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NETs在脓毒症凝血功能障碍中的作用研究进展
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作者 李淑芳 熊旭东 《岭南急诊医学杂志》 2024年第4期443-446,共4页
脓毒症凝血功能障碍是脓毒症患者死亡的主要原因之一。炎症反应和凝血功能障碍相互促进、相互影响是影响脓毒症预后的重要因素。NETs是活化中性粒细胞分泌的网状结构,在脓毒症炎症和凝血中起桥梁作用。本文从NETs形成,NETs与血管内皮细... 脓毒症凝血功能障碍是脓毒症患者死亡的主要原因之一。炎症反应和凝血功能障碍相互促进、相互影响是影响脓毒症预后的重要因素。NETs是活化中性粒细胞分泌的网状结构,在脓毒症炎症和凝血中起桥梁作用。本文从NETs形成,NETs与血管内皮细胞、凝血因子、血小板关系及针对NETs开展的相关药物研究等方面进行综述,为进一步探索干预脓毒症凝血功能障碍的方法提供理论依据。 展开更多
关键词 nets 脓毒症 血管内皮细胞 凝血因子 血小板
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Boundedness and liveness enforcement for labeled Petri nets using transition priority
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作者 Ye-Jia Liu Xun-Bo Li 《Journal of Electronic Science and Technology》 EI CSCD 2023年第4期75-90,共16页
This paper deals with the supervisory control problem of discrete event systems modeled by labeled Petri nets. The system is originally unbounded. First, the solvability of the problem is confirmed. A necessary condit... This paper deals with the supervisory control problem of discrete event systems modeled by labeled Petri nets. The system is originally unbounded. First, the solvability of the problem is confirmed. A necessary condition is given and proven for the existence of a feasible priority-based controller based on the notions of liveness and transition invariants. Next, a cyclic behavior graph is constructed, which shows the reachable markings that guarantee the maximum liveness of the system within a given bound vector. Finally, an on-line control strategy is proposed to enforce boundedness and liveness to the given system by appending priority relations to transitions. The dynamic priority relation changes flexibly according to the current state of the system and enforces the system evolving in a bounded and live manner. In addition, numerical examples are studied to verify the validity of the proposed approach that remains the structure of the plant net and is efficient for on-line control. 展开更多
关键词 BOUNDEDNESS Control strategy LIVENESS Petri nets PRIORITY Transition invariant
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Free form deformation and symmetry constraint‐based multimodal brain image registration using generative adversarial nets
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作者 Xingxing Zhu Mingyue Ding Xuming Zhang 《CAAI Transactions on Intelligence Technology》 SCIE EI 2023年第4期1492-1506,共15页
Multi‐modal brain image registration has been widely applied to functional localisation,neurosurgery and computational anatomy.The existing registration methods based on the dense deformation fields involve too many ... Multi‐modal brain image registration has been widely applied to functional localisation,neurosurgery and computational anatomy.The existing registration methods based on the dense deformation fields involve too many parameters,which is not conducive to the exploration of correct spatial correspondence between the float and reference images.Meanwhile,the unidirectional registration may involve the deformation folding,which will result in the change of topology during registration.To address these issues,this work has presented an unsupervised image registration method using the free form deformation(FFD)and the symmetry constraint‐based generative adversarial networks(FSGAN).The FSGAN utilises the principle component analysis network‐based structural representations of the reference and float images as the inputs and uses the generator to learn the FFD model parameters,thereby producing two deformation fields.Meanwhile,the FSGAN uses two discriminators to decide whether the bilateral registration have been realised simultaneously.Besides,the symmetry constraint is utilised to construct the loss function,thereby avoiding the deformation folding.Experiments on BrainWeb,high grade gliomas,IXI and LPBA40 show that compared with state‐of‐the‐art methods,the FSGAN provides superior performance in terms of visual comparisons and such quantitative indexes as dice value,target registration error and computational efficiency. 展开更多
