In this study,we have formulated the phase description of the neuronal oscillator with non-instantaneous synaptic inputs and external periodic stimulus by using the phase sensitivity function.By numerical simulation,w...In this study,we have formulated the phase description of the neuronal oscillator with non-instantaneous synaptic inputs and external periodic stimulus by using the phase sensitivity function.By numerical simulation,we have found that the phase of a neuronal oscillator undergoes periodic evolution or locked state,which is determined by the synaptic time constant.The synaptic time constant is also an important condition under which the global network is synchronized.When the synaptic time constant is relatively small,perfectly synchronized behavior quickly occurs in the neuronal population.As the synaptic time constant becomes slightly larger,periodic synchronization emerges in the neuronal population.However,synchronized activity in the neuronal population is lost for larger synaptic time constant.The external periodic stimulus can change the synchronization patterns in the neuronal population.With a weak low-frequency stimulus,the neuronal populations quick synchronized bursting;whereas a high-frequency stimulus can produce synchronized overlapping bursting.We have also found that neuronal oscillators with type-II phase response curves are more susceptible to synchronization than those with type-I phase response curves.展开更多
Advancing age and increased lifespan of human populations worldwide in the mid-nineteenth century,have led to a significant increase in the incidence of neurodegenerative diseases one of the major cause of disability ...Advancing age and increased lifespan of human populations worldwide in the mid-nineteenth century,have led to a significant increase in the incidence of neurodegenerative diseases one of the major cause of disability and death for most of those affected.Neurodegeneration is one of the biggest public health problems in modern society also because effective pharmacological interventions for prevention and treatment of the disease, are lacking. Based on the premise that oxidative stress underlies a number of neurodegenerative diseases, the identification of novel antioxidants as potential therapeutics is a prolific area of neuroscience research. There is also a close relationship between specific therapies and the induction of oxidative stress in chronic neurodegeneration, such as the case of levodopa in patients with Parkinson＇s disease （Mtiller et al., 2014）.展开更多
Diseases of the nervous system are characterized by axon dysfunction,axon degeneration,and neuronal cell death.The roster of neurodegenerative diseases is striking in the selective vulnerability of the affected neuron...Diseases of the nervous system are characterized by axon dysfunction,axon degeneration,and neuronal cell death.The roster of neurodegenerative diseases is striking in the selective vulnerability of the affected neuronal populations and the timing of the onset of disease manifestation and functional deficits.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.1123200511172086)
文摘In this study,we have formulated the phase description of the neuronal oscillator with non-instantaneous synaptic inputs and external periodic stimulus by using the phase sensitivity function.By numerical simulation,we have found that the phase of a neuronal oscillator undergoes periodic evolution or locked state,which is determined by the synaptic time constant.The synaptic time constant is also an important condition under which the global network is synchronized.When the synaptic time constant is relatively small,perfectly synchronized behavior quickly occurs in the neuronal population.As the synaptic time constant becomes slightly larger,periodic synchronization emerges in the neuronal population.However,synchronized activity in the neuronal population is lost for larger synaptic time constant.The external periodic stimulus can change the synchronization patterns in the neuronal population.With a weak low-frequency stimulus,the neuronal populations quick synchronized bursting;whereas a high-frequency stimulus can produce synchronized overlapping bursting.We have also found that neuronal oscillators with type-II phase response curves are more susceptible to synchronization than those with type-I phase response curves.
文摘Advancing age and increased lifespan of human populations worldwide in the mid-nineteenth century,have led to a significant increase in the incidence of neurodegenerative diseases one of the major cause of disability and death for most of those affected.Neurodegeneration is one of the biggest public health problems in modern society also because effective pharmacological interventions for prevention and treatment of the disease, are lacking. Based on the premise that oxidative stress underlies a number of neurodegenerative diseases, the identification of novel antioxidants as potential therapeutics is a prolific area of neuroscience research. There is also a close relationship between specific therapies and the induction of oxidative stress in chronic neurodegeneration, such as the case of levodopa in patients with Parkinson＇s disease （Mtiller et al., 2014）.
基金supported,in part,by NIH/NEI grants EY019949 and EY025061American Diabetes Association Research Grant#7-11-BS-182an Unrestricted Grant to the Department of Ophthalmology,SUNY-Buffalo,from Research to Prevent Blindness
文摘Diseases of the nervous system are characterized by axon dysfunction,axon degeneration,and neuronal cell death.The roster of neurodegenerative diseases is striking in the selective vulnerability of the affected neuronal populations and the timing of the onset of disease manifestation and functional deficits.
