Infrared neuron stimulation is regarded as an innovative approach for stimulating cochleae in animals while the exact mechanism still remains unknown.In this paper,we studied compound action potentials of guinea pig c...Infrared neuron stimulation is regarded as an innovative approach for stimulating cochleae in animals while the exact mechanism still remains unknown.In this paper,we studied compound action potentials of guinea pig cochleae with chronic or acute deafness.We recorded optical compound action potentials and analyzed stretched cochlear preparations by fiuorescence microscopy.Photoacoustic signals were measured by hydrophone and microphone,respectively.In our experiment,we observed a switch response effect in vitro and in vivo experiments.Therefore,we proposed photoacoustic effect could invoke auditory response in infrared neuron stimulation.展开更多
Most studies on peripheral nerve injury have focused on repair at the site of injury, but very few have examined the effects of repair strategies on the more proximal neuronal cell bodies. In this study, an approximat...Most studies on peripheral nerve injury have focused on repair at the site of injury, but very few have examined the effects of repair strategies on the more proximal neuronal cell bodies. In this study, an approximately 10-mm-long nerve segment from the ischial tuberosity in the rat was transected and its proximal and distal ends were inverted and sutured. The spinal cord was subjected to pulsed electrical stimulation at T10 and L3, at a current of 6.5 m A and a stimulation frequency of 15 Hz, 15 minutes per session, twice a day for 56 days. After pulsed electrical stimulation, the number of neurons in the dorsal root ganglion and anterior horn was increased in rats with sciatic nerve injury. The number of myelinated nerve fibers was increased in the sciatic nerve. The ultrastructure of neurons in the dorsal root ganglion and spinal cord was noticeably improved. Conduction velocity of the sciatic nerve was also increased. These results show that pulsed electrical stimulation protects sensory neurons in the dorsal root ganglia as well as motor neurons in the anterior horn of the spinal cord after peripheral nerve injury, and that it promotes the regeneration of peripheral nerve fibers.展开更多
Background and early studies： Endogenous tri-potential neural stem cells （NSCs） exist in the adult mammalian central nervous system （CNS）. In the spinal cord, NSCs distribute throughout the entire cord, but exist...Background and early studies： Endogenous tri-potential neural stem cells （NSCs） exist in the adult mammalian central nervous system （CNS）. In the spinal cord, NSCs distribute throughout the entire cord, but exist predominately in white matter tracts. The phenotypic fate of these cells in white matter is glial, largely oligodendrocyte, but not neuronal.展开更多
Transcranial magnetic stimulation-a tool used in humans：Transcranial magnetic stimulation（TMS）is a non-invasive widespread clinical tool used to stimulate cortical areas in human subjects.This technique utilizes a ...Transcranial magnetic stimulation-a tool used in humans：Transcranial magnetic stimulation（TMS）is a non-invasive widespread clinical tool used to stimulate cortical areas in human subjects.This technique utilizes a brief,highly intense magnetic field applied to cortical areas,which locally depolarized interneurons（Weber and Eisen,2002）.展开更多
Stroke is one of the fearsome causes of death that leads to high mortality and morbidity worldwide.Apparently,the management of choice for ischemic stroke is either by thrombolysis or thrombectomy.
The systemic health benefits of regular skeletal muscle activity are well documented.Increased skeletal muscle activity is associated with an improved systemic metabolic state,reduced incidence of diabetes and obesity...The systemic health benefits of regular skeletal muscle activity are well documented.Increased skeletal muscle activity is associated with an improved systemic metabolic state,reduced incidence of diabetes and obesity,and improved function with age.Despite these known systemic benefits,many healthy people do not meet the recommended daily dose of skeletal muscle activity（exercise）needed to prevent systemic metabolic disease,leading to an in-creased prevalence of obesity.展开更多
Traditionally,it has been thought that the mammalian central nervous system（CNS）does not regenerate.Possibly due to the inhibitory extracellular environment post-injury as well as the limited intrinsic characteristi...Traditionally,it has been thought that the mammalian central nervous system（CNS）does not regenerate.Possibly due to the inhibitory extracellular environment post-injury as well as the limited intrinsic characteristics of adult post-mitotic neurons（Smith et al.,2015）.展开更多
基金This projectwas supported by grants fromtheNature Science Foundation of China(Nos.NSFC81401539 and NSFC31271056)and the projects in the Shenzhen Medical Engineering Laboratory For Human Auditory-equilibrium Function.