关键词 Free‐form deformation Generative adversarial nets Multi‐modal brain image registration Structural representation Symmetry constraint
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Situational Analysis of Malaria Control Following the 2021 Distribution of Long Lasting Insecticide-Treated Bed Nets in the Tiko Health District, South West Region, Cameroon
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作者 Jini Victor Bongajum Nyasa Raymond Babila Esum Mathias Eyong 《Journal of Biosciences and Medicines》 2023年第4期153-172,共20页
Malaria is still a major public health concern in Cameroon as more than 20 million people are at risk of the disease. Despite the government’s effort to scale up the distribution of long lasting insecticide-treated b... Malaria is still a major public health concern in Cameroon as more than 20 million people are at risk of the disease. Despite the government’s effort to scale up the distribution of long lasting insecticide-treated bed nets (LLINs), full ownership and optimal use is still limited. In 2021, over a million LLINs were made available for distribution in the South West Region. However, the current situation of malaria has not yet been ascertained following the 2021 mass distribution campaign (MDC). Therefore, the aim of this study was to determine LLIN ownership, coverage, usage and the prevalence of malaria following the 2021 MDC in the Tiko Health District (THD), South West Region of Cameroon. A cross-sectional study was carried from May 1 to 27, 2022 in which a multi-stage sampling technique was used to enroll eligible participants. Data were collected from household heads using questionnaires and capillary blood samples collected from consented household members were used to test for malaria. Data were analyzed using SPSS version 25 at 0.05 significance level. From the 150 households surveyed, 96 (64.0%) owned a mosquito net before the recent MDC. There was an overall significant increase (p p = 0.644) in LLINs ownership between areas where door-to-door (79.5%) and fixed “Hit and Run” (75.8%) strategies were used in the distribution of LLINs in THD. The prevalence of malaria was 10.2%. The regular use of LLINs was significantly associated (p = 0.007) with low malaria prevalence. The 2021 MDC had an impact on malaria prevalence in those who properly used them. 展开更多
关键词 Long Lasting Insecticide Treated-Bed nets OWNERSHIP COVERAGE Use Malaria Prevalence
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Scale and Associated Factors of Using Pyrethroid-Impregnated Mosquito Nets as Fishing Tools on Nokoué Lake within Sô-Ava Municipality in Benin, 2020
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作者 Nicolas Ayokpon Hondo Horace Degnonvi +4 位作者 Rodrigue Landeou Franck Zinsou Mignanwande Zoulkifl Salou Bachirou Roch Christian Johnson Ghislain Emmanuel Sopoh 《Open Journal of Preventive Medicine》 2023年第6期199-212,共14页
Background: In lacustrine communities, whether in Benin or elsewhere, populations use impregnated mosquito nets (IMNs) as fishing nets. This depletes the lake of its fishery resources, which in turn are contaminated b... Background: In lacustrine communities, whether in Benin or elsewhere, populations use impregnated mosquito nets (IMNs) as fishing nets. This depletes the lake of its fishery resources, which in turn are contaminated by the pyrethroids impregnated in the nets. This study aims to determine the scale and factors associated with the use of pyrethroid-impregnated mosquito nets as fishing tools in the municipality of Sô-Ava in Benin. Methods: This is a cross-sectional and analytical study with two components. First, a