Background: Perinatal asphyxia is a common cause of mortality and of morbidity including motor and neurodevelopmental abnormalities. The aim of this study was to evaluate the post-hospital outcome of neonates treated ...Background: Perinatal asphyxia is a common cause of mortality and of morbidity including motor and neurodevelopmental abnormalities. The aim of this study was to evaluate the post-hospital outcome of neonates treated for perinatal asphyxia at the Douala Gynaeco-Obstetric and Pediatric Hospital (DGOPH) in Cameroon. Patients and Methods: We conducted a hospital-based cross-sectional study with both a retrospective and prospective data collection, conducted over a period of 3 months and involving neonates above 34 weeks of gestational age who were managed for perinatal asphyxia at DGOPH from August 2015 to February 2020. Socio-demographic, perinatal, motor, nutritional and neuro-developmental out-of-hospital data were recorded. The assessment of the child’s psychomotor development was evaluated through gross motor skills, fine motor skills, language and social contact. We calculated the development quotient (DQ) by dividing the developmental age (DA) by the actual age (RA) of the patient. The data were entered and analyzed using excel and Stata version 15 software. Results: Among the 58 newborns included in our study, males were the most represented (59%). The mean age was 36.5 ± 14.16 months (Extremes: 12 months and 66 months). The majority of patients were born at term (79%), had a birth weight between 2500 and 4000 grams (69%), were resuscitated (95%), and had an Apgar score < 7 at the 5<sup>th</sup> minute of life (67%). SARNAT stages II and III counted for 48%. Neurodevelopmental abnormalities were found in 25.5% of patients with gross motor delay (mainly tetraparesis) representing 23.5%, fine motor delay 27.5%, impairment in social contact 31% language speech delay. The majority of the children had a normal development quotient (78.4%). Conclusion: The short-term and long-term outcome of newborns who experienced perinatal asphyxia in our setting is marked by numerous impairments in developmental milestones leading to disability.展开更多
Urinary epidermal growth factor (EGF) excretion in normal newborn as well as neonates with asphyxia was investigated by using radioimmunoassay,and serum creatinine (Scr) levels determined at the same time. The results...Urinary epidermal growth factor (EGF) excretion in normal newborn as well as neonates with asphyxia was investigated by using radioimmunoassay,and serum creatinine (Scr) levels determined at the same time. The results showed that in severe asphyxia group the ratio of urinary EGF to urinarycreatinine (Cr) (EGF/Cr), an index reflecting EGF excretion, was decreased on the first day (P<0. 05) and reached the lowest level on the third day (P<0.01).However, EGF/Cr values were decreased only on the third day in neonates with mild asphyxia (P<0. 05). On the seventh day. EGF/Cr values of neonates with asphyxia rose to normal. There were a negative correlation between urinary EGF/ Cr and Scr. It is suggested that EGF may play a role in the repair of acute renal injury after asphyxia and the detection of urinary EGF concentration is useful in the judgment of seventy of renal injury and in the evaluation of the recovery of renal tubule after injury.展开更多
