Outcomes assessment of hepatitis C virus-positive psoriatic patients treated using pegylated interferon in combination with ribavirin compared to new Direct-Acting Antiviral agents

AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α plus ribavirin(P/R) therapy.METHODS This is a retrospective study involving psoriatic patients in biological therapy who underwent anti-hepatitis C virus(HCV) treatment at the Department of Dermatology Galeazzi Orthopaedic Institute Milan, Italy from January 2010 to November 2017. The patients were divided into two groups: patients that underwent therapy with DAAs and patients that underwent HCV treatment with P/R. Patients were assessed by a dermatologist for psoriasis symptoms, collecting Psoriasis Area Severity Index(PASI) scores and the Dermatology Quality of Life Index(DLQI). PASI and DLQI scores were evaluated 24 wk after the end of HCV treatment and were assumed as an outcome of the progression of psoriasis. Switching to a different b DMARD was considered as an inadequate response to biological therapy. The dropout of HCV therapy and sustained virological response(SVR) were considered as outcomes of HCV therapy.RESULTS Fifty-nine psoriatic patients in biological therapy underwent antiviral therapy for CHC. Of this, 27 patients were treated with DAAs and 32 with P/R. After 24 wk post treatment, the DLQI and the PASI scores were significantly lower(P < 0.001 and P < 0.005, respectively) in the DAAs group compared with P/R group. None of the patients in the DAAs group(0/27) compared to 8 patients of the P/R group(8/32) needed a shift in biological treatment.CONCLUSION DAAs seem to be more effective and safe than P/R in HCV-positive psoriatic patients on biological treatment. Fewer dermatological adverse events may be due to interferon-free therapy.

STUDIES ON TBP-NO_x——A NEW OXIDIZING AGENT PREPARED FROM NITROGEN OXIDES

Nitrogen oxides(NO_2 and NO)are absorbed by tributyl phosphorate(TBP)to fom a new complex mixture of TBP-NO_x. which is used as a selective oddizing agent to oxidize benzylalcohols to corresponding sldehydes or ketones In high yield. In the reaction process, nitrogen oxides are llberated mildly and mainly reduced to nitrogen, while tributyl phosphorate is recovered end recycled.

Building a New Socialist Countryside, Improving Commission and Agent System of “Village-level Accounting”

Rural finance is an issue concerned with rural people, improving rural financial management is important to close the relations of cadres and masses, maintain rural stability, and promote rural economic development. This article explained the main problems of village financial, the needs of introducing commission and agent system of ＂village-level accounting＂ for building a new socialist countryside, and the measures of improving commission and agent system of ＂village-level accounting＂.

Control Effects of a New Sex Pheromone Trap and Biological Agents on Sesamia inferens Walker and Argyroploce schistaceana (Snellen)

This study was conducted to explore and seek high-efficiency and safe green control techniques on sugarcane borers,promote green control of diseases and pests of sugarcane and build a resource-conserving,environmentally friendly and sustainable governance system of diseases and pests of sugarcane.A new sex pheromone trap of sugarcane borers,abamectin· Bacillus thuringiensis (Bt) and tebufenozide were selected and applied in field trials.The use of the new sex pheromone trap of sugarcane borers (6 traps/hm 2) in combination with 0.05% abamectin·10 billion active gemmae/g B.thuringiensis (Bt) WP (1.8 kg/hm 2) or new sex pheromone trap of sugarcane borers (6 traps/hm 2) in combination with 200 g/L tebufenozide SC (1.5 L/hm 2) were the best in the sugarcane production.New sex pheromone trap of sugarcane borers should be installed in early march,and biological agents were mixed with water 900 kg per hectare and sprayed evenly sugarcane plants at the beginning of April.Their control effects of dead heart rate and bored stalk rate could be more than 69.98% and 49.09%,respectively,which were superior to that of the control pesticide 3.6% bisultap GR (90 kg/hm 2).The results showed that new sex pheromone trap of sugarcane borers in combination with abamectin· B.thuringiensis (Bt) or tebufenozide was the optimum mode of green control techniques on sugarcane borers.When it was alternately or coordinately used with other technology,it could delay the emergence and development of drug resistance,and it was worthy of widespread popularization and application in sugarcane area.