quantitative component was made up of 280 volunteers who were interviewed in the seven districts of the city. Data collection was done in two phases: the first from September to October 2020, and the second in August 2022. Data were analyzed with Stata and logistic regression was used. Another qualitative component was made up of forty participants chosen by reasoned choice, of which 32 were split into four focus groups of eight members each, and the rest participated in semi-structured interviews. Triangulation of the different sources was used to analyze the data. Results: Around 67% of the population reported using impregnated mosquito nets as fishing tools and 33% exclusively for malaria. Seasonal fishermen (ORa = 2.03, CI = 1.35 - 4.97, P = 0.004) and years of professional experience (ORa = 1.53, CI = 1.00 - 2.05, P = 0.021) increase the risk of using these nets as fishing tools. The use of insecticide-treated mosquito nets against mosquitoes causes skin scratching and impairs breathing because of the impregnation products, as reported by respondents. Conclusion: A high prevalence of inappropriate use of impregnated mosquito nets in fishing practices is highlighted in this study. Interviews in the field revealed that nets are diverted for fishing purposes to increase the volume of catches. Consequently, it will be appropriate to assess the pyrethroid content in water and fishery products. 展开更多
关键词 Associated Factor Impregnated Mosquito nets PYRETHROIDS Fishing Tools Sô-Ava
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血清NETs、sVCAM-1表达水平对髋关节置换术后患者发生深静脉血栓的预测价值
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作者 尹佐萍 《中国伤残医学》 2023年第17期14-17,75,共5页
目的:研究和分析血清中性粒细胞胞外陷阱(neutrophil extracellular traps,NETs)、可溶性血管细胞黏附分子(soluble vascular cell adhesion molecule-1,sVCAM-1)表达水平对髋关节置换术后患者发生深静脉血栓的预测价值。方法:选择我院2... 目的:研究和分析血清中性粒细胞胞外陷阱(neutrophil extracellular traps,NETs)、可溶性血管细胞黏附分子(soluble vascular cell adhesion molecule-1,sVCAM-1)表达水平对髋关节置换术后患者发生深静脉血栓的预测价值。方法:选择我院2018年1月-2021年12月接受髋关节置换术治疗的80例患者作为研究对象,设为观察组,该组患者术后均出现深静脉血栓。另选同期在我院接受髋关节置换术治疗的80例患者作为研究对象,设为对照组,该组术后未出现深静脉血栓。对2组的临床资料及术前术后血清NETs、sVCAM-1表达水平进行对比分析,把髋关节置换术后是否出现深静脉血栓设为因变量,把有显著差异的影响因素设为自变量,然后进行Logistic回归分析,并分析血清NETs、sVCAM-1表达水平对髋关节置换术后患者发生深静脉血栓的预测价值。结果:2组年龄、体质量指数、术后髋关节抬高屈曲位相比,差异具有统计学意义(P<0.05);2组患者NETs表达水平比较,术后第1天、第3天观察组表达水平更高,差异具有统计学意义(P<0.05)。2组sVCAM-1表达水平比较,术后第1天、第3天观察组表达水平更高,差异具有统计学意义(P<0.05)。其它时间两个指标比较差异均不具有统计学意义(P>0.05);经过Logistic回归分析,结果提示年龄、体质量指数、术后髋关节抬高屈曲位及术后第1天、第3天的血清NETs、sVCAM-1表达水平是髋关节置换术后深静脉血栓的影响因素;术后第1天血清NETs表达水平AUC大于术后第3天,术后第1天血清sVCAM-1表达水平AUC大于术后第3天。结论:年龄大、体质量指数高、术后髋关节抬高屈曲位及术后较高的血清NETs、sVCAM-1表达水平均是髋关节置换术后深静脉血栓的影响因素,且术后第1天、第3天血清NETs、sVCAM-1表达水平可作为预测髋关节置换术后深静脉血栓的生物学标记物,应给予足够的重视。 展开更多
关键词 血清 nets SVCAM-1 髋关节置换术 深静脉血栓 预测价值
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The Evaluation of Social Sharing Nets Users’ Fundamental Principals According to Nickname Usage and Time Spent
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作者 Mehmet Ali Seven Mustafa Çağrı Engin +1 位作者 Mehmet Yıldız Ali Osman Engin 《Advances in Internet of Things》 2023年第2期31-62,共32页
This work;It was made to determine the positive and negative usage information, attitudes and behaviors of social networking networks for users. Today, it is well known how the wide social effects of social networking... This work;It was made to determine the positive and negative usage information, attitudes and behaviors of social networking networks for users. Today, it is well known how the wide social effects of social networking sites are widespread and effective. As far as it can be followed from written and visual media, it causes significant damages for attitudes and behaviors for individuals. Looking at the results of the study, it seems impossible to limit the time and necessity of these networks for people, but it is understood that people force their limits and capacity. It was