Mr.Liu Zhenya,general manager of the State Grid and Mr.Fu Zhifang,executive vice governor of Hebei Province together with their colleagues jointly inspected the development of new energy project in Zhangbei County,Zha...Mr.Liu Zhenya,general manager of the State Grid and Mr.Fu Zhifang,executive vice governor of Hebei Province together with their colleagues jointly inspected the development of new energy project in Zhangbei County,Zhangjiakou City,Hebei Province.展开更多
A series of coesite,coexisting with or without a liquid phase,was synthesized in the nominal system SiO2-H2O at800-1450℃and 5 GPa.Micro-Raman spectroscopy was used to identity the crystalline phase,electron microprob...A series of coesite,coexisting with or without a liquid phase,was synthesized in the nominal system SiO2-H2O at800-1450℃and 5 GPa.Micro-Raman spectroscopy was used to identity the crystalline phase,electron microprobe and LA-ICP-MS were employed to quantity some major and trace elements,and unpolarized FTIR spectroscopy was applied to probe the different types of hydrogen defects,explore water-incorporation mechanisms and quantify water contents.Trace amounts of A1 and B were detected in the coesite.Combining our results with the results in the literatures,we have found no positive correlation between the Al contents and the"Al"-based hydrogen concentrations,suggesting that previously proposed hydrogen-incorporation mechanism H^++Al^3+■Si^4+does not function in coesite.In contrast,we have confirmed the positive correlation between the B contents and the B-based hydrogen concentrations.The hydrogen-incorporation mechanism H^++B3^+■Si^4+readily takes place in coesite at different P-T conditions,and significantly increases the water content at both liquid-saturated and liquid-undersaturated conditions.For the SiO2-H2O system,we have found that type-Ⅰhydrogarnet substitution plays a dictating role in incorporating water into coesite at liquid-saturated condition,type-II hydrogarnet substitution contributes significantly at nearly dry condition,and both operate at conditions in between.The water solubility of coesite,as dictated by the type-Ⅰhydrogarnet substitution,positively correlates with both P and T,cH2O=-105(30)+5.2(32)×P+0.112(26)×T,with cH2O in wt ppm,P in GPa and T in℃.Due to its low water solubility and small fraction in subducted slabs,coesite may contribute insignificantly to the vertical water transport in subduction zones.Furthermore,the water solubility of any coesite in exhuming ultra-high pressure metamorphic rocks should be virtually zero as coesite becomes metastable.With an adequately fast waterdiffusion rate,this metastable coesite should be completely dry,which may have been the key factor to the partial preservation of most natural Coe.As a byproduct,a new IR experimental protocol for accurate water determination in optically anisotropic nominally anhydrous minerals has been found.Aided with the empirical method of Paterson(1982)it employs multiple unpolarized IR spectra,collected from randomly-orientated mineral grains,to approximate both total integrated absorbance and total integrated molar absorption coefficient.Its success relies on a high-level orientation randomness in the IR analyses.展开更多
Rapid urbanization and the booming of diversified community development requirements have challenged the development of community planning in China from theory to practice. Community planning, especially with localize...Rapid urbanization and the booming of diversified community development requirements have challenged the development of community planning in China from theory to practice. Community planning, especially with localized and practice-oriented characteristics, is now facing many limitations. These include aspects such as traditional urban planning techniques that mainly focus on space, a restricted research perspective, as well as basic planning theories that are mostly imported from the West. Using the perspective of socio-spatial dialectic for reference, this paper summarizes the evolution process of Chinese modern residential space planning and design from residential district planning under the planned economy system, to housing estate planning in the real estate development, and to community planning in the new era, presenting an important characteristic of transitioning from "producing space" to "production of space," with "society" gradually replacing "space" and returning to the goal of production. Based on the analysis on the main limitations and problems in the former work of community planning in China, the paper takes the practical exploration on community planning in the "New Qinghe Experiment" in Haidian District, Beijing for an example. Aimed at the prominent problem of an extreme imbalance between "urbanization of space" and "urbanization of population" in the current Qinghe area, the key objective, means, and technical path of new-type community planning are proposed, within which three significant transition features are demonstrated, including going from "need-oriented" to "capital-oriented," from "interest intervention" to "relationship intervention," and from "community construction" to "community building."展开更多
In recent years, tumor-nfiltrating lymphocytes (TILs) have been reported to be effective for tumors in experimental and clinical research. In order to increase the therapeutical effect, we modified some steps of Rosen...In recent years, tumor-nfiltrating lymphocytes (TILs) have been reported to be effective for tumors in experimental and clinical research. In order to increase the therapeutical effect, we modified some steps of Rosenberg's approach a. cold digestion with collagenase at 4C for 24 hours; b. sedimentation instead of centrifugation; c. elimination of tumor cells before the cultivation procedure. Compared with the original approach, the proliferation, activity and cytotoxicity of TILs obtained by the modified procedure were much improved. TILs' expansion-old was greater than that with the original approach. Cytotoxicity against rumor cells was more potent. Increased TILs' subsets were CD3 and CD8 cells. Meanwhile, we took tumor cells from tumor tissues to test their in vitro chemosensitivities to different drugs in order to select highly sensitive antitumor drugs for treatment of cases with advanced tumors. According to the design of using highly active TILs and highly sensitive drugs (H & H therapy), preliminary clinical results of 50 cases showed higher response rates than those in treatment with TIL / IL2, LAK / 1L2 and TIL+IL2+CTX. Less toxic side effects were observed in 14 patients.展开更多
文摘Mr.Liu Zhenya,general manager of the State Grid and Mr.Fu Zhifang,executive vice governor of Hebei Province together with their colleagues jointly inspected the development of new energy project in Zhangbei County,Zhangjiakou City,Hebei Province.
