Objective:To develop the missing link between hyperuricemia and hypertension.Methods:The study was conducted in Department of Biochemistry in collaboration with Nephrology Unit of Internal Medicine Department.Hyperten...Objective:To develop the missing link between hyperuricemia and hypertension.Methods:The study was conducted in Department of Biochemistry in collaboration with Nephrology Unit of Internal Medicine Department.Hypertension was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National Committee.Totally 205newly diagnosed and untreated essential hypertensive cases and age-sex matched nonnotensive controls were enrolled in the study.The potential confounding factors of hyperuricemia and hypertension in both cases and controls were controlled.Uric acid levels in all participants were analyzed.Results:Renal function between newly diagnosed hypertensive cases and nonnotensive healthy controls were adjusted.The mean serum uric acid observed in newly diagnosed hypertensive cases and in nonnotensive healthy controls were(290.05±87.03)μmol/L and(245.24±09.38)μmol/L respectively.A total of 59(28.8%)participants of cases and 28(13.7%)participants of controls had hyperuricemia(odds ratio 2.555(95%CI:1.549-4.213),P<0.00l).Conclusions:The mean serum uric acid leveb and number of hyperuricemic subjects were found to be significantly higher in cases when compared to controls.展开更多
Background: The aim of this study was to investigate the occurrence of subclinical atherosclerosis, evaluated by carotid artery intima-media thickness (CIMT) in subjects with newly diagnosed type 2 diabetes. Methods: ...Background: The aim of this study was to investigate the occurrence of subclinical atherosclerosis, evaluated by carotid artery intima-media thickness (CIMT) in subjects with newly diagnosed type 2 diabetes. Methods: A total of 167 subjects, 50 newly diagnosed type 2 diabetic subjects and 117 non-diabetic subjects were included in the study. Obese and overweight newly diagnosed type 2 diabetic patients were matched for age and BMI with obese and overweight non-diabetic subjects. Only postmenopausal women were selected. The following biomarkers were analyzed: fasting glucose, HbA1c, fasting insulin, fasting proinsulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, adiponectin, leptin, hs-CRP, urine albumin/creatinine ratio. 75 g oral glucose tolerance test was performed in all subjects. Ultrasound imaging was used to evaluate IMT of the common carotid artery. Results: CIMT was greater in newly diagnosed type 2 patients compared to non-diabetic subjects. When analyzed by BMI, the difference regarding CIMT between diabetic and non-diabetic subjects was significant only in overweight subjects, in both sexes. In univariate analysis in men with newly diagnosed type 2 diabetes, CIMT was positively correlated with age, SBP, triglycerides, leptin and negatively correlated with HDL-cholesterol and in women CIMT was positively correlated with SBP and leptin. Independent determinants of CIMT in patients with newly diagnosed type 2 diabetes were in men age (β = 0.556, p = 0.0028) and log leptin (β = 0.393, p = 0.049) and in women systolic blood pressure (β = 0.48, p = 0.026). Conclusions: Subclinical atherosclerosis is present in newly diagnosed type 2 diabetic subjects. Body fat accumulation in men and hypertension in postmenopausal women have a primary role in increase carotid intima-media thickness.展开更多
Objective:To investigate the effect of liraglutide combined with basal insulin on blood glucose control, lipid metabolism and oxidative stress in patients with newly diagnosed type 2 diabetes mellitus complicated by o...Objective:To investigate the effect of liraglutide combined with basal insulin on blood glucose control, lipid metabolism and oxidative stress in patients with newly diagnosed type 2 diabetes mellitus complicated by obesity.Methods: A total of 58 patients with newly diagnosed type 2 diabetes mellitus complicated by obesity who were diagnosed and treated in Xi'an No. 4 Hospital between February 2017 and August 2017 were divided into the control group (n=29) who received basal insulin therapy and the liraglutide group (n=29) who received