Influence of the Agreement on Enhancing International Arctic Scientific Cooperation on the approach of non-Arctic states to Arctic scientific activities

As the third legally-binding instrument of the Arctic Council, the Agreement on Enhancing International Arctic Scientific Cooperation was signed in May 2017 and entered into force on 23 May 2018. The Agreement not only reduces obstacles to the international scientific cooperation and promotes the movement of people and equipment across borders for the effective and efficient development of Arctic scientific knowledge, but also provides an improved international Arctic legal environment for conducting Arctic scientific cooperation based on UNCLOS and institutional arrangements. However, the observer states, the NGOs and IGOs, as well as Permanent Participants are rarely mentioned in this Agreement. This article chooses one group, non-Arctic states, as a case in point in order to critically discuss the influence of this new Arctic scientific cooperation agreement. It argues that the non-Arctic states are left behind at the original legal situation and trapped in an inferior status in Arctic science. Under these circumstances, this article suggests that non-Arctic states, especially those with competitive research abilities, should appeal for amendment of the Agreement to allow wider access to research areas and data sharing, especially when cooperating with the eight-member states of the Arctic Council. Also, non-Arctic states should take the Agreement as the reference when signing bilateral agreements with Arctic states so as to safeguard their interests when conducting Arctic scientific activities. Moreover, the active participation in other fora as well as various bilateral scientific projects can assist non-Arctic states to strengthen the relations with the Arctic states and build trust in the Arctic Council.

肥胖儿童non-HDL-C、remnant cholesterol与亚临床动脉粥样硬化的关系

目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化(AS)的关系。方法:根据甘油三酯(TG)水平将65例肥胖儿童(肥胖组)分为I组(TG≥2.3 mmol/L)32例,II组(TG<2.3 mmol/L)33例,与肥胖组儿童性别年龄相匹配的正常体质量儿童30例为III组(对照组)。比较3组儿童血脂指标,对肥胖组各项血脂指标与血浆致动脉粥样硬化指数(AIP)进行相关性分析,肥胖患儿体质指数、血脂指标与颈动脉内径、内膜-中层厚度(c-IMT)、血流参数进行相关性分析。结果:I组、II组的TG、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、non-HDL-C、remnant cholesterol、AIP均较对照组升高,高密度脂蛋白胆固醇(HDL-C)较对照组降低,且I组的remnant cholesterol、AIP均较II组升高。肥胖组儿童AIP与TG、non-HDL-C、remnant cholesterol呈正相关,与HDL-C呈负相关。37例行颈动脉超声检查的肥胖儿童的c-IMT较正常儿童的增厚。结论:non-HDL-C、remnant cholesterol在肥胖儿童亚临床AS中有重要作用,在肥胖儿童血脂异常的治疗中应关注non-HDL-C、remnant cholesterol的变化。

Non-3GPP对EPS的安全接入研究

Non-3GPP网络安全接入EPS是未来异构网络融合的重要基础。本文介绍了Non-3GPP网络接入时EPS系统的安全架构、可信的Non-3GPP网络接入EPS系统的认证机制、密钥协商流程等。

Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer： a meta-analysis

Objective： To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin（GP） in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods： we performed a systematicsearch in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database,Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database andWanfang Database up to 30 January 2017. Randomized controlled trials （RCT） of Shenqi Fuzheng Injectioncombined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs wereconducted on methodological quality assessment. Data extraction and data analysis were according to standards ofCochrane systematic review. Results： Eight trials were included including a total of 701 patients. Meta-analysisresults： Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functionalstatus of patients with NSCLC （OR = 3.44, 95% CI [2.26, 5.25], P 〈 0.0001） and clinical treatment efficacy （OR =（OR = 0.31, 95%CI [0.20, 0.47], P 〈 0.0001. The rate of leukopenia （OR = .31, 95%CI [0.20,0.47], P 〈 0.0001）,thrombocytopenia （OR = 0.58, 95%CI [0.37, 0.91], P = 0.020）, hemoglobin decline （（OR = 0.31, 95%CI [0.16,0.59], P = 0.0004） and incidence of gastrointestinal reactions （OR = 0.58,P 〈 0.05） could be reduced. Conclusion：Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtainedsignificantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-qualityresearch to further prove.