Introduction: Our aim was to identify the risk factors of clinical birth asphyxia and subsequent newborn death in the presence of nuchal cord in a sub-Saharan Africa setting. Methodology: It was a six-months’ case-co...Introduction: Our aim was to identify the risk factors of clinical birth asphyxia and subsequent newborn death in the presence of nuchal cord in a sub-Saharan Africa setting. Methodology: It was a six-months’ case-control study involving 117 parturients whose babies presented with a nuchal cord at delivery. The study was carried out at the Yaoundé Gyneco-Obstetric and Pediatric Hospital, Cameroon, from January 1st to June 30th 2013. Results: The risk factors of clinical birth asphyxia identified were: first delivery, absence of obstetrical ultrasound during pregnancy, nuchal cord with more than one loop, duration of second stage of labor more than 30 minutes during vaginal delivery. The risk factors for newborn death from clinical birth asphyxia in the presence of nuchal cord were: maternal age Conclusion: We recommend a systematic obstetrical ultrasound before labor, so as to detect the presence of a nuchal cord, its tightness and the number of loops. Also, cesarean section should be considered when a nuchal cord is associated with first delivery, tightness or multiple looping.展开更多
目的应用畸变产物耳声发射(DPOAE)对窒息新生儿与正常新生儿进行听力筛查,比较其听力损失的发生率。方法使用MAICO ERO SCAN新生儿筛查型耳声发射仪对195例窒息新生儿和3002例正常新生儿进行DPOAE听力筛查。根据1分钟Apgar评分,将195例...目的应用畸变产物耳声发射(DPOAE)对窒息新生儿与正常新生儿进行听力筛查,比较其听力损失的发生率。方法使用MAICO ERO SCAN新生儿筛查型耳声发射仪对195例窒息新生儿和3002例正常新生儿进行DPOAE听力筛查。根据1分钟Apgar评分,将195例窒息新生儿分为轻度(177例)和重度(18例)窒息。窒息新生儿初筛在病情稳定后进行,正常新生儿在出生后1～5天进行,窒息新生儿通过及未通过者均于出生后1、3、6、12个月分别再测试,监测有无迟发性耳聋的发生;正常新生儿未通过者在出生后42天进行复筛,两组两次检测仍未通过者在出生后3个月时用听性脑干反应(ABR)、40Hz-AERP和声导抗进行诊断性听力评估。采用SPSS10.0软件进行统计学分析。结果 195例窒息新生儿,初筛通过148例,初筛通过率为75.90%(148/195),未通过47例,未通过率为24.10%(47/195);3002例正常新生儿,初筛通过2504例,初筛通过率为86.41%(2504/3002),正常新生儿初筛通过率显著高于窒息新生儿(P<0.01)。轻度窒息新生儿177例,初筛通过138例,初筛通过率77.97%(138/177),重度窒息新生儿18例,初筛通过10例,初筛通过率55.56%(10/18),轻度窒息新生儿初筛通过率高于重度窒息新生儿(P<0.05)。窒息新生儿复筛通过率为92.59%(25/27),正常新生儿复筛通过率为97.49%,两者差异无统计学意义(χ2=0.916,P>0.05)。确诊窒息新生儿听力损伤1例,听力损失检出率5.13‰(1/195);正常新生儿听力损失6例,听力损伤检出率为2.00‰(6/3002),两者差异无统计学意义(χ2=0.574,P>0.05)。结论正常新生儿听力初筛通过率显著高于窒息新生儿,复筛通过率两组无差异,窒息新生儿与正常新生儿听力损失检出率无显著性差异,DPOAE可作为窒息新生儿与正常新生儿听力筛查的一种有效方法。展开更多
文摘Background: Perinatal asphyxia is a common cause of mortality and of morbidity including motor and neurodevelopmental abnormalities. The aim of this study was to evaluate the post-hospital outcome of neonates treated for perinatal asphyxia at the Douala Gynaeco-Obstetric and Pediatric Hospital (DGOPH) in Cameroon. Patients and Methods: We conducted a hospital-based cross-sectional study with both a retrospective and prospective data collection, conducted over a period of 3 months and involving neonates above 34 weeks of gestational age who were managed for perinatal asphyxia at DGOPH from August 2015 to February 2020. Socio-demographic, perinatal, motor, nutritional and neuro-developmental out-of-hospital data were recorded. The assessment of the child’s psychomotor development was evaluated through gross motor skills, fine motor skills, language and social contact. We calculated the development quotient (DQ) by dividing the developmental age (DA) by the actual age (RA) of the patient. The data were entered and analyzed using excel and Stata version 15 software. Results: Among the 58 newborns included in our study, males were the most represented (59%). The mean age was 36.5 ± 14.16 months (Extremes: 12 months and 66 months). The majority of patients were born at term (79%), had a birth weight between 2500 and 4000 grams (69%), were resuscitated (95%), and had an Apgar score < 7 at the 5<sup>th</sup> minute of life (67%). SARNAT stages II and III counted for 48%. Neurodevelopmental abnormalities were found in 25.5% of patients with gross motor delay (mainly tetraparesis) representing 23.5%, fine motor delay 27.5%, impairment in social contact 31% language speech delay. The majority of the children had a normal development quotient (78.4%). Conclusion: The short-term and long-term outcome of newborns who experienced perinatal asphyxia in our setting is marked by numerous impairments in developmental milestones leading to disability.
