Find It What do people clean before Chinese New Year?Conversation A(in the studio)Greg:Welcome,Tara!Happy Chinese New Year!Tara:Thank you!Greg:You know a lot about different cultures.What do people do to prepare for t...Find It What do people clean before Chinese New Year?Conversation A(in the studio)Greg:Welcome,Tara!Happy Chinese New Year!Tara:Thank you!Greg:You know a lot about different cultures.What do people do to prepare for this holiday?展开更多
As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy o...As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy output limit its profitability in the electricity market and hinder its market-based integration.This paper first constructs a wind-solar-thermalmulti-energy complementary system,analyzes its external game relationships,and develops a bi-level market optimization model.Then,it considers the contribution levels of internal participants to establish a comprehensive internal distribution evaluation index system.Finally,simulation studies using the IEEE 30-bus system demonstrate that the multi-energy complementary system stabilizes nodal outputs,enhances the profitability of market participants,and promotes the market-based integration of renewable energy.展开更多
In response to meeting the needs of cultivating applied talents in the construction of new engineering disciplines,based on the concept of Outcome-Based Education(OBE),this study analyzes the problems existing in the ...In response to meeting the needs of cultivating applied talents in the construction of new engineering disciplines,based on the concept of Outcome-Based Education(OBE),this study analyzes the problems existing in the teaching of the course Environmental Engineering Microbiology,and put forward some corresponding curriculum reform schemes.According to the target points of professional graduation requirements,the scheme proposes revising the syllabus of Environmental Engineering Microbiology,clarifying the curriculum objectives,updating the teaching content,and reforming the teaching methods.Through these measures,it is intended to achieve the unity of teachers way of"teaching"and students way of"learning",construct a new teaching mode,fully stimulate students subjective initiative,and enhance students innovative consciousness and practical ability.Besides,in this study,a"whole process-diversification"evaluation system is established to comprehensively evaluate students performance in theoretical knowledge learning and practical application,comprehensively evaluate students learning situation,and analyze the teaching effect in real time,so as to achieve continuous improvement,and ultimately achieve the goal of improving classroom quality.展开更多
Platelet rich plasma(PRP)is an autologous blood product rich in platelets,showing promise in reducing inflammation and accelerating healing.While extensively utilized in plastic surgery,dermatology,and osteoarthritis ...Platelet rich plasma(PRP)is an autologous blood product rich in platelets,showing promise in reducing inflammation and accelerating healing.While extensively utilized in plastic surgery,dermatology,and osteoarthritis treatment,its application in anterior cruciate ligament(ACL)injuries is limited.This article examines PRP's potential in ACL reconstruction(ACLR),exploring its history,current usage,controversies and future directions.PRP has demonstrated significant early benefits in ligamentisation and vascularisation post-ACLR,though its long-term efficacy is inconsistent.Studies suggest that PRP may serve as both an adjunct therapy in ACLR to enhance initial healing and reduce postoperative complications,and as a non-surgical alternative for small ACL tears.Despite these promising findings,outcome variability necessitates further high-quality research to optimize PRP formulations and determine its most effective applications.The exploration of PRP as a treatment modality in ACLR offers promising but varied outcomes.PRP holds considerable promise as both an adjunct and alternative to traditional ACLR.This article underscores the need for targeted research to fully realize PRP's therapeutic potential in ACL treatment,aiming to inform future studies and clinical practices.By understanding PRP's mechanisms of efficacy and identifying the most beneficial patient populations,PRP could significantly impact orthopaedics and sports medicine,improving recovery pathways and patient outcomes.展开更多
Is He Living or Is He Dead is mainly about an outstanding painter Francois Millet who pretend to be dead in order to get reputation and money,because at that time a great artist has never been acknowledged until after...Is He Living or Is He Dead is mainly about an outstanding painter Francois Millet who pretend to be dead in order to get reputation and money,because at that time a great artist has never been acknowledged until after he was starved and dead. Based on the critic approach of New Historicism, this thesis have analyzed how Millet subvert power and be contained by power, the capitalism and market, which criticized the phenomenon that the value of art is not decided by itself, but by power. No matter it is good or bad, if it is denied by power, it is valueless.展开更多
Louis Adrian Montrose has addressed literary,historical,and theoretical topics and issues concerned with New Historicism.He elegantly demonstrated how language and literary imagination shape cultural value;belief,and ...Louis Adrian Montrose has addressed literary,historical,and theoretical topics and issues concerned with New Historicism.He elegantly demonstrated how language and literary imagination shape cultural value;belief,and understanding;social distinction and interaction;and political control and contestation,thus significantly shaped contemporary studies of poetics and politics of culture.He refuted the oversimplified polarization of language and society of J.Hillis Miller and Edward Pechter's misunderstandings about "New Historicism" and stated his own understanding and expectations of New Historicism.From a detailed analysis of his ideas,the author points out the weakness in his arguments and advises researchers in this field to dialectically view the school of New Historicism.展开更多