determined that the general acceptance and rejection areas are mixed and the dominant distinctive effects were weakened. Unable to prevent social dissolution and deterioration was realized by these social networks of networks. However, we cannot only talk about negative effects because their positive effects should be mentioned. Data were obtained in this direction. For example, some segments encourage the users of these sites to have more freedom, to develop democracy and human rights awareness. However, the real problem is when and where to stand. This study;Social networking networks use information, attitudes and behaviors;It was carried out for the purpose of evaluating the use of nicknames and networks for the use of networks. The data of the study were obtained by the application of a questionnaire and the data obtained were analyzed with appropriate statistical analysis methods. In the first part of the study, field study/operational concept scanning is performed and theoretical information is included. In the second part, the purpose of the study, the problem status, the importance of the study, limitations, assumptions, problem question, research method, research universe and sample are specified and informed. In the third section, the data obtained using appropriate statistical methods are analyzed. In the last section, some important suggestions and comments are made in the light of the data obtained. 展开更多
关键词 Psycho-Social Effect of Facebook Facebook and Personal Harms Habitual Activity of Using Facebook Nickname Usage and Social Sharing nets
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基于Deep Belief Nets的中文名实体关系抽取 被引量:71
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作者 陈宇 郑德权 赵铁军 《软件学报》 EI CSCD 北大核心 2012年第10期2572-2585,共14页
关系抽取是信息抽取的一项子任务,用以识别文本中实体之间的语义关系.提出一种利用DBN(deepbelief nets)模型进行基于特征的实体关系抽取方法,该模型是由多层无监督的RBM(restricted Boltzmann machine)网络和一层有监督的BP(back-propa... 关系抽取是信息抽取的一项子任务,用以识别文本中实体之间的语义关系.提出一种利用DBN(deepbelief nets)模型进行基于特征的实体关系抽取方法,该模型是由多层无监督的RBM(restricted Boltzmann machine)网络和一层有监督的BP(back-propagation)网络组成的神经网络分类器.RBM网络以确保特征向量映射达到最优,最后一层BP网络分类RBM网络的输出特征向量,从而训练实体关系分类器.在ACE04语料上进行的相关测试,一方面证明了字特征比词特征更适用于中文关系抽取任务;另一方面设计了3组不同的实验,分别使用正确的实体类别信息、通过实体类型分类器得到实体类型信息和不使用实体类型信息,用以比较实体类型信息对关系抽取效果的影响.实验结果表明,DBN非常适用于基于高维空间特征的信息抽取任务,获得的效果比SVM和反向传播网络更好. 展开更多
关键词 DBN(deep BELIEF nets) 神经网络 关系抽取 深层网络 字特征
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基于不完备信息系统规则提取和Petri Nets的电力变压器故障诊断 被引量:11
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作者 荣雅君 赵杰 +2 位作者 王健 吴闻婧 葛葆华 《电力系统保护与控制》 EI CSCD 北大核心 2009年第18期1-4,10,共5页
鉴于电力变压器故障信息具有不完备性及复杂性,将不完备信息系统规则的提取与Petri Nets(PNs)有机结合在一起进行变压器故障诊断。利用不完备信息规则提取对信息表进行知识的简化与故障特征的压缩,获得最小诊断规则,并利用此规则建造PN... 鉴于电力变压器故障信息具有不完备性及复杂性,将不完备信息系统规则的提取与Petri Nets(PNs)有机结合在一起进行变压器故障诊断。利用不完备信息规则提取对信息表进行知识的简化与故障特征的压缩,获得最小诊断规则,并利用此规则建造PNs的模型。同时利用PNs实现并行推理,对变压器进行快速分析。故障实例分析表明,文中所提出的智能方法具有准确性,有效性。 展开更多
关键词 PETRI nets 电力变压器 故障诊断 规则提取 不完备信息系统
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Intrusion detection model based on deep belief nets 被引量:6
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作者 高妮 高岭 +2 位作者 贺毅岳 高全力 任杰 《Journal of Southeast University(English Edition)》 EI CAS 2015年第3期339-346,共8页
This paper focuses on the intrusion classification of huge amounts of data in a network intrusion detection system. An intrusion detection model based on deep belief nets (DBN) is proposed to conduct intrusion detec... This paper focuses on the intrusion classification of huge amounts of data in a network intrusion detection system. An intrusion detection model based on deep belief nets (DBN) is proposed to conduct intrusion detection,and the principles regarding DBN are discussed.The DBN is composed of a multiple unsupervised restricted Boltzmann machine (RBM) and a supervised back propagation (BP)network.First,the DBN in the proposed model is pre-trained in a fast and greedy way,and each RBM is trained by the contrastive divergence algorithm.Secondly,the whole network is fine-tuned by the supervised BP algorithm,which is employed for classifying the low-dimensional features of the intrusion data generated by the last RBM layer simultaneously.The experimental results on the KDD CUP 1999 dataset demonstrate that the DBN using the RBM network with three or more layers outperforms the self-organizing maps (SOM)and neural network (NN)in intrusion classification.Therefore,the DBN is an efficient approach for intrusion detection in high-dimensional space. 