Covalent Attachment of DNA to Glass Supports Using A New Silane Coupling Agent and Chemiluminescent Detection

A new kind of silane coupling agent, N- (β-aminoethyl ) - γ-aminopropyl triet hoxysilane, was used for DNA direct attachment on the surfaces of glass supports, then the immobilized DNA was hybridized with horseradish peroxidase (HRP)-labeled probe, and detected by using enhanced chemiluminescent method. In comparison with γ-aminopropyl triethoxysilane, the detection limits (S/N) of DNA were 10 pg and 75 pg respectively. Several experimental conditions of DNA attachING to glass supports were investigated, and the system of hybridization of nucleic acid on the surfaces of glass supports was developed.

THE SYNTHESIS OF ZSM-35 WITH A NEW KIND OF TEMPLATING AGENT

The present paper covers the synthesis of ZSM-35 molecular sieve with 1,6-hexanediamine as templating agent,the influence of the synthesis conditions, and a discussion concerning the crystal structures of the products.

A NEW BIFUNCTIONAL CHELATING AGENT α,ε-N,N'-BIS(L-CYSTEINYL)-L-LYSINE FOR RADIOLABELLING OF MONOCLONAL ANTIBODIES WITH TECHNETIUM-99M

α,ε-N,N'-bis(L-cysteinyl)-L-lysine was synthesized and char- acterized for the first time.It was then employed as a bifunctional chelating agent to chelate technetium-99m and subsequently conjugated to fragment F(ab')_2 of anti-gastric tumor monoclonal antibody 3G9.The radiolabelled antibody was satisfactorily stable and immunoreactive.

新型农业经营主体会计代理采用意愿及其影响因素实证分析

会计代理可以节约用工成本、提高效率和促进经营目标的实现,是当前推动新型农业经营主体财务规范的重要过渡阶段。基于湖北省891份调研数据,采用有序Logistic模型检验新型农业经营主体采用会计代理意愿的影响因素。结果表明:性别、年龄、受教育水平、流动资金投资、经营类型、产业类型、毛收入、示范级别、农业培训等因素显著影响新型农业经营主体采用会计代理意愿。据此提出加强经营主体会计知识培育,强化财务规范意识,夯实会计代理基础;建立资金管理台账,关注资金流向,推动会计代理行业发展;设立专项资金支持,提供会计代理对接服务,扩大会计代理行业覆盖面等建议。

产品差异化和市场开放度对城市群空间结构的影响研究

城市群是提高地区经济增长和深入实施区域协调发展战略过程中的重要载体。本文尝试结合“新”新经济地理学模型和基于agent计算经济学对多重异质性下城市差异化对企业和人口的空间演化影响进行研究,建立了一个企业生产效率与规模、居民工资等多重异质性的两区域空间经济模型对城市间人口和企业迁移进行动态模拟以研究空间经济演化过程。结果表明:(1)无论是否存在市场进入和退出机制,小城市内部工业产品的差异性越大,越有利于企业和人口向小城市迁移,企业和人口倾向于分散。但是存在市场机制能提高城市内产品差异化对人口和企业迁移的吸引力。(2)城市群中小城市要更多的企业和人口,需要继续鼓励创新生产差异化产品,使城市内的产品更加多样化和差异化。(3)为了使城市内产品差异化发挥更大的作用,整个地区需要更加健全企业进入和退出的市场机制,使得有利可图的资本可以进入市场,同时亏损的企业能够退出市场或者转型升级和改制。

