The identification and characterization of stem cells is a major focus of developmental biology and regenerative medicine.The advent of genetic inducible fate mapping techniques has made it possible to precisely label...The identification and characterization of stem cells is a major focus of developmental biology and regenerative medicine.The advent of genetic inducible fate mapping techniques has made it possible to precisely label specific cell populations and to follow their progeny over time.When combined with advanced mathematical and statistical methods,stem cell division dynamics can be studied in new and exciting ways.Despite advances in a number of tissues,relatively little attention has been paid to stem cells in the oral epithelium.This review will focus on current knowledge about adult oral epithelial stem cells,paradigms in other epithelial stem cell systems that could facilitate new discoveries in this area and the potential roles of epithelial stem cells in oral disease.展开更多
The quasi-neutral limit of time-dependent drift diffusion model with general sign-changing doping profile is justified rigorously in super-norm (i.e., uniformly in space). This improves the spatial square norm limit b...The quasi-neutral limit of time-dependent drift diffusion model with general sign-changing doping profile is justified rigorously in super-norm (i.e., uniformly in space). This improves the spatial square norm limit by Wang, Xin and Markowich.展开更多
基金the National Institutes of Health(F30-DE022509 to KBJ and R01-DE021420 to ODK)
文摘The identification and characterization of stem cells is a major focus of developmental biology and regenerative medicine.The advent of genetic inducible fate mapping techniques has made it possible to precisely label specific cell populations and to follow their progeny over time.When combined with advanced mathematical and statistical methods,stem cell division dynamics can be studied in new and exciting ways.Despite advances in a number of tissues,relatively little attention has been paid to stem cells in the oral epithelium.This review will focus on current knowledge about adult oral epithelial stem cells,paradigms in other epithelial stem cell systems that could facilitate new discoveries in this area and the potential roles of epithelial stem cells in oral disease.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10431060, 10701011,10771009)Beijing Science Foundation of China (Grant No. 1082001)
文摘The quasi-neutral limit of time-dependent drift diffusion model with general sign-changing doping profile is justified rigorously in super-norm (i.e., uniformly in space). This improves the spatial square norm limit by Wang, Xin and Markowich.