liraglutide combined with basal insulin therapy according to random number table. The differences in the levels of glycolipid metabolism indexes and the contents of oxidative stress indexes were compared between the two groups before and after treatment.Results: Before treatment, the differences in the levels of glycolipid metabolism indexes in peripheral blood and the contents of oxidative stress indexes in serum were not statistically significant between the two groups. After 1 month of treatment, glucose metabolism indexes FBG and HOMA-IR levels in peripheral blood of liraglutide group were lower than those of control group;lipid metabolism indexes TC, TG, ApoB levels in peripheral blood were lower than those of control group, ApoA1 level was higher than those of control group;serum oxidation indexes MDA and LHP contents were lower than those of control group whereas anti-oxidation indexes GSH-Px and T-AOC contents were higher than those of control group.Conclusion: Liraglutide combined with basal insulin therapy can further control the glucolipid metabolism levels and inhibit the systemic oxidative stress response in patients with newly diagnosed type 2 diabetes mellitus complicated by obesity.展开更多
目的探讨治疗前血浆D-二聚体水平在初诊弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)患者预后判断中的价值。方法回顾性分析2016年1月至2022年1月浙江大学医学院附属金华医院收治的156例初诊DLBCL患者的临床资料,采用受试...目的探讨治疗前血浆D-二聚体水平在初诊弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)患者预后判断中的价值。方法回顾性分析2016年1月至2022年1月浙江大学医学院附属金华医院收治的156例初诊DLBCL患者的临床资料,采用受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)确定治疗前血浆D-二聚体的最佳临界值,并根据临界值将患者分为低水平组和高水平组。比较两组患者的凝血功能指标、临床病理特征、总生存(overall survival,OS)及无进展生存(progression free survival,PFS)的差异,采用单因素及多因素Cox回归分析初诊DLBCL患者临床病理特征与预后的关系。结果两组患者的美国东部肿瘤协作组评分、国际预后指数评分、Ann Arbor分期、血红蛋白、结外病灶数目、B症状等比较差异均有统计学意义(P<0.05);高水平组患者的凝血酶原时间显著长于低水平组(P<0.05);高水平组患者的3年OS率显著低于低水平组(67.1%vs.86.7%,χ^(2)=11.152,P=0.001),3年PFS率显著低于低水平组(56.8%vs.74.3%,χ^(2)=5.371,P=0.020)。多因素Cox回归分析显示,D-二聚体≥858μg/L是影响初诊DLBCL患者OS的独立危险因素(P<0.05)。结论治疗前血浆D-二聚体升高与DLBCL患者生存不良有关,是初诊DLBCL患者OS的独立不良预后因子。展开更多
目的探讨水飞蓟宾治疗初诊2型糖尿病(T2DM)伴非酒精性脂肪肝(NAFLD)对患者肝纤维化进程、糖脂代谢紊乱的调节效果。方法选取2016年1月—2019年1月湖南省脑科医院收治的93例初诊T2DM伴NAFLD患者作为研究对象,采用随机数字表分为观察组47...目的探讨水飞蓟宾治疗初诊2型糖尿病(T2DM)伴非酒精性脂肪肝(NAFLD)对患者肝纤维化进程、糖脂代谢紊乱的调节效果。方法选取2016年1月—2019年1月湖南省脑科医院收治的93例初诊T2DM伴NAFLD患者作为研究对象,采用随机数字表分为观察组47例和对照组46例。两组患者均采取运动、饮食干预+二甲双胍治疗,观察组同时服用水飞蓟宾治疗;对比两组治疗前后的空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、三酰甘油(TG)、脂联素、瘦素、白细胞介素-6(IL-6)、超氧化物歧化酶(SOD)、Ⅲ型前胶原肽(Ⅲ-PC)、层黏蛋白(LN)、透明质酸(HA)、肝脏彩超评分及不良反应。结果治疗前,两组FPG、2 h PG、HbA1c、HOMA-IR、TC、TG、脂联素、瘦素、IL-6、SOD、彩超评分、Ⅲ-PC、LN、HA测定值比较,差异无统计学意义(P>0.05);治疗后,两组FPG、2 h PG、HbA1c、HOMA-IR、TC、TG、瘦素、IL-6、彩超评分、Ⅲ-PC、LN、HA较治疗前均降低,脂联素、SOD水平较治疗前均升高(均P<0.05),且观察组的TC、TG、瘦素、IL-6、彩超评分、Ⅲ-PC、LN、HA低于对照组,脂联素、SOD水平高于对照组(均P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论T2DM伴NAFLD患者采用水飞蓟宾联合运动、饮食干预+二甲双胍治疗在良好的控制血糖基础上,还能抑制肝纤维化进程,调节糖脂代谢紊乱,临床效果值得肯定。展开更多
基金Supported by Department of Biochemistry,Institute of Medicine.Tribhuvan University Teaching Hospital,Kathmandu.Nepal(Grant No.30-956/2013CEA)
文摘Objective:To develop the missing link between hyperuricemia and hypertension.Methods:The study was conducted in Department of Biochemistry in collaboration with Nephrology Unit of Internal Medicine Department.Hypertension was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National Committee.Totally 205newly diagnosed and untreated essential hypertensive cases and age-sex matched nonnotensive controls were enrolled in the study.The potential confounding factors of hyperuricemia and hypertension in both cases and controls were controlled.Uric acid levels in all participants were analyzed.Results:Renal function between newly diagnosed hypertensive cases and nonnotensive healthy controls were adjusted.The mean serum uric acid observed in newly diagnosed hypertensive cases and in nonnotensive healthy controls were(290.05±87.03)μmol/L and(245.24±09.38)μmol/L respectively.A total of 59(28.8%)participants of cases and 28(13.7%)participants of controls had hyperuricemia(odds ratio 2.555(95%CI:1.549-4.213),P<0.00l).Conclusions:The mean serum uric acid leveb and number of hyperuricemic subjects were found to be significantly higher in cases when compared to controls.
