Microstructure and mechanical properties of AZ61 magnesium alloy parts achieved by thixo-extruding semisolid billets prepared by new SIMA

New strain induced melt activation（new SIMA） method was employed to prepare high-quality semisolid billet of AZ61 magnesium alloy.Optical microscopy and tensile test were used to study the microstructure and mechanical properties of the thixo-extruded component.The results showed that the optimal process parameters for achieving the complete filling status involved the applied pressure of 784 MPa,the pressure holding time of 90 s and the die temperature of 450 ℃.Compared to semisolid isothermal treatment,high mechanical properties such as the tensile strength of 300.5 MPa and elongation of 22% and fine microstructure were obtained in the thixo-extruded parts.With increasing the isothermal temperature and holding time,the tensile strength and elongation were increased firstly and then decreased.When the press pass was increased from 1 to 4,the tensile strength and elongation of the thixo-extruded parts were greatly enhanced and microstructure was refined obviously.

A Preliminary Study on the New Activity Features of the Lajishan Mountain Fault Zone in Qinghai Province

The Lajishan Mountain fault zone consists of two NE_protruding arcuate faults, i.e. the northern and southern margin fault of Lajishan Mountain with the fault length of 230km and 220km respectively. The fault zone is located in the large_scale compressional structure zone and tectonic gradient zone in_between the NNW_trending right_lateral strike_slip Reshui_Riyueshan fault zone and the NWW_trending left_lateral strike_slip northern margin of west Qinling Ranges fault zone is also an important boundary fault zone, separating the Xining_Minhe basin and the Xunhua_Hualong basin at the southern and northern sides of the Lajishan Mountain respectively. Geologic geomorphic evidences of new activity revealed by field investigations indicate that the latest movement of the Lajishan fault zone was in late Epipleistocene (only a few segments were active in early Holocene) and is mainly of compressive thrusting with slightly left_lateral strike_slip component. The above movement has possibly resulted in the occurrence of about 20 moderate earthquakes of magnitude around 5.0. The Lajishan region can therefore be regarded as a seismotectonic window to reflect tectonic movement and earthquake activity.

New Discovery of Holocene Activity along the Weixi-Qiaohou Fault in Southeastern Margin of the Tibetan Plateau and its Neotectonic Significance

Objective The lateral extrusion eastward of the Tibetan Plateau leads to the formation of the Sichuan–Yunnan block, which is the most representative active block in the southeastern margin of the Tibetan Plateau, characterized by strong and frequent seismicity(Li Ping et al., 1975; Zhang Peizhen et al., 2003; Li Yong et al., 2017). Its eastern boundary is composed of sinistral faults including the Xianshuihe, Xiaojiang faults, etc., and the western

Synthesis and Antitumor Activity of New Derivatives of Podophyllotoxin

A series of analogues of etoposide (VP-16), the C-4 alkylamino-substituted 4'demethyl-epipodophyllotoxins, have been synthesized and studied for their activity to inhibit L1210 and KB cells in vitro. Most new compounds are as active or more active than VP-16 in their inhibition of both L1210 and KB cells.

CARBOXYMETHYLPACHYMAN(Ⅰ),A NEW WATER SOLUBLE POLYSACCHARIDE WITH MARKED ANTITUMOUR ACTIVITY

Carboxymethylpachyman(Ⅰ)was formed by carboxymethylation of β-pachyman.The antitumour activity of carboxymethylpachyman(Ⅰ)against S_(180)、EAC、 MA、U_(14)was measured.The structure of carboxymethylpachyman(Ⅰ)was proved by IR ^(13)CNMR spectroscopy.

New Activity of the Tanlu Fault Zone in the South of Huaihe to the Nvshanhu Segment since the Late Quaternary

Taking the Huaihe to the Nvshanhu segment of the Tanlu( Tancheng-Lujiang) fault zone as the main research target to explore whether there has been new activity since the late Quaternary,and based on the interpretation of remote sensing images and repeated surface investigations,we excavated trenches at the sections where the tectonic landform is significant,identified and recorded the deformation patterns of the fault and analyzed the activity behavior. Samples of new activity and deformation were collected and oriented slices were ground based on the samples ' original state to make the micro structural analysis and demonstration. All of the above research shows very clear linear tectonic geomorphology along the fault,three trenches across the fault zone all revealed new deformation traces since late Quaternary. The latest stratum dislocated by the fault is the late Quaternary and Holocene. The main slip mode is stick slip,as represented typically by fault scarps,wedge accumulation,the faults and the filled cracks and so on. In general,it shows the characteristics of brittle high-speed deformation and belongs to the prehistoric earthquake ruins. The above understanding was confirmed partially by microscopic analysis. In addition,the similarities and differences and the possible reasons for the characteristics of the latest activities of the Tancheng-Lujiang fault zone in the north and south of the Huaihe River regions are also discussed in this paper.

A New Metallomicelle with Hydrolytic Metalloenzymatic Activity

A new metallomicelle, formed by Cu2+ Or Zn2+ ion and N-tetradecyl-2-(N-2-hydroxyethyl aminomethyl) imidazol in the presence of cetyltrimethylammonium bromide, was found to possess remarkable catalytic activity to the hydrolysis of p-nitrophenyl picolinate.

A NEW EXPERIMENTAL AND CLINICAL APPROACH OF COMBINING USAGE OF HIGHLY ACTIVE TUMOR-INFILTRATING LYMPHOCYTES AND HIGHLY SENSITIVE ANTITUMOR DRUGS FOR THE ADVANCED MALIGNANT TUMOR

In recent years, tumor-nfiltrating lymphocytes (TILs) have been reported to be effective for tumors in experimental and clinical research. In order to increase the therapeutical effect, we modified some steps of Rosenberg's approach a. cold digestion with collagenase at 4C for 24 hours; b. sedimentation instead of centrifugation; c. elimination of tumor cells before the cultivation procedure. Compared with the original approach, the proliferation, activity and cytotoxicity of TILs obtained by the modified procedure were much improved. TILs' expansion-old was greater than that with the original approach. Cytotoxicity against rumor cells was more potent. Increased TILs' subsets were CD3 and CD8 cells. Meanwhile, we took tumor cells from tumor tissues to test their in vitro chemosensitivities to different drugs in order to select highly sensitive antitumor drugs for treatment of cases with advanced tumors. According to the design of using highly active TILs and highly sensitive drugs (H & H therapy), preliminary clinical results of 50 cases showed higher response rates than those in treatment with TIL / IL2, LAK / 1L2 and TIL+IL2+CTX. Less toxic side effects were observed in 14 patients.