The Virginian: A Horseman of the Plains (1902) has been considered as one of the masterpieces of American western novels for its successful depiction of cowboys and local customs, which earns Owen Wister the Father...The Virginian: A Horseman of the Plains (1902) has been considered as one of the masterpieces of American western novels for its successful depiction of cowboys and local customs, which earns Owen Wister the Father of Western fiction. The paper aims to reveal the relationship between The Virginian and its historical context by applying the doctrines of New Historicism: historicity of texts and textuality of history. By historicity of texts, it points out that the work is the emblem of disappearance of western frontier, and it symbolizes the union of the Wild West and the civilized east. By textuality of history, it detects the change of social class, the development of livestock industry and railway, and their influence on the work at the later part of 19th century.展开更多
Two new species of the genus Bifidocoelotes Wang,2002 are described from Guangxi Zhuang Autonomous Region of China:B.alviolatus sp.nov.(♂♀),B.latus sp.nov.(♀),and the male of B.elongatus Liao,Wang,Yin&Xu,2022 i...Two new species of the genus Bifidocoelotes Wang,2002 are described from Guangxi Zhuang Autonomous Region of China:B.alviolatus sp.nov.(♂♀),B.latus sp.nov.(♀),and the male of B.elongatus Liao,Wang,Yin&Xu,2022 is described for the first time.Detailed descriptions,morphological illustrations and a distribution map of Bifidocoelotes are provided.DNA barcodes of four Bifidocoelotes species are also provided,including the new species(B.alviolatus sp.nov.)and three known species(B.mammiformis Liao et al.,2022;B.quadratus Liao et al.,2022;B.elongatus Liao et al.,2022).展开更多
Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opport...Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opportunity for curative surgical intervention.This situation leads to lower quality of life and higher mortality rates.In recent years,the rapid development of endoscopic equipment and techniques has provided new avenues and possibilities for the early and minimally invasive diagnosis and treatment of GBC.This editorial comments on the article by Pavlidis et al.Building upon their work,we explore the new needs and corresponding models for managing GBC from the endoscopic diagnosis and treatment perspective.展开更多
This paper analyses Jane Eyre from the perspective of new historicism. In the first part,by explaining the influence of social background to the creation of Jane Eyre and the influence of characters in Jane Eyre to th...This paper analyses Jane Eyre from the perspective of new historicism. In the first part,by explaining the influence of social background to the creation of Jane Eyre and the influence of characters in Jane Eyre to the development of the society,it analyses the relationship between literature and history. The second part particularly elaborates the new historicism strategies used in the creation of Jane Eyre,such as to analyse history from personal perspective,subversion and oppression,self-fashioning and so on. The last part is a conclusion,which further expounds the significance of interpret Jane Eyre from the perspective of new historicism.展开更多
Edward.Albee’s masterpiece Who’s Afraid of Virginia Woolf?is generally considered as one of the representative works of Theatre of the Absurd.This paper will analyze the two sets of opposing power structure in the p...Edward.Albee’s masterpiece Who’s Afraid of Virginia Woolf?is generally considered as one of the representative works of Theatre of the Absurd.This paper will analyze the two sets of opposing power structure in the play from the perspective of New Historicism and further demonstrate the cultural and historical context implied in the play.展开更多
Boehmeria nivea var.strigosa Zeng Y.Wu&Y.Zhao,a new variety of B.nivea(Urticaceae)from Southwest China,is here described based on evidence from morphology and molecular phylogeny.This new variety is mainly charact...Boehmeria nivea var.strigosa Zeng Y.Wu&Y.Zhao,a new variety of B.nivea(Urticaceae)from Southwest China,is here described based on evidence from morphology and molecular phylogeny.This new variety is mainly characterized by its green abaxial leaf blade,partly connate stipules,and densely patent strigose hairs on stems and potioles.The phylogenetic analysis based on rbc L,nrDNA and rbc L+nrDNA datasets,revealed that all individuals of B.nivea var.strigosa formed a monophyletic group.The conservation status of B.nivea var.strigosa is assessed as“Near Threatened”(NT)according to IUCN evaluation criteria.The discovery of this new variety is not only crucial for the taxonomy of ramie,but also provides reference for the exploration and utilization of ramie.展开更多
The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their sickness.Minimally invasive surgery(MIS)has dominated the surgical realm...The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their sickness.Minimally invasive surgery(MIS)has dominated the surgical realm because of its lesser invasiveness.However,changes in anatomical structures of the body and reconstruction of internal organs or different organs are common after traditional surgery or MIS,decreasing the quality of life of patients post-operation.Thus,I propose a new treatment mode,super MIS(SMIS),which is defined as“curing a disease or lesion which used to be treated by MIS while preserving the integrity of the organs”.In this study,I describe the origin,definition,operative channels,advantages,and future perspectives of SMIS.展开更多
