,we found that
文摘We study special functions related to Lotka-Volterra equations and negative Volterra equation intro-duced from zero curvature representations . At first we show the relationships between Lotka-Volterra equations introduced from zero curvature representations and symmetric orthogonal polynomials. Sec-ondarily, we describe the relationships between negative Volterra equations with a special solutions and cylinder functions.
文摘Negative symptoms of schizophrenia including social withdrawal, diminished affective response, lack of interest, poor social drive, and decreased sense of purpose or goal directed activity predict poor functional outcomes for patients with schizophrenia. They may develop and be maintained as a result of structural and functional brain abnormalities, particularly associated with dopamine reward pathways and by environmental and psychosocial factors such as self-defeating cognitions and the relief from overstimulation that accompanies withdrawal from social and role functioning. Negative symptoms are more difficult to treat than the positive symptoms of schizophrenia and represent an unmet therapeutic need for large numbers of patients with schizophrenia. While antipsychotic medications to treat the symptoms of schizophrenia have been around for decades, they have done little to address the significant functional impairments in the disorder that are associated with negative symptoms. Negative symptoms and the resulting loss in productivity are responsible for much of the world-wide personal and economic burden of schizophrenia. Pharmacologic treatments may be somewhat successful in treating secondary causes of negative symptoms, such as antipsychotic side effects and depression. However, in the United States there are no currently approved treatments for severe and persistent negative symptoms(PNS) that are not responsive to treatments for secondary causes. Pharmacotherapy and psychosocial treatments are currently being developed and tested with severe and PNS as their primary targets. Academia, clinicians, the pharmaceutical industry, research funders, payers and regulators will need to work together to pursue novel treatments to address this major public health issue.
基金supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.13KJB110010)the Pre Study Foundation of Nanjing University of Finance&Economics(Grant No.YYJ2013016)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘Let Γ?R;be a regular anisotropic fractal. We discuss the problem of the negative spectrum for the Schr?dinger operators associated with the formal expression H;=id-?+βtr;,β∈R,acting in the anisotropic Sobolev space W;(R;), where ? is the Dirichlet Laplanian in R;and tr;is a fractal potential(distribution) supported by Γ.
基金supported by the National Natural Science Foundation of China, No. 30970890, 30770708 and 31100746the Scientific Foundation of Institute of Psychology,Chinese Academy of Sciences, No. Y0CX451S01+2 种基金the National Basic Research Program of China, No. 2010CB833904the Knowledge Innovation Program of the Chinese Academy of Sciences, No. KSCX2-EW-J-8Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
文摘Previous studies have reported that individual differences in reappraisal use are associated with partJcular patterns of neural activity. We hypothesized that if 'high reappraisers' (individuals who use reappraisal well in a behavioral experiment) completed two training sessions, they would exhibit more reliable patterns of neural activity related to cognitive reappraisal. In the present study, 13 high reappraisers were selected from 27 healthy volunteers through an initial behavioral experiment (first training) followed by a functional MRI experiment (second training). Emotional images selected from the International Affective Picture System were used for both the behavioral and functional MRI sessions of the experiment. The behavioral results revealed that reappraisal reduced subjective unpleasantness. The functional MRI results revealed that the cognitive reappraisal used by high reappraisers decreased the activation of emotion-responsive regions, including the amygdala, insula, and cingulate gyrus, and increased the activation of regulation-related regions, including the inferior prefrontal cortex, orbital prefrontal cortex, and dorsal medial prefrontal cortex. These findings suggest the involvement of inferior orbital and dorsal medial prefrontal cortex in constructing reappraisal strategies that modulate activity in emotion-processing systems.
基金Project supported by the National Natural Science Foundation of China (Nos. 10772104 and 10872045)the Innovation Project of Shanghai Municipal Education Commission (No. 09YZ12)the Shanghai Leading Academic Discipline Project (No. S30106)
文摘Mechanical properties, such as the deformation and stress distributions for venous walls under the combined load of transmural pressure and axial stretch, are examined within the framework of nonlinear elasticity with one kind of hyper-elastic strain energy functions. The negative pressure instability problem of the venous wall is explained through energy comparison. First, the deformation equation of the venous wall under the combined loads is obtained with a thin-walled circular cylindrical tube. The deformation curves and the stress distributions for the venous wall are given under the normal transmural pressure, and the regulations are discussed. Then, the deformation curves of the venous wall under the negative transmural pressure or the internal pressure less than the external pressure are given. Finally, the negative pressure instability problem is discussed through energy comparison.
基金Supported by National Natural Science Foundation of China under Grant No.90511009National Basic Research Program of China under Grant Nos.2006CB403600 and 2005CB42204
文摘In this paper,dependent and independent variable transformations are introduced to solve the negativemKdV equation systematically by using the knowledge of elliptic equation and Jacobian elliptic functions.It is shownthat different kinds of solutions can be obtained to the negative mKdV equation,including breather lattice solution andperiodic wave solution.
