Synthesis and Antitumor Activity of New Derivatives of Podophyllotoxin

A series of analogues of etoposide (VP-16), the C-4 alkylamino-substituted 4'demethyl-epipodophyllotoxins, have been synthesized and studied for their activity to inhibit L1210 and KB cells in vitro. Most new compounds are as active or more active than VP-16 in their inhibition of both L1210 and KB cells.

TWO NEW CINNAMIC ACID DERIVATIVES FROM MAGNOLIA BIONDII PAMP

Two new cinnamic acid derivatives named biondinin C and biondinin D were isolated from the flower buds of Magnolia biondii pamp. The structures were elucidated by the spectral data including ~1H, ~1H COSY, ~1H-^(13)C COSY spectra.

A NEW METHOD FOR THE PREPARATION OF PHENOLS AND ITS DERIVATIVES

a-Oxo ketene dithioacetals 2 via 1,2-nucleophilie addition by methallyl magnesius chloride afforded corresponding alcohols (3). Treated with water or methanol and catalyzed by Lewis acid, the alcohols 3 were converted regiospecifical ly to substituted phenols 5' or related phenol methyl ethers 5 respectively. This reaction is a novel approach to the synthesis of phenols and their derivatives starting from non-aromatic precursors.

SYNTHESIS OF NEW ESTRONE DERIVATIVES OF AMINO ACIDS AND PEPTIDES

A series of estrone derivatives of amino acids and peptides haze been synthesized by different coupling reagents and the binding affinity of deblocked derivatives to the estrogen receptor of rats uteri have been measured by a comptetive radiometric bind- ing assay.

CIMICIFUGAMIDE AND ISOCIMICIFUGAMIDE,TWO NEW CINNAMAMIDE DERIVATIVES ISOLATED FROM CIMICIFUGA DAHURICA

Two new cinnamamide derivatives designated as cimicifugamide((?))and isocimicifu- gamide((?)),have been isolated from the rhizomes of Cimicifuga dahurica(Turcz.)Maxim..Their structures were established based on spectral evidence as N-(3'-methoxy-4'-hydroxyphenethyl)- 4-0-β-D-galactopyrano syl-ferulamide(E)and N-(3'-methoxy-4'-hydroxyphenetnyl)-4-0-β-D-ga- lactopyranosyl-isoferulamide(Z)respectively.

NEW ORGANIC NONLINEAR OPTICAL MATERIALS OF CINNAMYLIDENE-ACETOPHENONE DERIVATIVES

we have synthesised a series of new optically nonlinear organic materials of cinnamylidene-acetophenone derivatives which have large nonl inear optical susceptibilities and short cut-off wavelengths.

A NEW AND EFFICIENT SYNTHESIS OF 3-IODO DERIVATIVES OF FLAVONES, THIOFLAVONES AND THIOCHROMONES

The title compounds are prepared in good yields by iodination of the corresponding flavones, thioflavones and thiochromones respectively using I_2-CAN(ceric ammonium nitrate) system. The compounds thus prepared are potentially useful precursors for the synthesis of C-3 linked binuclear compounds.

A NEW CONVENIENT SYNTHESIS OF S-ALKYL N,N-DIALKYL THIOPHOSPHORAMIDIC ACID DERIVATIVES

The chlorination of O,O-dialkyl N,N-dialkyl thiophosphoramidates with phosphorus oxychloride proceeds with isomerization to give S-alkyl N,N-dialkyl thiophosphoramidochloridates,which react further with various nucleophiles in the presence of base to give the title compounds.

A NEW WAY FOR DERIVING SOLITARY WAVE

This paper presents a new way for deriving solitary wave by using variational principle, which not only can be used to derive solitary wave according to Original Mathematical Equations (OME), but also can be used to derive solitary wave according to the Wave Equation (WE) derived from OME. With the same condition of wave height and water depth, WE-solitary wave and OME-solitary wave are compared in this paper.

A NEW WAY FOR DERIVING HIGH ORDER STOKES WAVES

Variational principle for non-vortex, non-linear wave theories is established in this paper. By using this variational principle and related functional minimum condition, the fifth and sixth order Stokes Vaves are given as an example and the results are compared with those in Reference (Skjel-breia, 1961).

A NEW GUANIDINE DERIVATIVE FROM ASTRAGALUS COMPLANATUS R.Br.

A new guanidine derivative,complanatin has been isolated from the seeds of Chinese traditional medicine Astragalus complanatus R.Br..Its structure was established on the basis of spectral data and X-ray crystallographic analysis to be N-[3-carboxypropyl]-N-[3-methyl-2-butenyl]guanidine.