Different literary criticism theories have paved the way to analyse and evaluate the literature works from various per?spectives. In the last century, especially during the 1940s to the 1960s, the New Criticism almost...Different literary criticism theories have paved the way to analyse and evaluate the literature works from various per?spectives. In the last century, especially during the 1940s to the 1960s, the New Criticism almost dominated the literature analysis field. However, in the 1970s and early 1980s, a kind of literary criticism theory which maintained that the personal biases could largely affect the interpretation of the literature work and all history could be subjective seized the literature critic's eyeballs. And the appearance of New Historicism marked a vital transition of literature criticism theories. By analyzing the historicity of texts and the textuality of history, New Historicism does not set a clear distinction between history and literature.New Historicism mainly connects the texts and history and puts an end to the texts isolation. By figuring out the origin of New Historicism, trying to analyse the historicity and textuality thoroughly in this literature criticism theory, and exploring the disputes over this theory, the origins, concepts,historicity and textualityof New Historicism will be clarified.展开更多
Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being dis...Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.展开更多
BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve development.Mutations in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language delay.CASE S...BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve development.Mutations in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language delay.CASE SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B gene.Three individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were analyzed.This article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment approach.Among the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had epilepsy.Antiepileptic treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat delayed.Whole exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(p.Arg1825trp),c.4120C>T(p.Gln1374*,593),c.14_15insC(p.His5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language delay.Although the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of life.Furthermore,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.展开更多
An analytic hierarchy process(AHP)was employed to assess the applicability of 18 new and superior varieties of flowers in Hefei City flower border applications.A total of 12 indicators were selected from three distinc...An analytic hierarchy process(AHP)was employed to assess the applicability of 18 new and superior varieties of flowers in Hefei City flower border applications.A total of 12 indicators were selected from three distinct aspects of adaptability,ornamental characteristics and use traits,in order to establish a comprehensive evaluation model.The results demonstrate that grade I(J≥2.685)exhibits excellent application value,encompassing six species of plants,such asHydrangeamacrophylla‘Endless Summer’;grade II(2.684≤J≤2.420)is also of notable application value,encompassing five species of plants,such asCallistemonrigidus;grade III(2.419≤J≤2.615)is of average application value,including five species of plants,such asCrocosmiacrocosmiflora;grade IV(J≤2.16)is of relatively poor application value.The evaluation results may be utilized as a theoretical reference for the promotion of new and superior varieties in the flower border of Hefei.展开更多
In the new era,the Communist Party of China(CPC)has made historic achievements in respecting and protecting human rights.Building upon the principle of the“two integrations”(integrating the basic tenets of Marxism w...In the new era,the Communist Party of China(CPC)has made historic achievements in respecting and protecting human rights.Building upon the principle of the“two integrations”(integrating the basic tenets of Marxism with China’s specific realities and fine traditional culture),it has nurtured new theories on respecting and protecting human rights in the new era,which can address the fundamental questions of whom and what the human rights protection efforts in the new era are for.Guided by the principle of“taking our own path,”it has charted a distinct course for the development of human rights,diverging from the Western approach.The CPC has maintained the unity between Party leadership and the respect for and protection of human rights,promoting progress in human rights through the pursuit of“high-quality development,”and ensuring various fundamental rights of the people through the rule of law.Building upon the past experience,the CPC has established the“source”of the institutional framework for respecting and protecting human rights in the new era,crafted the“body”of this institutional framework,and introduced its practical“application.”In promoting the comprehensive advancement of human rights protection,the CPC has facilitated the connotative development of human rights protection in China,empowering China in international human rights discourse,and contributing Chinese strength and wisdom to global human rights governance.展开更多
文摘Find It What do people clean before Chinese New Year?Conversation A(in the studio)Greg:Welcome,Tara!Happy Chinese New Year!Tara:Thank you!Greg:You know a lot about different cultures.What do people do to prepare for this holiday?