展开更多
关键词 intrusion detection deep belief nets restricted Boltzmann machine deep learning
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NETs在自身免疫性疾病发病机制中的作用研究进展 被引量:4
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作者 肖芳 郑成云 +1 位作者 蒋卫东 陈丽 《中国免疫学杂志》 CAS CSCD 北大核心 2017年第5期781-783,787,共4页
中性粒细胞作为人体固有免疫系统的哨兵,在血液的非特异性细胞免疫系统中起着十分重要的作用,它们由骨髓分化发育成熟后,进入血液或组织,当微生物病原体特别是化脓性细菌入侵、炎症发生时,在多种炎症和细胞因子的介导下,它们便会被迅速... 中性粒细胞作为人体固有免疫系统的哨兵,在血液的非特异性细胞免疫系统中起着十分重要的作用,它们由骨髓分化发育成熟后,进入血液或组织,当微生物病原体特别是化脓性细菌入侵、炎症发生时,在多种炎症和细胞因子的介导下,它们便会被迅速招募并趋化至炎症部位,通过分泌细胞因子、脱颗粒和吞噬作用等杀灭并清除病原体。 展开更多
关键词 自身免疫性疾病 发病机制 nets 细胞免疫系统 微生物病原体 分泌细胞因子 中性粒细胞 化脓性细菌
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Resource Allocation Using Timed Petri Nets and Heuristic Search 被引量:3
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作者 张志明 王越 +2 位作者 陶然 阎飞 周思永 《Journal of Beijing Institute of Technology》 EI CAS 2000年第2期148-154,共7页
Traditional models for project management have not adequately incorporated a number of factors that are important for resource allocation. This paper proposed a unified timed Petri net model in which scheduling and pl... Traditional models for project management have not adequately incorporated a number of factors that are important for resource allocation. This paper proposed a unified timed Petri net model in which scheduling and planning were collectively carried out to take full advantages of the flexibility of the FMS. Through the lens of system theory, two types of resources were distinguished: major role and auxiliary role, and the major role was used to construct the FMS' Petri net. The method simplified the Petri net's construction and gave a clear flow chart for scheduling. Hence, the auxiliary resource allocation could be easily carried out according to the schedule, which was proposed by heuristic search algorithm. At last, the efficacy of the Petri net model for online scheduling in a resource constrained environment was discussed. 展开更多
关键词 heuristic search Petri nets resource allocation
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基于粗糙集理论和Petri Nets的变压器故障诊断 被引量:2
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作者 荣雅君 赵杰 +1 位作者 王健 吴闻靖 《变压器》 北大核心 2008年第12期56-59,共4页
介绍了一种基于粗糙集理论和Petri Nets相结合的变压器故障诊断方法,并通过故障实例证实了该方法的准确性和高效性。
关键词 变压器 粗糙集 PETRI nets 故障诊断
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Structural Complexity Analysis of Information Systems Based on Petri Nets 被引量:3
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作者 王景光 甘仞初 《Journal of Beijing Institute of Technology》 EI CAS 1999年第4期416-423,共8页
Aim To present a quantitative method for structural complexity analysis and evaluation of information systems. Methods Based on Petri net modeling and analysis techniques and with the aid of mathematical tools in ge... Aim To present a quantitative method for structural complexity analysis and evaluation of information systems. Methods Based on Petri net modeling and analysis techniques and with the aid of mathematical tools in general net theory(GNT), a quantitative method for structure description and analysis of information systems was introduced. Results The structural complexity index and two related factors, i.e. element complexity factor and connection complexity factor were defined, and the relations between them and the parameters of the Petri net based model of the system were derived. Application example was presented. Conclusion The proposed method provides a theoretical basis for quantitative analysis and evaluation of the structural complexity and can be applied in the general planning and design processes of the information systems. 展开更多