文摘Background: The aim of this study was to investigate the occurrence of subclinical atherosclerosis, evaluated by carotid artery intima-media thickness (CIMT) in subjects with newly diagnosed type 2 diabetes. Methods: A total of 167 subjects, 50 newly diagnosed type 2 diabetic subjects and 117 non-diabetic subjects were included in the study. Obese and overweight newly diagnosed type 2 diabetic patients were matched for age and BMI with obese and overweight non-diabetic subjects. Only postmenopausal women were selected. The following biomarkers were analyzed: fasting glucose, HbA1c, fasting insulin, fasting proinsulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, adiponectin, leptin, hs-CRP, urine albumin/creatinine ratio. 75 g oral glucose tolerance test was performed in all subjects. Ultrasound imaging was used to evaluate IMT of the common carotid artery. Results: CIMT was greater in newly diagnosed type 2 patients compared to non-diabetic subjects. When analyzed by BMI, the difference regarding CIMT between diabetic and non-diabetic subjects was significant only in overweight subjects, in both sexes. In univariate analysis in men with newly diagnosed type 2 diabetes, CIMT was positively correlated with age, SBP, triglycerides, leptin and negatively correlated with HDL-cholesterol and in women CIMT was positively correlated with SBP and leptin. Independent determinants of CIMT in patients with newly diagnosed type 2 diabetes were in men age (β = 0.556, p = 0.0028) and log leptin (β = 0.393, p = 0.049) and in women systolic blood pressure (β = 0.48, p = 0.026). Conclusions: Subclinical atherosclerosis is present in newly diagnosed type 2 diabetic subjects. Body fat accumulation in men and hypertension in postmenopausal women have a primary role in increase carotid intima-media thickness.
文摘Objective:To investigate the effect of liraglutide combined with basal insulin on blood glucose control, lipid metabolism and oxidative stress in patients with newly diagnosed type 2 diabetes mellitus complicated by obesity.Methods: A total of 58 patients with newly diagnosed type 2 diabetes mellitus complicated by obesity who were diagnosed and treated in Xi'an No. 4 Hospital between February 2017 and August 2017 were divided into the control group (n=29) who received basal insulin therapy and the liraglutide group (n=29) who received liraglutide combined with basal insulin therapy according to random number table. The differences in the levels of glycolipid metabolism indexes and the contents of oxidative stress indexes were compared between the two groups before and after treatment.Results: Before treatment, the differences in the levels of glycolipid metabolism indexes in peripheral blood and the contents of oxidative stress indexes in serum were not statistically significant between the two groups. After 1 month of treatment, glucose metabolism indexes FBG and HOMA-IR levels in peripheral blood of liraglutide group were lower than those of control group;lipid metabolism indexes TC, TG, ApoB levels in peripheral blood were lower than those of control group, ApoA1 level was higher than those of control group;serum oxidation indexes MDA and LHP contents were lower than those of control group whereas anti-oxidation indexes GSH-Px and T-AOC contents were higher than those of control group.Conclusion: Liraglutide combined with basal insulin therapy can further control the glucolipid metabolism levels and inhibit the systemic oxidative stress response in patients with newly diagnosed type 2 diabetes mellitus complicated by obesity.
文摘目的探讨水飞蓟宾治疗初诊2型糖尿病(T2DM)伴非酒精性脂肪肝(NAFLD)对患者肝纤维化进程、糖脂代谢紊乱的调节效果。方法选取2016年1月—2019年1月湖南省脑科医院收治的93例初诊T2DM伴NAFLD患者作为研究对象,采用随机数字表分为观察组47例和对照组46例。两组患者均采取运动、饮食干预+二甲双胍治疗,观察组同时服用水飞蓟宾治疗;对比两组治疗前后的空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、三酰甘油(TG)、脂联素、瘦素、白细胞介素-6(IL-6)、超氧化物歧化酶(SOD)、Ⅲ型前胶原肽(Ⅲ-PC)、层黏蛋白(LN)、透明质酸(HA)、肝脏彩超评分及不良反应。结果治疗前,两组FPG、2 h PG、HbA1c、HOMA-IR、TC、TG、脂联素、瘦素、IL-6、SOD、彩超评分、Ⅲ-PC、LN、HA测定值比较,差异无统计学意义(P>0.05);治疗后,两组FPG、2 h PG、HbA1c、HOMA-IR、TC、TG、瘦素、IL-6、彩超评分、Ⅲ-PC、LN、HA较治疗前均降低,脂联素、SOD水平较治疗前均升高(均P<0.05),且观察组的TC、TG、瘦素、IL-6、彩超评分、Ⅲ-PC、LN、HA低于对照组,脂联素、SOD水平高于对照组(均P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论T2DM伴NAFLD患者采用水飞蓟宾联合运动、饮食干预+二甲双胍治疗在良好的控制血糖基础上,还能抑制肝纤维化进程,调节糖脂代谢紊乱,临床效果值得肯定。
