Drug discovery leading to robust and viable lead candidates’ remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural product...Drug discovery leading to robust and viable lead candidates’ remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. However, in addition to their chemical structure diversity and their biodiversity, the development of new technologies has revolutionized the screening of natural products in discovering new drugs. Applying these technologies compensates for the inherent limitations of natural products and offers a unique opportunity to re-establish natural products as a major source for drug discovery. The present article attempts to describe the utilization of compounds derived from natural resources as drug candidates, with a focus on the success of these resources in the process of finding and discovering new and effective drug compounds, an approach commonly referred to as “natural product drug discovery”.展开更多
供应商参与新产品开发(Supplier involvement in new product development,SINPD)作为一种新的合作创新模式受到广泛关注,对新产品开发绩效的研究已成为企业实施SINPD的关键。在文献资料和国内企业调研访谈的基础上,初步提出9个影响SINP...供应商参与新产品开发(Supplier involvement in new product development,SINPD)作为一种新的合作创新模式受到广泛关注,对新产品开发绩效的研究已成为企业实施SINPD的关键。在文献资料和国内企业调研访谈的基础上,初步提出9个影响SINPD实施绩效的关键因素。通过对问卷收集的数据进行实证研究,验证和提取出知识创造能力、知识吸收能力、知识整合能力、组织学习能力、供应商参与时机、供应商参与程度6个关键成功因素,并对实证研究结果进行分析讨论。展开更多
文摘Drug discovery leading to robust and viable lead candidates’ remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. However, in addition to their chemical structure diversity and their biodiversity, the development of new technologies has revolutionized the screening of natural products in discovering new drugs. Applying these technologies compensates for the inherent limitations of natural products and offers a unique opportunity to re-establish natural products as a major source for drug discovery. The present article attempts to describe the utilization of compounds derived from natural resources as drug candidates, with a focus on the success of these resources in the process of finding and discovering new and effective drug compounds, an approach commonly referred to as “natural product drug discovery”.
文摘供应商参与新产品开发(Supplier involvement in new product development,SINPD)作为一种新的合作创新模式受到广泛关注,对新产品开发绩效的研究已成为企业实施SINPD的关键。在文献资料和国内企业调研访谈的基础上,初步提出9个影响SINPD实施绩效的关键因素。通过对问卷收集的数据进行实证研究,验证和提取出知识创造能力、知识吸收能力、知识整合能力、组织学习能力、供应商参与时机、供应商参与程度6个关键成功因素,并对实证研究结果进行分析讨论。