文摘Urinary epidermal growth factor (EGF) excretion in normal newborn as well as neonates with asphyxia was investigated by using radioimmunoassay,and serum creatinine (Scr) levels determined at the same time. The results showed that in severe asphyxia group the ratio of urinary EGF to urinarycreatinine (Cr) (EGF/Cr), an index reflecting EGF excretion, was decreased on the first day (P<0. 05) and reached the lowest level on the third day (P<0.01).However, EGF/Cr values were decreased only on the third day in neonates with mild asphyxia (P<0. 05). On the seventh day. EGF/Cr values of neonates with asphyxia rose to normal. There were a negative correlation between urinary EGF/ Cr and Scr. It is suggested that EGF may play a role in the repair of acute renal injury after asphyxia and the detection of urinary EGF concentration is useful in the judgment of seventy of renal injury and in the evaluation of the recovery of renal tubule after injury.
文摘Introduction: Our aim was to identify the risk factors of clinical birth asphyxia and subsequent newborn death in the presence of nuchal cord in a sub-Saharan Africa setting. Methodology: It was a six-months’ case-control study involving 117 parturients whose babies presented with a nuchal cord at delivery. The study was carried out at the Yaoundé Gyneco-Obstetric and Pediatric Hospital, Cameroon, from January 1st to June 30th 2013. Results: The risk factors of clinical birth asphyxia identified were: first delivery, absence of obstetrical ultrasound during pregnancy, nuchal cord with more than one loop, duration of second stage of labor more than 30 minutes during vaginal delivery. The risk factors for newborn death from clinical birth asphyxia in the presence of nuchal cord were: maternal age Conclusion: We recommend a systematic obstetrical ultrasound before labor, so as to detect the presence of a nuchal cord, its tightness and the number of loops. Also, cesarean section should be considered when a nuchal cord is associated with first delivery, tightness or multiple looping.
文摘目的应用畸变产物耳声发射(DPOAE)对窒息新生儿与正常新生儿进行听力筛查,比较其听力损失的发生率。方法使用MAICO ERO SCAN新生儿筛查型耳声发射仪对195例窒息新生儿和3002例正常新生儿进行DPOAE听力筛查。根据1分钟Apgar评分,将195例窒息新生儿分为轻度(177例)和重度(18例)窒息。窒息新生儿初筛在病情稳定后进行,正常新生儿在出生后1～5天进行,窒息新生儿通过及未通过者均于出生后1、3、6、12个月分别再测试,监测有无迟发性耳聋的发生;正常新生儿未通过者在出生后42天进行复筛,两组两次检测仍未通过者在出生后3个月时用听性脑干反应(ABR)、40Hz-AERP和声导抗进行诊断性听力评估。采用SPSS10.0软件进行统计学分析。结果 195例窒息新生儿,初筛通过148例,初筛通过率为75.90%(148/195),未通过47例,未通过率为24.10%(47/195);3002例正常新生儿,初筛通过2504例,初筛通过率为86.41%(2504/3002),正常新生儿初筛通过率显著高于窒息新生儿(P<0.01)。轻度窒息新生儿177例,初筛通过138例,初筛通过率77.97%(138/177),重度窒息新生儿18例,初筛通过10例,初筛通过率55.56%(10/18),轻度窒息新生儿初筛通过率高于重度窒息新生儿(P<0.05)。窒息新生儿复筛通过率为92.59%(25/27),正常新生儿复筛通过率为97.49%,两者差异无统计学意义(χ2=0.916,P>0.05)。确诊窒息新生儿听力损伤1例,听力损失检出率5.13‰(1/195);正常新生儿听力损失6例,听力损伤检出率为2.00‰(6/3002),两者差异无统计学意义(χ2=0.574,P>0.05)。结论正常新生儿听力初筛通过率显著高于窒息新生儿,复筛通过率两组无差异,窒息新生儿与正常新生儿听力损失检出率无显著性差异,DPOAE可作为窒息新生儿与正常新生儿听力筛查的一种有效方法。