A New All-Aromatic Thermotropic Liquid Crystalline Polyester Derived from Acetylhydroquinone

A new all aromatic thermotropic liquid crystalline polyester from acetylhydroquinone was prepared by nucleophilic substitution reaction and characterized for its thermotropic liquid crystalline property. The new polyester was amorphous which had glass transition at 274 degrees C. Above Tg, the sample exhibited typical nematic texture. It showed high thermal stability (Td=487 degrees C).

NEW SOLID BASE DERIVED FROM AIPO4-5 SUPPORTED KF

Dispersion of KF on AlPO4-5 molecular sieve created basic sites and caused 1654 cm- band of bidentate carbonate in CO2 adsorption.After pre-treated above 823K. 5%KF/AlPO4-5exhibited basic catalytic activity in the isomerization of butenes at 273K. and the activity increasedwith the pre-treatment temperature up to 923K.

Vilsmeier-Haack Reagent： Synthesis of 2-Chloro-3-Formyl-1,8-Naphthyridine and Transformation into Different Functionalities

A simple and regioselective synthesis of 2-chloro-3-formyl-l,8-naphthyridine （1） through V ilsmeier-Haack cyclization of N-（pyridine-2-yl） acetamide has been reported. The reaction of compound （1） with sodium sulphide gives thione （2） and the reaction of compound （1） with Na2S/DMF followed by reaction with alkyl halide in one pot afforded thioether （3 and 4）. New naphthyridone （5） was synthesized from the action of acetic acid and POCI3 in compound （1）. The condensation of compounds （1 and 8） with hydroxylamine and aniline leads to the formation of compounds （6, 7 and 9）. The 2-chloro-3-formyl-l,8-naphthyridine was treated with sodium azide underwent cyclization to afford tetrazolo （l,5-a） （l,8-naphthyridine-4-carbaldehyde （8）. The azitidinone （10 and 12） and thioazolidinone （11 and 13） were synthesized from shift base intermediates by using chloroacetyl chloride and thioglycolic acid. The formyl group in compound （1） is subjected to cyano （14） and 3-alkoxycarbonyl （15）, respectively. The ester （15） was treated with hydrazine hydrate in ethanol to give acid hydrazide （16） then converted to thio semicarbazide （17） by their reaction with ammonium thiocyanate. New thiadiazolo （18）, triazolo （19） and oxadiazolo （20） have been prepared. The structures of synthesized compounds have been confirmed by suitable spectroscopic techniques such as IR （infrared spectrometry） and ^1H NMR （proton nuclear magnetic resonance）.

Lassa hemorrhagic fever model using new generalized Caputo-type fractional derivative operator

In some of the previous decades, we have observed that mathematical modeling hasbecome one of the most interesting research fields and has attracted many researchers.In this regard, thousands of researchers have proposed different varieties of mathematicalmodels to study the dynamics of a number of real-world problems. This research workis framed to analyzing the structure of the well-known Lassa hemorrhagic epidemic;adangerous epidemic for pregnant women, via new generalized Caputo type nonintegerorder derivative with the help of a modified Predictor–Corrector scheme. Lassa hemorrhagic disease is an epidemical and biocidal fever, whose negative impacts were initiallyrecognized in the countries of Africa. This virus has killed many pregnant women ascompared to the Ebola epidemic. It was noticed that Lassa virus was isolated in Verocell cultures from a blood pattern, and after 12 days it was ejective, after the climb ofthe sickness. In this research study, necessary theorems and lemmas are reminded toprove the existence of a unique solution and stability of given fractional approximationscheme. All necessary results are reminded to confirm the effectiveness of the proposedapproximation algorithm by graphical observations for various fractional-order values.In our practical calculations, we plotted the graphs for two different values of naturaldeath rate along with various values of given fractional-order operator. Our major target is to show the importance of the proposed modified version of the Predictor–Correctoralgorithm in epidemic studies by exploring the given Lassa hemorrhagic fever dynamics.

A new and efficient method for the synthesis of rocuronium bromide

Rocuronium bromide has been used as an aminosteroid non-depolarizing neuromuscular blocker and muscle relaxant.In this work,a new and efficient route for preparing a key intermediate 2β-（4-morpholinyl）-16β-（1-pyrrolidinyl）-5α-androstan-3α,17β-diol（6） was developed through a ring-opening of epoxide followed by introducing and pyrrolidine.Compound 6 can easily provide rocuronium bromide and the overall yield of compound 6 in 5 steps increased to 57.8%,which was higher than currently reported methods.Extraordinarily,this method would avoid the generation of disubstituted impurities E and F which are difficult to remove.