文摘Objective :To overall evaluate the change of global cardiac systolic performance and diastolic filling in hypovoleamia by LBNP, Methods:10 healthy male subjects were placed in a standard LBNP chamber. Baseline haemodynamic and echocardiographic measurements were made after a period of least 10 min resting supine within the chamber. Pressure was then decreased to -10,-20 and -30 mmHg, with each pressure maintained for 15 rain. The indices of four transvalvular and SVC flow were measured using Doppler echocardiography. Results :The results showed that S wave, Re wave ,and VTI of SVC progressively decreased with increasing LBNP. At -30 mmHg stage, S wave decreased by 35.4 % (change of 0.21±0.03 m/s, P 〈 0.001). This reduction in pre-load Was associated with a progressive decrease in SV(by 21.5 ± 4.5 ml at -30 mmHg,P 〈 0.001 ), decrease in CO(by 1.2 ± 0.2 L min^-1 at -30 mmHg LBNP,P 〈 0.001 ). The diastolic filling of mitral and tricuspid flow also reduced significantly. At -30 mmHg stage, the E wave of MVF and TVF decreased 31% and 32% respectively (change of 0.23 ± 0.05 m/s,P 〈 0.001 and 0.18 ± 0.01 m/s,P 〈 0.001). VTI of MVF and TVF decreased 27% and 27.7% respectively(change of 5.55 ± 1.41cm,P 〈 0.01 and 4.25 ± 0.44 cm,P 〈 0.01). A wave of both sides did not change significantly. Conclusion:Doppler indices changes in different LBNP stage can roughly reflect the degree of hypovoleamia caused by blood volume redistribution. The indices of Doppler echocardiography are more sensitive than traditional physiological indexes in evaluating cardiovascular responses of LBNP. Echocardiography techniques overall can evaluate the global cardiac function including systolic performance and diastolic filling.
文摘Zero-inflated negative binomial distribution is characterized in this paper through a linear differential equation satisfied by its probability generating function.
文摘A kind of mixed tensor product negative Bemstein-B6zier basis function is presented in this paper. Some important prop- erties of this kind of basis function are discussed and mixed tensor product negative Bemstein-B6zier is defined based on it. The ba- sic properties of the such surface are discussed. Via de Casteljan algorithm, the evaluation algorithm and subdivision algorithm for mixed tensor product negative Bernstein-B6zier surfaces are derived as extensions of the algorithms of B6zier curves and negative Bernstein curves.
基金supported by the project of the National Natural Science Foundation of China entitled“Distribution and change characteristics of construction land on slope gradient in mountainous cities of southern China”(No.41961039).
文摘In China,numerous cities are expanding into sloping land,yet the quantitative distribution patterns of urban built-up land density along the slope gradient remain unclear,limiting the understanding of sloping land urbanization.In this paper,a simple negative exponential function was presented to verify its applicability in 19 typical sloping urban areas in China.The function fits well for all case urban areas(R^(2)≥0.951,p<0.001).The parameters of this function clearly describe two fundamental attributes:initial value a and decline rate b.Between 2000 and 2020,a tends to increase,while b tends to decrease in all urban areas,confirming the hypothesis of mutual promotion between flatland densification and sloping land expansion.Multiple regression analysis indicates that the built-up land density and the ruggedness of background land can explain 70.7%of a,while the average slope ratio of built-up land to background land,the built-up land density and the built-up land area can explain 82.1%of b.This work provides a quantitative investigative tool for distribution of urban built-up land density along slope gradient,aiding in the study of the globally increasing phenomenon of sloping land urbanization from a new perspective.
文摘BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer.However,there is a debate concerning their differential effects on cognitive function,anxiety,and depression in patients undergoing this procedure.AIM To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function,anxiety,depression,and organ function in patients undergoing radical resection of gastric cancer.METHODS A total of 80 patients were involved in this research.The subjects were divided into two groups:Propofol group and sevoflurane group.The evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment(LOTCA),and anxiety and depression were assessed with the aid of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Hemodynamic indicators,oxidative stress levels,and pulmonary function were also measured.RESULTS The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane group.Additionally,the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol group.The sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol group.Moreover,the sevoflurane group displayed better pulmonary function and less lung injury than the propofol group.CONCLUSION Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric cancer.Propofol anesthesia has a minimal effect on patients'pulmonary function,consequently enhancing their postoperative recovery.Sevoflurane anesthesia causes less impairment on patients'cognitive function and mitigates negative emotions,leading to an improved postoperative mental state.Therefore,the selection of anesthetic agents should be based on the individual patient's specific circumstances.