基金funded by the National Key R&D Program of China,grant number 2019YFB1505400.
文摘As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy output limit its profitability in the electricity market and hinder its market-based integration.This paper first constructs a wind-solar-thermalmulti-energy complementary system,analyzes its external game relationships,and develops a bi-level market optimization model.Then,it considers the contribution levels of internal participants to establish a comprehensive internal distribution evaluation index system.Finally,simulation studies using the IEEE 30-bus system demonstrate that the multi-energy complementary system stabilizes nodal outputs,enhances the profitability of market participants,and promotes the market-based integration of renewable energy.
基金Supported by Higher Education Teaching Reform Project of Zhaoqing University (zlgc2024058&zlgc202242)Curriculum Ideological and Political Reform Demonstration Project of Zhaoqing University.
文摘In response to meeting the needs of cultivating applied talents in the construction of new engineering disciplines,based on the concept of Outcome-Based Education(OBE),this study analyzes the problems existing in the teaching of the course Environmental Engineering Microbiology,and put forward some corresponding curriculum reform schemes.According to the target points of professional graduation requirements,the scheme proposes revising the syllabus of Environmental Engineering Microbiology,clarifying the curriculum objectives,updating the teaching content,and reforming the teaching methods.Through these measures,it is intended to achieve the unity of teachers way of"teaching"and students way of"learning",construct a new teaching mode,fully stimulate students subjective initiative,and enhance students innovative consciousness and practical ability.Besides,in this study,a"whole process-diversification"evaluation system is established to comprehensively evaluate students performance in theoretical knowledge learning and practical application,comprehensively evaluate students learning situation,and analyze the teaching effect in real time,so as to achieve continuous improvement,and ultimately achieve the goal of improving classroom quality.
文摘Platelet rich plasma(PRP)is an autologous blood product rich in platelets,showing promise in reducing inflammation and accelerating healing.While extensively utilized in plastic surgery,dermatology,and osteoarthritis treatment,its application in anterior cruciate ligament(ACL)injuries is limited.This article examines PRP's potential in ACL reconstruction(ACLR),exploring its history,current usage,controversies and future directions.PRP has demonstrated significant early benefits in ligamentisation and vascularisation post-ACLR,though its long-term efficacy is inconsistent.Studies suggest that PRP may serve as both an adjunct therapy in ACLR to enhance initial healing and reduce postoperative complications,and as a non-surgical alternative for small ACL tears.Despite these promising findings,outcome variability necessitates further high-quality research to optimize PRP formulations and determine its most effective applications.The exploration of PRP as a treatment modality in ACLR offers promising but varied outcomes.PRP holds considerable promise as both an adjunct and alternative to traditional ACLR.This article underscores the need for targeted research to fully realize PRP's therapeutic potential in ACL treatment,aiming to inform future studies and clinical practices.By understanding PRP's mechanisms of efficacy and identifying the most beneficial patient populations,PRP could significantly impact orthopaedics and sports medicine,improving recovery pathways and patient outcomes.
文摘Is He Living or Is He Dead is mainly about an outstanding painter Francois Millet who pretend to be dead in order to get reputation and money,because at that time a great artist has never been acknowledged until after he was starved and dead. Based on the critic approach of New Historicism, this thesis have analyzed how Millet subvert power and be contained by power, the capitalism and market, which criticized the phenomenon that the value of art is not decided by itself, but by power. No matter it is good or bad, if it is denied by power, it is valueless.