智能体:主体与客体相统一的“中介体”——兼论智能体在新闻生产中的地位和作用

认识智能体在新闻生产中的地位和作用,首先需要准确把握智能体的性质。智能体既不是“人主体”,也不是“一般人造客体”,而是人类总体能力对象化的创造物,是主体与客体相统一的“中介体”。在新闻生产实践中,新闻智能体由提供算力的动力机器系统、结成网络的传动机器系统、供给算法的控制机器系统、直接参与新闻生产的工作机器系统共同构成。就目前来看,新闻智能体是创构、保障、调适新闻生产网络体系的基础设施型生产工具,它以新闻生产数据化的方式,催生出新的新闻劳动分工,从而在人与新闻双向运动中发挥中介体作用。

基于大语言模型的新型电力系统用户特性立体应用模式初探

随着新型负荷的广泛接入与虚拟电厂建设的不断推进,新型电力系统中多元的负荷结构与频繁的网荷交互使得用户特性应用在数据融合、特性挖掘和业务赋能面临关键挑战。因此,该文首先深入分析了用户特性的研究现状,以此为基础提出了新型电力系统用户特性立体应用模式,贯通了“多源数据-多维特性-多元模块-多样业务”的应用链路。然后,针对该模式实践中海量多源数据可用性差、特性刻画灵活性低、业务贯通复杂性高的核心技术难题,立足于近期大语言模型备受关注的显著能力与智能体应用范式,分别在自适应数据治理、对话式数据交互、自动数据分析与机器学习、多智能体应用系统架构方面提出了解决方案。进一步,更通过用电数据库交互与业扩报装接入优化的案例表明所提方案能够自动化、智能化、个性化地开展用户特性应用,有望在实际中应对用户侧业务面临的关键挑战。最后,对大语言模型赋能用户侧海量资源管控以及系统智能水平跃升进行了展望。

基于多智能体深度确定策略梯度算法的火力发电商竞价策略

火电是新型电力系统的重要支撑,研究火力发电商的竞价策略以及不同出清机制的影响,对保障其低碳高效运营具有重要意义。构建基于多智能体深度确定策略梯度算法的竞价策略模型,分析不同火力发电商组合的竞价差异化策略,优化多主体报价报量策略,探究边际统一出清、按报价支付出清和随机匹配出清3种典型出清机制的市场影响。结果表明,该策略模型可引导火力发电商采取合理的竞价方式以提高市场效率;在新能源渗透率较低时,不同出清机制对各类型机组的影响有所不同;随着新能源渗透率的提高,采用按报价支付出清机制可以兼顾经济和环境效益;当新能源渗透率达到较高水平时,采用随机匹配出清机制可有效应对市场波动风险。

加氢装置开工预硫化期间加热炉烟气SO_(2)浓度超标原因分析及对策

在加氢装置开工预硫化期间,加热炉烟气SO_(2)浓度多次异常上升甚至超标,企业被迫停止回收火炬气。通过对开工预硫化期间循环氢、低压分离器气和火炬气中硫化物的类型和含量进行分析,推测是因为所使用的硫化剂二甲基二硫醚分步分解产生的甲硫醇和甲硫醚随着火炬气进入燃料气系统,甲硫醇、甲硫醚燃烧生成的SO_(2)导致加热炉烟气中的SO_(2)浓度超标。针对这一问题,可以通过优化火炬气脱硫溶剂、使用器外真硫化催化剂、使用新型硫化剂等方式解决。

陕西省核桃黑斑病新病原的鉴定及室内药剂筛选

分离田间红仁核桃(Juglans regia ‘Robert Livermore’)病叶上的黑斑病病原细菌,通过科赫氏试验明确致病菌,并通过病原菌生化试验以及分子生物学技术明确病原菌的分类学地位。结果表明,从红仁核桃的田间核桃病叶中分离到23株菌落形态一致的细菌菌株,从中随机选取菌株进行科赫氏回接试验能引起红仁核桃叶片发病,通过生理生化表型试验,结合基于16S rDNA、gyrB、rpoD基因序列的多位点序列分析,将该病原鉴定为扁桃假单胞菌(Pseudomonas amygdali)。随后对12种药剂进行室内毒力测定,筛选出的6种药剂对该病原菌具有明显抑制作用。其中,四霉素抑菌效果最好,EC50为50.353 4 μg/mL,其他药剂抑菌效果表现为中生菌素>春雷霉素>噻菌酮>噻唑锌>氢氧化铜。