Analysis of Numerical Results in High Temperature Congealment and Chemistry Non-equilibrium Flow Field

Using the air plasma ignition technique, physicochemical process of burning can be accelerated; concentration limit ofretrofires both can be extended; reliability of retrofires and stability of burning can be improved. In this paper, using internalequivalent heat area in place of electric are that created Ohm heat, the flow fields of thermodynamic equilibrium chemistry con-gealment and chemistry non-equilibrium in the plasma generator were simulated. The influences of the inlet prerotation angleof air, the inlet total pressure of air and the airflow compression angle of spray nozzle on the temperature on the surface of elec-

Turbulent Flow Action of Pulp in Wet - Laid Non - Woven Processes

The paper deals with the fluid field of web forming in wet-laid non-woven production.The influence of the turbulent flow on blending fiber and occluded fluid produced in pulp flow has been discussed in theory and practice.The suitable use of the imported velocity of pulp is very important in producing wet-laid products of good quality.

CYFRA 21-1 as an early predictor of first line chemotherapy response in advanced non small cell lung cancer

Objective： In an era of ever evolving, promising new therapies for advanced non small cell lung cancer （NSCLC）, early predictors of response to therapy, are needed. We evaluated early variations in CYFRA 21-1 serum levels of patients with advanced NSCLC receiving first line chemotherapy and correlated the results with objective tumor response. Methods： 29 consecutive, previously untreated, patients of advanced non small cell lung cancer, with measurable disease on CT scan were evaluated. All patients were treated with conventional systemic chemotherapy, although the choice of chemotherapy was left to the discretion of the treating physicians. Serum samples were obtained immediately before the start of 1st and 2nd cycles of chemotherapy. CYFRA 21-1 was measured with an electrochemiluminescense immunoassay on an automatic analyzer （Elecsys 2000; Roche Diagnostics）. Response was evaluated using Response evaluation criteria in solid tumors （RECIST） criteria. Results： 10 patients had partial response, 9 patients had stable disease and 9 had progressive disease. None of the patients had complete response. 21/29 （72%） patients had an elevated baseline value of CYFRA 21-1.62% patients （18/29） had a decrease in CYFRA 21-1 after 1 cycle of chemotherapy. The average reduction in the 2nd reading was irrespective of whether baseline value was normal or not. The average reduction was statistically significant （P = 0.002; 95% CI, from 0.8369 to 3.49464; t test）. 8 out of 10 （80%） patients with partial response had a reduction in their 2nd reading of. CYFRA （P = 0.019; 95% CI, from 0.81965 to 7.20035; t test） which was significant. We also observed that 6/9 （66%） patients whose disease remains stable also had a decrease in their subsequent reading （P = 0.0106; 95% CI, from -0.44942 to 3.82720; t test）, though it was not significant statistically. Although 5 out of 9 （55%） patients, who had an increase in their CYFRA 21-1 level, had progressive disease, but it was not statistically significant （P = 0.537; 95% CI, from -1.20021 to 2.13354; ttest）. 14 out of 19 （73%） who either had partial response or had stable disease, had a reduction in their 2nd value of CYFRA 21-1 and was significant statistically （P = 0.004; 95% CI, from 0.74792 to 3.50208; t test）. We also observed that except for 1 patient, all patients who had a decrease of 42% or more in their subsequent CYFRA 21-1 level, were those who had either responded to chemotherapy or had stable disease （P = 0.001）, which was statistically significant. Conclusion： We can conclude that monitoring of serum marker CYFRA 21-1, early dudng first-line chemotherapy may be a useful prognostic tool for evaluation of early tumor response in patients with advanced NSCLC.

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.