文摘Louis Adrian Montrose has addressed literary,historical,and theoretical topics and issues concerned with New Historicism.He elegantly demonstrated how language and literary imagination shape cultural value;belief,and understanding;social distinction and interaction;and political control and contestation,thus significantly shaped contemporary studies of poetics and politics of culture.He refuted the oversimplified polarization of language and society of J.Hillis Miller and Edward Pechter's misunderstandings about "New Historicism" and stated his own understanding and expectations of New Historicism.From a detailed analysis of his ideas,the author points out the weakness in his arguments and advises researchers in this field to dialectically view the school of New Historicism.
文摘The Virginian: A Horseman of the Plains (1902) has been considered as one of the masterpieces of American western novels for its successful depiction of cowboys and local customs, which earns Owen Wister the Father of Western fiction. The paper aims to reveal the relationship between The Virginian and its historical context by applying the doctrines of New Historicism: historicity of texts and textuality of history. By historicity of texts, it points out that the work is the emblem of disappearance of western frontier, and it symbolizes the union of the Wild West and the civilized east. By textuality of history, it detects the change of social class, the development of livestock industry and railway, and their influence on the work at the later part of 19th century.
基金supported by the National Natural Sciences Foundation of China(32070429/31772423/31471963/31372160)Hunan Provincial Natural Science Foundation of China(2023JJ30399)the Hunan Provincial Innovation Foundation for Postgraduate(CX20230525).
文摘Two new species of the genus Bifidocoelotes Wang,2002 are described from Guangxi Zhuang Autonomous Region of China:B.alviolatus sp.nov.(♂♀),B.latus sp.nov.(♀),and the male of B.elongatus Liao,Wang,Yin&Xu,2022 is described for the first time.Detailed descriptions,morphological illustrations and a distribution map of Bifidocoelotes are provided.DNA barcodes of four Bifidocoelotes species are also provided,including the new species(B.alviolatus sp.nov.)and three known species(B.mammiformis Liao et al.,2022;B.quadratus Liao et al.,2022;B.elongatus Liao et al.,2022).
基金the Education and Teaching Reform Project of the First Clinical College of Chongqing Medical University,No.CMER202305the Program for Youth Innovation in Future Medicine,Chongqing Medical University,No.W0138.
文摘Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opportunity for curative surgical intervention.This situation leads to lower quality of life and higher mortality rates.In recent years,the rapid development of endoscopic equipment and techniques has provided new avenues and possibilities for the early and minimally invasive diagnosis and treatment of GBC.This editorial comments on the article by Pavlidis et al.Building upon their work,we explore the new needs and corresponding models for managing GBC from the endoscopic diagnosis and treatment perspective.
文摘This paper analyses Jane Eyre from the perspective of new historicism. In the first part,by explaining the influence of social background to the creation of Jane Eyre and the influence of characters in Jane Eyre to the development of the society,it analyses the relationship between literature and history. The second part particularly elaborates the new historicism strategies used in the creation of Jane Eyre,such as to analyse history from personal perspective,subversion and oppression,self-fashioning and so on. The last part is a conclusion,which further expounds the significance of interpret Jane Eyre from the perspective of new historicism.
文摘Edward.Albee’s masterpiece Who’s Afraid of Virginia Woolf?is generally considered as one of the representative works of Theatre of the Absurd.This paper will analyze the two sets of opposing power structure in the play from the perspective of New Historicism and further demonstrate the cultural and historical context implied in the play.
文摘Boehmeria nivea var.strigosa Zeng Y.Wu&Y.Zhao,a new variety of B.nivea(Urticaceae)from Southwest China,is here described based on evidence from morphology and molecular phylogeny.This new variety is mainly characterized by its green abaxial leaf blade,partly connate stipules,and densely patent strigose hairs on stems and potioles.The phylogenetic analysis based on rbc L,nrDNA and rbc L+nrDNA datasets,revealed that all individuals of B.nivea var.strigosa formed a monophyletic group.The conservation status of B.nivea var.strigosa is assessed as“Near Threatened”(NT)according to IUCN evaluation criteria.The discovery of this new variety is not only crucial for the taxonomy of ramie,but also provides reference for the exploration and utilization of ramie.
基金Supported by National Key R&D Programs of China,No.2022YFC2503600.
