Four new complexes: [Cu(NFA)(H2O)(8-HQ)] ClO4·H2O,[Cu(NFA)(Bipy)(H2O)]2ClO4·2.5H2O,[Cu(NFA)(Dafo)2(ClO4)] ClO4·7.5H2O and [Cu(NFA)(5,6-Dione)2 ] 2ClO4·9.5H2O(NFA= Norfloxacin,8-HQ=8 –hydroxyquinol...Four new complexes: [Cu(NFA)(H2O)(8-HQ)] ClO4·H2O,[Cu(NFA)(Bipy)(H2O)]2ClO4·2.5H2O,[Cu(NFA)(Dafo)2(ClO4)] ClO4·7.5H2O and [Cu(NFA)(5,6-Dione)2 ] 2ClO4·9.5H2O(NFA= Norfloxacin,8-HQ=8 –hydroxyquinoline,Bipy =2,2’-bipyridyl,Dafo =4,5-diazofluorene-9-ketone,and 5,6-Dione = 1,10-phenanthroline-5,6-dione),are synthesized and characterized by elemental analysis,molar conductivity,IR and Uv-vis spectroscopes.The interaction between the complexes and CT-DNA has been studied by fluorescence and UV spectra.The complexes are assayed against gram-positive and gram-negative bacteria by punch method.The results indicate that the complexes can interact with DNA by partial intercalation,and have strong antibacterial activities.展开更多
文摘Four new complexes: [Cu(NFA)(H2O)(8-HQ)] ClO4·H2O,[Cu(NFA)(Bipy)(H2O)]2ClO4·2.5H2O,[Cu(NFA)(Dafo)2(ClO4)] ClO4·7.5H2O and [Cu(NFA)(5,6-Dione)2 ] 2ClO4·9.5H2O(NFA= Norfloxacin,8-HQ=8 –hydroxyquinoline,Bipy =2,2’-bipyridyl,Dafo =4,5-diazofluorene-9-ketone,and 5,6-Dione = 1,10-phenanthroline-5,6-dione),are synthesized and characterized by elemental analysis,molar conductivity,IR and Uv-vis spectroscopes.The interaction between the complexes and CT-DNA has been studied by fluorescence and UV spectra.The complexes are assayed against gram-positive and gram-negative bacteria by punch method.The results indicate that the complexes can interact with DNA by partial intercalation,and have strong antibacterial activities.