关键词 information system Petri nets structural complexity element complexity factor connection complexity factor
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新发现的中性粒细胞杀菌途径NETs 被引量:2
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作者 谢东北 郝选明 《中国免疫学杂志》 CAS CSCD 北大核心 2008年第7期669-670,F0003,共3页
关键词 中性粒细胞 杀菌机制 nets NADPH氧化酶 吞噬小体 快速反应部队 感染部位 超氧阴离子
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基于Time Petri Nets的UML时序图分析 被引量:1
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作者 徐景辉 刘文海 张根度 《计算机工程》 EI CAS CSCD 北大核心 2005年第19期105-107,共3页
引入一种称为Clock的变迁,用来改进TPNs,讨论了如何将时序图转换为基于Clock变迁的TPNs,使这种TPNs能正确反映时序图的流程和时间约束。最后,利用普通Petri网的可达性分析技术对时序图模型进行了分析和验证。
关键词 UML时序图 TIME PETRI nets 可达性分析
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从新版NETS·T看教师教育技术能力建设的新发展 被引量:9
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作者 王奕标 《电化教育研究》 CSSCI 北大核心 2009年第10期115-120,共6页
2008年6月30日美国国际教育技术协会公布了新版的《美国教师国家教育技术标准》。以新版《美国教师教育技术标准》实施为契机,教育技术研究和教育技术能力建设将会迎来新的发展。本文阐述了新版标准的内容结构及其创新之处,并对教育技... 2008年6月30日美国国际教育技术协会公布了新版的《美国教师国家教育技术标准》。以新版《美国教师教育技术标准》实施为契机,教育技术研究和教育技术能力建设将会迎来新的发展。本文阐述了新版标准的内容结构及其创新之处,并对教育技术研究和教师教育技术能力建设的新发展进行探讨。 展开更多
关键词 nets·T 创新学习 教育技术能力 建设
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基于Petri Nets和遗传算法结合的配变变压器故障的恢复研究 被引量:2
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作者 孙雅明 宋轶博 《继电器》 CSCD 北大核心 2004年第15期14-18,58,共6页
在基于PetriNets(PN)模型的配电变电站的在线故障恢复研究中,重点研究了变压器的PN恢复处理模型与优化策略模块的结合:PN模型依据配变运行模式、非故障变压器容量对转移负载和过载的承受力来考虑恢复策略的求解操作;在甩负荷操作时,则... 在基于PetriNets(PN)模型的配电变电站的在线故障恢复研究中,重点研究了变压器的PN恢复处理模型与优化策略模块的结合:PN模型依据配变运行模式、非故障变压器容量对转移负载和过载的承受力来考虑恢复策略的求解操作;在甩负荷操作时,则按供电可靠性的原则对负荷重要性排序,按尽量少的操作次数、按流过母联功率最小作约束,构造有序优化约束目标的全局优化GA算法来完成。该文的变压器故障恢复方法,不仅保证了PN模型数学求解的快速优势,而且可克服单一PN模型恢复中优化处理和刻画动态特性的局限性。仿真结果表明研究方法是可行、有效的,具有较高的实用价值。 展开更多
关键词 配变变压器 故障恢复 遗传算法 PETRI nets 电力系统 供电可靠性
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基于Petri Nets的数据流结构设计与模拟 被引量:1
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作者 瞿俊杰 陈咏恩 《同济大学学报(自然科学版)》 EI CAS CSCD 北大核心 2004年第3期411-415,共5页
数据流结构被广泛应用于数据流信号处理算法的硬件实现中 .通过建立数据流结构的PetriNets模型 ,动态模拟各个硬件处理单元在不同数据率输入信号下的状态 ,以此确定数据流结构中最佳的设计参数 。
关键词 数据流结构 PETRI nets 硬件建模
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Modeling method of hybrid systems using extended Petrinets 被引量:1
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作者 周炳海 王世进 陶丽华 《Journal of Southeast University(English Edition)》 EI CAS 2005年第3期304-309,共6页
In order to model effectively hybrid systems,a new modeling method of extended Petri nets,which is called extended object-orient hybrid Petri net (EOHPN),is proposed.To deal with the complexity of hybrid systems, ob... In order to model effectively hybrid systems,a new modeling method of extended Petri nets,which is called extended object-orient hybrid Petri net (EOHPN),is proposed.To deal with the complexity of hybrid systems, object-oriented abstraction mechanisms such as encapsulation and classifications are merged into EOHPN models.To combine the continuous part and discrete part of hybrid systems and to reduce the complexity of hybrid systems,a hybrid Petri net is introduced and extended with object-oriented modeling technology.Development of object models is suggested on the basis of the defined EOHPN.Finally, an application-oriented case is presented to illustrate that how the proposed EOHPN is used to model hybrid systems.The resulting model validates that the EOHPNs can deal with the modeling complexity of hybrid systems. 展开更多
关键词 Petri nets object-oriented model hybrid system MODELING
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