基金financially supported by the DREAM project of MOST,China(Grant No.2016YFC0600408)the Strategic Priority Research Program(B)of Chinese Academy of Sciences(Grant No.XDB18000000)the Program of the National Mineral Rock and Fossil Specimens Resource Center from MOST,China。
文摘A series of coesite,coexisting with or without a liquid phase,was synthesized in the nominal system SiO2-H2O at800-1450℃and 5 GPa.Micro-Raman spectroscopy was used to identity the crystalline phase,electron microprobe and LA-ICP-MS were employed to quantity some major and trace elements,and unpolarized FTIR spectroscopy was applied to probe the different types of hydrogen defects,explore water-incorporation mechanisms and quantify water contents.Trace amounts of A1 and B were detected in the coesite.Combining our results with the results in the literatures,we have found no positive correlation between the Al contents and the"Al"-based hydrogen concentrations,suggesting that previously proposed hydrogen-incorporation mechanism H^++Al^3+■Si^4+does not function in coesite.In contrast,we have confirmed the positive correlation between the B contents and the B-based hydrogen concentrations.The hydrogen-incorporation mechanism H^++B3^+■Si^4+readily takes place in coesite at different P-T conditions,and significantly increases the water content at both liquid-saturated and liquid-undersaturated conditions.For the SiO2-H2O system,we have found that type-Ⅰhydrogarnet substitution plays a dictating role in incorporating water into coesite at liquid-saturated condition,type-II hydrogarnet substitution contributes significantly at nearly dry condition,and both operate at conditions in between.The water solubility of coesite,as dictated by the type-Ⅰhydrogarnet substitution,positively correlates with both P and T,cH2O=-105(30)+5.2(32)×P+0.112(26)×T,with cH2O in wt ppm,P in GPa and T in℃.Due to its low water solubility and small fraction in subducted slabs,coesite may contribute insignificantly to the vertical water transport in subduction zones.Furthermore,the water solubility of any coesite in exhuming ultra-high pressure metamorphic rocks should be virtually zero as coesite becomes metastable.With an adequately fast waterdiffusion rate,this metastable coesite should be completely dry,which may have been the key factor to the partial preservation of most natural Coe.As a byproduct,a new IR experimental protocol for accurate water determination in optically anisotropic nominally anhydrous minerals has been found.Aided with the empirical method of Paterson(1982)it employs multiple unpolarized IR spectra,collected from randomly-orientated mineral grains,to approximate both total integrated absorbance and total integrated molar absorption coefficient.Its success relies on a high-level orientation randomness in the IR analyses.
文摘Rapid urbanization and the booming of diversified community development requirements have challenged the development of community planning in China from theory to practice. Community planning, especially with localized and practice-oriented characteristics, is now facing many limitations. These include aspects such as traditional urban planning techniques that mainly focus on space, a restricted research perspective, as well as basic planning theories that are mostly imported from the West. Using the perspective of socio-spatial dialectic for reference, this paper summarizes the evolution process of Chinese modern residential space planning and design from residential district planning under the planned economy system, to housing estate planning in the real estate development, and to community planning in the new era, presenting an important characteristic of transitioning from "producing space" to "production of space," with "society" gradually replacing "space" and returning to the goal of production. Based on the analysis on the main limitations and problems in the former work of community planning in China, the paper takes the practical exploration on community planning in the "New Qinghe Experiment" in Haidian District, Beijing for an example. Aimed at the prominent problem of an extreme imbalance between "urbanization of space" and "urbanization of population" in the current Qinghe area, the key objective, means, and technical path of new-type community planning are proposed, within which three significant transition features are demonstrated, including going from "need-oriented" to "capital-oriented," from "interest intervention" to "relationship intervention," and from "community construction" to "community building."
文摘In recent years, tumor-nfiltrating lymphocytes (TILs) have been reported to be effective for tumors in experimental and clinical research. In order to increase the therapeutical effect, we modified some steps of Rosenberg's approach a. cold digestion with collagenase at 4C for 24 hours; b. sedimentation instead of centrifugation; c. elimination of tumor cells before the cultivation procedure. Compared with the original approach, the proliferation, activity and cytotoxicity of TILs obtained by the modified procedure were much improved. TILs' expansion-old was greater than that with the original approach. Cytotoxicity against rumor cells was more potent. Increased TILs' subsets were CD3 and CD8 cells. Meanwhile, we took tumor cells from tumor tissues to test their in vitro chemosensitivities to different drugs in order to select highly sensitive antitumor drugs for treatment of cases with advanced tumors. According to the design of using highly active TILs and highly sensitive drugs (H & H therapy), preliminary clinical results of 50 cases showed higher response rates than those in treatment with TIL / IL2, LAK / 1L2 and TIL+IL2+CTX. Less toxic side effects were observed in 14 patients.