Critical limb ischemia is a medical condition that decreases blood flow and limb oxygen supply;this disease in its late stages of progression leads to only two possible options: either surgical bypass revascularizatio...Critical limb ischemia is a medical condition that decreases blood flow and limb oxygen supply;this disease in its late stages of progression leads to only two possible options: either surgical bypass revascularization or limb amputation. We investigated a novel method using autologous transplantation of progenitor cells derived from mobilized peripheral blood bone marrow mononuclear cells to evaluate its long-term effect as a cell therapy to induce neo-angiogenesis and restore blood flow in the affected ischemic limbs. A total of 20 ischemic limbs from critical limb ischemia diagnosed patients, non candidates to surgical revascularization were transplanted with autologous progenitor cells by either intramuscular combined with intravenous (group A) or intramuscular (group B) procedure. Patients were monitored during 31 months. Treatment efficacy was evaluated according to the following parameters: ankle brachial index which increased at a range of 0.29-1.0 in group A and 0.40-0.90 in group B;pain-free walking distance which increased at a range of 50-600 m in group A and 50-300 m in group B;and blood perfusion (measured by Laser Doppler) which increased at a range of 48-299 in group A and 135-225 in group B. We achieved 90% treated ischemic limbs free of amputation in both transplanted groups. Results here described provide a safe, efficient and minimally invasive therapy with progenitor cells to induce angiogenesis and preserve limbs from amputation in CLI diagnosed patients.展开更多
The radial symmetric motion problem was examined for a spherical shell composed of a class of imperfect incompressible hyper-elastic materials, in which the materials may be viewed as the homogeneous incompressible is...The radial symmetric motion problem was examined for a spherical shell composed of a class of imperfect incompressible hyper-elastic materials, in which the materials may be viewed as the homogeneous incompressible isotropic neo-Hookean material with radial perturbations. A second-order nonlinear ordinary differential equation that describes the radial motion of the inner surface of the shell was obtained. And the first integral of the equation was then carded out. Via analyzing the dynamical properties of the solution of the differential equation, the effects of the prescribed imperfection parameter of the material and the ratio of the inner and the outer radii of the underformed shell on the motion of the inner surface of the shell were discussed, and the corresponding numerical examples were carded out simultaneously. In particular, for some given parameters, it was proved that, there exists a positive critical value, and the motion of the inner surface with respect to time will present a nonlinear periodic oscillation as the difference between the inner and the outer presses does not exceed the critical value. However, as the difference exceeds the critical value, the motion of the inner surface with respect to time will increase infinitely. That is to say, the shell will be destroyed ultimately.展开更多
文摘Critical limb ischemia is a medical condition that decreases blood flow and limb oxygen supply;this disease in its late stages of progression leads to only two possible options: either surgical bypass revascularization or limb amputation. We investigated a novel method using autologous transplantation of progenitor cells derived from mobilized peripheral blood bone marrow mononuclear cells to evaluate its long-term effect as a cell therapy to induce neo-angiogenesis and restore blood flow in the affected ischemic limbs. A total of 20 ischemic limbs from critical limb ischemia diagnosed patients, non candidates to surgical revascularization were transplanted with autologous progenitor cells by either intramuscular combined with intravenous (group A) or intramuscular (group B) procedure. Patients were monitored during 31 months. Treatment efficacy was evaluated according to the following parameters: ankle brachial index which increased at a range of 0.29-1.0 in group A and 0.40-0.90 in group B;pain-free walking distance which increased at a range of 50-600 m in group A and 50-300 m in group B;and blood perfusion (measured by Laser Doppler) which increased at a range of 48-299 in group A and 135-225 in group B. We achieved 90% treated ischemic limbs free of amputation in both transplanted groups. Results here described provide a safe, efficient and minimally invasive therapy with progenitor cells to induce angiogenesis and preserve limbs from amputation in CLI diagnosed patients.
基金国家自然科学基金，Municipal Key Subject Program of Shanghai
文摘The radial symmetric motion problem was examined for a spherical shell composed of a class of imperfect incompressible hyper-elastic materials, in which the materials may be viewed as the homogeneous incompressible isotropic neo-Hookean material with radial perturbations. A second-order nonlinear ordinary differential equation that describes the radial motion of the inner surface of the shell was obtained. And the first integral of the equation was then carded out. Via analyzing the dynamical properties of the solution of the differential equation, the effects of the prescribed imperfection parameter of the material and the ratio of the inner and the outer radii of the underformed shell on the motion of the inner surface of the shell were discussed, and the corresponding numerical examples were carded out simultaneously. In particular, for some given parameters, it was proved that, there exists a positive critical value, and the motion of the inner surface with respect to time will present a nonlinear periodic oscillation as the difference between the inner and the outer presses does not exceed the critical value. However, as the difference exceeds the critical value, the motion of the inner surface with respect to time will increase infinitely. That is to say, the shell will be destroyed ultimately.