文摘The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their sickness.Minimally invasive surgery(MIS)has dominated the surgical realm because of its lesser invasiveness.However,changes in anatomical structures of the body and reconstruction of internal organs or different organs are common after traditional surgery or MIS,decreasing the quality of life of patients post-operation.Thus,I propose a new treatment mode,super MIS(SMIS),which is defined as“curing a disease or lesion which used to be treated by MIS while preserving the integrity of the organs”.In this study,I describe the origin,definition,operative channels,advantages,and future perspectives of SMIS.
文摘Different literary criticism theories have paved the way to analyse and evaluate the literature works from various per?spectives. In the last century, especially during the 1940s to the 1960s, the New Criticism almost dominated the literature analysis field. However, in the 1970s and early 1980s, a kind of literary criticism theory which maintained that the personal biases could largely affect the interpretation of the literature work and all history could be subjective seized the literature critic's eyeballs. And the appearance of New Historicism marked a vital transition of literature criticism theories. By analyzing the historicity of texts and the textuality of history, New Historicism does not set a clear distinction between history and literature.New Historicism mainly connects the texts and history and puts an end to the texts isolation. By figuring out the origin of New Historicism, trying to analyse the historicity and textuality thoroughly in this literature criticism theory, and exploring the disputes over this theory, the origins, concepts,historicity and textualityof New Historicism will be clarified.
基金supported by the National Natural Science Foundation of China(32141003 and 82330110)the CAMS Innovation Fund for Medical Sciences(CIFMS+2 种基金2021-I2M-1-039)the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32)the Fundamental Research Funds for the Central Universities(2021-PT350-001).
文摘Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.
基金Key Health Science and Technology Development Project of Nanjing City,Jiangsu Province,No.ZKX19038.
文摘BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve development.Mutations in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language delay.CASE SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B gene.Three individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were analyzed.This article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment approach.Among the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had epilepsy.Antiepileptic treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat delayed.Whole exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(p.Arg1825trp),c.4120C>T(p.Gln1374*,593),c.14_15insC(p.His5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language delay.Although the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of life.Furthermore,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.
基金by Undergraduate Innovation and Entrepreneurship Training Program of Anhui Province(S202312216042)Natural Science Key Research Project of Colleges and Universities in Anhui Province(2023AH051816)General Teaching Research Project of Anhui Province(2022jyxm665).
文摘An analytic hierarchy process(AHP)was employed to assess the applicability of 18 new and superior varieties of flowers in Hefei City flower border applications.A total of 12 indicators were selected from three distinct aspects of adaptability,ornamental characteristics and use traits,in order to establish a comprehensive evaluation model.The results demonstrate that grade I(J≥2.685)exhibits excellent application value,encompassing six species of plants,such asHydrangeamacrophylla‘Endless Summer’;grade II(2.684≤J≤2.420)is also of notable application value,encompassing five species of plants,such asCallistemonrigidus;grade III(2.419≤J≤2.615)is of average application value,including five species of plants,such asCrocosmiacrocosmiflora;grade IV(J≤2.16)is of relatively poor application value.The evaluation results may be utilized as a theoretical reference for the promotion of new and superior varieties in the flower border of Hefei.
基金a phased achievement of the National Social Science Foundation’s major bidding project “Research on the Theoretical System and Optimization Path of China’s Human Rights Development Path”(Project Approval Number 23ZDA067)
文摘In the new era,the Communist Party of China(CPC)has made historic achievements in respecting and protecting human rights.Building upon the principle of the“two integrations”(integrating the basic tenets of Marxism with China’s specific realities and fine traditional culture),it has nurtured new theories on respecting and protecting human rights in the new era,which can address the fundamental questions of whom and what the human rights protection efforts in the new era are for.Guided by the principle of“taking our own path,”it has charted a distinct course for the development of human rights,diverging from the Western approach.The CPC has maintained the unity between Party leadership and the respect for and protection of human rights,promoting progress in human rights through the pursuit of“high-quality development,”and ensuring various fundamental rights of the people through the rule of law.Building upon the past experience,the CPC has established the“source”of the institutional framework for respecting and protecting human rights in the new era,crafted the“body”of this institutional framework,and introduced its practical“application.”In promoting the comprehensive advancement of human rights protection,the CPC has facilitated the connotative development of human rights protection in China,empowering China in international human rights discourse,and contributing Chinese strength and wisdom to global human rights governance.