文摘Infrared neuron stimulation is regarded as an innovative approach for stimulating cochleae in animals while the exact mechanism still remains unknown.In this paper,we studied compound action potentials of guinea pig cochleae with chronic or acute deafness.We recorded optical compound action potentials and analyzed stretched cochlear preparations by fiuorescence microscopy.Photoacoustic signals were measured by hydrophone and microphone,respectively.In our experiment,we observed a switch response effect in vitro and in vivo experiments.Therefore,we proposed photoacoustic effect could invoke auditory response in infrared neuron stimulation.
基金supported by the Key Scientific and Technological Program of Linyi City of China,No.201313026
文摘Most studies on peripheral nerve injury have focused on repair at the site of injury, but very few have examined the effects of repair strategies on the more proximal neuronal cell bodies. In this study, an approximately 10-mm-long nerve segment from the ischial tuberosity in the rat was transected and its proximal and distal ends were inverted and sutured. The spinal cord was subjected to pulsed electrical stimulation at T10 and L3, at a current of 6.5 m A and a stimulation frequency of 15 Hz, 15 minutes per session, twice a day for 56 days. After pulsed electrical stimulation, the number of neurons in the dorsal root ganglion and anterior horn was increased in rats with sciatic nerve injury. The number of myelinated nerve fibers was increased in the sciatic nerve. The ultrastructure of neurons in the dorsal root ganglion and spinal cord was noticeably improved. Conduction velocity of the sciatic nerve was also increased. These results show that pulsed electrical stimulation protects sensory neurons in the dorsal root ganglia as well as motor neurons in the anterior horn of the spinal cord after peripheral nerve injury, and that it promotes the regeneration of peripheral nerve fibers.
文摘Background and early studies： Endogenous tri-potential neural stem cells （NSCs） exist in the adult mammalian central nervous system （CNS）. In the spinal cord, NSCs distribute throughout the entire cord, but exist predominately in white matter tracts. The phenotypic fate of these cells in white matter is glial, largely oligodendrocyte, but not neuronal.
文摘Transcranial magnetic stimulation-a tool used in humans：Transcranial magnetic stimulation（TMS）is a non-invasive widespread clinical tool used to stimulate cortical areas in human subjects.This technique utilizes a brief,highly intense magnetic field applied to cortical areas,which locally depolarized interneurons（Weber and Eisen,2002）.
文摘Stroke is one of the fearsome causes of death that leads to high mortality and morbidity worldwide.Apparently,the management of choice for ischemic stroke is either by thrombolysis or thrombectomy.
基金supported in part by awards from the National Institutes of Health–National Center for Medical Rehabilitation Research(R01HD084645R01HD082109)
文摘The systemic health benefits of regular skeletal muscle activity are well documented.Increased skeletal muscle activity is associated with an improved systemic metabolic state,reduced incidence of diabetes and obesity,and improved function with age.Despite these known systemic benefits,many healthy people do not meet the recommended daily dose of skeletal muscle activity（exercise）needed to prevent systemic metabolic disease,leading to an in-creased prevalence of obesity.
文摘Traditionally,it has been thought that the mammalian central nervous system（CNS）does not regenerate.Possibly due to the inhibitory extracellular environment post-injury as well as the limited intrinsic characteristics of adult post-mitotic neurons（Smith et al.,2015）.