基于多主体评估的上海市工人新村更新优化策略

文章首先梳理上海市工人新村当前采用的拆除重建、综合改造、维护升级3种更新方式,并通过多主体评估与群决策方法对典型案例进行分析,总结3种更新方式在建筑性能改善、室外环境优化、更新过程与配套服务中存在的问题,进而提出相应的优化提升建议。

基于多Agent的新产品市场扩散仿真研究

基于多Agent的仿真是一种基于微观层次的建模仿真方法 ,具有广泛适用性、分布性、智能性和交互性等特征。该文探讨了多Agent仿真的基本思路和系统分析过程 ,构建了一个基于多Agent的新产品市场扩散仿真模型 ,并在AgentSheets平台上实现了该模型。

制造景观:项目经营下的乡村建设

项目下乡中的经营行为引发了景观化建设现象,研究以湖北T村为例,从空间实践、生产机制和治理效应三方面对此展开分析。从景观化的空间实践来看,T村在项目试点中的密集投入和差异化建设,导致景观密集生产和村庄空间分化,并凸显了景观的工具价值。从景观化的生产机制来看,主要源于对项目的经营。在决策层面,省级政府以行政发包配合项目下发,容易导致资源堆砌和重复试点;在下发过程中,县乡政府缺少代理人,强化了项目的集中下发冲动;在执行层面,项目捆绑产生了较强的执行压力,导致目标对照基础上的空间营造。从景观化的治理效应来看,一方面有利于空间更新、基础设施改善和组织权威强化,另一方面又导致景观的后续养护难题、对生活景观的排斥、对村民生计的影响以及村民隔阂等。这种好坏参半的治理效应体现了“项目悬浮”问题,即项目与村民需求脱节。最后,研究还提出了基层社会从“经营项目”向“经营空间”的延伸。

新型捕收剂KMC756浮选四川某铜矿试验研究

四川某铜矿主要目的元素铜、钼的品位分别为0.73%、0.031%。在不改变四川某铜矿现场主体流程和磨矿参数的条件下,采用新型药剂KMC756为捕收剂开展了选矿条件试验,获得铜钼精矿Cu品位26.995%、Mo品位0.7918%,Cu回收率94.94%、Mo回收率84.80%。与其他浮选药剂进行了对比,该药剂对铜钼具有更好的选择性能,使得铜钼金属得到有效的回收。

基于加权关联规则和文本挖掘的金融新闻传播Agent实现

针对传统的金融预测系统仅仅依靠股票价格和市场指数等定量数据而不能很好地满足实时性和高准确性的问题,提出一种基于加权关联规则和文本挖掘的新闻传播Agent实现方法。首先,利用中文知识与信息处理系统将每个新闻标题分离得到每个中文单词;然后,利用加权关联规则算法检测频繁出现在同一条新闻标题中的多个术语,并提取名词、动词和复合语;最后,根据新闻供给市场第一个交易日股票交易金融价格指数为提取的关键字分配权重,并根据新闻标题的权重值判断其对股票价格的影响程度。新闻标题特征数据库上的实验验证了该方法在金融新闻标题的实时信息发布应用中的可行性,实验结果表明,相比其他几种预测方法,该方法取得了更高的预测准确率和召回率。

用于纳米材料功能化改性的新型硅烷偶联剂制备分析

随着纳米科技的发展,纳米材料由于其独特的小尺寸效应、宏观量子隧道效应等特性成为材料领域无可替代的新星。对纳米材料的功能化改性是提升材料物化性能的重要手段。在此,对用于纳米材料功能化改性的新型硅烷偶联剂的研究进展进行总结,并提出了一种可用于聚合物基体改性以提高纳米复合材料热稳定性的新型硅烷偶联剂制备方法。