《美墨加协定》“毒丸条款”法律性质之辨析

《美墨加协定》第32.10条强行赋予缔约方不得与一个“非市场经济国家”达成自由贸易协定的单向性义务。从性质上讲,该条款属于“驱逐”条款,而非“退出”条款,目的在于迫使缔约方与中国作切割,因为美国、墨西哥、加拿大三国目前都未正式承认中国为市场经济国家。美国政府官员也毫不讳言将此视为孤立中国的“毒丸条款”。面对以美国为首的西方国家推出的涉华贸易制裁新措施,我们需要正视“非市场经济国家”概念背后的法律逻辑和随之而来的救济难度。在美国力图架空WTO规则的背景下,解析“毒丸条款”的非法性对于我们认清贸易保护主义本质和捍卫多边贸易体制具有重要意义。与此同时,中国也可以通过积极加入区域贸易协定来化解涉华贸易制裁带来的消极影响。

互不挖人协议《反垄断法》规制的理据与进路

认定和规制互不挖人协议,是《反垄断法》亟须回应的现实问题。互不挖人协议分为横向互不挖人协议与纵向互不挖人协议。其中,纵向互不挖人协议兼具横向垄断协议与纵向垄断协议的部分特征,故超出了《反垄断法》的规制框架。回归垄断协议的实质性判断标准,运用劳动经济学分析工具,可证成互不挖人协议的《反垄断法》规制正当性。借鉴域外经验,回归我国劳动力市场特征,可从短期、长期两个角度为我国互不挖人协议的《反垄断法》规制找到理想路径。在未来的法律修订中,《反垄断法》应从价值目标、分析方法、豁免规则三个方面作出整全的制度回应:一是明确劳动者利益保护之立场,二是重设相关市场之分析方法,三是调整针对垄断协议的豁免规则。

行政协议非诉执行制度的审视与完善--以《行政协议司法解释》第24条第2款为对象

《行政协议司法解释》第24条第2款规定了以“行政处理决定”为前置程序的行政协议非诉执行制度。而“监督履行职权”属于行政优益权的应有之义,作出“要求履行协议书面决定”或“行政处理决定”属于行政机关自由裁量权范围。《行政协议司法解释》第24条第2款应当与第1款合并为一款。基于行政协议的契约性,作为行政协议非诉执行制度前置程序之一的“行政处理决定”不得独立为行政相对人增设义务。为保障行政相对人合法性程序权利,行政协议非诉执行制度应当确立事前告知制度、说明理由制度与听证制度。

非涉外协议管辖制度的裁判规则与实务指引——基于2023年最高人民法院裁判文书的实证研究

协议管辖制度作为我国民事诉讼法中的重要制度,其法律规定相对稳定,仅于2012年增加了“实际联系原则”作为兜底性条款。鉴于目前国内学界对协议管辖制度的研究主要集中于涉外协议管辖领域,对非涉外协议管辖领域的关注较少且多集中在规范研究,本文通过描述性统计的方法对最高人民法院2023年涉及协议管辖的案件进行实证研究,从案由、争议焦点、协议管辖适用结果、裁定适用法律依据等角度对存在共同特征的案件之裁判规则进行分析;同时,针对上述裁判规则,对民事主体订立管辖协议条款时应关注的问题作出了实务指引,力求使管辖协议或协议管辖条款能够在诉讼解决的过程中得到适用。

互不挖角协议的反垄断法规制

互不挖角协议发生于劳动力市场,是用人单位之间达成的不招揽或雇佣对方员工的合意。互不挖角协议具有降低生产成本、稳定劳动力竞争秩序的价值,但同时也会产生减损劳动力市场和产品市场竞争、扭曲竞争和交易公平、降低市场效率的垄断后果,并最终损害消费者福利和社会公共利益。基于对互不挖角协议的竞争损害和反垄断法适用性的不确定,大多数法域对以反垄断法规制互不挖角协议尚持慎重态度。实际上,互不挖角协议对竞争的损害确有规制必要。反垄断法存在规制互不挖角协议的现实需求,且相较于其他规制手段更具效益优势,因而是互不挖角协议最适当的规制手段。在我国之后可能的制度设计中,还可以考虑对互不挖角协议分类设计具体规则,并引入相关性分析手段,以提升反垄断法规制互不挖角协议的实效。

行政协议非诉执行司法审查规则的检视与重构

在单向诉讼结构下,行政非诉执行成为行政机关诉请行政相对人按照协议履行约定的唯一救济方式。但行政协议非诉执行司法审查过程中却存在非诉执行主体与行政协议主体不对应、执行对象与审查标的不同一、各地审查强度参差不齐和制度的控权功能与司法实效耦合度低四大问题。究其原因,主要集中于法律进程滞后于社会治理发展的客观窒碍、行政协议自愿性与非诉执行强制性的正面对撞及现有具体规则无法满足行政协议非诉执行审查需求三个方面。为此,建议围绕启动要件、审查程序和裁判规则三个审查节点,构建区别于一般非诉执行、适合行政协议非诉执行案件的司法审查规则。

论美欧FTAs数字产品非歧视待遇规制模式

在全球数字治理进程中,区域贸易协定下的数字经贸规则在推动数字法治的同时,受制于其孤岛化与碎片化的固有特性,难以避免地围绕着区域贸易主导国的经济诉求,相继形成区域性的数字贸易规则模板。数字产品非歧视待遇领域也不例外,无论是独立条款下的美式规制模式,还是普通条款下的欧式规制模式,其规则偏好的本质都是国家利益诉求的差异化。因此,当我国面对这两种截然相反的规制进路时,结合条款本身的前瞻性与国家数字经济发展战略,可以得出我国应当选择独立的数字产品非歧视待遇条款的结论,并通过例外条款的具体适用分析,实现对数字产品开放与保护并济的双重目标。

竞业限制协议泛化背景下协议效力审查规则探究

我国通常只针对掌握商业秘密的高级管理人员、高级技术人员和其他负有保密义务的员工实施竞业限制。然而,目前有部分企业随意扩大竞业协议适用主体,将限制措施无差别地应用于所有员工,打击了劳动者就业创业的积极性。法院在确认竞业限制协议效力时,面临立法和司法2个方面的问题。立法上,过于强调当事人之间的意思自治,法律规定不够明晰;司法上,法院往往倾向于维护用人单位的利益,呈现重形式审查而忽视实质审查的倾向。因此,为了有效规范竞业限制协议,重构协议效力的审查规则迫在眉睫。文章认为,应引入“合理性”审查标准,对协议的适用主体、期限、范围、经济补偿条款等方面进行实质性审查,以更好地平衡用人单位与劳动者之间的利益。

FAREY SEQUENCE OF NONLINEAR DIFFERENTIAL DYNAMIC SYSTEM IN TWO DIMENSIONS

In this paper , through the discrim ination of Farey sequence in the forced Brusselator withweak coupling , it is proved that there is a topological translation fro m a nonlinear differen tial system ( limit cycle) to the circle m ap .

竞业限制协议滥用反垄断规制的理论检证

用以维护企业商业秘密和防止“搭便车”的竞业限制协议,可能被滥用而异化为排除、限制竞争行为,但劳动法内部的规则调适无法抵消协议的反竞争效果,且当前也缺乏取缔竞业限制制度的实践基础与学理支撑。相比之下,反垄断法的介入有其正当性:公共利益理念构成竞业限制协议滥用反垄断规制的法理基础,同等准用于劳动力市场竞争秩序的维护阐释了反垄断法适用的实践逻辑。但是,竞业限制的反垄断法规制有其功能限度,因而应当确立保护竞争过程、关照劳动者福利的价值目标,进而通过竞争影响合理分析的个案化考量,实现反垄断法和既有规制路径之间的合理调适。

The post-Paris approach to mitigating Arctic warming——perspectives from shipping emissions reduction

The availability of increased Arctic shipping as a consequence of sea ice decline is a regional issue that is closely linked with international climate governance and global governance of the maritime industry. Sea ice decline creates favorable circumstances for the development of merchant shipping, but is accompanied by increases in greenhouse gas emissions. Reduction of greenhouse gas emissions from the shipping industry is of utmost importance to prevent the destruction of the fragile Arctic ecosystem. This paper focuses on the core content of the Paris Agreement and suggests that the International Maritime Organization could guide the shipping industry to reach a fair agreement with states that includes market-based measures, capacity building, and voluntary actions of shipping companies as non-state actors.

Ways to Overcome Anxiety in the English Listening Class in College (SUN JING-YU KE SU-FEN)

In my ten-yeat experience of tenching English as major in college , I feel that students experience more difficulties in listening lessons than in other lessons. What, then, prevents students from achieving success in the listening class? I suggest that anxiety is one of the major factors, which interferes with students listening comprehension. And I would agree with writers such as Gardner and Horwitz et al. (1991)that anxiety may impede learner’s ability to perform successfully in all aspects of learning a foreign language. I feet it is particularly significant for listening.